Clinical trials: Vascular Risk
Venous Thromboembolism
A Comparison of Extended Versus Conventional Duration of Enoxaparin Prophylaxis (i.e., Preventive Treatment) for Venous Thromboembolism (VTE, i.e., Blood Clots in the Veins) and Bleeding Event Risk in a Population With Acute Medical Illness
Venous Thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is associated with an increase in risk of mortality and long-term disability and is a major contributor to global disease burden.
- Trial name
- NCT05819112
- Where
- United States
- Volunteers
- 14,799 people
- Sponsor
- Sanofi
Chronic Myeloproliferative Disorders, Leukemia
Measuring Changes in Blood in Patients at High Risk of Cytomegalovirus Infection After Undergoing Donor Bone Marrow Transplant or Peripheral Blood Stem Cell Transplant
RATIONALE: Tests that measure certain changes in blood in patients at high risk of cytomegalovirus infection may help doctors learn more about predicting cytomegalovirus infection after donor stem cell transplant.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00716911
- Testing
- ganciclovir, polymerase chain reaction, flow cytometry
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Hypertension
Theobromine From Cocoa and Cardiovascular Risk Factors
The goal of this clinical trial is to examine whether consumption of dark chocolate affects blood pressure and a cardiovascular risk factor called trimethylamine N-oxide in Thai male participants with hypertension.
- Trial name
- NCT06820944
- Testing
- dark chocolate, white chocolate
- Where
- Thailand
- Volunteers
- 53 people
- Sponsor
- Chiang Mai University
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Imaging Markers of High-Risk Plaque Phenotype for Predicting Post-PCI Outcomes
Despite the widespread use of stents, previous studies have shown that stent implantation mainly relieves symptoms but may not significantly improve long-term outcomes in patients with stable coronary artery disease.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention (PCI), Atherosclerosis of Coronary Artery
- Trial name
- IMPACT-PCI (NCT07117084)
- Testing
- CCTA-derived Plaque Quantification
- Where
- 3 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Multiple Myeloma
Allo Transplant Followed by Lenalidomide and Sirolimus Maintenance in High-Risk Multiple Myeloma (MM)
One of the complications that can occur after a stem cell transplant is called graft versus host disease (GVHD). Another complication is that multiple myeloma may come back (relapse).
- Trial name
- NCT01303965
- Testing
- Sirolimus, Tacrolimus, Lenalidomide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Sherif S. Farag
Autosomal Dominant Polycystic Kidney Disease (ADPKD
Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease
The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance…
- Trial name
- HIYA-PKD (NCT07260071)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- King's College London
Sedentary Behavior, Cardiovascular Risk Factor
A Nurse Led Intervention to Promote Physical Activity
Regular physical activity should be the essence of treatment in patients with cardiovascular risk factors. Unfortunately, these interventions are usually insufficiently promoted and therefore have only limited efficacy.
- Trial name
- STEP-IT-UP (NCT04235647)
- Testing
- Nurse led tutorial on lifestyle management and pedometer hand-out, Steps goal setting and supporting phone calls
- Where
- Poland
- Volunteers
- 199 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Sleep Disorder (Disorder), Cardio Vascular Disease
Assessment of the Association Between Sleep Disorders Detected by a Simplified Questionnaire and Cardiovascular Diseases
The goal of this observational study is to validate a simplified questionnaire, adapted for routine clinical use, to quickly detect sleep disorders in patient during a cardiology consultation.
- Trial name
- CARDIOSOM (NCT07432828)
- Testing
- Online questionnaire
- Where
- 2 sites in France
- Volunteers
- 1,500 people
- Sponsor
- French Cardiology Society
Coronary Artery Disease
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
The goal of this randomized controlled trial is to assess the impact of disclosing a high polygenic risk result for coronary artery disease on change in cardiovascular health over one year.
- Trial name
- PROACT 1 (NCT05819814)
- Testing
- Disclosure of high polygenic risk result for coronary artery disease
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Venous Thromboembolism
StAtins for Venous Event Reduction in Patients With Venous Thromboembolism Pilot Study
The SAVER pilot is a randomized, open-label pilot study to determine the feasibility of recruitment. In addition to feasibility data, the investigators will carefully collect clinical data to determine if rosuvastatin can reduce…
- Trial name
- SAVER (NCT02679664)
- Testing
- Rosuvastatin
- Where
- 6 sites in Canada, Norway
- Volunteers
- 312 people
- Sponsor
- Ottawa Hospital Research Institute
Cerebral Hemorrhage
Early Intensive Antihypertensive Treatment in High-Risk Population of intraCerebral Hemorrhage ExpanSion Predicted by Artificial Intelligence
The goal of this clinical trial is to clarify the efficacy, safety and feasibility of early intensive antihypertensive treantment in intracerebral hemorrhage (ICH) patients at high risk of hematoma expansion based on artificial…
- Trial name
- ARCHES (NCT06242938)
- Testing
- Early intensive antihypertensive treatment
- Volunteers
- 680 people
- Sponsor
- Beijing Tiantan Hospital
Venous Thromboembolism (VTE)
Collaborative Risk-stratified Investigation in Thrombosis-prone Inpatients With Critical Illness: Anticoagulation With LMWH in Teens for ThromboProphylaxis (CRITICAL-Teens-TP).
Critically ill adolescents are at greatest risk for developing hospital-acquired venous thromboembolism. To date, no phase 3 randomized controlled trials have been conducted for pharmacological thromboprophylaxis as primary…
- Trial name
- NCT06628778
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 802 people
- Sponsor
- Johns Hopkins All Children's Hospital
Aneurysmal Subarachnoid Hemorrhage, Vasospasm
Transcriptomic Signature of Vasospasm Consecutive to Sub-arachnoid Aneurismal Hemorrhage
Rational: The main danger with intracranial aneurism is its rupture conjugated with subarachnoid hemorrhage (SAH) occurrence. SAH is a severe pathology leading not only to neurological but also extra cerebral disorders.
- Trial name
- NCT01779713
- Testing
- Case-control transcriptomic study
- Where
- France
- Volunteers
- 89 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Coronary Artery Disease (CAD), Renal Impairment
Renal Effects of Three Iodinated Contrast Media (CM) in Patients at Risk Undergoing Coronary Angiography
The study is to evaluate and compare the effects on kidney function of three iodinated contrast media (CM) in patients at risk of kidney damage evaluating serum creatinine (Scr) concentrations up to three days after CM…
- Conditions
- Coronary Artery Disease (CAD), Renal Impairment, Diabetes Mellitus
- Trial name
- NCT00335101
- Testing
- Iodixanol, Ioversol, Iopromide
- Where
- 2 sites in United States, Germany
- Sponsor
- GE Healthcare
Diabetes, Hypertension
Effects of Dengzhanxixin Capsule on Platelet Function in Individuals at High Risk for Cardiovascular Disease
The main objective of this clinical trial is to evaluate whether the antiplatelet efficacy of the Dengzhanxixin capsule is better than that of placebo in individuals at high-risk for atherosclerotic cardiovascular disease (ASCVD).
- Conditions
- Diabetes, Hypertension, Hypercholesterolemia
- Trial name
- FUTURE (NCT05459519)
- Where
- China
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Atherosclerosis
Individualized Comprehensive Atherosclerosis Risk-reduction Evaluation Program
This study will evaluate the effectiveness of an individualized approach to diagnosing and/or treating atherosclerosis. This will be done by combining genetic information, lifestyle information, participant education, and imaging…
- Trial name
- iCARE (NCT00969865)
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Piedmont Healthcare
Symptomatic Haemorrhoidal Disease Requiring Surgical Management
Randomized Controlled Trial Comparing Transanal Doppler-guided Arterial Ligation With Mucopexy and Stapled Haemorrhoidopexy
This multicentre RCT aims to compare two surgical treatments of haemorrhoidal disease: doppler-guided arterial ligation with mucopexy (DGALM) and stapled haemorrhoidopexy according to Longo (SH).
- Trial name
- LIGALONGO (NCT01240772)
- Testing
- doppler-guided arterial ligation with mucopexy, stapled haemorrhoidopexy according to Longo
- Where
- 22 sites in France
- Volunteers
- 407 people
- Sponsor
- Nantes University Hospital
Dementia, Mild Cognitive Impairment
Norwegian COgnitive Impairment After STroke (NorCOAST) Study
A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke
- Conditions
- Dementia, Mild Cognitive Impairment, Stroke
- Trial name
- Nor-Coast (NCT02650531)
- Where
- Norway
- Volunteers
- 816 people
- Sponsor
- Norwegian University of Science and Technology
Stroke, Cerebrovascular Disorders
Comprehensive Management of High-risk PopuLatIon for Stroke Based on Social Network
The purpose of this study is to evaluate the effectiveness of social network in improving drug compliance and risk factors control rate of stroke high-risk population after discharge.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- COMPLIANCE-MT (NCT05963828)
- Testing
- conventional care, Social network-based intervention
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Changhai Hospital
Intracranial Aneurysm
Risk Factors for Intracranial Aneurysm Recanalization After Endovascular Treatment.
Endovascular treatment is now the first line treatment for the management of intracranial aneurysms. However aneurysm recanalization is an important limitation to this treatment.
- Trial name
- ARETA (NCT01942512)
- Testing
- Endovascular treatment of intracranial aneurysm
- Where
- 22 sites in France
- Volunteers
- 1,275 people
- Sponsor
- CHU de Reims
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