Clinical trials: Vascular Risk
Left-Sided Heart Failure, Right-Sided Heart Failure
Echocardiography as Risk-Assessment for Major Adverse Cardiac Events in Major Vascular Surgery Patients
Patient with coronary artery disease (CAD), heart failure and abnormal heart function undergoing major vascular surgery have a high associated high morbidity and mortality with myocardial infarction accounting for 33-50% of…
- Conditions
- Left-Sided Heart Failure, Right-Sided Heart Failure, Heart Valve Diseases
- Trial name
- NCT04836702
- Volunteers
- 813 people
- Sponsor
- University of Virginia
Cardiovascular Diseases
Impact of Hibiscus on Cardiovascular Disease Risk
Hibiscus sabdariffa calyces (HSC) extract is consumed in different parts of the world as a cold or hot drink and is available in the United Kingdom (UK) markets in different forms including tea bags.
- Trial name
- PHYTOVAS (NCT02165553)
- Testing
- Hibiscus sabdariffa calyces extract as a cold drink
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Reading
Multiple Myeloma
A Study of Ciltacabtagene Autoleucel and Talquetamab for the Treatment of Participants With High-Risk Multiple Myeloma
The purpose of this study is to define the safety of Ciltacabtagene Autoleucel (Cilta-cel) and Talquetamab in participants with high-risk multiple myeloma (MM).
- Trial name
- MonumenTAL-8 (NCT06550895)
- Testing
- Cilta-cel, Talquetamab
- Where
- 9 sites in United States, Australia
- Volunteers
- 11 people
- Sponsor
- Janssen Research & Development, LLC
Epilepsy, Hypertension
Cardiovascular Risk Reduction in Epilepsy
Epilepsy is a disabling and lethal neurological disease which affect 3.47 million Americans. Significant health care disparities exist in people with epilepsy (PWE).
- Conditions
- Epilepsy, Hypertension, Hyperlipidemia (E.G., Hypercholesterolemia)
- Trial name
- NCT05704439
- Testing
- Neurologist Initiated Treatment
- Sponsor
- University of California, Los Angeles
Coronary Heart Disease, Physical Activity
Effect of Monitoring Continuous Glucose Levels and Physical Activity Via Wearables on Cardiovascular Risk Factors
The study aims to assess the effect of smart watches and continuous glucose measuring devices on cardiovascular risk factors.
- Conditions
- Coronary Heart Disease, Physical Activity, Cardiovascular Risk Factors
- Trial name
- NCT05969665
- Testing
- Fitbit Inspire 2, Abbott Freestyle Libre 3
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute Coronary Syndrome
Veliflapon (DG-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina
The purpose of this study is to determine if veliflapon (DG-031)can prevent a heart attack or stroke in African American patients with a history of unstable angina or myocardial infarction.
- Trial name
- NCT00353067
- Testing
- veliflapon (DG-031)
- Where
- 11 sites in United States
- Volunteers
- 3,450 people
- Sponsor
- deCODE genetics
Atherosclerotic Cardiovascular Disease
Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in SJLIFE
Childhood cancer survivors are at increased risk for premature atherosclerotic cardiovascular disease (ASCVD) due to cancer treatment-related exposures, including radiation therapy and platinum-based chemotherapy.
- Trial name
- NCT07594392
- Testing
- Coronary Artery Calcium Scan, Carotid Artery Ultrasound, Lipoprotein(a) Measurement
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- St. Jude Children's Research Hospital
Atherosclerosis
Strategy for Unstable Coronary Plaque in Patients Presenting to Emergency Department for Chest Pain Suspected of Coronary Artery Disease
Primary prevention of coronary disease and especially its major complication, inaugural myocardial infarction, is based on any prodromal symptoms identification and on risk profile establishment.
- Trial name
- SPECTRE (NCT06013722)
- Testing
- 18F-Na PET Scan
- Where
- Monaco
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Covid19, Hiv
Effects of COVID-19 on Endothelium in HIV-Positive Patients in Sub-Saharan Africa
Background: Coronavirus disease 2019 (COVID-19) has affected almost every country in the world, especially in terms of health system capacity and economic burden.
