Clinical trials: Vascular Remodeling
Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction
Impact of Cardiac Rehabilitation Programs on Left Ventricular Remodeling After Acute Myocardial Infarction - the REHAB Trial
The aim of REHAB trial is to investigate the impact of early mobilization after AMI in reducing left ventricular remodeling, as assessed by cardiac magnetic resonance imaging.
- Conditions
- Acute Myocardial Infarction, Non-ST Elevation Myocardial Infarction, Systemic Inflammation, Ventricular Remodeling
- Trial name
- NCT04161378
- Testing
- Cardiac imaging, Laboratory analysis
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Left Ventricular Remodeling, Plasma Multi-Omics
Prediction of LVAR and MACE in STEMI Though Plasma Multiomics Analysis
To identify plasma multi-omics biomarkers that predict left ventricular adverse remodeling (LVAR) and major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction, and to…
- Conditions
- Left Ventricular Remodeling, Plasma Multi-Omics, Acute ST-segment Elevation Myocardial Infarction, Immunomics
- Trial name
- NCT06885619
- Testing
- Diagnostic Test: echocardiography and blood collection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Anzhen Hospital
HFrEF - Heart Failure With Reduced Ejection Fraction, Myocardial Infarction (MI)
Vericiguat for Heart Failure With Reduced Ejection Fraction After Myocardial Infarction
The effects of vericiguat on cardiac remodeling in patients with chronic stable heart failure after myocardial infarction have not been reported.
- Trial name
- HFrEF (NCT06717204)
- Testing
- Vericiguat Oral Tablet [Verquvo], Prescription Drugs
- Where
- 3 sites in China
- Volunteers
- 210 people
- Sponsor
- Qilu Hospital of Shandong University
Diabetic Retinopathy
Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy
The retinal vasculature changes dramatically in patients with diabetic retinopathy especially between non-proliferative and proliferative disease. The retinal vasculature can be imaged and quantified using special dyes.
- Trial name
- NCT00411333
- Testing
- triamcinolone acetonide (Kenalog)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Myocardial Infarction
Intracoronary Darbepoetin-alpha to Reduce The Infarct Size and Post-Infarct Remodeling
Prospective, randomized and open label trial Hypothesis Infusion of intracoronary darbepoetin-alpha at the time of reperfusion may reduce infarct size and post-infarct pathologic left ventricular remodeling in patients with…
- Trial name
- NCT01538771
- Testing
- Darbepoetin alfa, Control Saline
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Hypertension, Ischemic Heart Disease
A Morbidity-Mortality and Remodeling Study With Valsartan
The JIKEI HEART Study has been designed to investigate whether concomitant treatment with valsartan, an angiotensin II receptor blocker (ARB), in addition to conventional treatment, will improve the prognosis of 3000 Japanese…
- Conditions
- Hypertension, Ischemic Heart Disease, Congestive Heart Failure
- Trial name
- NCT00133328
- Testing
- valsartan
- Where
- Japan
- Volunteers
- 3,000 people
- Sponsor
- Jikei University School of Medicine
Acute Myocardial Infarction, Ventricular Remodeling
Thrombectomy and Improvement of Left Ventricular Function in AMI
To study the effect of a simple and fast 'modus operandi' by aspiration of thrombus and debris with the Export catheter in an acute occlusion, on microvascular (re)perfusion and late left ventricular remodeling.
- Trial name
- NCT00288665
- Testing
- Export catheter (Medtronic)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- R&D Cardiologie
Myocardial Infarction
Warning Model of Myocardial Remodeling After Acute Myocardial Infarction Using Multimodal Feature Structure Technology
Acute myocardial infarction (AMI) is one of the most important diseases threatening human life. The existing MI prognosis prediction scales mostly predict the incidence of death, recurrent MI and heart failure through 6-8…
- Trial name
- NCT06062316
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Renal Insufficiency, Chronic, Vascular Stiffness
Effect of Vitamin D3 Supplementation on Arterial and Bone Remodeling in Chronic Kidney Disease Patients
To evaluate in patients with chronic kidney disease the impact of two dosages of per os vitamin D3 supplementation (cholecalciferol) on large arterial stiffness (evaluated non invasively by pulse wave velocity and high-resolution…
- Conditions
- Renal Insufficiency, Chronic, Vascular Stiffness, Bone Diseases, Metabolic
- Trial name
- NCT02999204
- Testing
- Vitamin D3
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- Jewish General Hospital
Heart Failure, Myocardial Infarction
Diffusion MRI in Heart Failure
The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood.
