Clinical trials: Vascular Surgical Procedures
Acute Aortic Dissection
Mechanism and Early Intervention Research on ALI During Emergence Surgery of Acute Stanford A Aortic Dissection
The morbidity rate of Stanford A type Acute Aortic Dissection（AAD） has been increasing, about 5-10/100,000* per year. Emergency surgery has been the main treatment for Acute Aortic Dissection, however perioperative mortality rate…
- Trial name
- NCT01894334
- Testing
- Ulinastatin, Tranexamic acid, Edaravone
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Vasoplegic Syndrome of Cardiac Surgery
Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery
This is a randomized, double-blind clinical trial designed to compare the inotropic effects of vasopressin versus norepinephrine in patients who develop vasoplegic syndrome in the immediate postoperative period following cardiac…
- Trial name
- INVASC (NCT06934798)
- Testing
- Vasopressin intravenous infusion, Norepinephrine intravenous infusion
- Where
- Brazil
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Peripheral Vascular Disease
A Prospective Study to Assess the Screening Value of N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP) for the Identification of Patients That Benefit From Additional Cardiac Testing Prior to Vascular Surgery
The purpose of this study is to validate the screening potential of NT-proBNP for the identification of patients scheduled for vascular surgery who would benefit from additional pre-operative cardiac testing.
- Trial name
- NCT00519961
- Testing
- Elecsys®proBNP
- Where
- 2 sites in Ireland, Netherlands
- Volunteers
- 1,800 people
- Sponsor
- Hoffmann-La Roche
Hemorrhoidectomy, Hemorrhoid
Definition and Validation of HeQAS for the Assessment of Technical Quality in Excisional Hemorrhoidectomy
This observational multicenter study aims to develop and validate the Hemorrhoidectomy Quality Assessment Scale (HeQAS), a histopathological tool designed to assess the technical quality of excisional hemorrhoidectomy.
- Trial name
- NCT07719881
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Son Llatzer
Atherosclerosis, Periodontitis
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Periodontitis.
A randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with periodontitis and without any cardiovascular disease.
- Trial name
- NCT05906797
- Testing
- Non-surgical periodontal treatment by Q-SI, Non surgical periodontal debridement using MINST approach
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Catania
Symptomatic Non-ruptured Abdominal Aortic Aneurysms
Investigating Practice Patterns in Symptomatic Non-ruptured Abdominal Aortic Aneurysms (AAA) in Europe
Symptomatic non-ruptured abdominal aortic aneurysms (snrAAA) remain a clinical challenge due to limited evidence and heterogeneous definitions and management strategies.
- Trial name
- DETHINE (NCT07184723)
- Where
- Austria
- Volunteers
- 130 people
- Sponsor
- Wilhelminenspital Vienna
Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm Without Rupture
Elective Treatment Rates and Surgical Non-eligibility Among Men and Women With Intact Abdominal Aortic Aneurysms
The overall aim is to determine the frequency by which women and men with intact abdominal aortic aneurysms (AAA) are treated with elective surgery at three vascular outpatient clinics in Europe, and to investigate whether the…
- Conditions
- Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm Without Rupture, Aneurysm, Aortic Aneurysm
- Trial name
- NCT05346289
- Testing
- Elective surgery for intact AAA
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska University Hospital
Minimally Invasive Surgical Procedures, Laparoscopy
Post-market Clinical Follow-up Study of Reusable Clip Applier Cartridge Devices for LAParoscopic Surgery
This is a Post-Market Clinical Follow-up (PMCF) investigation to determine the long-term effectiveness and safety of the Multi-Fire Clip System in laparoscopic surgery.
- Conditions
- Minimally Invasive Surgical Procedures, Laparoscopy, Leakage of Cardiac Device
- Trial name
- RELAP (NCT05363813)
- Testing
- M/L-10 Multi-Fire Clip Applier and M/L-10 Clip Cartridge (Multi-Fire Clip System)
- Where
- 7 sites in Portugal, Spain
- Volunteers
- 245 people
- Sponsor
- Microline Surgical, Inc.
Infections
Reduction of Groin Wound Infections After Vascular Surgery by Using an Incision Management System (IMS)
Comparison of the Prevena™ IMS with the standard wound management method of sterile plaster in vascular surgery patients.
- Trial name
- IMS (NCT02395159)
- Testing
- Prevena™ IMS, sterile plaster dressings
- Where
- 2 sites in Germany
- Volunteers
- 204 people
- Sponsor
- RWTH Aachen University
Retinal Detachment, Diabetic Retinopathy
Avastin for PDR (Proliferative Diabetic Retinopathy)
The purpose of this study is to determine the effect of anti-VEGF drug (Avastin) adminstration in eyes prior to surgical treatment for Traction retinal detachment (TRD) in patients with Proliferative Diabetic Retinopathy (PDR).
- Trial name
- PDR (NCT01270542)
- Testing
- Avastin (bevacizumab)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Vascular Surgery, Ischemia-reperfusion
Effects of Ischemic Preconditioning After Aortic Clamping
Open surgery for aneurysmal aortic disease can lead to cardiac, renal, pulmonary or muscular complications, essentially due to the aortic clamping. Ischemic preconditioning can be useful in order to decrease these complications.
