Clinical trials: Vascular Patients
Acute Stroke, Mechanical Thrombectomy
BraiN20® Monitoring in Acute Stroke Undergoing Thrombectomy
N20 somatosensory evoked potential (SEP) response shows high predictive accuracy of functional recovery in patients with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT).
- Trial name
- PROMISE20 (NCT06149754)
- Testing
- BraiN20(R) monitoring of N20 somatosensory evoked potential
- Where
- 3 sites in Spain
- Volunteers
- 65 people
- Sponsor
- Fundació Institut Germans Trias i Pujol
DEMMMI, Nine-Hole-PEG-Test, mRS, Stroke, Acute
Ghrelintrial With Patients With Stroke
Patients are assigned to KSW's Stroke Unit as part of the emergency treatment. There the patients are included in the study and treated according to the concept on the Stroke Unit within the complex treatment.
- Trial name
- NCT03264742
- Testing
- Ghrelin
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Kantonsspital Winterthur KSW
Multiple Myeloma
Vorinostat Plus Lenalidomide and Dexamethasone or Lenalidomide Plus Dexamethasone in Multiple Myeloma Patients Who Experience Biochemical Relapse During Lenalidomide Maintenance Therapy
Histone deacetylase (HDAC) inhibitors represent a potential new class of antitumor agents. Vorinostat (suberoylanilide Hydroxamic acid, SAHA) inhibits the activity of all 11 known human class I and II HDACs.
- Trial name
- ZLd_Ld (NCT01501370)
- Testing
- Vorinostat, Lenalidomide, Dexamethasone
- Where
- 8 sites in Italy
- Sponsor
- Tiziana Marangon
Coronary Artery Disease, Coronary Artery Bypass Grafting
Effects of PEEP on Parameters of Tissue Perfusion in Patients Post Cardiac Surgery
Pulmonary dysfunction is a condition inherent in cardiac surgery because of various interventions, such as general anesthesia, a median sternotomy, cardiopulmonary bypass and establishment of internal thoracic artery dissection.
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Acute Lung Injury
- Trial name
- NCT03753022
- Testing
- Group G5, Group G10, Group G15
- Volunteers
- 125 people
- Sponsor
- Federal University of São Paulo
Chronic Total Occlusion (CTO)
FAPI Imaging Assessment of Chronic Total Occlusion
This registry will include consecutive patients presenting with at least one chronic total coronary occlusion (CTO) identified via coronary angiography or cardiac computed tomography angiography (CCTA) at our center.
- Trial name
- FACT (NCT06655922)
- Testing
- FAPI Imaging
- Where
- 2 sites in China
- Volunteers
- 167 people
- Sponsor
- Lin Zhao
Myeloma Multiple, Myeloma
Treatment of Selinexor in Combination With Clarithromycin, Pomalidomide and Dexamethasone for Relapsed Refractory Multiple Myeloma Patients
The purpose of this study is to determine the efficacy and safety of investigational combination therapy of Selinexor, Clarithromycin, Pomalidomide and Dexamethasone (ClaSPd) for patients with relapsed/refractory multiple…
- Conditions
- Myeloma Multiple, Myeloma, Refractory Multiple Myeloma
- Trial name
- ClaSPd (NCT04843579)
- Testing
- Selinexor, Clarithromycin, Pomalidomide
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Weill Medical College of Cornell University
Brain and Central Nervous System Tumors, Metastatic Cancer
Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver radioactive tumor-killing substances to them without harming normal cells. This may be effective treatment for primary or metastatic brain tumors.
- Conditions
- Brain and Central Nervous System Tumors, Metastatic Cancer, Neuroblastoma
- Trial name
- NCT00003461
- Testing
- surgical procedure, astatine At 211 monoclonal antibody 81C6
- Where
- United States
- Sponsor
- Duke University
Coronary Artery Disease, Congestive Heart Failure
Cardiac Stem Cell Infusion in Patients With Ischemic CardiOmyopathy (SCIPIO)
The purpose of this study is to investigate the safety of intracoronary cardiac stem cells (CSCs) therapy in humans. Currently, there is no effective intervention to regenerate (regrow) dead heart muscle after a heart attack.
- Trial name
- SCIPIO (NCT00474461)
- Testing
- Treatment group
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Louisville
Multiple Myeloma, Fall Risk Factors
Fall Risk Assessment and an Exercise Intervention for Prevention of Falls in Multiple Myeloma Patients
Approximately one third of the population over the age of 65 falls at least once a year. The risk of falling is in increased in older patients with tumor diseases.
- Conditions
- Multiple Myeloma, Fall Risk Factors, Strength Training Effects, Balance Training Effects
- Trial name
- Myfall (NCT07044427)
- Testing
- Strength and balance training in combination with a treadmill-based pertubation intervention
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Heidelberg
Hypertension, Renal Insufficiency, Chronic
A Research Study to Show Aprocitentan is Efficacious and Safe to Treat Patients With Uncontrolled Blood Pressure and Chronic Kidney Disease.
