Clinical trials: Vascular Risk
Smoldering Multiple Myeloma
Selinexor for the Treatment of Intermediate and High-Risk Smoldering Multiple Myeloma
Selinexor is a drug that has been approved in the treatment of patients with symptomatic multiple myeloma. The standard of care for patients with Smoldering Multiple Myeloma remains observation, but there are numerous clinical…
- Trial name
- NCT05597345
- Testing
- Selinexor
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Rochester
Coronary Artery Disease
Development of a Risk Prediction Algorithm Through the Investigation of Genetic Risk Factors and the Complexity of Coronary Artery Disease to Estimate Future Risk of Cardiovascular Events: Angiographic (SYNTAX Score), Clinical and Pharmacogenetic Analysis.
The purpose of the research project is to investigate the potential association of 207 genetic polymorphisms with the complexity and the severity of coronary artery disease (SYNTAX score), along with the patients' response to…
- Trial name
- GESS (NCT03150680)
- Testing
- SNPs associated with CAD, SNPs associated with pharmacological response to clopidogrel and statins
- Where
- Greece
- Volunteers
- 1,080 people
- Sponsor
- AHEPA University Hospital
Acute Chest Pain, Acute Coronary Syndrome
Prognostic Value of Cardiovascular Risk of sST2 and Troponin I-hs in Patients With Acute Chest Pain
The role of the sST2 biomarker has been widely explored in heart failure, so much so that it was included in the AHA guidelines in 2013 and 2017.
- Trial name
- sST2 (NCT05752188)
- Testing
- Multimarker approach in acute coronary syndrome
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease
Relationship Between Coronary CT Angiography Findings and Prognosis Of Patients Undergoing PCI
Researchers at Cerrahpaşa Medical School in Istanbul are studying how a heart imaging test called coronary CT angiography can help improve care for people with coronary artery disease.
- Trial name
- NCT07051473
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Kawasaki Disease
Defibrotide in Children With High Risk Kawasaki Disease
This study evaluates the safety of defibrotide with IVIG in children with high risk Kawasaki disease.
- Trial name
- NCT04777422
- Testing
- Defibrotide
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- New York Medical College
Cardiovascular Risk Factors, Blood Pressure
Effect of a Specific Phenolic Compound on Blood Pressure
The study's main objective is to investigate the effects of acute consumption of a preparation containing 100 mg of a specific phenolic compound (patent pending, P201531587) on systolic BP after ingestion of a high fat meal.
- Trial name
- PHENOLPRESS (NCT02628353)
- Testing
- phenolic compound
- Where
- Spain
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Hypercholesterolemia
Mercury II - Compare the Efficacy and Safety of Lipid Lowering Agents Atorvastatin and Simvastatin With Rosuvastatin in High Risk Subjects With Type IIa and IIb Hypercholesterolemia
The purpose of this study is to determine whether treatment with rosuvastatin following atorvastatin or simvastatin treatment will improve health outcomes for patients at high risk of Coronary heart disease compared to…
- Trial name
- NCT00654407
- Testing
- Rosuvastatin, Atorvastatin, Simvastatin
- Volunteers
- 4,875 people
- Sponsor
- AstraZeneca
Diabetes (DM), Diabetes Complication
Feasibility of Home Monitoring of Visual Function in DR
Diabetes is a serious condition where patients can develop complications in their body including their eyes which can lead to sight loss.
- Conditions
- Diabetes (DM), Diabetes Complication, Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetic Retinopathy (DR)
- Trial name
- NCT07386613
- Testing
- Okko Health App
- Where
- 3 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- Queen's University, Belfast
Cardiovascular Risk Factor
Choline and Cardiometabolic Health
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular…
- Trial name
- NCT04764162
- Testing
- Choline
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Cardiovascular Risk Factor, Cardiovascular Diseases
Umbrella Review of the DASH Dietary Pattern and Cardiometabolic Risk
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding the Dietary Approaches to Stop Hypertension (DASH) diet, a dietary pattern that emphasizes fruits and…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Coronary Heart Disease, Stroke
- Trial name
- NCT03542370
- Testing
- DASH dietary pattern
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Coronary Disease, Cardiovascular Diseases
Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS])
Heart disease is the leading cause of death in the United States and is responsible for 30% of all deaths in the United States. This study will examine how risk factors for heart disease in young and middle aged people affect…
- Trial name
- CHAS (NCT00626379)
- Where
- United States
- Volunteers
- 1,395 people
- Sponsor
- Northwestern University
Endoleak, Abdominal Aortic Aneurysm
Contrast Enhanced Ultrasound, Endoleak Detection Following EVAR v1.3
A single site cross-sectional comparison of paired diagnostic imaging modalities. This study will show the sensitivity and specificity of CEUS in detecting the various types of endoleaks, in comparison to tCTA, following EVAR.