- Conditions
- Heart Failure, Myocardial Infarction, Left Ventricular Hypertrophy
- Trial name
- NCT02973633
- Testing
- Diffusion Tensor MRI (DTI), Gadolinium DOTA Meglumine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Disease
Impact of Presurgical Exercise on Hemodialysis Fistula Outcomes
The purpose of this research study is to determine whether two different types of forearm exercise, performed before fistula creation surgery, can improve surgery success and fistula maturation.
- Trial name
- NCT02205944
- Testing
- Progressive Handgrip Exercise
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University Health Network, Toronto
Atherosclerosis Cerebral, Carotid Plaque
RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling
Carotid artery stenosis is a major cause of ischemic stroke. However, many strokes occur in patients with only mild-to-moderate stenosis.
- Conditions
- Atherosclerosis Cerebral, Carotid Plaque, Vulnerable Plaque, Carotid Stenosis
- Trial name
- RESCUE (NCT07819643)
- Testing
- Intervention 1, Intervention 3, Intervention 2
- Volunteers
- 120 people
- Sponsor
- Keqiang Zhao
Atrial Fibrillation
Reappraisal of Atrial Fibrillation: RACE-V - Work Package 5
In the proposed study the investigators aim to clarify the relative contribution of these different mechanisms to the progression of atrial fibrillation (AF).
- Trial name
- RACE V- WP 5 (NCT03124576)
- Testing
- Implantable loop recorder
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Acute Coronary Syndrome
Study on Prediction of Left Ventricular Remodeling Using ST2
Patients who underwent percutaneous coronary intervention after diagnosis of acute coronary syndrome should be enrolled in the study and follow - up.
- Trial name
- TRUSTED (NCT03841214)
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Keimyung University Dongsan Medical Center
Aortic Dissection, Acute DeBakey I Dissection
Post-market Registry of the AMDS for the Treatment of Acute DeBakey Type I Dissection
The objective of this registry is to collect information on the performance and clinical benefits of the AMDS (Ascyrus Medical Dissection Stent) to treat patients with acute "DeBakey type I dissections" and with or without so…
- Conditions
- Aortic Dissection, Acute DeBakey I Dissection, Acute Type A Dissection, Intramural Hematoma
- Trial name
- PROTECT (NCT03894033)
- Testing
- Ascyrus Medical Dissection Stent (AMDS)
- Where
- Germany
- Volunteers
- 301 people
- Sponsor
- JOTEC GmbH
Atrial Fibrillation
Reappraisal of Atrial Fibrillation: Interaction Between HyperCoagulability, Electrical Remodeling, and Vascular Destabilisation in the Progression of Atrial Fibrillation
The purpose of this study is to study clinical factors and (blood) biomarkers related to progression of Atrial Fibrillation (AF) in patients diagnosed with self-terminating AF with special reference to hypercoagulability.
- Trial name
- RACE V (NCT02726698)
- Where
- 9 sites in Netherlands
- Volunteers
- 750 people
- Sponsor
- University Medical Center Groningen
Heart Failure, Myocardial Infarction
PARACHUTE III Pressure Volume Loop Sub-Study
The primary objective is to assess the longterm safety of the CardioKinetix Parachute Implant and Delivery System in the partitioning of the left ventricle in patients with heart failure due to ischemic heart disease.
- Trial name
- PIII PV Loop (NCT02241837)
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 11 people
- Sponsor
- CardioKinetix, Inc
Heart Failure and ST Elevation Myocardial Infarction
Predictors of Heart Failure After ST-segment Elevation Myocardial Infarction (HF-EXPRESS)
Objective: The purpose of this project is to study the post miyocardial infaction (MI) damage and subsequently developed post-infarct cardiac repair process on the basis of cellular, molecular and imaging techniques.
- Trial name
- HF-EXPRESS (NCT02650934)
- Testing
- Percutanous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 312 people
- Sponsor
- Dr. Nafiz Korez Sincan State Hospital
Hypertension
Compare Effectiveness of Eplerenone vs Atenolol in Reversing the Remodelling Resistance Arteries in Subjects With HT
To investigate the impact of antihypertensive therapy with the selective mineralocorticoid receptor blocker, eplerenone, on small resistance artery remodeling, compared to the effect of equivalent blood pressure control achieved…
- Trial name
- NCT00147563
- Testing
- Eplerenone
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Pfizer
Heart Failure With Preserved Ejection Fraction
Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic
The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.
- Trial name
- NCT05839028
- Where
- Russia
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences