Clinical trials: Vascular Occlusive Disease
Coronary Artery Disease
Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease.
- Trial name
- NCT01719016
- Testing
- Cardiac PET, Coronary catheterization
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Cincinnati
Coronary Artery Disease, Ischaemic Heart Desease
Virtual Reality for Patient Preparation Before Cardiac Catheterization in Oman
Background: Cardiovascular disease is considered one of the most prevalent diseases in recent times, and cardiac catheterization is widely used to diagnose and treat cardiovascular disease.
- Conditions
- Coronary Artery Disease, Ischaemic Heart Desease, Cardiac Catheterization
- Trial name
- NCT07320248
- Testing
- Virtual Reality Education
- Volunteers
- 120 people
- Sponsor
- Sultan Qaboos University
Coronary Artery Disease, Cardiac Rehabilitation
Comparison of Conventional and Tele-cardiac Rehabilitation
This study aimed to compare the effects of tele-cardiac rehabilitation (TCR) and hospital-based cardiac rehabilitation (HBCR) on functional capacity (maximum oxygen consumption), fear of activity and quality of life in patients…
- Conditions
- Coronary Artery Disease, Cardiac Rehabilitation, Telecardiac Rehabilitation, Aerobic Exercise
- Trial name
- NCT06614634
- Testing
- Remotely supervised exercise at home or outdoors, Hospital-based exercise program, Cardiovascular risk modification
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Coronary Artery Disease
Duration of Platelet Inhibition by Aspirin
The well established importance of regular aspirin administration stands on firm grounds, as large meta-analyses have shown this therapy to significantly reduce the risk of death.
- Trial name
- NCT00671021
- Testing
- Platelet aggregation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Cardiovascular Disease, Coronary Artery Calcification
7 Year Follow-up Study of the DanRisk Population
OBJECTIVES: To investigate the incidence of cardiovascular events as well as progression of coronary artery calcium (CAC) in healthy middle-aged subjects over a period of 7 years, and the relation to traditional as well as new…
- Conditions
- Cardiovascular Disease, Coronary Artery Calcification, Atherosclerosis
- Trial name
- NCT02913144
- Volunteers
- 1,257 people
- Sponsor
- Odense University Hospital
Diastolic Heart Failure
Ranolazine in Diastolic Heart Failure
Patients with CAD and clinical symptoms of heart failure or patients with suspected heart failure with preserved ejection fraction (HFpEF) will be enrolled.
- Trial name
- RALI-DHF (NCT01163734)
- Testing
- Ranolazine
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Gilead Sciences
Coronary Artery Disease
Long-Term Follow-up Study of Patients Who Received PB127 Ultrasound Imaging Agent
The purpose of this study is to collect longer term follow-up information concerning health and survival on selected patients who received PB127 for injectable suspension in the pivotal trial (127-014).
- Trial name
- NCT00584714
- Where
- 39 sites in United States
- Volunteers
- 300 people
- Sponsor
- Point Biomedical
Cardiovascular Diseases, Heart Diseases
Reducing Total Cardiovascular Risk in an Urban Community
PLEASE NOTE: THIS STUDY IS ONLY ENROLLING PATIENTS CURRENTLY BEING TREATED AT BELAIR-EDISON FAMILY HEALTH CENTER. The purpose of this study is to compare the clinical effectiveness and cost effectiveness of two cardiovascular…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Diabetes Mellitus
- Trial name
- COACH (NCT00241904)
- Testing
- Lifestyle Changes, Antiplatelet Agents, Beta Blocker
- Where
- United States
- Volunteers
- 525 people
- Sponsor
- Johns Hopkins University
Neovascular Age-related Macular Edema, Diabetic Macular Edema
Anti-VEGF in Real-world
Anti-vascular endothelial growth factor therapy is the major intervention for treating ischemic retina diseases. According to FDA and China Food and Drug Administration, Ranibizumab, Aflibercept, and Conbercept are major types of…
- Conditions
- Neovascular Age-related Macular Edema, Diabetic Macular Edema, Choroidal Neovascular Membrane, Non-proliferative Diabetic Retinopathy
- Trial name
- NCT05222633
- Testing
- Ranibizumab, Aflibercept, Conbercept
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Wenbin Wei
Intracranial Atherosclerotic Stenosis-Related Large Vessel Occlusion, Acute Ischemic Stroke
Efficacy and Safety of Bailout Intracranial Angioplasty or Stenting After Thrombectomy for Acute Intracranial Atherosclerotic Large Vessel Occlusion (ANGEL-REBOOT 2)
A multicenter, randomized, open-label, blinded-endpoint trial with a concurrent prospective observational cohort to compare bailout intracranial angioplasty or stenting versus standard therapy on functional outcome, stroke…
- Conditions
- Intracranial Atherosclerotic Stenosis-Related Large Vessel Occlusion, Acute Ischemic Stroke, Bailout Angioplasty or Stenting
- Trial name
- NCT07618052
- Testing
- Bailout Intracranial Angioplasty or Stenting, Standard Thrombectomy
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Feng Gao
Coronary Artery Disease, Coronary Disease
Evaluation of Effectiveness and Safety of XIENCE Sierra in Routine Clinical Practice
The objective of this study is to evaluate effectiveness and safety of Xience Sierra stent in the "real world" daily practice as compared with other drug-eluting stents.
