Clinical trials: Vascular Surgery
Hypertension
Bariatric Surgery and Cardiovascular Responses to Sodium Nitrate
Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as S-nitrosothiols via the nitrate-nitrite-NO pathway.
- Trial name
- NCT06303830
- Testing
- Sodium nitrate
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Message-based Rehabilitation for Peripheral Artery Disease Patients
Effectiveness of Text Message-based Rehabilitation Program for Patients With Peripheral Artery Disease
Background: Many patients with peripheral artery disease are unable to achieve healthy lifestyle after revascularization. There is evidence that rehabilitation program could result in decreased re-admission, reduced…
- Trial name
- NCT03640767
- Testing
- Message-based lifestyle intervention
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 160 people
- Sponsor
- Caritas Institute of Higher Education
Abdominal Aortic Aneurysm
Prognostic Impact of NLR, PLR, and MPV in Patients Undergoing AAA Open Repair
Abdominal aortic aneurysm (AAA) is a multifactorial degenerative disorder, which if untreated might lead to catastrophic complications.
- Trial name
- NCT05031195
- Testing
- 1st tertile, 2nd tertile, 3rd tertile
- Where
- South Korea
- Volunteers
- 334 people
- Sponsor
- Gangnam Severance Hospital
Heart Diseases, Heart Diseases, Ischemic
Upper Extremity Elevation and Lungfunction After Open Heart Surgery
The purpose of this study is to assess if arm elevation, with or without simultaneous deep breathing, affects oxygen saturation and lung function on patients two to four days after open heart surgery.
- Conditions
- Heart Diseases, Heart Diseases, Ischemic, Heart Disease, Valvular
- Trial name
- NCT05278819
- Testing
- upper extremity elevation, upper extremity elevation with deep breathing
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Michael Reinhart
Peripheral Arterial Vascular Occlusion
dCell Vascular Patch in Peripheral Vascular Surgery Study for CE Mark Submission
The study is designed to produce early safety and performance data in a small group of patients requiring repair of a peripheral vascular endarterectomy (incision into an artery feeding the limbs which requires a patch to repair…
- Trial name
- NCT00958230
- Testing
- dCell Vascular Patch
- Where
- 4 sites in Hungary, Netherlands
- Volunteers
- 21 people
- Sponsor
- Tissue Regenix Ltd
Coronary Artery Disease
Outcomes of Surgically Ineligible Patients With Multivessel CAD
The OPTIMUM registry is a minimal risk observational study that uses a prospective cohort design to follow patients who have multivessel or left main coronary artery disease ("surgical anatomy" according to ACC/AHA…
- Trial name
- OPTIMUM (NCT02996877)
- Where
- 21 sites in United States
- Volunteers
- 750 people
- Sponsor
- Saint Luke's Health System
Lumbar Disc Disease, Lumbar Spinal Stenosis
The Effects of Anesthesia on Cerebral Perfusion in Patients With High Blood Pressure
High blood pressure is a serious and common health problem. This disease affects 1 billion people all over the world and responsible for 7,1 million deaths.
- Conditions
- Lumbar Disc Disease, Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Fracture
- Trial name
- NCT04587401
- Testing
- normotensive patients, patients with hypertension diagnosis, patients who do not know they are hypertensive but actual blood pressure is high
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Akdeniz University
Menopause Surgical
Hormonal Regulation of Cardiometabolic Health Study
The goal of this observational study is to understand how the loss of ovarian function after oophorectomy affects the health and well being of women aged 35-50. The study focuses on four areas: 1.
- Trial name
- HoCa (NCT07406412)
- Testing
- Surgical removal of ovaries, Hormone Replacement Therapy (HRT)
- Where
- 7 sites in Finland
- Volunteers
- 120 people
- Sponsor
- University of Jyvaskyla
Aortic Disease
Dosing of Amicar and Measure of Fibrinolysis by TEG During Cardiac Surgery
This study hopes to determine the optimal antifibrinolytic dosing to decrease bleeding and blood transfusion after cardiac surgery without increasing adverse events
- Trial name
- EACA (NCT01965730)
- Testing
- epsilon-aminocaproic acid (EACA)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
Cardio Vascular Disease, Cardiopulmonary Bypass
Perioperative Vericiguat in Patients Undergoing Cardiovascular Surgery
The purpose of this study is to evaluate the efficacy and safety of perioperative vericiguat in patients undergoing cardiovascular surgery.
