Clinical trials: Vasoconstriction
Postural Tachycardia Syndrome
Local Vasoconstriction in Postural Tachycardia Syndrome
The investigators study will determine how often blood flow regulation abnormalities and abnormalities of sympathetic regulation produced by nitric oxide, angiotensin-II, and oxidative stress occur in POTS and the mechanism(s) of…
- Trial name
- NCT01210430
- Testing
- Losartan, Ascorbic Acid (Vitamin C), Normal Saline
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- New York Medical College
COVID-19, Hypoxic Respiratory Failure
Almitrine and COVID-19 Related Hypoxemia
In severe COVID-19 pulmonary failure, the profound hypoxemia is mainly related to pulmonary vasodilation with altered hypoxic pulmonary vasoconstriction (HPV).
- Trial name
- NCT04380727
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France
Mechanical Ventilation, Thoracic Surgery
Effects of Oxygen Supply After Lung Isolation in Thoracic Surgery
The goal of this randomized clinical trial is to compare a liberal versus restrictive oxygen supply (fraction of inspired oxygen, FiO2) strategy in patients scheduled for thoracic surgery requiring one-lung ventilation during…
- Conditions
- Mechanical Ventilation, Thoracic Surgery, One-Lung Ventilation
- Trial name
- NCT05946707
- Testing
- restrictive oxygen supply, liberal oxygen supply
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Medical University Innsbruck
Chronic Sinusitis
Comparison of Topical Vasoconstriction in Endoscopic Sinus Surgery
The purpose of our study is to assess the effect of topical vasoconstriction (cocaine 4% versus adrenaline 1/1000) on the surgical field during endoscopic sinus surgery.
- Trial name
- NCT01706952
- Testing
- Cocaine, Adrenaline
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Marc Tewfik
Emphysema
Hypoxic Pulmonary Vasoconstriction Pilot Study
The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction…
- Trial name
- NCT03733470
- Testing
- Sildenafil study group
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Eric A. Hoffman
Hemorrhage, Postpartum, Hemorrhage
A Pilot Study to Assess the Feasibility and Tolerability of the AccuFlow Perfusion Sensor for Intrapartum Hemorrhage
Obstetric hemorrhage is one of the leading causes of maternal death worldwide. One of the challenges in management of hemorrhage is that young, healthy women compensate for blood loss via peripheral vasoconstriction, so they…
- Conditions
- Hemorrhage, Postpartum, Hemorrhage, Vasoconstriction
- Trial name
- NCT04370639
- Testing
- AccuFlow sensor, Survey
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Megan Lord
Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD)
Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery
This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass…
- Conditions
- Coronary Artery Disease With Need for Bypass Surgery, Coronary Artery Disease(CAD), Coronary Artery Bypass, Off Pump Coronary Artery Bypass Graft
- Trial name
- OPTICAB (NCT07163858)
- Testing
- passive leg raising for hemodynamic management during open-heart coronary bypass grafting, Use of Noradrenaline only in control group
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Infirmerie Protestante de Lyon
Reversible Cerebral Vasoconstriction Syndrome
Triggers And Risk Factors to Develop a Reversible Cerebral Vasoconstriction Syndrome
This study will be the first to evaluate the role played by potential precipitating factors and risk factors in Reversible Cerebral Vasoconstriction Syndrome (RCVS) through of prospective selection of carefully characterised…
- Trial name
- TARDIS (NCT04179383)
- Testing
- Constitution of a biobank
- Where
- France
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
One-Lung Ventilation, Thoracic Surgery
Dexmedetomidine Improved Oxygenation and Reduced Shunt in One-Lung Ventilation at High-Risk Pediatric Thoracic Surgery
Children with high anesthetic risk who underwent Thoracic surgery with OLV (one lung ventilation) technique during general anesthesia were divided into two groups.
- Trial name
- NCT06505772
- Testing
- Dexmedetomidine, Normal saline
- Where
- Syria
- Volunteers
- 78 people
- Sponsor
- Damascus University
Healthy
Pivotal Bioequivalence Study of Topically Delivered Clobetasol Propionate Lotion in Healthy Adult Subjects
To compare the relative vasoconstrictive effects of two topical clobetasol propionate 0.05% lotions in asymptomatic subjects.
- Trial name
- NCT00864500
- Testing
- Clobetasol Propionate 0.05% lotion, single exposure, Clobex TM 0.05% Lotion, single exposure
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Hypothermia; Anesthesia
The Comparison of Remimazolam With Propofol in Core Body Temperature
1. Core body temperature is normally tightly regulated to within a few tenths of a degree. The major thermoregulatory defences in humans are sweating, arteriovenous shunt vasoconstriction, and shivering. 2.
- Trial name
- NCT05215834
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Wonkwang University Hospital
Bioequivalence Study
Bio-equivalence Vasoconstriction Activity Study for Topically Applied Clocortolone Pivalate 0.1% Cream
To compare pharmacodynamic vasoconstriction response profile of Clocortolone Pivalate 0.1% Cream and Cloderm® (Clocortolone Pivalate) 0.1% Cream in normal skin of healthy male and female adults
- Trial name
- NCT04358770
- Testing
- Clocortolone Pivalate
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Reversible Cerebral Vasoconstriction Syndrome
Endothelial Dysfunction in Reversible Cerebral Vasoconstriction Syndrome
Reversible Cerebral Vasoconstriction Syndrome (RCVS) is a syndrome described at the end of the 20th century. Generally, it has a benign course.
- Trial name
- DESS (NCT04463212)
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Vasoconstriction, Vasodilation
Role of Acetylcholine in Blood Flow Regulation in Healthy Adults: Effects of Age and Exercise Training
The overall goal of this study is to address fundamental questions regarding how the molecule acetylcholine interacts with the sympathetic nervous system to regulate blood flow and oxygen delivery to working skeletal muscle in…
- Trial name
- NCT03972683
- Testing
- Handgrip Exercise Training, Acetylcholine, Adenosine Triphosphate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Colorado State University
Cardiac Output, High, Cardiac Output, Low
Pulse Contour Analysis and Tissue Oxymetry in Changing Vascular Tone
The purpose of this study is to compare changes of minimally invasive arterial pulse contour cardiac output with changes of intermittent and continuous thermodilution cardiac output by pulmonary artery catheter in hemodynamic…
- Conditions
- Cardiac Output, High, Cardiac Output, Low, Vasodilation, Vasoconstriction
- Trial name
- NCT00583687
- Testing
- Vigileo TM / Flotrac TM (Minimally invasive cardiac output system consisting of arterial line sensor and cardiac output monitor), Passive leg raising, Volume challenge / Change of vasoactive drugs or inotropics
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hyperinsulinemia
Effect of Insulin on Endothelin-Dependent Vascular Tone in the Forearm Circulation
Previous studies have shown that insulin may stimulate the release of endothelin (ET) from endothelial cells. This mechanism may contribute to the adverse vascular effects determined by chronic hyperinsulinemia.
- Trial name
- NCT00001624
- Testing
- Insulin
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Hypoxia, Pulmonary Arterial Hypertension
Iron Status and Hypoxic Pulmonary Vascular Responses
On exposure to hypoxia (low oxygen) the normal response is for pulmonary arterial systolic blood pressure (PASP, blood pressure through the lungs) to increase.
- Conditions
- Lung Hypoxia, Pulmonary Arterial Hypertension, Iron Deficiency
- Trial name
- NCT01847352
- Testing
- Intravenous administration of ferric carboxymaltose, Subacute hypoxic exposures
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Psoriasis Vulgaris
Vasoconstriction Trial With LEO 90100 Aerosol Foam
Vasoconstriction study with LEO 90100
- Trial name
- NCT02973776
- Testing
- LEO 90100 aerosol foam, Dermoval®/Dermovate®, Diprosone
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Cardiovascular Diseases, Cardiovascular Risk Factor
The Effect of Antioxidants on Skin Blood Flow-BH4
The goal of this study is to examine possible mechanisms of heightened vasoconstriction in Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
- Trial name
- NCT03680573
- Testing
- Control: Lacated Ringers, Apocynin, Allopurinol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Healthy
Effect of Antioxidants on Oxygen Induced Vasoconstriction in Lipopolysaccharide (LPS) Induced Inflammatory Model in Humans
Oxidative stress has been implicated in playing a pathogenic role in many disease processes, especially in age-related disorders.
- Trial name
- NCT00914576
- Testing
- Vitamin and mineral supplement, 100% Oxygen, Escherichia coli Endotoxin
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna