Clinical trials: Vascular Patients
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Loss of Expression (MATCH-Subprotocol P)
This phase II MATCH treatment trial identifies the effects of GSK2636771 in patients whose cancer has a complete loss of PTEN expression.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Refractory Lymphoma
- Trial name
- NCT04439188
- Testing
- PI3K-beta Inhibitor GSK2636771
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Cancer Institute (NCI)
Arterial Ischemic Stroke
A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)
The primary study objective is to assess the safety of afamelanotide while the secondary objective is to assess whether the therapy affects the size of the penumbra, by increasing blood flow, restoring oxygen supply to the brain…
- Trial name
- NCT04962503
- Testing
- Afamelanotide
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Stroke, Brain Injuries
Investigating Usability of c-SIGHT in the Homes of Brain Injury Survivors
A brain injury can damage the brain, so that it no longer receives information about the space around one side of the world. If this happens, people may not be aware of anything on one side, usually the same side they also lost…
- Conditions
- Stroke, Brain Injuries, Spatial Neglect, Attention Deficit
- Trial name
- c-SIGHT (NCT03963661)
- Testing
- c-SIGHT (computorized spatial innatention grasping home-based therapy)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of East Anglia
Coronary Artery Disease, Type 2 Diabetes Mellitus
Comparison Between Pioglitazone and SES With type2 DM
Drug-eluting stents have been shown to decrease restenosis, but were associated with an increased rate of death, as compared with bare-metal stents.
- Trial name
- NCT00482183
- Testing
- Pioglitazone
- Volunteers
- 38 people
- Sponsor
- Showa University
Coronary Artery Bypass Grafting
Comparing Point of Care Clotting Tests in the OR Versus Standard Laboratory Clotting Tests
The purpose of this study is determine the agreement of point of care (POC) clotting tests (INR and aPTT) by the POC device by Hemochron Jr versus standard laboratory clotting tests (INR and aPTT) in patients undergoing elective…
- Trial name
- NCT00892905
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Diabetes Mellitus Type 2, Hypertension
Mobile Sipoo - Telemonitoring With Combined With Active Assistance Technology
Mobile Sipoo is a randomized controlled trial aiming to improve selfcare and outcomes of diabetes and hypertensive patients by introducing a remote patient monitoring system supported with automatic patient decision support.
- Trial name
- NCT01547156
- Testing
- Intervention group
- Where
- Finland
- Volunteers
- 56 people
- Sponsor
- VTT Technical Research Centre of Finland
Subarachnoid Hemorrhage, Anxiety
Massage Technique for Pain, Anxiety and Delirium in SAH Patients
This research study seeks to explore the effects of massage techniques on pain and anxiety relief among patients with subarachnoid hemorrhages in the ICU setting in comparison to subarachnoid hemorrhagic patients using standard…
- Conditions
- Subarachnoid Hemorrhage, Anxiety, Pain, Delirium
- Trial name
- NCT01982656
- Testing
- Massage
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sara E. Hocker, M.D
Fibromuscular Dysplasia, Early Onset CAD
CAUSE Trial: Patient Specific-Cellular Characterization of Fibromuscular Dysplasia and High-Risk Atherosclerotic Endothelium
The purpose of this project is to see if heritable alterations in the function, biology and vascular repair capacity of vascular cells make a major contribution to the burden of coronary artery disease (CAD), fibromuscular…
- Trial name
- NCT01808729
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cerebrovascular Accident
To Determine the Therapeutic Effect of the Music Glove and Conventional Hand Exercises to Subacute Stroke Patients
The investigators are trying to determine the therapeutic effect of the music glove and conventional hand exercise program to the subacute stroke patients. All participants will be randomized into two groups: AB and BA.
- Trial name
- NCT02410629
- Testing
- Music Glove, Conventional Hand Exercise Program
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- David Reinkensmeyer
Hypertension
Safety and Efficacy Study of Renal Artery Ablation in Resistant Hypertension Patients
This is a prospective, multicenter, feasibility study on the safety and efficacy of renal denervation in patients with resistant hypertension.
