Clinical trials: Vascular Risk
Assessment of Vascular Health Risk Factors
Innsbruck Health Promotion Program
The primary goal of this single-centre. single-arm, unblinded, pre-post interventional study is to evaluate whether a one-time health assessment and intervention affects the overall vascular health evaluated through the Life's…
- Trial name
- INNHEALTH (NCT06813677)
- Testing
- In-person health promotion
- Where
- Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Pregnancy Related
Diagnostic Performance of Antenatal Ultrasound for High-Risk Intestinal Malrotation
The aims of this study are: To assess the performance of third-trimester ultrasound scan in the localization of intestinal structures (small bowel, gut, mesenteric vessels..) involved in malrotations with a higher-risk of…
- Trial name
- MALGRE (NCT03968107)
- Testing
- Reference ultrasound examination
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Insulin Resistance, Atherosclerosis
The Effect of Cranberry Extract Supplementation on Cardiovascular Risk Factors in Obese, Insulin Resistant Humans
The purpose of this study is to determine the health benefits of cranberry extract in people who are at risk for diabetes and heart problems.
- Trial name
- NCT02068144
- Testing
- Cranberry Extract
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Hypertension, Cardiovascular Disease
Socioeconomic Status, Psychosocial Factors, and CVD Risk in Mexican-American Women
Cardiovascular disease (CVD) is the leading cause of death in American women, claiming on average 40% of all female deaths each year.
- Conditions
- Hypertension, Cardiovascular Disease, Metabolic Disorders
- Trial name
- NCT00387166
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Multiple Myeloma, Lymphocytic Leukemia, Chronic
Study of Low-Intensity Conditioning for Allogeneic Stem Cell Transplant
The purpose of this study is to determine whether a reduced intensity conditioning regimen for stem cell transplant with donor cells will allow the donor cells to be effective without causing health problems.
- Conditions
- Multiple Myeloma, Lymphocytic Leukemia, Chronic, Lymphoma, Low-Grade
- Trial name
- NCT00143845
- Testing
- Reduced intensity conditioning, Rapid immunosuppressive taper, Prophylactic donor leukocyte infusions
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Michigan Rogel Cancer Center
Hypertension
Study of the Impact of Low Fat Dairy and High Fat Dairy Consumption on Daytime Ambulatory Blood Pressure
Market trends depicted by Agriculture and Agri-Food Canada suggest stagnation in cheese consumption, with potentially important impact on this key industry in Canada.
- Trial name
- GABA2 (NCT02763930)
- Testing
- Control diet, Milk diet, GABA-rich cheese diet
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Hypertension, African Americans
Giving a Low Carbohydrate Diet to Overcome Hypertension
This study will test the preliminary efficacy of adding a very low carbohydrate dietary intervention to the evidence-based DPP-GLB on blood pressure reductions for lower-income AA men and women in a community-based clinic.
- Conditions
- Hypertension, African Americans, Diet, Carbohydrate-Restricted, Risk Reduction Behavior
- Trial name
- GLOH (NCT04230928)
- Testing
- Very low carbohydrate diet, Standard DPP-GLB diet, Standard DPP-GLB program modules
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Stable Angina, Acute Kidney Injury
CI-AKI in Patients With Stable CAD and Comorbidities. Are we Doing Better?
Patients aged 18-89 with stable CAD and comorbidities receiving optimal medical treatment requiring PCI with iodinated contrast media.
- Conditions
- Stable Angina, Acute Kidney Injury, Contrast-induced Nephropathy
- Trial name
- NCT04014153
- Testing
- Iodinated contrast media
- Volunteers
- 1,023 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Hypertension
A Randomized Trial of Changing Medication Adherence In Hypertensive African-American Patients
The long-term objective is to determine whether better adherence to prescribed medications can be achieved through positive affect induction and self-affirmation leading to reduction in hypertension-related outcomes such as…
- Trial name
- NCT00248872
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 278 people
- Sponsor
- Weill Medical College of Cornell University
Multiple Myeloma
Efficacy and Safety Study of bb2121 Versus Standard Regimens in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)
This is a multicenter, randomized, open-label, Phase 3 study comparing the efficacy and safety of bb2121 versus standard regimens in subjects with relapsed and refractory multiple myeloma (RRMM).
