Clinical trials: Vascular Pathology
Stroke, Cerebral Infarction
Study of NeuroAid In Enhancing Recovery After Stroke
TIERS is a phase II to generate detailed preliminary data on the efficacy of NeuroAid in post-stroke recovery, and to assess the utility of the rehabilitation outcome measure instruments used.
- Trial name
- TIERS (NCT00721825)
- Testing
- Neuroaid
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Moleac Pte Ltd.
Hereditary Hemorrhagic Telangiectasia
A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)
The purpose of this study is to: evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of ALN-6400 in healthy volunteers evaluate the efficacy, safety, tolerability and PD of…
- Trial name
- InsigHHT (NCT06659640)
- Testing
- ALN-6400
- Where
- 16 sites in United States, Australia and 4 more
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Intermittent Claudication, Metabolic Syndrome X
Prevalence of Metabolic Syndrome in Patients With Intermittent Claudication
Metabolic syndrome, a group of cardiovascular risk factors related to insulin resistance, is a major determinant of cardiovascular mortality. Intermittent claudication is a symptom of an early stage of atherosclerosis.
- Trial name
- NCT00946868
- Where
- Brazil
- Volunteers
- 170 people
- Sponsor
- University of Sao Paulo
Coronary Artery Disease, Brain Injury
Neuroprotective Effect of Mild Hypothermia Versus Normothermia During Cardiopulmonary Bypass of Coronary Artery Surgery
In high-income countries, coronary artery bypass grafting (CABG) remains a common procedure, with approximately 36.7 operations per 100,000 inhabitants annually, corresponding to about 136,000 procedures in the European Union.
- Trial name
- HYPNOCABG (NCT07316868)
- Testing
- Normothermic cardiopulmonary bypass, Hypothermic cardiopulmonary bypass
- Where
- Finland
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Psoriasis, Atherosclerotic Cardiovascular Disease
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
Background: Psoriasis causes chronic inflammation in the body. Researchers want to see if a kind of vitamin B3 dietary supplement can help. This might lead to more treatment options.
- Conditions
- Psoriasis, Atherosclerotic Cardiovascular Disease, Obesity, Dyslipidemia
- Trial name
- NCT04271735
- Testing
- Niagen
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diastolic Dysfunction, Hypertension
Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients
This study evaluated the association between HMGB1 and diastolic dysfunction in hypertensive patients. HMGB1 level were tested in all patients, and diastolic function determined by echocardiographic.
- Conditions
- Diastolic Dysfunction, Hypertension, Inflammation
- Trial name
- NCT03177408
- Volunteers
- 100 people
- Sponsor
- Jing Li
Chronic Renal Failure, Hypertension
Low Sodium Dialysate and Ambulatory Blood Pressure Measurement Parameters
End stage renal disease (ESRD) is related with increased cardiovascular mortality and morbidity. Hypertension (HT) is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients.
- Trial name
- NCT02621450
- Testing
- standart dialysis, low sodium dialysis
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Coronary Artery Disease, Stenosis
Clinical Usefulness of Fractional Flow Reserve Measurement for Significant Stenosis in Proximal Coronary Artery
Fractional flow reserve (FFR) is a pressure-wire-based index that is used during coronary angiography to assess the potential of a coronary stenosis to induce myocardial ischemia.
- Trial name
- NCT02475291
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Yonsei University
Stroke, Cardiac Disease
Multifactorial Risk Stratification in Stroke Patients With Cardiac Disease
Prospective registry for multifactorial risk factor assessment, enrolling consecutive ischemic stroke/transient ischemic attack patients with structural, inflammatory, or arrhythmogenic cardiac disease, who are admitted to our…
- Trial name
- NCT04352790
- Volunteers
- 878 people
- Sponsor
- University Hospital Tuebingen
Ischemic Stroke
DIRECT-SAFE: A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval
The study will be a multicentre, prospective, randomized, open label, blinded endpoint (PROBE) phase 3 trial (2 arm with 1:1 randomization) in ischemic stroke patients within 4.5 hours of stroke onset.
