Clinical trials: Vascular Thrombosis
Venous Thrombosis, Neoplasms
Optimal Duration of Anticoagulation Therapy for Isolated Distal Deep Vein Thrombosis in Patients With Cancer Study
The purpose of this study is to determine the optimal duration of anticoagulation therapy (3 months versus 12 months) with direct oral anticoagulant (edoxaban) for isolated distal deep vein thrombosis.
- Conditions
- Venous Thrombosis, Neoplasms, Anticoagulant
- Trial name
- ONCO DVT (NCT03895502)
- Testing
- 12-month Edoxaban, 3-month Edoxaban
- Where
- Japan
- Volunteers
- 605 people
- Sponsor
- Takeshi Morimoto
Restenosis
Is There A LIfe for Drug Eluting Stent (DES) After Discontinuation of Clopidogrel
The ITALIC PLUS Trial was designed with the objective of extending to other countries the enrollment of patients into the ITALIC trial initially conducted in France, in order to achieve statistical significance by pooling the…
- Trial name
- ITALICplus (NCT01476020)
- Where
- France
- Volunteers
- 1,240 people
- Sponsor
- Gilard, Martine
Bleeding, Colorectal Disorders
Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery
The goal of this prospective pragmatic randomized clinical trial is to determine if preoperative administration of tranexamic acid (TXA) reduces bleeding during and after major colorectal surgery.
- Conditions
- Bleeding, Colorectal Disorders, Thromboembolism, Tranexamic Acid
- Trial name
- NCT06657924
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Kristen Ban
Deep Vein Thrombosis
The Learning Curve of Emergency Physicians Performed Lower-extremity Ultrasonography in the Diagnosis of DVT
If deep vein thrombosis (DVT) is suspected among patients who have symptoms such as pain or swelling of the lower extremities, duplex ultrasound of the lower limb is the first-line imaging modality to diagnose DVT.
- Trial name
- NCT04913688
- Testing
- bedside ultrasound performed group
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Samsung Medical Center
Extracorporeal Circulation, Inflammation
Rheoparin-coated Tubing System for Minimized Extracorporeal Circulation (MECC)
In this study, the investigators would like to compare a heparin-coated tubing system for minimized extracorporeal circulation (MECC) with the conventional tubing system for MECC, which does not contain heparin coating.
- Conditions
- Extracorporeal Circulation, Inflammation, Blood Coagulation, Intracranial Embolism
- Trial name
- RheoMECC (NCT02321917)
- Testing
- MECC system with rheoparin coating
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Coronary Syndrome
Comparison of Bio-Active-Stent to the Everolimus-Eluting Stent in Acute Coronary Syndrome
The purpose of the trial is to compare the safety and effectiveness of bio-active-stent (BAS) and everolimus-eluting stent (EES) in patients presenting with acute coronary syndrome.
- Trial name
- BASE-ACS (NCT00819923)
- Testing
- Percutaneous coronary intervention
- Where
- 6 sites in Finland
- Volunteers
- 825 people
- Sponsor
- The Hospital District of Satakunta
Pregnancy, Heart; Complications, Valve, Prosthesis
Anticoagulation Regimens in Pregnant Patients With Prosthetic Heart Valves
Pregnancy is associated with increased risk of thrombosis among women with mechanical prosthetic heart valves.However, the best anticoagulant treatment strategies for pregnant patients with prosthetic heart valves have been…
- Trial name
- NCT02240927
- Testing
- Low Molecular Weight Heparine : Enoxaparine, Enoxaparine and 2.5 mg Warfarin, Enoxaparine and 4mg Warfarin
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Myocardial Infarction
THE REOPEN-AMI STUDY - Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction
The occurrence of no-reflow phenomenon after recanalization of the infarct related artery in acute myocardial infarction is described in up to 40% of cases.
- Trial name
- REOPEN-AMI (NCT00590070)
- Testing
- adenosine, nitroprusside
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Catholic University of the Sacred Heart
Premature, Thrombosis
Thrombophilic Risk Factors in Preterm and Infants Treated at Ha'Emek Medical Center Between the Years 1990 to 2010
There are several factor that can be related to Neonatal Thrombotic events. Among them hypercoagulability can be the cause of those events.
- Trial name
- NCT01443273
- Testing
- Medical Records study
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Thrombosis
Clinical Assessment of Thrombosis in Children After Heart Surgery
Thromboembolic complications (TCs) are important causes of morbidity and mortality after pediatric cardiac surgery, resulting in longer hospital stay, increased risk of early and late post-surgical complications, early…
- Trial name
- CATCH (NCT01435473)
- Testing
- Cardiac Surgery
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- The Hospital for Sick Children
Pulmonary Embolism
Risk Assessment Strategies in Pulmonary Embolism
The aim of this study is to evaluate different scores of risk assessment in patients with pulmonary embolism. This study aim to compare the accuracy of these scores in predicting mortality during hospital admission.