- Trial name
- NCT02688751
- Testing
- time-resolved CT Angiography, Contrast Enhanced Ultrasound
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Cardiovascular Risk Factor
Vascular Effects of Dietary Potassium
The purpose of this study is to determine if dietary potassium can attenuate the deleterious effects of high sodium on blood vessel function in healthy, salt-resistant participants.
- Trial name
- NCT03265353
- Testing
- Moderate Potassium/Low Sodium Diet, Moderate Potassium/High Sodium Diet, High Potassium/High Sodium Diet
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Transient Ischemic Attack (TIA)
Canadian TIA Score Versus ABCD2 Score in Risk Stratification of Transient Ischemic Attack (TIA)
This study aims to evaluate the superiority of a clinical score (Canadian TIA score) compared to the currently more widely used score in clinical practice (ABCD2 score) in stratifying the risk of stroke or carotid…
- Trial name
- NCT06718075
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Coronary Artery Disease
CCTA to Optimize the Diagnostic Yield of Invasive Angiography
This study aims to reduce patient risk and costs to the healthcare system by improving the diagnostic yield of invasive coronary angiography through existing triage processes to improve risk stratification using Coronary Computed…
- Trial name
- CarDIA (NCT03554057)
- Testing
- Coronary Computed Tomographic Angiography
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- Hamilton Health Sciences Corporation
Brain Tumor, Vascular Lesion
Factor XIII and Pulmonary Embolism in Neurosurgical Patients
Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy.
- Conditions
- Brain Tumor, Vascular Lesion, Factor XIII Deficiency, Pulmonary Embolism
- Trial name
- NCT01106937
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Ludwig-Maximilians - University of Munich
ASCVD, Hyperlipidemia
Duke Cardiometabolic Prevention Clinic's Impact on High-risk Cardiovascular Patients With Uncontrolled Risk Factors
This project is studying whether a team-based specialty clinic can help people with type 2 diabetes and heart disease better manage their blood pressure and cholesterol.
- Conditions
- ASCVD, Hyperlipidemia, Hypertension
- Trial name
- DUKE PREVENT (NCT07117695)
- Testing
- Referral to the Duke Cardiometabolic Prevention Clinic
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Atherosclerotic Cardiovascular Disease
EHR Nudges: Optimizing a Clinical Decision Support System for Evidence-Based Statin Medication Prescribing to Reduce the Risk of Cardiovascular Disease
The overall objective of this proposal is to develop and optimize a CDSS, including several nudges, to increase guideline-concordant statin prescribing for CVD risk (Nudge-CVD-CDSS).
- Trial name
- NCT07914777
- Testing
- EHR Nudge
- Where
- United States
- Volunteers
- 7,501 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alcohol Misuse, Hypertension
Telehealth Treatment of Veterans With Alcohol Misuse at Risk for Cardiovascular Disease
The primary objective of this project is to refine a cognitive-behavioral intervention for comorbid alcohol misuse and modifiable CVD risk with diverse stakeholder input, so that the intervention can be deployed within existing…
- Conditions
- Alcohol Misuse, Hypertension, Elevated Cardiovascular Risk
- Trial name
- ACME-TM (NCT04838457)
- Testing
- Alcohol and CVD Management and Engagement through Telehealth and mHealth (ACME-TM)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cardiovascular Disease, Hypertension
The GoodNEWS Lifestyle Enhancement Program
This study will train Lay Health Promoters (LHPs) from African-American churches to administer healthy living lessons and activities to their congregations in order to improve overall health and address cardiovascular disease.
- Conditions
- Cardiovascular Disease, Hypertension, Diabetes, Obesity
- Trial name
- GoodNEWS (NCT00669630)
- Testing
- Lay Health Promoter (LHP) with maintenance
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
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