Clinical trials: Vasodilation
Familial Hypercholesterolemia
Effect of APL180 on Endothelial Function in Familial Hypercholesterolemia Patients
This study will evaluate the effect of APL180 on endothelial function measured by forearm venous occlusion plethysmography in patients with familial hypercholesterolemia.
- Trial name
- NCT00751608
- Testing
- APL180
- Sponsor
- Novartis Pharmaceuticals
Thrombosis, Menopause
Exercise Training and Thrombotic Risk in Post-menopausal Women
At menopausal transition, the risk of cardiovascular diseases increases. This is partly due to aging, but largely also the loss of estrogen, which has many positive effects on the circulation and protects against cardiovascular…
- Conditions
- Thrombosis, Menopause, Exercise Training, Vascular Dilation
- Trial name
- TIME (NCT04596501)
- Testing
- Early and late postmenopausal women
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
COPD Patients, Healthy Subjects
Pulmonary Arterial Pressure Response During Exercise
Background: The extent of increase in systolic pulmonary arterial pressure (PAPs) during exercise in patients with COPD is unpredictable from lung function data.
- Conditions
- COPD Patients, Healthy Subjects, Semi-supine Echo (SSE), Flow-mediated Vasodilatation (FMD)
- Trial name
- PAPCOPDHS (NCT00949195)
- Testing
- Measure pulmonary artery pressure change during exercise, Pulmonary pressure response during exercise
- Where
- Hungary
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Szeged University
Flicker-induced Vasodilatation
Effect of Breathing a Mixture of 92% Oxygen (O2) + 8% Carbon Dioxide (CO2) on Flicker Induced Blood Flow Changes in Ocular Perfusion
It has been shown that diffuse luminance flicker increases retinal and optic nerve head blood flow. This indicates that a neuro-vascular coupling between neural activity and blood flow exists in the retina as described previously…
- Trial name
- NCT00719342
- Testing
- Oxygen + Carbondioxide, full field flickering light at 12.5 Hz
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Bicuspid Aortic Valve (BAV), Aortic Aneurysm
Research on Aneurysm Growth Prediction in Vascular Dilation Caused by Bicuspid Aortic Valve Based on VDM and CFD
Bicuspid aortic valve (BAV) is the most common congenital valvular malformation, characterized by heterogeneous phenotypic subtypes that predispose patients to secondary aortic pathologies, including valvular dysfunction and…
- Conditions
- Bicuspid Aortic Valve (BAV), Aortic Aneurysm, TAVR
- Trial name
- NCT07782918
- Testing
- Transcatheter Aortic Valve Replacement
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Frail Elderly Syndrome
Low Intensity Training Combined With KAATSU on Muscle Vasodilatation and Arterial Stiffness in the Elderly Population
The purpose of the present study is to evaluate the acute and chronic effect of low intensity strength training with or without moderate blood flow restriction on muscle vasodilation and arterial stiffness in elders with low gait…
- Trial name
- NCT03272737
- Testing
- 1RM Test, Speed gait test, Venous occlusion plethysmography protocol
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Acute Coronary Syndrome
Vascular Healing After Deployment of Titanium-nitride-oxide-coated OPTIMAX™ Stent and PROMUS-ELEMENT™ Everolimus-Eluting Stent
The purpose of this study is to compare vascular healing of the stented segment after deployment of titanium-nitride-oxide coated cobalt-chromium Optimax™-stent stent and Promus-Element™ everolimus-eluting stent in patients with…
- Trial name
- TIDES-OCT (NCT02280720)
- Testing
- Stenting using Optimax™, Stenting using PROMUS Element™ Plus
- Where
- 4 sites in Finland
- Volunteers
- 40 people
- Sponsor
- The Hospital District of Satakunta
Sleep Apnea, Healthy
Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences
The overall goal of this project is to better understand the effect of intermittent hypoxia (IH) on sympathetic neuronal discharge patterns in humans, as well as mechanisms that mediate persistent sympathoexcitation with IH.
- Conditions
- Sleep Apnea, Healthy, Vasoconstriction, Vasodilation
- Trial name
- NCT05146089
- Testing
- Hypoxic exposure, modified Oxford test, Oral Bosentan 62.5 mg
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Adenosine Metabolism
The Effect of Rosuvastatin on Adenosine Metabolism
The aim of this study is to show whether rosuvastatin influences adenosine metabolism. Therefore we will determine whether rosuvasatin increases dipyridamole-induced vasodilation by increased adenosine receptor stimulation.
- Trial name
- NCT00554138
- Testing
- rosuvastatin
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center