Clinical trials: Vasospasm, Cerebral
Aneurysm, Ruptured, Vasospasm, Intracranial
Minocycline for Aneurysmal Subarachnoid Hemorrhage (MASH)
Previous work has demonstrated patients presenting with ruptured aneurysms that develop radiographic and clinical vasospasm have a higher permeability of the blood brain membrane.
- Conditions
- Aneurysm, Ruptured, Vasospasm, Intracranial, Delayed Cerebral Ischemia, Blood Brain Barrier Defect
- Trial name
- NCT04876638
- Testing
- Minocyclin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Aneurysmal Subarachnoid Hemorrhage, Vasospasm
Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial
To investigate whether patients with cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage have a better prognosis with intrathecal nicardipine injection via extraventricular drainage or lumbar drainage.
- Trial name
- NCT06329635
- Testing
- Intrathecal Nicardipine, No intervention
- Where
- 28 sites in China
- Volunteers
- 396 people
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Cerebral Nimodipine Concentrations Following Oral, Intra-venous and Intra-arterial Administration
Nimodipine reduces the risk of poor outcome and delayed cerebral ischemia in patients suffering aneurysmal subarachnoid haemorrhage (SAH), but its mode of action is unknown.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral
- Trial name
- NCT04649398
- Testing
- Nimodipine
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm
Cerebrospinal Fluid Hemoglobin to Monitor for Aneurysmal Subarachnoid Hemorrhage Related Secondary Brain Injury
The primary objective of this study is to evaluate the association between hemoglobin levels in the cerebrospinal fluid (CSF-Hb) and the occurrence of secondary brain injury in patients after aneurysmal subarachnoid hemorrhage…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Delayed Cerebral Ischemia, Delayed Ischemic Neurological Deficit
- Trial name
- HeMoVal (NCT04998370)
- Where
- 8 sites in Austria, Germany and 1 more
- Volunteers
- 366 people
- Sponsor
- University of Zurich
Subarachnoid Hemorrhage
The Mortality and Changes in Quality of Life of Patients Suffering From SAH With Different Hydration Strategies
Purpose: Vasospasm and secondary ischemia following subarachnoidal hemorrhage considerably affect the clinical outcome. The purpose of this study is to determine whether crystalloid (Lactated Ringer's solution) or colloid…
- Trial name
- NCT02064075
- Testing
- Lactated Ringer's solution, Hydroxyethyl starch
- Where
- Hungary
- Volunteers
- 96 people
- Sponsor
- University of Debrecen
Sub Arachnoid Hemorrhage, Vasospasm
An Innovative Non-invasive Acoustic Approach to Detect and Monitor Cerebral Vasospasm
The lack of a precise diagnostic technique for cerebral vasospasm associated with traumatic brain injury (TBI) limits the ability to detect and treat this phenomenon.
- Trial name
- NCT02093182
- Where
- Israel
- Sponsor
- HeadSense Medical
Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia
Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial
Soluble epoxide hydrolase (sEH) is the metabolizing enzyme of epoxyeicosatrienoic acids (EETs), which may play a role in reducing neuroinflammation and regulating cerebral blood flow after subarachnoid hemorrhage (SAH).
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia, Vasospasm, Cerebral, Endothelial Dysfunction
- Trial name
- SUSHI (NCT03318783)
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Alzheimer's Disease, Glaucoma
Cellular Proteome From Leukocytes of Glaucoma Patients in Comparison With Patients With Alzheimer's Disease
Glaucoma is a worldwide leading cause of blindness. The key feature of this ocular neuropathy is characterized by an excavating optic nerve head.
- Trial name
- NCT00691340
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Subarachnoid Hemorrhage, Aneurysmal, Subarachnoid Hemorrhage
Remote Ischemic Preconditioning in Subarachnoid Hemorrhage
Rupture of brain aneurysms is a common cause of death and disability, accounting for as many as 10% of stroke cases in the United States.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Subarachnoid Hemorrhage, Cerebral Vasospasm, Intracranial Aneurysm
- Trial name
- RIPC-SAH (NCT01158508)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Subarachnoid Hemorrhage, Aneurysmal
Mild Hypothermia During Intracranial Aneurysm Clipping
The purpose of this study is to determine whether mild hypothermia causes reduction of vasoconstriction in microcirculation after clipping of aneurysms, and affects the blood flow in small diameter arteries at operating site…
- Trial name
- NCT02544256
- Testing
- Mild hypothermia
- Where
- Czechia
- Sponsor
- University Hospital Hradec Kralove
Subarachnoid Hemorrhage
Ventriculostomy in Subarachnoid Hemorrhage (SAH): Intracranial Pressure (ICP) Open or Not?