- Conditions
- Covid19, Hiv, ART
- Trial name
- ENDOCOVID (NCT04709302)
- Testing
- COVID-19, HIV, ART
- Where
- 3 sites in Nigeria, South Africa
- Volunteers
- 342 people
- Sponsor
- Medical University of Graz
Hypertension, Cardiovascular Risk Factor
Central Arterial Hemodynamics and Resistance Training
Resistance exercise training is one of the popular exercise modes that has been drawn the public's attention. However, existing evidence showed high-intensity resistance exercise training-induced negative adaptation on vascular…
- Trial name
- NCT04546308
- Testing
- Resistance exercise training
- Where
- Taiwan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Leukemia, Acute Myeloid Leukemia
Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders
This is a Phase II study of allogeneic hematopoietic stem cell transplant (HCT) using a myeloablative preparative regimen (of either total body irradiation (TBI); or, fludarabine/busulfan for patients unable to receive further…
- Conditions
- Acute Leukemia, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Lymphoma
- Trial name
- NCT03314974
- Testing
- HSCT with TBI Regimen, HSCT with Non-TBI Regimen
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hypertension, Diabetes
Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations
The purpose of this study is to evaluate the control effect of smart wearable devices on key risk factors in the high-risk populations for stroke
- Conditions
- Hypertension, Diabetes, Atrial Fibrillation, Dyslipidemia
- Trial name
- AISP (NCT06935513)
- Testing
- Wearable Devices
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Affiliated Hospital of Nantong University
Coronary Artery Disease
Personal Genomics for Preventive Cardiology
The purpose of this study is to see if providing information to a person on their inherited (genetic) risk of cardiovascular disease (CVD) helps to motivate that person to change their diet, lifestyle or medication regimen to…
- Trial name
- NCT01406808
- Testing
- genetic risk score for coronary risk factors
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stanford University
Multiple Myeloma, Smoldering Multiple Myeloma
A Study of JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide for Multiple Myeloma, Newly Diagnosed AL Amyloidosis, and High-risk Smoldering Multiple Myeloma or JNJ-79635322 in Combination With Pomalidomide for Multiple Myeloma
The primary purpose of this study for Part 1 (Dose Escalation) is to identify the safe effective dose (recommended Phase 2 doses [RP2Ds]) and schedule for JNJ-79635322 treatment regimen in combination with daratumumab with or…
- Conditions
- Multiple Myeloma, Smoldering Multiple Myeloma, Immunoglobulin Light-chain Amyloidosis
- Trial name
- NCT06768489
- Testing
- JNJ-79635322, Daratumumab, Pomalidomide
- Where
- 16 sites in United States, Australia and 3 more
- Volunteers
- 276 people
- Sponsor
- Janssen Research & Development, LLC
Acute Coronary Syndrome (ACS), High Bleeding Risk(HBR)
Safety and Efficacy of De-escalation Dual Antiplatelet Therapy After BioFreedom™ Stenting in ACS Patients With Moderate-to-high Ischemic and High Bleeding Risk
Patients with acute coronary syndrome (ACS) who have both high ischemic risk and high bleeding risk represent a challenging population following percutaneous coronary intervention (PCI), as prolonged dual antiplatelet therapy…
- Conditions
- Acute Coronary Syndrome (ACS), High Bleeding Risk(HBR), Coronary Artery Disease (CAD)
- Trial name
- NCT07374718
- Testing
- IVUS-guided BioFreedomTM Drug-Coated Stent Implantation + 1-Month DAPT Followed by 11-Month P2Y12 Inhibitor Monotherapy, Angiography-guided Conventional Drug-Eluting Stent Implantation + 12-Month Dual Antiplatelet Therapy (Aspirin + P2Y12 Inhibitor)
- Where
- China
- Volunteers
- 468 people
- Sponsor
- Shenyang Northern Hospital
Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma
Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma
This phase III trial compares chest computed tomography (CT) to chest x-ray (CXR) for lung surveillance after curative-intent resection of high-risk truncal-extremity soft tissue sarcoma.
- Conditions
- Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma, AJCC Grade 3 Sarcoma, Alveolar Soft Part Sarcoma
- Trial name
- NCT06526897
- Testing
- Biopsy, Chest Computed Tomography, Chest Radiography
- Volunteers
- 1,582 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Atherosclerosis
Subclinical Atherosclerosis in Juvenile Systemic Lupus Erythematosus
The aim of this study is to evaluate subclinical atherosclerosis in children and adolescents with juvenile SLE by measuring carotid intima-media thickness (CIMT), and to determine its associations with traditional cardiovascular…
- Trial name
- NCT07545408
- Volunteers
- 70 people
- Sponsor
- Assiut University
Peripheral Vascular Diseases
Micronet Covered Stent in in Arterial Locations Beyond the Carotid Bifurcation - FLOW-Guard Study
Prospective observational study of MicroNet covered stent implantation in the elevated risk peripheral lesions (high lesion load, thrombus containing, highly calcified). Open-label, non randomized, single arm observational study.
- Trial name
- FLOW-Guard (NCT04461717)
- Testing
- MicroNet covered stent implantation in the increased risk arterial lesions beyond the carotid bifurcation
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- John Paul II Hospital, Krakow
Hypertension, Aging
ACE Inhibitors Combined With Exercise for Seniors - Pilot Study
The purpose of this study is to compare, when combined with chronic exercise, the effects of perindopril, losartan, and hydrochlorothiazide.
- Trial name
- ACES-P (NCT01891513)
- Testing
- Exercise, ACE inhibitor + exercise, Thiazide diuretic + exercise
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Florida
Obesity, Cardiovascular Diseases
Inflammatory Status of Monocytes in Obesity
The study of the pro-inflammatory activation of circulating monocytes/macrophages in obesity is the main problem of this project.
- Trial name
- NCT05490862
- Testing
- Lifestyle Modification, Traditional Recommendations
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Federal State Budgetary Scientific Institution