Clinical trials: Vascular Remodeling
Aortic Geometry, Vascular Remodeling
Impact of Aortic Geometry on Vascular Remodeling After Stent Implantation in Coarctation of the Aorta
This study aims to assess: 1. Aortic geometrical changes and their relationship to hypertension and cardiovascular events. 2. Aortic geometrical differences between healthy individuals and patients with repaired coarctation of…
- Conditions
- Aortic Geometry, Vascular Remodeling, Coarctation of Aorta, Blood Pressure
- Trial name
- NCT07131111
- Testing
- CT aortography, CMR
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Vascular Diseases, Cardiovascular Diseases
The Long-term and Short-term Efficacy and Safety of Transplantation Autologous Bone Marrow Cells (BMCs) in Patients With the First STEMI (ST Segment Elevation Myocardial Infarction)
The purpose of this study is to test the hypothesis that the intracoronary transplantation of autologous mononuclear and CD 133 + bone marrow cells will improve left ventricular contractile function and will reduce the combined…
- Conditions
- Vascular Diseases, Cardiovascular Diseases, Acute Myocardial Infarction
- Trial name
- ESTABOMA (NCT01748383)
- Testing
- Transplantation of BMMCs, Transplantation of CD 133+ cells, stenting of IRA
- Where
- Russia
- Volunteers
- 85 people
- Sponsor
- Russian Academy of Medical Sciences
Coronary Artery Disease
Dynamic Change of Coronary Artery Curvature
The novolimus-eluting DynamX bioadaptor system is composed of 71 µm cobalt-chromium sinusoidal rings connected to each other axially by three S-links Each ring contains three uncaging elements that are positioned at equal…
- Trial name
- DC3 (NCT04936191)
- Testing
- DynamX Bioadaptor
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Stenosis, Internal Carotid Artery
Pilot Study of Autoarterial Remodeling of Bifurcation of the Common Carotid Artery
Comparison of two methods for revascularization of the bifurcation of common carotid artery: carotid endarterectomy with longitudinal incision carotid endarterectomy patch angioplasty compared with new technique of carotid…
- Trial name
- NCT03027752
- Testing
- Operation carotid endarterectomy with plastic of xenopericardial patch, New method of operation сarotid endarterectomy with autoarterial remodeling of bifurcation CCA
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Post Myocardial Infarction
Daily REmote Ischaemic Conditioning Following Acute Myocardial Infarction
Remote ischaemic conditioning (RIC) is known to reduce infarct size post MI when used in the peri/immediate post infarct period.
- Trial name
- DREAM (NCT01664611)
- Testing
- Remote Ischaemic Conditioning administered via the inflation of a blood pressure cuff on the upper arm
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Leicester
Type B Aortic Dissection, Tevar
Research on Predicting Aortic Remodeling Following TEVAR for Type B Aortic Dissection Based on VDM and CFD
This study proposes a retrospective analysis that systematically integrates multidimensional biomechanical and anatomical data to construct an early and accurate predictive model for adverse aortic remodeling following thoracic…
- Conditions
- Type B Aortic Dissection, Tevar, CFD
- Trial name
- NCT07779291
- Testing
- Thoracic Endovascular Aortic Repair
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Acute Myocardial Infarction
Effects of Intracoronary Progenitor Cell Therapy on Coronary Flow Reserve After Acute MI
Coronary flow reserve is an important measure of the integrity of the coronary microcirculation. Moreover, impaired coronary flow reserve is a predictor of future cardiovascular events and poor prognosis in patients after acute…
- Trial name
- REPAIR-ACS (NCT00711542)
- Testing
- autologous bone marrow-derived progenitor cells
- Where
- 2 sites in Germany
- Volunteers
- 31 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Myocardial Infarction
High-Intensity Interval Training Early After Left Ventricular Myocardial Infarction
Several studies have shown that high-intensity interval training (HIIT) is more effective than moderate-intensity continuous exercise training (MICE) at improving functional capacity and quality of life in stable cardiac patients…
- Trial name
- HIIT-EARLY (NCT02627586)
- Testing
- HIIT, MICE
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Aortic Syndrome, Aortopathy
Protective Effect of Statin Against Negative Cardiovascular Remodeling and Organ Dysfunction After Acute Aortic Syndrome Surgery (PANDA III)
Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year…
- Trial name
- PANDA (NCT04699279)
- Testing
- Rosuvastatin 10mg
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Myocardial Infarction
Early Treatment of ARNI on Myocardial Remodeling and Progress
Myocardial remodeling following myocardial infarction (MI) is an important prognostic factor for heart function and adverse cardiovascular events, especially are intimately linked with heart failure.