- Trial name
- KarMMa-3 (NCT03651128)
- Testing
- bb2121, Daratumumab, Pomalidomide
- Where
- 62 sites in United States, Belgium and 11 more
- Volunteers
- 386 people
- Sponsor
- Celgene
Cardiovascular Diseases, Heart Diseases
Genetics of CVD Risk Factors in Samoans
To evaluate the role of known genes involved in lipid metabolism on serum lipid and apolipoprotein levels in Samoans residing in American and Western Samoa, who were exposed to the biobehavioral changes of modernization.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Atherosclerosis
- Trial name
- NCT00005528
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension, Diabetes
Study of a Community Based Approach to Control Cardiovascular Risk Factors in India
The study is a 2 year community based cluster randomized controlled trial to assess the role that a community health worker led intervention, in concert with physician education, can play in controlling the principal…
- Conditions
- Hypertension, Diabetes, Smoking, Cardiovascular Diseases
- Trial name
- SEHAT (NCT02115711)
- Testing
- Community health worker
- Where
- India
- Volunteers
- 1,242 people
- Sponsor
- University Hospitals Cleveland Medical Center
Type 2 Diabetes Mellitus, Endothelial Dysfunction
Huangqi Gegen Decoction for Endothelial Function in Type 2 Diabetes at Very High ASCVD Risk
This clinical trial evaluates whether Huangqi Gegen Decoction can improve blood vessel function in adults with type 2 diabetes mellitus who are at very high risk of atherosclerotic cardiovascular disease and meet the traditional…
- Conditions
- Type 2 Diabetes Mellitus, Endothelial Dysfunction, Cardiovascular Risk
- Trial name
- NCT07775664
- Testing
- Huangqi Gegen Decoction Granules, Conventional Treatment
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Putuo Hospital, Shanghai University of Traditional Chinese Medicine
Alzheimer Disease, Frontotemporal Dementia
Computational Tools for Early Diagnosis of Memory Disorders
The Virtual Physiological Human: DementiA Research Enabled by IT (VPH-DARE@IT) is a four-year IT-project funded through the European Union (EU).
- Conditions
- Alzheimer Disease, Frontotemporal Dementia, Dementia, Vascular, Mild Cognitive Impairment
- Trial name
- ProsKuopio (NCT02050464)
- Where
- 3 sites in Finland
- Volunteers
- 126 people
- Sponsor
- University of Eastern Finland
Cardiovascular Risk Factor, Heat Stress
Exercise and Sauna on Blood Pressure and Cardiovascular Health
The study aims to investigate the effects of including regular heat therapy when included to exercise. Specifically, participants in the sauna intervention group will undergo 15 minutes of sauna exposure immediately after a…
- Conditions
- Cardiovascular Risk Factor, Heat Stress, Sedentary Behavior
- Trial name
- ES2019 (NCT04540718)
- Testing
- Exercise, Sauna
- Where
- Finland
- Volunteers
- 47 people
- Sponsor
- University of Jyvaskyla
Elevated Blood Pressure, Habitual Sleep Duration of Less Than or Equal to 7 Hours
Sleep Technology Intervention to Target Cardiometabolic Health
The goal of this study is to test the efficacy of a behavioral sleep extension intervention on sleep duration, cardio-metabolic disease risk factors, and health behaviors among adults with elevated blood pressure/hypertension and…
- Trial name
- STITCH (NCT04766424)
- Testing
- Sleep extension intervention, Health education
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Utah
Inotropy, Fluid Management
RESIPI for Reducing Perioperative Major Adverse Cardiac Events
This study aims to evaluate the effect of a novel hemodynamic management and monitoring strategy for reducing cardiac bio marker elevations and major adverse cardiac events.
- Conditions
- Inotropy, Fluid Management, Cardiac Event, Perioperative Cardiac Risk
- Trial name
- RESIPI (NCT03208023)
- Testing
- RESIPI Management Strategy, No intervention
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Vanderbilt University Medical Center
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Pulmonary Embolism With Acute Cor Pulmonale
Catheter-directed Thrombectomy in High and Intermediate-high Risk Pulmonary Embolism
Pulmonary embolism is one of the leading causes of cardiovascular death. Pulmonary embolism may be life-threatening condition with an estimated 30-day mortality rate about 10-30%.
- Trial name
- CATH-PE (NCT04473560)
- Testing
- Catheter-directed thrombectomy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
HYPERTENSION
Hypertension and Cardiovascular Risk Factors
A study to evaluate the efficacy of valsartan+chydochlorothiazide in patients with stage 2 hypertension and cardiovascular risk factors.
- Trial name
- NCT00171782
- Testing
- VALSARTAN+HYDROCHLOROTHIAZIDE
- Volunteers
- 76 people
- Sponsor
- Novartis
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