Clinical trials: Vasopressor Agents
Hypotension, Cesarean Section
"Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section"
Spinal anesthesia-induced hypotension is one of the most frequent and clinically significant complications of obstetric anesthesia, occurring in up to 50-80% of parturients undergoing elective cesarean section.
- Conditions
- Hypotension, Cesarean Section, Hemodynamic Instability, Anxiety, Anticipatory
- Trial name
- BREATHE-CS (NCT07494955)
- Testing
- Mindfulness-Based Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Aysenur Dostbil
Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN)
Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE)
This pilot randomized clinical trial compares dopamine and norepinephrine as first-line vasoactive therapies in term and late preterm neonates with pulmonary hypertension associated with hypoxemic respiratory failure and systemic…
- Conditions
- Hypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN), Hypoxemic Respiratory Failure
- Trial name
- DONE (NCT07322133)
- Testing
- Dopamine administration, Norepinephrine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Cerebral Perfusion Pressure, Vasopressor Agents
Physiologic Study of Cerebral Perfusion
The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients
- Conditions
- Cerebral Perfusion Pressure, Vasopressor Agents, Shock, Magnetic Resonance Imaging (MRI), Functional
- Trial name
- NCT02744625
- Testing
- Higher doses of vasopressor therapy for a MAP of 75 mmHg, Lower doses of vasopressor therapy for a MAP of 65 mmHg, Propofol for light sedation
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Septic Shock
Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock
The purpose of this trial is to investigate the potential of FE 202158 as a treatment which can stabilize blood pressure for treatment of patients in early septic shock.
- Trial name
- NCT01612676
- Testing
- FE 202158
- Where
- 4 sites in Belgium, Denmark
- Volunteers
- 31 people
- Sponsor
- Ferring Pharmaceuticals
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
Arterial Hypertension
Measurement of Noradrenaline Concentrations Using Different Dilution Methods
Norepinephrine is the vasopressor of choice for the treatment of peri-anesthetic arterial hypotension. The use of this drug at significantly lower concentrations (dilution factor between 40 and 200) than the commercial…
- Trial name
- NCT04772599
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Perfusion Index
Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis
In this thesis we will use the current state of knowledge that PI can provide a reliable information about the state of peripheral microcirculation during the state of sepsis and septic shock in ICU patients and that can…
- Conditions
- Sepsis, Perfusion Index, Vasopressor
- Trial name
- NCT06860438
- Testing
- Vasoconstrictor Agents
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Circulatory Collapse and Shock
ICU Norepinephrine Load
Norepinephrine is recommended as first-line vasopressor in critically ill patients, regardless of shock etiology. Its advantages over dopamine and/or epinephrine have been demonstrated, especially by reducing tachycardia events.
- Trial name
- ICU_NE_LOAD (NCT05032261)
- Testing
- Circulatory shock with norepinephrine in ICU
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sedative Adverse Reaction, Sedation Complication
Vasopressor Requirements Depends on Sedation Strategy
Most of the patients after cardiac surgery need sedation in the iCU. Sedation strategy could impact the incidence of vasopressor use.
- Conditions
- Sedative Adverse Reaction, Sedation Complication, Hemodynamic Instability, Agitation on Recovery From Sedation
- Trial name
- NCT05451381
- Testing
- Propofol, Dexmedetomidine, Dexmedetomidine and Propofol
- Where
- Ukraine
- Volunteers
- 356 people
- Sponsor
- Anesthesia Research Group UA
Septic Shock
Weaning Approaches for Vasopressin in Sepsis
In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.
- Trial name
- WAVES (NCT07067866)
- Testing
- Titrated weaning of vasopressin., Abrupt weaning of vasopressin.
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Intraoperative Hypotension
Bispectral Index Guided Sevoflurane Titration
Electroencephalographic-based monitoring systems such as the bispectral index (BIS) may reduce anaesthetic overdose rates. The investigators hypothesised that goal-directed sevoflurane administration (guided by BIS monitoring)…
- Trial name
- NCT02515019
- Testing
- Bispectral index Monitoring
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Coronary Artery Disease
Dynamic Arterial Elastance for Prediction of Vasopressor Requirement After Anesthesia Induction in Elective On-Pump CABG
This study aims to determine whether dynamic arterial elastance (EaDyn), measured after anesthesia induction, can predict the need for vasopressor treatment in patients undergoing elective on-pump coronary artery bypass graft…
- Trial name
- NCT07871201
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Elzem SEN
Shock, Septic
Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis
This multicentre, randomised controlled trial will enrol 1000 patients presenting with septic shock to the emergency department (ED) of participating hospitals in Australia and New Zealand.
- Trial name
- ARISE FLUIDS (NCT04569942)
- Testing
- Vasopressor, Fluids
- Where
- 50 sites in Australia, Ireland and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Sepsis, Hypotension
Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion
The purpose of this study is to determine whether continued administration of Drotrecogin Alfa (Activated) up to additional 72 hours - after the so far recommended 96 hour infusion period - results in a more rapid resolution of…
- Trial name
- NCT00190788
- Testing
- Drotrecogin Alfa (Activated)
- Where
- 2 sites in United States, France
- Volunteers
- 200 people
- Sponsor
- Eli Lilly and Company
Critically Ill Adults in the ICU, Requiring Endotracheal Intubation
Effect of a FLUid Bolus or a Low Dose VAsopressor Infusion on Cardiovascular Collapse Among Critically Ill Adults Undergoing Tracheal Intubation.
Tracheal intubation, which is one of the most commonly performed procedures in the care of critically ill patients in intensive care unit, is associated with a high incidence of complications.
- Trial name
- FLUVA (NCT05318066)
- Testing
- Ringer Lactate and Norepinephrine infusion
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
Fluid Therapy, Vasopressor Therapy
Practice of Fluid Therapy in Critically Ill Invasively Ventilated Patients
The goal of this woldwide observational study is to investigate various aspects of fluid and vasopressor therapy in critically ill invasively ventilated patients.
- Conditions
- Fluid Therapy, Vasopressor Therapy, Critical Illness, Invasive Ventilation
- Trial name
- PRoFLUID (NCT05968066)
- Where
- Netherlands
- Volunteers
- 2,508 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Shock, Septic
Effect of Albumin Administration on Vasopressor Duration in Resolving Septic Shock
The role of albumin in sepsis has been controversial for decades. Although hypoalbuminemia has been associated with worse outcomes in sepsis, definitive evidence does not exist that replacing albumin in these patients improves…
- Trial name
- NCT02716597
- Testing
- 25% Albumin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Alexander Flannery, 859-323-4011
Septic Shock, Acute Kidney Injury
Renin and Renal Biomarker Response to Angiotensin II
Septic shock continues to exert a large economic burden around the world. Several developments have occurred that lead to the current study.
- Trial name
- NCT04558359
- Testing
- Standard of Care, Angiotensin II
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alexander Flannery
Perioperative Care, Hemodynamics
ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management
The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries.
- Conditions
- Perioperative Care, Hemodynamics, Monitoring Blood Pressure, Arterial Lines
- Trial name
- IPAMS (NCT06982001)
- Testing
- Brachial line guided hemodynamic management, Radial line guided hemodynamic management, Radial line catheterization
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Urologic Surgical Procedures, Body Mass Index
Body Mass Index and Spinal Anesthesia in Urological Surgery
This single-center prospective observational study investigates the effect of body mass index (BMI) on intraoperative vasopressor requirements and spinal block characteristics in adult patients undergoing urological surgery under…
- Conditions
- Urologic Surgical Procedures, Body Mass Index, Vasopressor Therapy
- Trial name
- NCT07653217
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Adiyaman University