- Conditions
- Vascular Surgery, Ischemia-reperfusion, Ischemia Preconditioning
- Trial name
- NCT02254642
- Testing
- Ischemic preconditioning during aortic clamping, Procedure/Surgery: usual surgery
- Where
- 4 sites in France
- Volunteers
- 59 people
- Sponsor
- University Hospital, Strasbourg, France
Peripheral Arterial Occlusive Disease
The Effect of High Dose Arginine Infusion on Hemodynamic and Peripheral Microcirculation
The aim of this study was to investigate the effect of a 24- hrs L-arginine infusion on hemodynamic and on parameters of microcirculation in patients with peripheral arterial occlusive disease (PAOD).
- Trial name
- NCT01682889
- Testing
- Arginine
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical Scientific Fund of the Mayor of Vienna
Blood Loss, Surgical, Coagulation Disorder
Phase 3 Trial of Reltodecacog Alfa (VMX-C001) vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.
The goal of this clinical trial is to learn if reltodecacog alfa (VMX-C001) works to to allow blood clotting control in participants who take FXa Direct Oral Anticoagulants (DOACs) during surgery or other invasive procedures that…
- Trial name
- EQUILIBRIX-S (NCT07288489)
- Testing
- Reltodecacog alfa, Usual Pharmacological Care
- Where
- 77 sites in United States, Australia and 16 more
- Volunteers
- 800 people
- Sponsor
- VarmX B.V.
Frailty, Anesthesia
Complexity and Frailty in Cardiothoracic and Vascular Anesthesia (CAfCA). Prospective Multicentric Observational Study
Frailty is a multidimensional syndrome characterized by a decline in physiological homeostatic reserve, which translates into an increased susceptibility to adverse events and unfavorable outcomes following even small exposures…
- Conditions
- Frailty, Anesthesia, Thoracic Surgery, Cardiothoracic Surgery
- Trial name
- CAfCA (NCT05968456)
- Testing
- Data collection
- Where
- 8 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Diabetes Mellitus, Insulin Resistance
Insulin Infusion Diabetes Ulcer
Normoglycemia is important for the outcome of surgical and medical conditions. Insulin infusions have been studied to achieve normoglycemia during these circumstances and have proved to be useful.
- Conditions
- Diabetes Mellitus, Insulin Resistance, Hyperglycemia, Surgery
- Trial name
- IINDU (NCT00700154)
- Testing
- Insulin infusion
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Atrial Fibrillation
nContactSurgical Numeris-AF Tethered Coagulation System for Treatment of Persistent & LSP AF
This is a multi center, non-randomized, prospective, open label, clinical trial evaluating the safety and efficacy of the nContact Surgical Numeris-AF Tethered Coagulation System when used to treat patients with persistent and…
- Trial name
- NCT00950092
- Testing
- Numeris-AF Tethered Coagulation System with VisiTrax
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- nContact Surgical Inc.
Frail Elderly Syndrome, Frailty
Frailty Assessment by Edmonton Frail Scale to Predict Outcome in Patients Undergoing Cardiovascular Surgery
The aim of the study is to assess frailty of patients admited for cardio-vascular surgery in Cliniques Universitaires Saint Luc in Brussels.
- Conditions
- Frail Elderly Syndrome, Frailty, Surgery
- Trial name
- FRAIL-HEART (NCT03913299)
- Where
- 3 sites in Belgium
- Volunteers
- 2,080 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Exertional Compartment Syndrome
Comparison of Non-Surgical Treatment Options for Chronic Exertional Compartment Syndrome (CECS)
Chronic Exertional Compartment Syndrome (CECS) in the lower leg is a debilitating condition in highly active individuals. Pain occurs in 1 or several leg compartments upon an exertional activity, typically running, that quickly…
- Trial name
- NCT04409600
- Testing
- Supervised Gait Retraining, Home Based Gait Retraining, Saline Injection
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Walter Reed National Military Medical Center
Coronary Artery Disease
Prevention of Autogenous Vein Graft Failure in Coronary Artery Bypass Procedures
The purpose of this study is to determine the efficacy of graft pretreatment with CGT003 (E2F Duplex Decoy), as compared to placebo, on the incidence of patients experiencing vein graft failure after coronary artery bypass…
- Trial name
- NCT00042081
- Testing
- CGT003 (E2F Duplex Decoy)
- Where
- 154 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Anesiva, Inc.
Postoperative Complications, Cardiovascular Complication
Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery
Postoperative cardiovascular complications are common after noncardiac surgery. The association between perioperative inflammation and the occurrence of cardiovascular complications after surgery is still unknown.
- Conditions
- Postoperative Complications, Cardiovascular Complication, Myocardial Ischemia, Inflammation
- Trial name
- INSIGHT (NCT04753307)
- Testing
- Laboratory measurements
- Where
- Austria
- Volunteers
- 1,400 people
- Sponsor
- Medical University of Vienna