- Trial name
- NCT04342351
- Testing
- sacubitril/valsartan, perindopril, Cardiopulmonary Exercise Test
- Where
- China
- Volunteers
- 280 people
- Sponsor
- RenJi Hospital
Congenital Heart Disease, Fontan Operation
The Role of the Pulmonary Vasculature in the Fontan Circulation
This study aims to explore the structural and functional characteristics of the pulmonary vasculature in adult Fontan patients. Objectives: Determine the effect of pulmonary vasodilatation on indexed cardiac output during…
- Conditions
- Congenital Heart Disease, Fontan Operation, Pulmonary Vascular Resistance, Pulmonary Vascular Remodeling
- Trial name
- NCT02414321
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Hypertension,Essential, Obstructive Sleep Apnea
A Cardiosleep Research Program on Obstructive Sleep Apnea, Blood Pressure Control and Maladaptive Myocardial Remodeling
The objective of this proposal is to evaluate whether mandibular advancement device (MAD) is non-inferior to continuous positive airway pressure (CPAP) in the treatment of obstructive sleep apnea (OSA) and blood pressure…
- Trial name
- CRESCENT (NCT04119999)
- Testing
- Mandibular Advancement Device, Continuous Positive Airway Pressure
- Where
- Singapore
- Volunteers
- 321 people
- Sponsor
- National University of Singapore
Myocardial Infarction, Diabetes Mellitus, Type 2
SGLT2 Inhibitors on Clinical Outcomes and Left Ventricular Remodeling in Type 2 Diabetic Patients with Acute Myocardial Infarction, a Prospective, Multi-center Registry Study
Prospective trials performed on type 2 diabetes patients without established cardiovascular disease has shown that SGLT2 inhibitors reduce cardiovascular risk.
- Trial name
- RECORD-AMI (NCT05770687)
- Testing
- SGLT2 inhibitor
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Kiyuk Chang
Cardiac Remodeling, Myocardial Infarction
Paroxetine-mediated GRK2 Inhibition to Reduce Cardiac Remodeling After Acute Myocardial Infarction
This study evaluates the off-target effect of paroxetine to reverse cardiac remodeling and improve left ventricular ejection fraction in patients after acute myocardial infarction.
- Trial name
- CARE-AMI (NCT03274752)
- Testing
- Paroxetine
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
STEMI
The Protective Effect of Prostaglandin on Coronary Microcirculation and Ventricular Remodeling After Reperfusion Therapy in Acute ST-segment Elevation Myocardial Infarction
To explore the protective effect of prostaglandin sodium on coronary microcirculation function and ventricular remodeling after reperfusion treatment of acute ST-segment elevation myocardial infarction.
- Trial name
- NCT05043558
- Testing
- beprostaglandin sodium
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Shenzhen People's Hospital
Coronary Arterial Disease (CAD)
AVS Pulse Intravascular Lithotripsy™ (Pulse IVL™) to Open Vessels With Calcific Walls and Enhance Vascular Compliance and Remodeling for Coronary Artery Disease
A prospective, open-label, multi-site, FIH with up to fifteen (n=15) patients to assess the safety and preliminary effectiveness of the AVS Pulse Intravascular Lithotripsy™ System (Pulse IVL™ System) when used for the treatment…
- Trial name
- POWER CAD I (NCT07510438)
- Testing
- Pulse Intravascular Lithotripsy (Pulse IVL)
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 15 people
- Sponsor
- Amplitude Vascular Systems, Inc.
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Heart Failure With Preserved Ejection Fraction
Association Between Coronary and Peripheral Vascular Injury in Heart Failure Patients With Preserved Ejection Fraction.
Heart failure with preserved ejection fraction (HPEF, defined as LVEF ≥50%) represents 50% of hospital admissions for heart failure.
- Trial name
- COROVASC (NCT05884346)
- Testing
- Ultrahigh-frequency ultrasound
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction, Ventricular Remodeling
Disparities in Myocardial Infarction Remodeling According to Gender
Following myocardial infarction, female individuals demonstrate a poorer prognosis, characterized by elevated rates of mortality and heart failure. A primary hypothesis suggests unfavorable cardiac remodeling in women.
- Trial name
- REMOVE 2 (NCT06343844)
- Testing
- cardiac imaging to assess left ventricular volumes and function
- Where
- France
- Volunteers
- 1,650 people
- Sponsor
- University Hospital, Angers
Intracranial Aneurysm
Cascade Clinical Data Collection Protocol
This study is a multi-center, single arm, open label, retrospective and prospective clinical data collection of CascadeTM, Non-Occlusive Remodeling Net, in adults with intracranial aneurysms, demonstrating the effectiveness and…
- Trial name
- NCT04760925
- Testing
- CascadeTM, Non-Occlusive Remodeling Net
- Where
- 7 sites in Bulgaria, Germany and 3 more
- Volunteers
- 112 people
- Sponsor
- Perflow Medical