- Trial name
- NCT07594509
- Testing
- Vericiguat, Standard of Care Group
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Nanjing Medical University
Surgery, Blood Loss, Surgical
Investigation of the Transfusion Practices in Surgical Patients in Turkey
The aim of this study is to describe the transfusion practices in patients undergoing major surgery in Turkey. The transfusion rates of red blood cells (RBC), fresh frozen plasma (FFP) and platelets; the transfusion predictors…
- Conditions
- Surgery, Blood Loss, Surgical, Blood Loss Anemia, Blood Transfusion
- Trial name
- CeKATU (NCT03468738)
- Testing
- Blood transfusion
- Where
- 61 sites in Turkey (Türkiye)
- Volunteers
- 6,481 people
- Sponsor
- Diskapi Teaching and Research Hospital
Intracerebral Hemorrhage
Observational Study of Safety and Outcomes After Minimally Invasive Surgery for Intracerebral Hemorrhage
This pilot study will examine the safety and the clinical outcomes after minimally invasive surgery (using a parafascicular technique guided by diffusion-tensor imaging) for intracerebral hemorrhage in patients selected according…
- Trial name
- MiSPACE (NCT01920763)
- Testing
- Clinical Measurement
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Diabetic Foot Ulcer, Diabetic Foot
Treatment of Chronic Diabetic Foot Ulcers by Minimally Invasive Surgery
Despite the development of the control of DM and the great interest for the complications of the disease, even today the diabetic foot represents a challenge for the orthopaedic surgeon.
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Diabetic Foot Infection, Diabetic Foot Ulcer Neuropathic
- Trial name
- DiabeticMIS1 (NCT03010215)
- Testing
- Distal Metatarsal Minimally invasive Osteotomy (DMMO)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Heart Septal Defects, Ventricular, Double Outlet Right Ventricle, Noncommitted VSD
A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect
The purpose of this study is to investigate the security and validity of transesophageal echocardiography(TEE)-guided perventricular device closure(TPDC) through minithoracotomy in treatment of infundibular ventricular septal…
- Conditions
- Heart Septal Defects, Ventricular, Double Outlet Right Ventricle, Noncommitted VSD, Double Outlet Right Ventricle, Subaortic VSD, Double Outlet Right Ventricle, Subpulmonary VSD
- Trial name
- NCT02361008
- Testing
- TEE-guided perventricular device closure without CBP, Surgery repair with CBP
- Where
- China
- Volunteers
- 20,121,212 people
- Sponsor
- Bentong Yu
Abdominal Aortic Aneurysm, Surgery
ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair.
Aim of the ACTION-1 study is to determine whether ACT guided heparinization decreases thrombo-embolic complications (TEC) and mortality after elective open AAA surgery, without causing more bleeding complications.
- Conditions
- Abdominal Aortic Aneurysm, Surgery, Arterial Disease
- Trial name
- ACTION-1 (NCT04061798)
- Testing
- ACT guided heparinization, 5 000 IU of heparin
- Where
- 22 sites in Germany, Netherlands
- Volunteers
- 294 people
- Sponsor
- Dijklander Ziekenhuis
Chronic Ulcers: Non-healing Deep Cavity Wounds (e.g., Diabetic Foot Ulcers, Arterial Ulcers, Post-surgical Wound Healing Disorders)
INJECTHEAL - Investigation of Chronic Wound Exudate and Biofilm
This prospective observational study will collect routine clinical waste material from 72 adults with chronic, non-healing wounds, including wound exudate from negative pressure therapy containers or sponges and wound…
- Trial name
- INJECTHEAL (NCT07745764)
- Testing
- standard of care
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Barbara Wolff-Winiski
Recurrent Melanoma, Stage IA Skin Melanoma
Intravital Microscopy for Identifying Tumor Vessels in Patients With Stage IA-IV Melanoma That is Being Removed by Surgery
This pilot clinical trial studies intravital microscopy for identifying tumor vessels in patients with stage IA-IV melanoma that is being removed by surgery.
- Conditions
- Recurrent Melanoma, Stage IA Skin Melanoma, Stage IB Skin Melanoma, Stage IIA Skin Melanoma
- Trial name
- NCT01886235
- Testing
- Diagnostic Microscopy, Fluorescein Sodium Injection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Roswell Park Cancer Institute
Coronary Artery Disease
Coronary Bypass Grafting With Minimal Extracorporeal Circulation System Versus Off-pump Coronary Surgery
The investigators aimed to evaluate the clinical results and the inflammatory response of the minimal extracorporeal circulation system (MECC) Compared with off-pump coronary revascularization (OPCABG).
- Trial name
- NCT02118025
- Testing
- Off-pump coronary artery bypass graft, Mini extracorporeal circulation bypass
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Atrial Fibrillation, Thromboembolism
Impact of Left Atrial Appendage Exclusion on Short-Term Clinical Outcomes and Long-Term Stroke Incidence
Stroke is a major cause of morbidity in western society, and an infrequent complication of cardiac surgery. The majority of thromboembolic strokes arise from the left atrium, in particular the left atrial appendage.
- Conditions
- Atrial Fibrillation, Thromboembolism, Cerebrovascular Accident
- Trial name
- NCT00486915
- Testing
- Left Atrial Appendage Ligation
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- London Health Sciences Centre
Coronary Artery Disease, Cardiopulmonary Bypass
Long-Term Cognitive Decline After Coronary Artery Bypass Grafting: is Off-Pump Surgery Beneficial?
Coronary artery bypass surgery is associated with postoperative cognitive decline, which has largely been attributed to the use of the heart lung machine.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Cognition Disorders
- Trial name
- NCT00189215
- Testing
- cardiac stabilizer instead of cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- UMC Utrecht