Clinical trials: Vascular Occlusive Disease
Transient Ischemic Attack, Vascular Cognitive Impairment
Reshaping the Path of Vascular Cognitive Impairment (VCI)
The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter health and improving cognitive…
- Conditions
- Transient Ischemic Attack, Vascular Cognitive Impairment, Subcortical Vascular Dementia
- Trial name
- NCT02669394
- Testing
- Resistance exercise training, Control: stretching and relaxation program
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of British Columbia
Acute Ischemic Stroke
Efficacy and Safety of Human Urinary Kallidinogenase Combined With Endovascular Therapy in Acute Ischemic Stroke With Large Vessel Occlusion
The purpose of this study is to evaluate the safety and efficacy of Human Urinary Kallidinogenase combined with endovascular therapy in acute ischemic stroke (AIS) patients with large vessel occlusion.
- Trial name
- HEAL (NCT06211712)
- Testing
- Experimental: Human Urinary Kallidinogenase
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Carotid Artery Stenosis, Carotid Artery Diseases
Study on the Trans-Carotid Artery Occlusion Shunt System Combined With Introducer Sets
The objective of the study is to evaluate the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets for Cerebral Protection During Carotid Angioplasty
- Trial name
- NCT06959628
- Testing
- Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shenzhen Wecan Medical Technology Co.,Ltd
Coronary Artery Disease
OCT Evaluation of Early Healing of EPC Capturing (GENOUS) Stent (EGO Study)
All patients who have received GENOUS stent implantation at Queen Mary Hospital for treatment of ischemic heart disease are eligible for this study.
- Trial name
- EGO (NCT01272895)
- Testing
- Coronary Intervention (GENOUS stent)
- Where
- Hong Kong
- Volunteers
- 53 people
- Sponsor
- Prof. Stephen Lee
Diabetes, Wounds
Plerixafor in Diabetic Wound Healing
Chronic non-healing wounds represent a major source of morbidity, disability, and mortality in diabetic patients. Diabetes is the leading cause of non-traumatic limb amputations worldwide.
- Conditions
- Diabetes, Wounds, Critical Limb Ischemia
- Trial name
- MOZOBL07740 (NCT02790957)
- Testing
- Plerixafor
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Gian Paolo Fadini
Coronary Stenosis
IRIS-BioFreedom Cohort in the IRIS-DES Registry
The objective of this study is to evaluate effectiveness and safety of BIOFREEDOM™ FAMILY stent in the "real world" daily practice as compared with other drug-eluting stents.
- Trial name
- IRISBioFreedom (NCT03190057)
- Testing
- BIOFREEDOM™ FAMILY stent
- Where
- 8 sites in South Korea
- Volunteers
- 218 people
- Sponsor
- Seung-Jung Park
Ischemia, Retinal Vein Occlusion
Study of 2.0 mg Ranibizumab in Subjects With Ischemic Central Retinal Vein Occlusion (RAVE2)
The RAVE 2 trial is a phase I, open label, 12-month trial of intravitreal ranibizumab 2.0 mg in patients with ischemic CRVO who have been either previously treated with ranibizumab or treatment naïve.
- Conditions
- Ischemia, Retinal Vein Occlusion, Pathologic Processes, Retinal Diseases
- Trial name
- RAVE2 (NCT01225146)
- Testing
- ranibizumab
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- David M. Brown, M.D.
Coronary Artery Disease, Stable Angina
Validation of the MedHub AutocathFFR Software Device for Non-Invasive Fractional Flow Reserve (FFR)
This observational study evaluated how well the AutocathFFR software measures fractional flow reserve (FFR) from coronary angiogram images.
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina, Non-ST-Elevation Myocardial Infarction
- Trial name
- NCT07763769
- Testing
- MedHub AutocathFFR
- Where
- 4 sites in United States
- Volunteers
- 277 people
- Sponsor
- Medhub Ltd.
Coronary Arteriosclerosis, Myocardial Infarction
Radial Artery Bypass Graft Study of Tromsø
The purpose of this study is to answer, among others, the following questions: 1) What are the outcomes when using the radial artery as a bypass graft in coronary artery bypass surgery (CABG)? 2) Can multidetector computed…
- Trial name
- NCT00113451
- Where
- Norway
- Volunteers
- 119 people
- Sponsor
- University Hospital of North Norway
Alzheimer's Disease, Vascular Dementia
BAC in Patient With Alzheimer's Disease or Vascular Dementia
The primary objective of this study is to evaluate the efficacy of BAC patients with Alzheimer's disease or vascular dementia.The secondary objective of this study is to evaluate the safety of BAC patients with Alzheimer's…
- Trial name
- NCT02467413
- Testing
- BAC, BAC Matched Vehicle
- Where
- Taiwan
- Sponsor
- Botanicure Co., Ltd.
