Clinical trials: Vascular Occlusive Disease
Fall, Fall Injury
Integrating Fall Prevention Balance Exercises Into a Program for Older Adults With Peripheral Artery Disease (PAD): A Mixed Methods Feasibility Study
The overarching objective of this study is to improve fall prevention efforts in community-dwelling older adults with peripheral artery disease (PAD) to reduce falls.
- Conditions
- Fall, Fall Injury, Peripheral Artery Disease, Peripheral Arterial Disease
- Trial name
- NCT05090774
- Testing
- Adapted Otago Exercise Program (OEP)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Peripheral Artery Disease, Atherectomy in Diseased Lower Extremity Arteries
Rotational Atherectomy and Drug-Coated Balloon Angioplasty With Embolic Protection for Superficial Femoral Artery Occlusions
Peripheral artery disease can reduce blood flow to the legs. In some patients, the superficial femoral artery, a major artery in the thigh, is completely blocked over a long segment.
- Trial name
- NCT07803718
- Testing
- Rotational Atherectomy With Distal Embolic Protection and Drug-Coated Balloon Angioplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Peripheral Arterial Disease
The Effects of Physical Training, ASA (Aspirin), and Clopidogrel on the Walking Capacity of Patients With Stage II Peripheral Arterial Disease (PAD)
To evaluate the change in walking capacity after a well organized and structured intensive physical training program with supportive pharmacotherapy with Clopidogrel or ASA.
- Trial name
- NCT00189618
- Testing
- Aspirin, Clopidogrel
- Where
- 16 sites in Germany, Switzerland
- Volunteers
- 250 people
- Sponsor
- Arteriogenesis Competence Network
Stable Angina, Multivessel Coronary Artery Disease
Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery…
- Trial name
- ORBITA-MOON (NCT06400290)
- Testing
- Percutaneous coronary intervention (PCI), Symptom assessment during experimentally induced ischaemia
- Where
- 8 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Paroxysmal Atrial Fibrillation, Coronary Artery Disease
Surgical Pulmonary Vein Isolation Efficiency Study
A substantial proportion of patients undergoing elective coronary artery bypass grafting have a history of paroxysmal atrial fibrillation. Paroxysmal atrial fibrillation has adverse short-and long term postoperative effects.
- Trial name
- FIN-PVI (NCT01791218)
- Testing
- CABG, AVR or CABG+AVR and PVI, CABG, AVR or CABG+AVR
- Where
- Finland
- Volunteers
- 2 people
- Sponsor
- Kuopio University Hospital
Internal Carotid Artery Stenosis
MICHI™ Neuroprotection System (NPS+f) Filter Debris Analysis Study (The F-1 Study)
This study will be conducted in up to 10 hospitals in Europe, up to 75 patients will be enrolled. The purpose of the study is to evaluate any debris that may be captured in the inline filter of the MICHI(TM) Neuroprotection…
- Trial name
- NCT01877174
- Testing
- MICHI(TM) NPS+f, transcarotid stenting
- Where
- 6 sites in Belgium, Germany and 1 more
- Volunteers
- 24 people
- Sponsor
- Silk Road Medical
Coronary Disease, Coronary Arteriosclerosis
Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease
Diet can play a key role in atherosclerosis and coronary heart disease (CHD), but little interventional data exists, and the mediators of possible anti-atherosclerotic effects of diet are unclear.
- Conditions
- Coronary Disease, Coronary Arteriosclerosis, Myocardial Infarction, Chronic Coronary Syndrome
- Trial name
- NORDHEART (NCT06701968)
- Testing
- Healthy Nordic Diet, Usual Care
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Sickle Cell Leg Ulcer
Test of the Safety, Effectiveness, & Acceptability of An Improvised Dressing for Sickle Cell Leg Ulcers in the Tropics
One in 300 Jamaicans have HbSS sickle cell disease, and of these, up to 70% will suffer from sickle cell leg ulcers (SCLUs). Of these, 24% will have a chronic SCLU (one lasting longer than 6 months).
