Clinical trials: Vascular Occlusive Disease
Neovascular Glaucoma
Minimally Invasive Suprachoroidal Drainage for the Treatment of Neovascular Glaucoma
To explore the efficacy and safety of minimally invasive suprachoroidal drainage for the treatment of advanced neovascular glaucoma
- Trial name
- NCT07201415
- Testing
- minimally invasive suprachoroidal drainage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhongnan Hospital
Coronary Artery Disease
Angiogenesis Using VEGF-A165/bFGF Plasmid Delivered Percutaneously in No-option CAD Patients; a Controlled Trial
Achieving therapeutic angiogenesis with gene therapy using a plasmid coding human VEGF-A165/bFGF injected into ischemic myocardium of refractory coronary artery disease patients, employing a percutaneous catheter-based technique…
- Trial name
- VIF-CAD (NCT00620217)
- Where
- Poland
- Volunteers
- 52 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Femoropopliteal Artery Occlusion, Atherosclerosis Obliterans
Lesion Preparation in Femoropopliteal Artery Occlusion Disease
Peripheral arterial disease (PAD) carries a significant global health burden, and can limit functional capacity and quality of life.
- Conditions
- Femoropopliteal Artery Occlusion, Atherosclerosis Obliterans, Lesion; Vascular, In-stent Restenosis
- Trial name
- CIVILIAN (NCT05473884)
- Testing
- lesion preparation devices, conventional balloon
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai Pudong Hospital
Diabetes Mellitus, Heart Failure
Nt-proBNP Guided Primary Prevention of CV Events in Diabetic Patients
Increased levels of NT-proBNP are known to increase the risk of cardiac events in diabetic patients. The other way around, patients with normal values have an excellent prognosis on short-term.
- Conditions
- Diabetes Mellitus, Heart Failure, Coronary Artery Disease
- Trial name
- PONTIAC (NCT00562952)
- Testing
- Telmisartan, Bisoprolol
- Where
- 2 sites in Austria
- Volunteers
- 300 people
- Sponsor
- Medical University of Vienna
Susac Syndrome
Phenotypic and Etiological Characterization of Susac Syndrome
SUSAC's Syndrome (SS) is characterized by the clinical triad of encephalopathy, hearing loss, and retinal artery branch occlusions.
- Trial name
- CARESS Cohorte (NCT06881368)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atherosclerosis, Metabolic Syndrome
Risk Factor Analysis for Coronary Atherosclerosis Measured by MDCT
Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as…
- Trial name
- NCT01589224
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Korea University
HIV
Effects of Eplerenone on Cardiovascular Disease in HIV (MIRACLE HIV Study)
HIV-infected individuals treated with antiretroviral medications are living longer, but have an increased risk of heart disease when compared to non-HIV-infected individuals.
- Trial name
- NCT02740179
- Testing
- Eplerenone, Lifestyle Modification
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease (CAD)
Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Observe whether the administration of caffeine prior to regadenoson will affect the interpretation of test results in subjects with coronary artery disease (CAD) undergoing SPECT MPI
- Trial name
- NCT00826280
- Testing
- regadenoson, overencapsulated caffeine, technetium
- Where
- 25 sites in United States
- Volunteers
- 347 people
- Sponsor
- Astellas Pharma Inc
Vitrectomy
Vitrectomy for Branch Retinal Vein Occlusion
To evaluate the long term outcomes of pars plana vitrectomy (PPV), with and without internal limiting membrane (ILM) peeling, in eyes with persistent macular edema secondary to branch retinal vein occlusion (BRVO).
- Trial name
- NCT00685490
- Testing
- Vitrectomy w/o ILM peeling for macular edema with BRVO
- Where
- Japan
- Volunteers
- 70 people
- Sponsor
- Shinjo Ophthalmologic Institute
Coronary Artery Disease
Role of Stress CMR in Predicting Adverse Clinical Events in Patients With Known or Suspected IHD
The investigators plan to use retrospective data to assess heart function and structure abnormalities through the use of an approved vasodilating agent for stress cardiac MRI tests.