- Trial name
- NCT03494920
- Testing
- Direct endovascular clot retrieval, Bridging thrombolysis followed by ECR
- Where
- 33 sites in Australia, China and 2 more
- Volunteers
- 295 people
- Sponsor
- Neuroscience Trials Australia
Lung Transplant; Complications
Bypass vs. Ecmo in Lung Transplantation (BELT)
This study seeks to compare outcomes of 2 different methods of cardiopulmonary support during lung transplant surgeries.
- Trial name
- BELT (NCT03021538)
- Testing
- Extracorporeal Membrane Oxygenation, Cardiopulmonary Bypass
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- The Cleveland Clinic
HR Vaiability, Aerobic Physical Fitness,Blood Pressure, Blood Sugar Level, Blood HDL, LDL
Aerobic Exercise Training & the Autonomic System In Patients After Myocardial Infarction or Stroke
The purpose of this study is to examine the effect of Aerobic Physical Activity on the function of the Autonomic System in patients after Myocardial Infarction or Stroke.
- Trial name
- NCT00259948
- Testing
- Aerobic exercise training
- Where
- Israel
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Stroke, Acute, Atherosclerosis
Diagnostic and Prognostic Role of Clot Analysis in Stroke Patients
BACKGROUND AND RATIONALE OF THE STUDY The analysis of the composition of the clot constitutes a promising tool for investigating the possible pathogenetic mechanisms underlying ischemic stroke.
- Conditions
- Stroke, Acute, Atherosclerosis, Atrial Fibrillation
- Trial name
- DICAS (NCT05760326)
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypoxic Ischaemic Encephalopathy (HIE)
EFFICACY OF MELATONIN IN MANAGEMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE) IN NEONATES
To compare the survival rate and improvement in stage of hypoxic ischemic encephalopathy (HIE) at day 7 of treatment in neonates treated with versus without melatonin in addition to standard supportive therapy.
- Trial name
- NCT07305350
- Testing
- Melatonin, intravenous (IV) fluids, intensive monitoring, broad-spectrum antibiotic cover
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Healthy, Diabetes Type 2
Assessment of Three Instruments for the Non-invasive Measurement of Arterial Stiffness.
The ASI Non-Invasive Arterial Stiffness Screening Device (ASI Device) is an investigational device under development for the non-invasive assessment of arterial stiffness.
- Conditions
- Healthy, Diabetes Type 2, Obesity, Coronary Artery Disease
- Trial name
- ASI-2012 (NCT01722474)
- Testing
- ASI Device
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hemiplegia, Stroke
Effects of Wearable Vibratory Devices on Arm Function in Subacute Stroke Patients
Hemiplegia, or paralysis of one side of the body, often results from stroke and severely limits arm function. Standard physiotherapy helps, but recovery is often slow.
- Trial name
- WEVIB-HEMI (NCT07641790)
- Testing
- Wearable Focal Muscle Vibrator
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Faisalabad
Myocardial Infarction, Diastolic Dysfunction
Angiotensin-Neprilysin Inhibition in Diastolic Dysfunction After AMI
This study examines the effect of Entresto on central hemodynamic parameters during exercise in patients with diastolic dysfunction following acute myocardial infarction.
- Trial name
- ARNiAMI (NCT04149990)
- Testing
- Entresto Pill
- Where
- 2 sites in Denmark
- Volunteers
- 51 people
- Sponsor
- Jacob Moller
Intraoperative Hypotension
Hypotension Decision Assist - Use, Safety and Efficacy
This clinical investigation will investigate whether Hypotension Decision Assist (HDA) is a feasible, safe and effective patient clinical decision support system to enhance an anaesthetist's ability to manage a patient's…
- Trial name
- HDA-USE (NCT05101590)
- Testing
- Monitored by HDA
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Directed Systems Limited
Stroke, Hemiplegia, Spastic
Condensed and Distributed Robotic Therapy in Spastic Stroke Post Botulinum Toxin Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A (BoNT-A) injection between condensed and distributed robot-assisted training (RT) programs in patients…
- Trial name
- NCT03321097
- Testing
- condensed RT group, distributed RT group
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Coronary Artery Diseases
BIOFLOW-III UK Satellite Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). 500 subjects will be enrolled in this registry.
- Trial name
- NCT02257710
- Testing
- Orsiro
- Where
- 4 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Biotronik UK Ltd.