Clinical trials: Vasoplegia
Vasoplegic Syndrome, Vasoplegia
Analysis of miRNAs Expression in Vasoplegic Syndrome After On-pump Coronary Artery Bypass Surgery
This study looks for a correlation between microRNAs (miRNAs) and vasoplegic syndrome after on-pump coronary artery bypass surgery.
- Conditions
- Vasoplegic Syndrome, Vasoplegia, Surgery-Complications, Surgery
- Trial name
- PREVENT (NCT05354193)
- Testing
- vasoplegic syndrome
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- University of Sao Paulo General Hospital
Vasoplegia Syndrome
Dynamic Arterial Elastance Measured by Uncalibrated Pulse Contour Analysis Predicts Arterial Pressure Response to a Decrease in Norepinephrine
Dynamic arterial elastance (Eadyn) has been proposed as an indicator of arterial tone that can predict norepinephrine-dependent arterial pressure.
- Trial name
- VESA (NCT03455738)
- Testing
- vasoplegic syndrome
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Septic Shock
Effects of Hemoadsorption on Vascular Integrity in Septic Shock
This study aims to investigate the effects of adjunctive CytoSorb hemoadsorption therapy versus standard medical treatment on endothelial dysfunction in patients with refractory septic shock.
- Trial name
- ADSORP-VIP (NCT07711197)
- Testing
- CytoSorb hemoadsorption, Standard Medical Therapy (SMT)
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Vasoplegic Shock, Cardiopulmonary Bypass
Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)
The goal of this study is to conduct a prospective trial implementing a modified version of the Emory Protocol for administering ANG II to patients with post cardiac bypass vasoplegia.
- Conditions
- Vasoplegic Shock, Cardiopulmonary Bypass, Vasoplegia
- Trial name
- ANGII_V (NCT07671365)
- Testing
- Angiotensin II (Giapreza®)
- Volunteers
- 329 people
- Sponsor
- Methodist Healthcare System of San Antonio
Sepsis, Vasoplegia
Characterisation of Endothelial Cells in Different Inflammatory Pathologies
The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery.
- Trial name
- JEDI-2 (NCT06613256)
- Testing
- Endothelial cell biopsy
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Shock, Vasoplegic Syndrome
Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II.
Shock is a life-threatening condition which can cause multiple organ failure and even death. One characteristic of shock is low blood pressure which is managed with drugs called vasopressors.
- Trial name
- TENSINTEST (NCT06539234)
- Where
- 2 sites in Slovenia
- Volunteers
- 121 people
- Sponsor
- University Medical Centre Maribor
Vasoplegic Syndrome
Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass
Several studies have described the use of alternative drugs as methylene blue (MB) (3) other than the standard limited options of the use of vasopressors and systemic corticosteroids (4) especially in the face of increasing…
- Trial name
- NCT06160219
- Testing
- Hydroxycobalamin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Vasoplegia
Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
Vasopressors are medications that are given intravenously to increase the blood pressure of patients with illnesses that cause dangerous blood pressure drops.
- Trial name
- NCT05058612
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Scheduled Cardiac Surgery With Extracorporeal Circulation, Vasoplegic Syndrome
Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation
This is a randomized, double blind, multicenter study following surgery with extracorporeal circulation to compare blood pressure optimization with vasopressin versus noradrenaline.
- Trial name
- NOVACC (NCT05568160)
- Testing
- Vasopressin, Norepinephrine, Collection of clinical data
- Where
- France
- Volunteers
- 840 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Vasoplegia, Cardiac Surgery
Low Dose Corticosteroid Infusion in Vasoplegia After Cardiac Surgery (CORTIVAS-CS)
Vasoplegia is an important determinant for adverse postoperative outcome and is observerd in 5% to 54% of patients undergoing cardiac surgery using cardiopulmonary bypass (CPB).
- Trial name
- CORTIVAS-CS (NCT04301479)
- Testing
- hydrocortisone sodium succinate, Saline
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Instituto do Coracao
Postperfusion Syndrome
Reperfusion Syndrome and Vasoplegic Syndrome in Liver Transplant Surgery
The incidence of postreperfusion syndrome (PRS) and vasoplegic syndrome (VS) is unknown, and occasionally can be confused since these syndromes share some hemodynamic characteristics.
