Clinical trials: Vascular Risk
Cardiovascular Risk Factor
Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans
Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature.
- Trial name
- NCT04101188
- Testing
- Moderate Potassium/Low Sodium Diet, Moderate Potassium/High Sodium Diet, High Potassium/High Sodium Diet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Cardiovascular Diseases, Hypertension
ICA-CHAMP: Indo-Central Asian Cardiovascular Health Assessment and Management Program
Research has shown that the presence of heart disease and stroke is higher in the Indo-Asian population compared to other ethno-cultural groups.
- Conditions
- Cardiovascular Diseases, Hypertension, Hyperlipidemia
- Trial name
- ICA-CHAMP (NCT00627159)
- Testing
- High risk assessment, Low to moderate risk
- Where
- 2 sites in Canada
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Atrial Fibrillation, Atrial Flutter
Combined Use of BIOTRONIK Home Monitoring and Predefined Anticoagulation to Reduce Stroke Risk
The IMPACT Study will investigate the potential clinical benefit of the combined use of BIOTRONIK Home Monitoring (HM) technology and a predefined anticoagulation plan compared to conventional device evaluation and…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Stroke, Embolism, Systemic Arterial
- Trial name
- IMPACT (NCT00559988)
- Testing
- Home Monitoring Guided OAC, Physician-Directed OAC
- Where
- 80 sites in United States, Australia and 4 more
- Volunteers
- 2,718 people
- Sponsor
- Biotronik, Inc.
Age-related Macular Degeneration, Coronary Artery Disease
Ranibizumab and the Risk of Arterial Thromboembolic Events
The investigators assume that ranibizumab might be dangerous in patients with history of coronary artery disease or cerebrovascular events.
- Conditions
- Age-related Macular Degeneration, Coronary Artery Disease, Cerebrovascular Disorders
- Trial name
- RATE (NCT01319188)
- Testing
- 0.5 mg of ranibizumab, 0.5 mg of ranibizumab + photodynamic therapy
- Where
- 2 sites in Netherlands, Russia
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Ural State Medical University
Overweight and Obesity, Type IIb Hyperlipidaemia
Low Carbohydrate Diet - Effect on Plasma Lipids and Metabolic Markers
Low carbohydrate diet may influence the plasma lipid levels.
- Conditions
- Overweight and Obesity, Type IIb Hyperlipidaemia, Hypercholesterolemia Aggravated
- Trial name
- NCT01476436
- Testing
- Low carbohydrate dietary advice, Continue usual diet
- Where
- 2 sites in Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Aortic Stenosis, Aortic Sclerosis
Risk Factors Associated With Calcification of the Aortic Valve
The purpose of this study is to determine the degree of endothelial dysfunction and inflammation in calcific aortic valve disease associated with coronary artery disease(CAD).
- Trial name
- NCT00375336
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Charles University, Czech Republic
Acute Ischemic Stroke
An Application That Can Provide Early Warning of Temperature Health Risks and Give Protective Suggestions or Personalized Suggestions Based on Patients' Own Secondary Prevention Risk Factors Was Applied to Intervene, and the Intervention Effect of APP on Stroke Recurrence Risk Was Analyzed
This study employs individualized temperature health risk early warning and risk factor management interventions for stroke, and explores their actual intervention effects.
- Trial name
- NCT06904664
- Testing
- Individualized temperature health risk early warning and risk factor management, Temperature health risk early warning, Risk factor management
- Volunteers
- 10,184 people
- Sponsor
- Xuanwu Hospital, Beijing
Neutropenia, Sickle Cell Disease
Decitabine for High-Risk Sickle Cell Disease
Background: In sickle cell disease (SCD), the proteins in the red blood cells that carry oxygen do not behave normally. In parts of the body where there are low levels of oxygen or where oxygen is used more, the sickle hemoglobin…
- Trial name
- NCT01375608
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
The Effect of a Healthy Diet Containing Flaxseed and Olive Oil on Cardiovascular Disease Risk Markers
Flaxseed and olive oil consumption have beneficial effects on cardiovascular risk factors. Nonetheless the effects of their simultaneous consumption have not yet been studied.The purpose of this study is to investigate the…
- Trial name
- NCT04767230
- Testing
- Dietary Intervention
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Myocarditis, Heart Failure
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
Magnetic properties of myocardial tissue change in the presence of disease. This is detectable in the change of rate of magnetic relaxation, and measurable by T1 and T2 mapping using cardiovascular magnetic resonance (CMR).