- Trial name
- NCT04327960
- Testing
- Cardiac troponin (cTn)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Thrombosis
Alteplase for Blood Flow Restoration in Hemodialysis Catheters
We are investigating a new way of administering alteplase to remove clots from hemodialysis catheters. Currently, alteplase is left to dwell inside the catheter between dialysis treatments to dissolve the clot and restore blood…
- Trial name
- NCT00303420
- Testing
- Alteplase "push" protocol, alteplase dwell arm
- Where
- 9 sites in Canada
- Volunteers
- 180 people
- Sponsor
- University of Manitoba
Polycythemia Vera
Large-scale Trial Testing the Intensity of CYTOreductive Therapy in Polycythemia Vera (PV)
CYTO-PV is a phase III Prospective, Randomized, Open-label, with Blinded Endpoint evaluation (PROBE), multi-center, clinical trial in patients with diagnosis of Polycythemia vera (PV) treated at the best of recommended therapies…
- Trial name
- CYTO-PV (NCT01645124)
- Testing
- Hydroxyurea, Phlebotomy
- Where
- 26 sites in Italy
- Volunteers
- 365 people
- Sponsor
- Consorzio Mario Negri Sud
Cerebral Venous Thrombosis
The Role of Factor XIII Activation Peptide and D-dimer Values for the Diagnosis of Cerebral Venous Thrombosis (CVT)
The investigators aim to assess the overall accuracy of D-dimer values and FXIII activation peptide (FXIII-AP), using a newly developed ELISA test, to exclude CVT in patients with clinical suspicion of CVT.
- Trial name
- NCT00924859
- Testing
- ELISA Test
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 401 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pulmonary Embolism (PE)
Soluble Fibrin for Diagnosing Pulmonary Embolism
The purpose of the study is to evaluate the performances of Soluble Fibrin for diagnosing Pulmonary Embolism. Secondary objective is to compare the diagnostic performances of the Soluble Fibrin Assay and the D-Dimer test.
- Trial name
- SOFIE (NCT02438462)
- Testing
- Soluble Fibrin
- Where
- France
- Volunteers
- 480 people
- Sponsor
- Diagnostica Stago R&D
Pulmonary Embolism
Pulmonary Embolism Registry
Acute Pulmonary Embolism (PE) is the most serious clinical presentation of venous thromboembolism (VTE), a leading cause of cardiovascular mortality, exceeded only by stroke and myocardial infarction.
- Trial name
- PER (NCT05391646)
- Volunteers
- 500 people
- Sponsor
- Universidade do Porto
Myocardial Injury, Atherosclerosis Cardiovascular Disease
Multimodal Biomarkers in Coronary Artery Disease Pathogenesis: The Oxford Acute Myocardial Infarction Study (OXAMI Study)
Coronary artery disease is one of the most common causes of illness and death. It develops when fatty deposits, known as plaques, build up in the arteries that supply blood to the heart.
- Conditions
- Myocardial Injury, Atherosclerosis Cardiovascular Disease, Cardiac Imaging Techniques, Genetics
- Trial name
- OXAMI (NCT07772570)
- Testing
- blood sampling, Intracoronary Imaging, Cardiovascular Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Thrombosis
Vitamin K2 Intervention in Patients With Vitamin K Antagonists
The objective of the SAFE K study is to demonstrate that in patients treated with the antagonists of vitamin K (VKA), a daily intake of vitamin K2 (75 micrograms/day) as naturally produced by the ferments used in fermented dairy…
- Trial name
- SAFEK (NCT01533441)
- Testing
- Vitamin K2
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danisco
Sepsis, Sepsis-induced Coagulopathy
Early Detection and Kinetics of Sepsis-Induced Coagulopathy in Severe Burn Patients
Sepsis is a major and life-threatening complication in patients with severe burn injuries, frequently progressing to sepsis-induced coagulopathy (SIC) and disseminated intravascular coagulation (DIC).
- Conditions
- Sepsis, Sepsis-induced Coagulopathy, Disseminated Intravascular Coagulation, Burns
- Trial name
- SIC-BURN-JAAM2 (NCT07914205)
- Testing
- Prospective calculation and kinetic monitoring of the revised Japanese Association for Acute Medicine (JAAM-2) score using biological parameters (platelet count/kinetics, PT/INR, D-dimer/FDP) measured
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Center for Traumatology and Major Burns, Ben Arous
Central Retinal Vein Occlusion
Hemodilution Versus Ranibizumab in Early-onset Central Retinal Vein Occlusion
The purpose of this study is to compare ranibizumab injection to hemodilution at the early phase of Central Retinal Vein Occlusion (CRVO) and to determine if the combination of both treatments may have a synergic effect.
- Trial name
- CHIC-3 (NCT01448018)
- Testing
- ranibizumab, hemodilution
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
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