- Trial name
- IRIS Sierra (NCT03967158)
- Testing
- Xience Sierra stent
- Where
- 10 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seung-Jung Park
Coronary Artery Diseases
NOYA CoCr Biodegradable Coating Sirolimus-Eluting Coronary Stent System
A single blind, multi-center, randomized study is preformed to compare NOYA CoCr biodegradable coating sirolimus-eluting stents with Firebird2 drug-eluting stents from MicroPort Medical (Shanghai) Co., Ltd.
- Trial name
- NCT01226355
- Testing
- stent
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Medfavour (Beijing) Medical Co., Ltd
Peripheral Artery Disease, Vascular Disease
Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)
Patients scheduled for major extremity lower amputation to receive bone marrow cells (cBMA) injected IM in the leg proximal to the amputation in the index limb to prevent ischemic wound complications after surgery.
- Conditions
- Peripheral Artery Disease, Vascular Disease, Critical Limb Ischemia
- Trial name
- MarrowCHAMP (NCT02863926)
- Testing
- Injection of cBMA aspirate into the index leg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Michael Murphy
Heart Failure Due to Coronary Artery Disease
Optimizing Strategy of Coronary Revascularization in Patients With Multivessel Lesions Combined Heart Failure
As the end stage of almost all cardiovascular diseases, heart failure has become an increasingly common cause of cardiovascular morbidity and mortality worldwide.
- Trial name
- OSCRM-HF (NCT02775578)
- Testing
- Coronary Artery Bypass Grafting, Percutaneous Coronary Intervention, Hybrid Coronary Revascularization
- Where
- China
- Volunteers
- 525 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Ischemic Attack, Transient, Transient Ischemic Attack
Pocket-size Cardiovascular Ultrasound in Stroke
Among patients admitted with cerebral ischemia (stroke and transitory ischemic attack (TIA)) it is important to reveal the underlying cause of the disease.
- Conditions
- Ischemic Attack, Transient, Transient Ischemic Attack, Stroke, Cerebrovascular Accident
- Trial name
- NCT02141932
- Testing
- Bed-side pocket size ultrasound imaging, GE Ultrasound Vscan
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Helse Nord-Trøndelag HF
Coronary Artery Disease
CCTA and Dynamic CT Perfusion for the Diagnosis of Myocardial Ischemia in Patients With Coronary Stents
A single centre prospective trial in which patients with a prior PCI for stable CAD who are referred for invasive angiography will undergo state-of-the art CCTA and dynamic CT perfusion.
- Trial name
- PACIFIC-III (NCT04742933)
- Testing
- There is no intervention in this observational trial
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- Amsterdam UMC, location VUmc
Large Vessel Occlusion, Acute Ischemic Stroke
Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large…
- Trial name
- NUVISTA2 (NCT07404852)
- Testing
- transcutaneous auricular vagal nerve stimulation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Washington University School of Medicine
Coronary Arteriosclerosis
Modified-release Dipyridamole/Aspirin (200mg/25mg bd) Versus Aspirin (75mg) in Aspirin-resistant Patients
The primary objective of this study is to assess whether adding modified-release dipyridamole to aspirin (Asasantin Retard) has measurable effects on markers of platelet function (for example, platelet aggregation) in patients…
- Trial name
- NCT00129038
- Testing
- modified-release dipyridamole/aspirin, aspirin
- Where
- 2 sites in Ireland
- Volunteers
- 11 people
- Sponsor
- Boehringer Ingelheim
Mi Q Wave, Coronary Artery Disease
New Time Clock for ST-elevation MI Based on Biochemical Myocardial Infarction Onset Time
ST segment elevation myocardial infarction (STEMI) is one of the leading causes of death across the world and immediate treatment with either thrombolytics or percutaneous coronary intervention (PCI) results in lower mortality.
- Trial name
- BIT-STEMI (NCT04389814)
- Testing
- Biochemical markers
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Tabba Heart Institute
Critical Limb Ischemia
Proteomics and Stem Cell Therapy as a New Vascularization Strategy
Neovascularization (NV) is the innate capability to enlarge collateral arteries ("arteriogenesis"), and to stimulate growth of new capillaries, arterioles and venules at the tissue level ("angiogenesis").
- Trial name
- NCT02802852
- Testing
- Pneumatic calf compression, Filgrastim
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Illinois Chicago
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