- Trial name
- SCLUJamaica (NCT04479618)
- Testing
- Usual Practice, Improvised dressing, Advanced dressing
- Where
- Jamaica
- Volunteers
- 48 people
- Sponsor
- Benskin, Linda, PhD, RN, SRN (Ghana), CWCN, CWS, DAPWCA
Coronary Artery Disease
Brain-heart Interaction in Coronary Plaque Stability and Cardiovascular Events
The effect of brain-heart interaction remains unclear. The study aims to investigate the biological interconnection between brain neural activity and coronary plaque morphological and inflammatory features, as well as their…
- Trial name
- Blueprint (NCT05545618)
- Testing
- CCTA and 18F-FDG-PET/CT
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Shanghai Zhongshan Hospital
Ischemic Stroke, Acute
Intra-arterial Recombinant Human TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Thrombolysis for Acute Large Vascular Occlusion After Successful Mechanical Thrombectomy Recanalization
The goal of this clinical trial is to evaluate whether intra-arterial (IA) rhTNK-tPA thrombolysis can improve neurological outcomes in acute large vessel occlusion patients after successful mechanical thrombectomy (MT)…
- Trial name
- ANGEL-TNK (NCT05624190)
- Testing
- Recombinant Human tenecteplase Tissue-type Plasminogen Activator (rhTNK-tPA), Best Medical Management
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Coronary Arteriosclerosis
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)
In this multicenter, international study we are evaluating two approaches to determine which coronary artery narrowings require stent placement in patients with multivessel coronary artery disease.
- Trial name
- NCT00267774
- Testing
- Fractional flow reserve, Angio-guided PCI
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 1,005 people
- Sponsor
- Stanford University
Atherosclerosis
Vitamin D Supplementation on Surrogate Markers of Atherosclerosis
For this study, our sample population is individuals with prediabetes, who are at an increased risk for atherosclerosis. In this proposed randomized placebo-controlled prospective trial, we would be enrolling 120 subjects with…
- Trial name
- NCT05478291
- Testing
- Vitamin D supplementation
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Coronary Artery Disease
Noninferiority Trial Of Sirolimus With Ascorbic Acid Versus Everolimus in All-comers
The objective of this study is to demonstrate the primary hypothesis that, in patients with chronic and acute coronary syndromes requiring percutaneous coronary intervention (PCI), the novel sirolimus-ascorbic acid eluting stent…
- Trial name
- NOVA (NCT07566091)
- Testing
- Sirolimus-Ascorbic Acid Eluting Stent, Everolimus-Eluting Stent
- Where
- South Korea
- Volunteers
- 2,034 people
- Sponsor
- Jung-min Ahn
Sinusoidal Obstruction Syndrome, Colorectal Liver Metastases
Prevention of the Hepatic Sinusoidal Obstruction Syndrome by Means of Anticoagulants
The purpose of the study is to determine whether anticoagulant use (i.e. salicylates, clopidogrel, low-molecular weight heparin, or coumarin derivates) is able to prevent the development of the sinusoidal obstruction syndrome…
- Trial name
- NCT00885950
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Maastricht University Medical Center
Coronary Artery Disease
HCR vs. CABG Study
The purpose of the study is to find out if hybrid coronary revascularization (HCR) and coronary artery bypass grafting (CABG) procedure outcomes are similar.
- Trial name
- NCT02892474
- Testing
- Hybrid Coronary Revascularization (HCR), Coronary Artery Bypass Grafting (CABG)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Emory University
Homozygous Familial Hypercholesterolemia (HoFH)
A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501
This long-term observational study is designed to follow subjects who, during another Clinical Study, received gene therapy treatment used to treat their Homozygous Familial Hypercholesterolemia (HoFH) disease.
- Trial name
- NCT04080050
- Testing
- Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 8 people
- Sponsor
- REGENXBIO Inc.
Familial Hypercholesterolemia, Atherosclerosis
Familial Hypercholesterolemia in Turkey (A-HIT2)
A-HIT2, is also designed as a National FH registry. At least 1000 FH patients will be recruited from 30 outpatient clinics representing the 12 Nuts statistical Regions in Turkey proportional to the 2015 Turkey's Population…
- Trial name
- A-HIT2 (NCT03110250)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Ege University
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Ischemic Heart Disease, Coronary Artery Disease
Controlled Trial of High-risk Coronary Intervention With Percutaneous Left Ventricular Unloading
Over 100,000 coronary stent procedures, where small balloons are used to stretch open a narrowed blood vessel, are performed every year in the United Kingdom to treat people who have conditions such as angina or have suffered a…
- Trial name
- CHIP-BCIS3 (NCT05003817)
- Testing
- Percutaneous left ventricular unloading
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Congestive Heart Failure, Diabetes
Evaluation of Programs of Coordinated Care and Disease Management
This is a Congressionally mandated study. In the original study, 16 demonstration programs provided care coordination services to beneficiaries with chronic illness in Medicare's fee-for-service program.
- Conditions
- Congestive Heart Failure, Diabetes, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- Coca (NCT00627029)
- Testing
- Care Coordination
- Where
- 15 sites in United States
- Volunteers
- 18,277 people
- Sponsor
- Mathematica Policy Research, Inc.
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