- Trial name
- EnligHTN-I (NCT01438229)
- Testing
- St. Jude Medical renal artery ablation system: RF ablation generator (IBI 1500T11.5) and Renal artery ablation catheter (DS3D001, DS3D002)
- Where
- 4 sites in Australia, Greece
- Volunteers
- 47 people
- Sponsor
- Abbott Medical Devices
Acute Stroke Patients Requiring Invasive Mechanical Ventilation
Stroke Prognosis in Intensive CarE
The S.P.I.C.E registry is an investigator-initiated prospective multicenter cohort study which will be conducted in 35 ICUS in the Paris area.The aim of the study is to determine the trajectory of acute stroke patients requiring…
- Trial name
- SPICE (NCT03335995)
- Where
- France
- Volunteers
- 364 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Acute Coronary Syndrome, Renal Failure
Adaptation Dose of Enoxaparin in Moderate Renal Failure Patients With Acute Coronary Syndrome
The objective of the VALIDE study is to validate that a 25% dose reduction of enoxaparine in patients with moderate renal failure (creatinine clearance between 30 and 50 ml/min) and hospitalized for an acute coronary syndrome…
- Trial name
- NCT00412802
- Testing
- dose adaptation of Enoxaparin, normal injection of Enoxaparine
- Where
- 9 sites in France
- Volunteers
- 67 people
- Sponsor
- French Cardiology Society
Upper Motor Neuron Disease
Efficiency of Spatially Distributed Sequential Stimulation (Sdss) for Functional Electrical Stimulation (FES) of Upper Motor Neuron Syndrome (UMR) Patients
To determine whether Spatially Distributed Sequential Functional Electrical Stimulation is more effective than Standard Electrical Stimulation During Functional Electrical Stimulation in Upper Motor Neuron Patients
- Trial name
- SDSS_UMS (NCT06421753)
- Testing
- SDSS, Standard Electrical Stimulation During Functional Electrical Stimulation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- UGECAM Rhône-Alpes
Venous Thromboembolism
Once-daily Oral Direct Factor Xa Inhibitor BAY59-7939 in Patients With Acute Symptomatic Deep-vein Thrombosis
The purpose of this study is to determine the optimal dose of BAY 59-7939 and to compare the safety and effectiveness of this new drug with the standard way of treatment of deep vein thrombosis (heparin infusion plus one of the…
- Trial name
- NCT00395772
- Testing
- Xarelto (Rivaroxaban, BAY59-7939), (LMW) Heparin + Vitamin K Antagonist
- Where
- 78 sites in United States, Australia and 11 more
- Volunteers
- 543 people
- Sponsor
- Bayer
Hypertension
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients
Hypertension (HTN) is the single most prevalent risk factor for cardiovascular disease, diabetes, obesity and metabolic syndrome.
- Trial name
- NCT02133872
- Testing
- Minocycline 50mg/d, Minocycline 100mg/d, Minocycline 200mg/d
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Florida
Stroke
Treadmill Training With Functional Electric Stimulation After Stroke
The purpose of this study was to investigate the effects of the treadmill training with functional electric stimulation on sensorimotor cortical reorganization and functional improvement in subjects with chronic stroke.
- Trial name
- NCT02812472
- Testing
- Treadmill training with functional electrical stimulation, Treadmill training without functional electrical stimulation
- Volunteers
- 18 people
- Sponsor
- National Yang Ming Chiao Tung University
Cardiogenic Shock
Effect of Peripheral VA-ECMO Flow Variations on the Pulmonary Arterial Occlusion Pressure (PAPO) in Patients With Refractory Cardiogenic Shock.
This study focuses on a population of adult patients placed under peripheral Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) for refractory cardiogenic shock.
- Trial name
- PAPO-Flow (NCT06250439)
- Testing
- ECMO-Flow variations
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Lymphoma (Non-Hodgkin's Lymphoma), Hodgkin's Disease or Multiple Myeloma
A Multi-centre, Open Label, Single-arm Study Intended to Further Investigate the Safety and Efficacy of Plerixafor as a Front-line Mobilisation Agent in Combination With G-CSF in Patients With Lymphoma or MM (Multiple Myeloma).
This is a research study intended to further investigate the safety and efficacy of plerixafor in patients with NHL, HD, or MM. Patients who have previously failed stem cell mobilisation attempts or who have previously received…
- Conditions
- Lymphoma (Non-Hodgkin's Lymphoma), Hodgkin's Disease or Multiple Myeloma, Front Line Mobilization, Transplantation
- Trial name
- PREDICT (NCT00838357)
- Testing
- Generic = Plerixafor
- Where
- 26 sites in France, Germany and 5 more
- Volunteers
- 118 people
- Sponsor
- Genzyme, a Sanofi Company
Coronary Artery Disease, Coronary Stenosis
Maastricht Biomarker CT Study
Introduction Cardiovascular disease is the leading cause of death in the Western world. The main cause for cardiovascular events is the development of atherosclerosis in the coronary arteries.
- Trial name
- NCT01671930
- Where
- Netherlands
- Volunteers
- 5,000 people
- Sponsor
- Maastricht University Medical Center
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