Clinical trials: Vascular Risk
Phlebitis
Reducing the Risk of Phlebitis From Peripheral Venous Catheter
Nurses frequently use peripheral venous catheters in hospitals to provide medications and fluids for therapeutic and diagnostic purposes.
- Trial name
- NCT05714137
- Testing
- Evaluation of the Effect of Proximal Massage and Fist Clenching in Reducing the Risk of Phlebitis From Peripheral Venous Catheter
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Hypertension, Hypercholesterolemia
Vascular Intervention Strategies Trial for Alzheimer's
The proposed pharmacist-led study is a feasibility pilot trial for the management of vascular risk factors of hypertension and hypercholesterolemia in 10 APOE ε4 carriers, 50-75, at-risk for dementia.
- Conditions
- Hypertension, Hypercholesterolemia, Dementia Risk Factors
- Trial name
- VISTA (NCT07447206)
- Testing
- Angiotensin Receptor Blockers (ARBs), Hydrophilic Statins or Non-Statin Alternative
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Coronary Heart Disease
A Phase II Study of the Safety and Efficacy of MPSK3169A in Patients With Coronary Heart Disease or High Risk of Coronary Heart Disease
The purpose of this study is to evaluate the safety and cholesterol lowering effects of MPSK3169A when given as subcutaneous (SC) injections over a 24-week period to patients with a high risk of cardiovascular events and LDL-c…
- Trial name
- NCT01609140
- Testing
- MPSK3169A
- Where
- 73 sites in United States, Canada and 7 more
- Volunteers
- 248 people
- Sponsor
- Genentech, Inc.
Venous Thromboembolism
Risk of Recurrent Venous Thrombosis: A Validation Study of the Vienna Prediction Model
Because of a high recurrence risk after unprovoked venous thromboembolism (VTE) indefinite anticoagulation is recommended, but confers a considerable bleeding risk.
- Trial name
- NCT01972243
- Testing
- no intervention
- Where
- Austria
- Volunteers
- 800 people
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Active Detection of the Extension of Atherothrombosis in High Risk Coronary Patients
Coronary artery disease is the first cause of death related to atherothrombosis.
- Trial name
- AMERICA (NCT00445835)
- Testing
- Arterial doppler for screening asymptomatic and significant extracoronary arterial stenoses in all arterial beds, Conservative arm
- Where
- France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leukemia, Lymphoma
Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00002989
- Testing
- busulfan, cyclophosphamide, idarubicin
- Where
- 9 sites in Belgium, France and 3 more
- Volunteers
- 207 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Major Depression
Brain Abnormalities in Late-Onset Major Depression
The objective of this project is to examine the state of the brain in people over 50 years old suffering from late-onset depression by means of an extensive clinical assessment programme, including magnetic resonance imaging…
- Trial name
- NCT00260468
- Testing
- Clinical examination program
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension
The Effect of Timing of Antihypertensive Medication on Diurnal Fluctuations in Blood Pressure Using a Wearable Sensor With Continuous Monitoring
Minimal or absent of diurnal fluctuation in blood pressure, and specifically conditions in which BP values are elevated during the night compared to daytime (rather than "nighttime dipping"), are associated with higher rates of…
- Trial name
- ABPM (NCT04826250)
- Testing
- Timing of medication
- Where
- Israel
- Sponsor
- Tel Aviv University
Pulmonary Embolism
Validation of Different Risk Assessment Strategies in Normotensive Pulmonary Embolism
A risk stratification in hemodynamically stable patients with acute pulmonary embolism (PE) is deemed necessary to guide patient management.
- Trial name
- NCT02843243
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Azienda Ospedaliera Cosenza
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Development of a Novel Risk Prediction Tool for Emergency Department Patients Symptoms of Coronary Artery Disease
Patients with chest pain and symptoms of acute coronary syndromes (ACS) account for over 600,000 emergency department (ED) visits annually in Canada.