- Conditions
- Myocarditis, Heart Failure, Myocardial Fibrosis, Vascular Inflammation
- Trial name
- IMPReSSION (NCT04444128)
- Testing
- Cardiac Imaging
- Where
- Germany
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Coronary Stenosis, Acute Coronary Syndrome
Coronary Plaque Geometry and Acute Coronary Syndromes
The aim of GEOMETRY study is to investigate the correlation between coronary plaque geometric modifications and lesion vulnerability in patients with suspected coronary artery disease referred for cardiac computed tomography…
- Conditions
- Coronary Stenosis, Acute Coronary Syndrome, Acute Myocardial Infarction, Atherosclerosis
- Trial name
- NCT03702764
- Testing
- CCTA
- Where
- Romania
- Volunteers
- 1,000 people
- Sponsor
- Cardio Med Medical Center
Cardiovascular Diseases, Heart Diseases
VLDL and LDL Particle Types as Coronary Heart Disease Risk Factors
To evaluate very low density lipoprotein (VLDL) and low density lipoprotein (LDL) particle types as predictors of initial coronary events.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00065793
- Volunteers
- 1,478 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Thoracic Aortic Aneurysm (TAA)
Genetic Aortic Diseases and Cardiovascular Complications. An Observational Survey of Risk Factors.
The aim of this observational study is to define the behavioural and cardiovascular risk factor profiles of patients with genetic aortopathies.
- Trial name
- PROM-1 (NCT07391293)
- Testing
- Journey to diagnosis, Quality of life, functional health and well-being, Awareness and self-esteem, acceptance of the condition
- Where
- Italy
- Volunteers
- 208 people
- Sponsor
- IRCCS Policlinico S. Donato
Chest Pain, Acute Coronary Syndrome
Computerized Medical History Taking for Acute Chest Pain
The aim is to determine the additional value of computerized, patient-entered medical histories for the management of patients presenting at the emergency department with chest pain.
- Trial name
- CLEOS-CPDS (NCT03439449)
- Testing
- CLEOS software program, Physician taken history
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Karolinska Institutet
Obesity, Diabetes
Effect of a Treatment of Lifestyle Changes on the Prevalence of Metabolic Syndrome and Body Weight in Mexican Women
The metabolic syndrome is a group of cardiometabolic risk factors that reflect a sedentary lifestyle and the excessive intake of food among the risk factors that comprise it are located the obesity, hyperglycemia, dyslipidemia…
- Conditions
- Obesity, Diabetes, High Blood Pressure, Dyslipidemia
- Trial name
- MPATPCDNC (NCT02247635)
- Testing
- Healthy lifestyle and adherence
- Where
- Mexico
- Volunteers
- 180 people
- Sponsor
- Mexican National Institute of Public Health
Hypertension
Effect of Isometric Handgrip Training on Cardiovascular Risk in Hypertensives
The main purpose this study is to analyze the effects of isometric handgrip training on cardiovascular risk in hypertensive. For this, approximately 60 hypertensive, under anti-hypertensive medication, will be selected and…
- Trial name
- NCT02348138
- Testing
- Isometric handgrip training
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- University of Pernambuco
Exercise Capacity, Physical Activity
Cardiovascular Risk Factors After Renal Transplantation in Children and Adults
Renal transplantation of children started in Norway in 1970.Since the beginning, >80% of renal transplants are provided from Living Donors(mainly parents), short pre-transplant dialysis time( median 4 months) and 50% of…
- Conditions
- Exercise Capacity, Physical Activity, Hypertension, Overweight and Obesity
- Trial name
- HENT (NCT01008306)
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Multiple Myeloma
MLN9708 and Dexamethasone for High-Risk Smoldering Multiple Myeloma
Background: Smoldering multiple myeloma (SMM) is a condition that can lead to multiple myeloma, a type of blood cancer. In many high-risk cases, SMM can develop into multiple myeloma in less than 2 years.
- Trial name
- NCT01660997
- Testing
- MLN9708, Dexamethasone
- Sponsor
- National Cancer Institute (NCI)
AML, ALL
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders
Allogeneic stem cell transplantation may provide long-term remissions for some patients with hematological malignancies. However, allogeneic transplantation is associated with a significant risk of potentially life threatening…
- Conditions
- AML, ALL, CLL, Myelodysplastic Syndrome
- Trial name
- NCT00533923
- Testing
- Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Atherosclerosis, Cardiovascular Diseases
Intensive Glycemic Control and Skeletal Health Study
The purpose of the ACCORD-BONE Study is to investigate the effects of intensive glycemic control for type 2 diabetes (in ACCORD participants) on factors related to bone health, including, fractures, falls, and bone mineral…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Hypercholesterolemia, Hypertension
- Trial name
- ACCORD-BONE (NCT00324350)
- Testing
- hypoglycemic agents, hydroxymethylglutaryl-CoA Reductase inhibitors, hypertensive agents
- Where
- 5 sites in United States, Canada
- Volunteers
- 7,287 people
- Sponsor
- University of California, San Francisco
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