- Trial name
- NCT05658120
- Testing
- noradrenaline/adrenaline
- Where
- Spain
- Volunteers
- 246 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Vasoplegia Syndrome, Vasoplegia
Femoral Versus Radial Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients
Background: Acute circulatory failure, often presenting as arterial hypotension, is a major contributor to postoperative morbidity and mortality.
- Conditions
- Vasoplegia Syndrome, Vasoplegia, Cardiac Surgical Procedures, Arterial Pressure
- Trial name
- FERARI (NCT06952907)
- Testing
- Femoral artery catheterization for continuous invasive arterial blood pressure monitoring, Radial artery catheterization for continuous invasive arterial blood pressure monitoring
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- Guillaume BESCH
Cardiac Surgery
Thiamine Supplementation in High Risk Cardiac Surgery Patients
This pilot trial will evaluate the ability of thiamine to affect on postoperative vasoplegia in high risk cardiac surgery patients
- Trial name
- APPLY (NCT03306732)
- Testing
- Thiamine hydrochloride (200mg) dissolved in 100 ml of normal saline, Normal saline (100ml)
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Liver Transplant; Complications, Vasoplegia
Angiotensin II in Liver Transplantation
The purpose of this study is to determine the efficacy and safety of Angiotensin II as a second-line vasopressor (drug that raises the blood pressure) during liver transplantation.
- Trial name
- AngLT-1 (NCT04901169)
- Testing
- Angiotensin II, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Distributive Shock
Angiotensin II for Distributive Shock
This is a single-center, randomized, double-blind, placebo-controlled pilot study. A total of 40 patients who develop distributive shock, intra-operatively or post-operatively within 48 hours of heart transplant or left…
- Trial name
- NCT04904562
- Testing
- Angiotensin II
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Northwestern University
Vasoplegia, Shock
Norepinephrine Weaning Guided by the Hypotension Prediction Index in Vasoplegic Shock After Cardiac Surgery
In postoperative cardiac surgery under extracorporeal circulation, the patient may develop a vasoplegic syndrome, characterized by arterial hypotension (mean arterial pressure (MAP) < 65 mmHg); a decrease in vascular resistance…
- Conditions
- Vasoplegia, Shock, Norepinephrine, Surgery
- Trial name
- NORAHPI (NCT05922982)
- Testing
- norepinephrine weaning protocol, norepinephrine weaning protocol and guided by the HPI
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Vasoplegic Syndrome of Cardiac Surgery
Mic Mac: Micro- and Macrocirculatory Assessment During Cardiac Surgery in Patients at Risk of Vasoplegic Syndrome: A Prospective Study.
This research focuses on understanding the vasoplegic syndrome after cardiac surgery under extracorporeal circulation and in the aftermath of your surgery in the ICU.
- Trial name
- MicMac (NCT07059715)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- European Georges Pompidou Hospital
Vasoplegic Syndrome, Liver Transplant; Complications
Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients
This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.
- Trial name
- NCT04054999
- Testing
- Hydroxocobalamin, Methylene Blue
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction
RaGuS Trial by Postoperative Patients
Vasoplegic syndrome is characterized clinically by reduced systemic vascular resistance and normal or increased cardiac output. It is principally observed in cardiovascular and orthopedic interventions and is characterized by a…
- Conditions
- Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction, Orthostatic Hypotension
- Trial name
- RaGuS (NCT04440085)
- Testing
- Midodrine Hydrochloride
- Volunteers
- 50 people
- Sponsor
- Bürgerspital Solothurn
Vasoplegic Syndrome
Vitamin B12a Vasoplegic Syndrome
The study team will evaluate the medication Hydroxocobalamin (B12a) for treatment of low blood pressure after cardiac surgery.
- Trial name
- NCT03735316
- Testing
- Hydroxocobalamin, Cardiopulmonary Bypass
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic