Clinical trials: Vascular Risk
Atherosclerosis and Blood Flow in Coronary Artery
Geometrical Influences on Atherosclerosis and Blood Flow
The study investigates the use of advanced imaging techniques and computational methods to identify high-risk plaques in coronary arteries.
- Trial name
- NCT07002697
- Where
- Bangladesh
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bangladesh University of Engineering and Technology
HIV, Cardiovascular Diseases
Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults
People with HIV are at risk for cardiovascular disease (CVD). This study evaluated the use of pitavastatin to reduce the risk of CVD in adults with HIV on antiretroviral therapy (ART).
- Trial name
- REPRIEVE (NCT02344290)
- Testing
- Pitavastatin
- Where
- 137 sites in United States, Botswana and 11 more
- Volunteers
- 7,769 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Foot Ulcer
Becaplermin Use and Cancer Risk in a Patient Population of U.S. Veterans With Diabetes
The purpose of this study is to evaluate risk of cancer incidence and mortality associated with the use of REGRANEX (becaplermin) in patients with diabetes who are members of a U.S. Veterans Health Administration.
- Conditions
- Diabetes Mellitus, Foot Ulcer, Diabetic Foot, Diabetic Neuropathies
- Trial name
- NCT01235260
- Testing
- Becaplermin nonusers, Becaplermin users
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hypertension, Cardiovascular Risk Factor
HIGH Altitude CArdiovascular REsearch Latin America Population Study
High blood pressure (BP) is one of the principal cardiovascular risk factors. While BP levels and hypertension prevalence are well characterized in many populations, information on BP and on cardiovascular risk profile in high…
- Conditions
- Hypertension, Cardiovascular Risk Factor, Altitude Hypoxia, Altitude Sickness
- Trial name
- HIGHCARE-LAPS (NCT04751292)
- Testing
- Exposure to high altitude
- Where
- Peru
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Essential Hypertension, Cardiovascular Disease
Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment
The HYGIA study was designed to investigate prospectively 1. the prognostic value of ambulatory blood pressure (BP) monitoring among subjects primarily evaluated at primary care settings 2.
- Conditions
- Essential Hypertension, Cardiovascular Disease, Stroke, Chronic Kidney Disease
- Trial name
- HYGIA (NCT00741585)
- Testing
- Any antihypertensive medication alone or in combination, Ambulatory blood pressure monitoring
- Where
- 20 sites in Spain
- Volunteers
- 21,983 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Cancer-associated Thrombosis, Genetic Predisposition
A New Clinic-Genetic Risk Score for Predicting Venous Thromboembolic Events in Cancer Patient
Venous thromboembolism (VTE) is a common disease in cancer patients and one of the major causes of cancer-associated mortality. Risk for developing VTE increases when cancer patients are receiving chemotherapy.
- Trial name
- ONCOTHROMB (NCT03114618)
- Where
- 9 sites in Spain
- Volunteers
- 416 people
- Sponsor
- Andres muñoz
Shift-Work Sleep Disorder
Shift Work and Risk of Cardio-vascular Disease
The purpose of this research is to test the hypothesis that those with non-traditional work schedules (e.g. shift workers) have a higher cardio-metabolic risk than those with traditional work schedules (e.g.
- Trial name
- NCT02901860
- Testing
- Sleep, Dietary and Cardio-metabolic Measurements
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Hypertension, Cardiovascular Diseases
Effects of Cured Pork Peptides on Blood Pressure & Cardiovascular Risk Factors
Spanish dry-cured ham has been shown a source of antihypertensive peptides in mice. To date, no clinical study has been performed in humans to check the effects of bioactive peptides produced naturally during the processing of…
- Trial name
- PocPep-CVD (NCT02585089)
- Testing
- Spanish cured-pork ham, Cooked pork ham
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Acute Myocardial Infarction, Acute Coronary Syndrome
MERITnI - Mindray-hs-cTnI Assay: Analytical and Clinical Evaluation for the Diagnosis and RIsk AssessmenT of Myocardial InfarctIon.
The Mindray High Sensitivity Troponin-I Measurement System is an in vitro diagnostic test for the quantitative determination of high sensitivity cardiac troponin I (hs-cTnI) in human serum or plasma.
- Trial name
- MERITnI (NCT05853042)
- Testing
- high-sensitivity cardiac troponin testing
- Where
- United States
- Volunteers
- 1,559 people
- Sponsor
- Fred Apple
Type 2 Diabetes
Evaluation of Myocardial Perfusion Heterogeneity Imaging in Diabetes Patients (EVADIAB)
Long-term additive prognostic value of heterogeneity myocardial perfusion imaging of SPECT over clinical and ischemia in high-risk diabetic patients
- Trial name
- EVADIAB (NCT02316054)
- Testing
- MPHI
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Grenoble
Atherosclerotic Cardiovascular Disease, Familial Hypercholesterolemia
Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)
This study is a Phase II, placebo-controlled, double-blind, randomized trial in 480 participants with atherosclerotic cardiovascular disease (ASCVD) or ASCVD-risk equivalents (for example, diabetes and familial…
- Conditions
- Atherosclerotic Cardiovascular Disease, Familial Hypercholesterolemia, Diabetes
- Trial name
- ORION-1 (NCT02597127)
- Testing
- ALN-PCSSC, Normal Saline
- Where
- 54 sites in United States, Canada and 3 more
- Volunteers
- 501 people
- Sponsor
- The Medicines Company
Fitness Trackers, Sedentary Time
Fullscale_Intervention Study: Genetic Risk Communication in Coronary Heart Disease and Wearables
Background: This study aims to determine the effects of communicating genetic risk for Coronary Heart Disease (CHD) alone or in combination with goal setting and prompts from a wearable device on objectively measured sedentary…
- Conditions
- Fitness Trackers, Sedentary Time, Genetic Predisposition to Disease, Coronary Heart Disease
- Trial name
- NCT05789966
- Testing
- Genetic Risk Estimate+Health Coaching, Genetic Risk Estimate + Fitbit Functions+Health Coaching
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pregnancy, High Risk Pregnancies
DVA Risk Pregnancy
Maternal obesity, overweight and hypertensive disorders are among the most important risk factors for complications during pregnancy.
- Trial name
- NCT02340442
- Testing
- Obstetrical care parameters, DVA measurements, Fundus photographs
- Where
- 2 sites in Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Multiple Myeloma
Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone
A Clinical Phase II, multicenter, Open-label study evaluating iNduction, consolidation and maintenance treatment with Isatuximab (SAR650984), Carfilzomib, LEnalidomide and Dexamethasone (I-KRd) in Primary diagnosed high-risk…
- Trial name
- NCT03104842
- Testing
- Isatuximab, Carfilzomib, Lenalidomide
- Where
- 17 sites in Germany
- Volunteers
- 246 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
HIV-1-infection, Coronary Microvascular Dysfunction
Improving Coronary Vascular Health in Women
Women with HIV have an increased risk of having a myocardial infarction (heart attack) as compared to women without HIV. One of the mechanisms underlying the increased risk of myocardial infarction among women with HIV may…
- Conditions
- HIV-1-infection, Coronary Microvascular Dysfunction, Metabolic Disease
- Trial name
- INFORM_2 (NCT06843902)
- Testing
- Health Education, Subspecialty clinic referral
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Cardiovascular Diseases, Coronary Disease
Lifetime Risk for Cardiovascular Disease Among Non-White Ethnic Groups
Cardiovascular disease (CVD) is one of the leading causes of death in the United States. Currently, there is little information about the lifetime risk of CVD among non-white ethnic groups.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Failure, Congestive, Atrial Fibrillation
- Trial name
- NCT00377702
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes, Diabetes Mellitus
Computer-Assisted Cancer Risk Behavior Counseling
To test whether or not giving patients information before their doctor visits changes the care they receive and what type of information is best to give before the doctor visit.
- Conditions
- Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- NCT00242645
- Testing
- Health Information, Preventive Services, Computer tailored information
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Cardiovascular Diseases, Hypertension
The African-PREDICT Study
The African-PREDICT study aims to (i) generate new knowledge on the early pathophysiology accompanying hypertension development in black South Africans; and (ii) to identify early novel markers or predictors for the development…
- Conditions
- Cardiovascular Diseases, Hypertension, Health Risk Behaviors, Arterial Stiffness
- Trial name
- PREDICT (NCT03292094)
- Where
- South Africa
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- North-West University, South Africa
Neoplasms Malignant, Covid19
Thromboembolic Risk Screening in Patients With Cancer and COVID-19
Study Rational Since December 2019, outbreak of COVID-19 caused by a novel virus SARS-Cov-2 has spread rapidly around the world and became a pandemic issue.
- Conditions
- Neoplasms Malignant, Covid19, Thromboembolism
- Trial name
- NEOTHROCOVID (NCT04616846)
- Testing
- Peripheral venous ultrasound
- Where
- 6 sites in France, Monaco
- Volunteers
- 88 people
- Sponsor
- Centre Antoine Lacassagne
Hypertension, Cardiovascular Diseases
China Salt Substitute Study
Cardiovascular disease is a leading cause of death and disability worldwide, and blood pressure is a leading determinant of this risk.
- Trial name
- NCT00145756
- Testing
- low sodium high potassium salt substitute
- Where
- 6 sites in China
- Volunteers
- 600 people
- Sponsor
- The George Institute
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.