The purpose of this study is to explore two currently accepted methods of intracranial pressure (ICP) management through cerebral spinal fluid (CRF) drainage for patients diagnosed with subarachnoid hemorrhage (SAH).
- Trial name
- VISION 2 (NCT01169454)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Subarachnoid Aneurysm Hemorrhage, Cerebral Vasospasm After Subarachnoid Hemorrhage
Delayed Cerebral Infarction Beyond Endoluminal Spasmolysis and Induced Hypertension
An observational study of patients with emerging or established severe cerebral vasospasm after subarachnoid haemorrhage, employing multimodal neuromonitoring.
- Trial name
- Decibel (NCT07305922)
- Testing
- Induced hypertension with norepinephrine, Endoluminal Spasmolysis
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Stockholm
Subarachnoid Hemorrhage
Quantification of Cerebral Blood Flow by Arterial Spin Labeling in Vasospasm in Subarachnoid Haemorrhage
A technique of MRI infusion -l'Arterial Spin Labeling-, non-invasive and non-irradiating, repeatable over time, appears promising in the field.
- Trial name
- ASL-HSA (NCT02557607)
- Testing
- MRI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Subarachnoid Hemorrhage
Predictive Value of Mean Flow Velocity by TCD in Early Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage
Aim of this work is to evaluate the transcranial doppler in prediction of cerebral vasospasm in aneurysmal subarachnoid hemorrhage and also to evaluate their advantages over clinical scales in predicting CV.
- Trial name
- NCT04329208
- Testing
- Transcranial doppler
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Hospital
Oral Nimodipine, Milrinone
Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy
To evaluate the efficacy and safety of oral Nimodipine and IV milrinone combination therapy for management of cerebral spasm after aneurysmal subarachnoid hemorrhage.
- Conditions
- Oral Nimodipine, Milrinone, Vascular Spasm After Traumatic Subarachnoidhaemorrhage
- Trial name
- NCT05131867
- Testing
- nimodipine, Oral Nimodipine and milrinone
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Zagazig University
Subarachnoid Hemorrhage
Evaluation of Cerebral Spinal Fluid and Blood in Patients With Subarachnoid Hemorrhage
In this project we are collecting cerebrospinal fluid and blood from patients at Vanderbilt Medical Center who have a subarachnoid hemorrhage which has followed the rupture of a brain aneurysm.
- Trial name
- NCT00593268
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University Medical Center
Subarachnoid Hemorrhage
Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)
The primary objective of this project is to investigate the effect of statin therapy on cerebral blood flow in patients with aneurysmal SAH who are randomized to receive or not receive statins in a blinded design.
- Trial name
- NCT00795288
- Testing
- Simvastatin, 80 mg/day for 21 days
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm
Stellate Ganglion Block in Preventing Cerebral Vasospasm Secondary to Subarachnoid Hemorrhage
To investigate whether the stellate ganglion block is helpful in relieving cerebral vasospasm during aneurysmal coil embolism surgery. The effect was assessed by Transcranial Doppler (TCD).
- Trial name
- NCT04512859
- Testing
- Stellate Ganglion Block
- Volunteers
- 160 people
- Sponsor
- Beijing Tiantan Hospital
Subarachnoid Hemorrhage, Delayed Vasospasm
A Randomized, Double-Blind, Placebo-Controlled Trial of Simvastatin on Subarachnoid Hemorrhage-Induced Vasospasm
To determine whether HMG-CoA reductase inhibitor simvastatin prevents or ameliorates subarachnoid hemorrhage-induced delayed vasospasm and its ischemic consequences.
- Trial name
- NCT00235963
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Brigham and Women's Hospital
Aneurysmal Subarachnoid Hemorrhage
Cilostazol and Nimodipine Combined Therapy After Aneurysmal Subarachnoid Hemorrhage (aSAH)
The investigators seek to demonstrate that the combined use of cilostazol and nimodipine will significantly decrease the rate of delayed cerebral infarction and cerebral vasospasm after cerebrovascular intervention when compared…
- Trial name
- NCT04148105
- Testing
- Cilostazol 100 MG
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Henry Ford Health System