- Trial name
- NCT01821924
- Where
- 2 sites in United States
- Volunteers
- 2,347 people
- Sponsor
- Brigham and Women's Hospital
Healthy Participants
A Study to Investigate the Safety, Tolerability and Pharmacodynamics of AZD4144 in Participants With Obesity
The aim of this study is to evaluate the safety and tolerability, and pharmacodynamics (PD) of AZD4144 administered as repeated daily oral dosing.
- Trial name
- NCT06942923
- Testing
- AZD4144
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Coronary Artery Disease
The Effect of Reiki and Acupressure on Pain, Anxiety and Vital Signs
This research aims to determine the effects of reiki and acupressure applied after percutaneous coronary intervention on pain, anxiety and vital signs during femoral catheter extraction.
- Trial name
- NCT05381246
- Testing
- Acupressure, Reiki
- Volunteers
- 84 people
- Sponsor
- Mersin University
Acute Ischemic Stroke, Endovascular Thrombectomy
The Prediction of Hemorrhage Transformation by Cerebral Autoregulation in AIS Patient After Endovascular Thrombectomy
This observational study was designed for observe the cerebral hemodynamics and dynamic cerebral autoregulation (dCA) after endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) patients.
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Dynamic Cerebral Autoregulation
- Trial name
- PHASE (NCT06361017)
- Testing
- endovascular thrombectomy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Coronary Artery Disease, Acute Coronary Syndrome
Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES
New-generation metallic drug-eluting stents represent the standard of care among patients undergoing percutaneous coronary intervention (PCI).
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome, Myocardial Infarction
- Trial name
- PARTHENOPE (NCT04135989)
- Testing
- Percutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease., Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease., Personalized DAPT duration
- Where
- 13 sites in Italy
- Volunteers
- 2,106 people
- Sponsor
- Federico II University
Coronary Artery Disease
Aspirin Effectiveness Study
Aspirin is an effective medicine for prevention of heart attacks in patients with coronary artery disease and works by preventing clots from forming.
- Trial name
- NCT01113060
- Where
- Ireland
- Volunteers
- 500 people
- Sponsor
- Royal College of Surgeons, Ireland
Atherosclerosis
Hemodynamic Change of Coronary Atherosclerotic Plaque After Evolocumab Treatment
Compelling evidences indicate that lipid-lowering therapy can reduce the high-risk plaque feathers and improve the coronary flow reserve.
- Trial name
- NCT04416425
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zibo Central Hospital
Coronary Artery Disease
Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis
The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying…
- Trial name
- NCT00921440
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Coronary Atherosclerosis, Inflammation
Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients
In this study, we, the investigators at National Taiwan University Hospital, will evaluate the efficacy of pharmacological therapy targeted to reduce insulin resistance (pioglitazone) on the progression and compositional change…
- Conditions
- Coronary Atherosclerosis, Inflammation, Coronary Heart Disease
- Trial name
- NCT00155350
- Testing
- pioglitazone
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease
Effect of Intraoperative Arterial Oxygen Targets on Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin
This single-center randomized trial compared two intraoperative arterial oxygen tension (PaO2) target strategies in adults undergoing elective isolated coronary artery bypass graft surgery.
- Trial name
- NCT04627220
- Testing
- Intraoperative Oxygenation Strategy: PaO2 200 mmHg or Greater, Intraoperative Oxygenation Strategy: PaO2 80 to Less Than 200 mmHg
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Coronary Occlusion
Safety and Efficacy of the CiTop™ Guidewire for Crossing Chronic Total Occlusions in Coronary Arteries
The CiTop™ guidewire Coronary study is a feasibility open label study, to evaluate the safety and efficacy of the CiTop™ Guidewire for crossing chronic total occlusion in Coronary arteries.
- Trial name
- NCT00618020
- Testing
- CiTop(tm) Guidewire
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Ovalum
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