The purpose of this research study is to show the blood pressure lowering effect of aprocitentan, a new drug, when added to the background antihypertensive therapy in patients with uncontrolled blood pressure and chronic kidney…
- Trial name
- INSPIRE-CKD (NCT04162366)
- Testing
- Aprocitentan 25 mg
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Atrial Fibrillation, Stroke
Computerized Decision Support to Prevent Stroke in Atrial Fibrillation
Atrial fibrillation (AF) is the most preventable cause of stroke. However, despite widely available risk stratification tools, numerous options for oral anticoagulation, and evidence-based practice guidelines, anticoagulation for…
- Trial name
- AF-ALERT3 (NCT06355986)
- Testing
- Alert-based computerized decision support
- Where
- 2 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Brigham and Women's Hospital
Chronic Obstructive Pulmonary Disease, Heart Failure
Well Being and Rehabilitation in Chronically Ill Patients: Structured Patient Education and Physical Exercise
This study addresses self management and maintenance of health through evaluation of a program of patient education in combination with physical training and with a structured follow-up.
- Conditions
- Chronic Obstructive Pulmonary Disease, Heart Failure, Stroke
- Trial name
- NCT00989456
- Testing
- Self management education programme, exercise only
- Where
- 5 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Artery Disease
Dietary Intervention to Stop COronary Atherosclerosis in Computed Tomography
The aim of the study is to determine, wheather strict dietary intervention with the use of the DASH diet atop of optimal medical treatment reduces previously diagnosed coronary atherosclerotic lesions assessed witch coronary…
- Trial name
- DISCO-CT (NCT02571803)
- Testing
- Dietary And Lifestyle Counseling, Optimal Medical Treatment
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
B-cell Chronic Lymphocytic Leukemia, Contiguous Stage II Grade 1 Follicular Lymphoma
Alvocidib, Fludarabine Phosphate, and Rituximab in Treating Patients With Lymphoproliferative Disorders or Mantle Cell Lymphoma
This phase I trial studies the side effects, best way to give, and the best dose of alvocidib when given together with fludarabine phosphate and rituximab in treating patients with previously untreated or relapsed…
- Conditions
- B-cell Chronic Lymphocytic Leukemia, Contiguous Stage II Grade 1 Follicular Lymphoma, Contiguous Stage II Grade 2 Follicular Lymphoma, Contiguous Stage II Mantle Cell Lymphoma
- Trial name
- NCT00058227
- Testing
- alvocidib, fludarabine phosphate, rituximab
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Cancer Institute (NCI)
Stroke Sequelae
Effect of Air Splints on Sensoriomotor Disturbances of the Affected Upper Extremity and Trunk Control in the Adult Post-stroke Patient
Objective: Sensory impairment in the affected upper limb occurs in approximately 50% of post-stroke patients and negatively impacts functional capacity and quality of life.
- Trial name
- NCT07029061
- Testing
- Air splints
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Alfonso X El Sabio University
Diabetes Mellitus, Diabetic Retinopathy
Evaluation of Early Retinal Nerve Injury in Type 2 Diabetes Patients Without Diabetic Retinopathy
The object of this study is to investigate the damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GCL+) in diabetic patients without retinal microangioma as detected by fundus fluorescein angiography…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Nerve Injury
- Trial name
- NCT03970161
- Testing
- routine ophthalmic examination
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Multiple Myeloma
A Study of ATN-224 and Bortezomib in Patients With Multiple Myeloma
The purpose of this study is to describe the safety and effect of ATN-224 in combination with bortezomib (Velcade®) in patients with Multiple Myeloma who are relapsed from or refractory to bortezomib.
- Trial name
- NCT00352742
- Testing
- ATN-224 + bortezomib
- Where
- 10 sites in United States
- Volunteers
- 46 people
- Sponsor
- Attenuon
Coronary Artery Disease, Arrhythmias, Cardiac
Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics
The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear.
- Conditions
- Coronary Artery Disease, Arrhythmias, Cardiac, Heart Valve Diseases, Aortic Dissection
- Trial name
- PROSPECT (NCT06001073)
- Testing
- Observational; No Interventions were given.
- Where
- China
- Volunteers
- 25,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Thrombosis, Deep Venous Thrombosis
Venous Thromboembolism and Haemostatic Disturbances in Patients With Upper Gastrointestinal Cancer
Cancer is a well known risk factor for venous thromboembolism (VTE) such as deep venous thrombosis (DVT) and pulmonary embolism (PE).
- Conditions
- Thrombosis, Deep Venous Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- GIVTE (NCT00660205)
- Where
- Denmark
- Volunteers
- 285 people
- Sponsor
- University of Aarhus
Deep Vein Thrombosis, Pulmonary Embolism
Registry of Hospitalized Patients Treated With Fondaparinux
Registry of Hospitalized patients at Brigham and Women's Hospital treated with Fondaparinux
- Trial name
- NCT00549705
- Volunteers
- 220 people
- Sponsor
- Brigham and Women's Hospital
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