Central Retinal Vein Occlusion
Comparing Injection Frequency Between Aflibercept and Ranibizumab in Patients With CRVO With a Treat& Extend Regimen
Comparing ranibizumab and aflibercept in a treat and extend algorithm evaluating the number of needed injections over a 18 month period in patients with newly diagnosed CRVO.
- Trial name
- NCT02274259
- Testing
- Aflibercept, Ranibizumab
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Anders Kvanta
Critical Limb Ischemia
UT-15C SR in the Treatment of Critical Limb Ischemia
This study will evaluate UT-15C sustained release tablets in subjects experiencing ischemic lower limb rest pain related to advanced peripheral arterial disease.
- Trial name
- NCT00445159
- Testing
- UT-15C SR (treprostinil diethanolamine) 1mg oral tablets
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Southern Arizona Vascular Institute
Coronary Artery Disease
Evaluation of Everolimus-Eluting Stents (The K-XIENCE Registry)
The objective of this study is to evaluate effectiveness and safety of everolimus-eluting stents (XIENCE, Abbott) in the "real world" daily practice as compared with first-generation drug-eluting stents (sirolimus-eluting stents).
- Trial name
- NCT01350869
- Testing
- Xience
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Seung-Jung Park
Coronary Artery Bypass Grafting
Randomized Endo-Vein Graft Prospective
Coronary artery bypass grafting (CABG) is the most common major surgical procedure in the United States with over 300,000 cases performed each year.
- Trial name
- REGROUP (NCT01850082)
- Testing
- Vein Harvesting Procedures
- Where
- 16 sites in United States
- Volunteers
- 1,150 people
- Sponsor
- VA Office of Research and Development
Coronary Artery Disease
FFRangio Accuracy vs. Standard FFR
This is a prospective, observational, multi-center, single-arm, clinical trial designed to assess the efficacy of FFRangio in measuring FFR obtained from angiography compared to Invasive FFR for diagnosing hemodynamically…
- Trial name
- FAST-FFR (NCT03226262)
- Testing
- FFRangio
- Where
- 9 sites in United States, Belgium and 2 more
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- CathWorks Ltd.
Angioplasty, Balloon, Disease, Peripheral Artery
Post-market Registry to Assess the Clinical Performance and Safety of the Passeo-18 Lux in Infrainguinal Arteries
The purpose of his study is to collect short term and long term clinical evaluation data of the Passeo-18 Lux Paclitaxel releasing balloon catheter, subject to patients who visit hospital from arteriosclerosis in the…
- Trial name
- NCT05175703
- Testing
- Passeo-18 Lux Paclitaxel releasing Balloon Catheter
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Coronary Artery Disease
Sulfasalazine and Endothelial Function
Experimental studies suggest that systemic inflammation leads to endothelial dysfunction and atherosclerosis. This study will examine the effects of the anti-inflammatory drug sulfasalazine on endothelial function in patients…
- Trial name
- NCT00554203
- Testing
- Sulfasalazine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston University
Cardiovascular Diseases, Coronary Arteriosclerosis
Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS)
To determine if supplements of vitamin C, vitamin E, beta-carotene, and B-vitamins (a combination of folic acid, vitamins B6 and B12) reduce risk of major cardiovascular events in high risk women with a prior history of…
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- WAFACS (NCT00000541)
- Testing
- dietary supplements, vitamin C, vitamin E
- Sponsor
- Brigham and Women's Hospital
Peripheral Artery Disease, Femoropopliteal Stenosis
Histological Segmentation of the Superficial Femoral Artery From Microscan to CT Using Artificial Intelligence
The femoropopliteal artery segment (FPAS) is one of the longest arteries in the human body, undergoing torsion, compression, flexion and extension due to lower limb movements.
- Trial name
- CTPred (NCT06260488)
- Testing
- Endovascular surgery
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Metabolic Syndrome
The Effect of Pioglitazone and Rosiglitazone on Atherosclerotic and Inflammatory Markers in Patients With Metabolic Syndrome
Pioglitazone and rosiglitazone are used in the treatment of diabetic patients. Thiazolidinediones increase insulin sensitivity and show favorable effect blood glucose levels and lipid profiles.
- Trial name
- NCT00314561
- Testing
- Pioglitazone, Rosiglitazone
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Korea University Anam Hospital
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