- Trial name
- NCT06743672
- Where
- Canada
- Volunteers
- 6,500 people
- Sponsor
- University of Calgary
Venous Thromboembolism, Deep-Vein Thrombosis
Implementing a Tool to Identify Risk for Venous Thromboembolism in Cancer Patients
Cancer increases the risk of deep vein blood clots and clots traveling to the lungs (emboli) which cause morbidity (leg swelling, pain, and shortness of breath), sudden death, delays cancer treatment, and decreases cancer…
- Conditions
- Venous Thromboembolism, Deep-Vein Thrombosis, Pulmonary Embolism, Cancer
- Trial name
- NCT01602432
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Thorax Injuries, Embolism Vein
Retrospectively Analyze the Risk Factors of VTE in 5774 Patients With Thoracic Trauma From 33 Hospitals in China, and Established a Risk Prediction Model
Retrospectively analyze the risk factors of VTE in 5774 patients with thoracic trauma from 33 hospitals in China, and established a risk prediction model
- Conditions
- Thorax Injuries, Embolism Vein, Embolism, Pulmonary, Rib Fractures
- Trial name
- MCTTVTE (NCT05770232)
- Where
- China
- Volunteers
- 5,774 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Coronary Artery Disease
CCTA-FFR Registry for Risk Prediction
The investigators sought to investigate the prognostic implication of qualitative and quantitative plaque analysis on coronary CT angiography (CCTA) according to fractional flow reserve (FFR).
- Trial name
- NCT04037163
- Testing
- Fractional flow reserve, Coronary CT angiography
- Volunteers
- 747 people
- Sponsor
- Seoul National University Hospital
Coronary Heart Disease, Risk Reduction Behavior
Adherence to an Exercise and Healthy Diet Program in Patients With Coronary Heart Disease Aged ≥ 60 Years
The purpose of the study is to implement a multimodal lifestyle intervention over 3 months in individuals ≥ 60 years of age with coronary heart disease and to examine the adherence to this intervention program.
- Conditions
- Coronary Heart Disease, Risk Reduction Behavior, Adherence, Treatment
- Trial name
- RE-Start60+ (NCT06178263)
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- University Medicine Greifswald
Pediatric Hypertension, Primary Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial…
- Conditions
- Pediatric Hypertension, Primary Hypertension, Endothelial Dysfunction
- Trial name
- HYPER-endoEV-c (NCT07728643)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Venous Thrombosis
Prevention of Thrombosis Recurrence in Patients With Low Circulating Levels of Antithrombin.
The aim of this study is to estimate the incidence of spontaneous and provoked recurrent VTE and the bleeding events during a 10-year follow-up in subjects experiencing a first VTE stratified according to % AT levels and to…
- Trial name
- NCT01382550
- Testing
- long-lasting OAT or 12-month OAT
- Where
- Italy
- Volunteers
- 900 people
- Sponsor
- Federico II University
Social Determinant of Health, Intracranial Aneurysms
Risk Analysis of Intracranial Aneurysm Rupture Through Social Determinants of Health
Intracranial aneurysms (IA) are arterial malformations affecting about 3% of the overall population. Rupture is the most severe complication, as it is associated with nearly 30% of death or severe disability.
- Conditions
- Social Determinant of Health, Intracranial Aneurysms, Subarachnoid Hemorrhage, Treatment Outcomes
- Trial name
- ARAMISS (NCT06866210)
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- Nantes University Hospital
Stroke
Mindful Meditation for Chronic Stroke
Falls have significant consequences for older adults, including fracture, disability, and death (1). Risk factors for falls include both impaired physical and cognitive function (1).
- Trial name
- NCT02687048
- Testing
- Otago Exercise program, Mindful meditation
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiovascular Diseases, Heart Diseases
Epidemiology of Cardiovascular and Non-Cardiovascular Risk In Chicago
To continue the comprehensive research program on the epidemiology of cardiovascular and other major chronic diseases, including cancer and diabetes, in four Chicago population cohorts.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Cerebrovascular Disorders
- Trial name
- NCT00005140
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus
New Patient-specific Functional Assessment of the Anomalous Aortic Origin of Coronary Arteries.
Anomalous Aortic Origin of the Coronary Arteries (AAOCA) is a rare congenital disease that may cause sudden death in young subjects.
- Conditions
- Anomalous Coronary Artery Origin, Anomalous Coronary Artery Arising from the Opposite Sinus, Anomalous Coronary Artery Course, Anomalous Coronary Artery with Aortic Origin and Course Between the Great Arteries
- Trial name
- NECESSARY (NCT05159791)
- Testing
- Invasive coronary blood flow assessment and simulations and fluid dynamic patient specific simulation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Policlinico S. Donato
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