Clinical trials: Vasospasm, Cerebral
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety Study of Carotid Body Neurostimulation to Treat Cerebral Vasospasm
The purpose of this study is to evaluate the safety and performance of the Delta system in the treatment of cerebral vasospasm post aneurysmal subarachnoid hemorrhage (aSAH) patients.
- Trial name
- NCT02129413
- Testing
- Delta system
- Where
- 7 sites in Czechia, Germany and 1 more
- Volunteers
- 23 people
- Sponsor
- Samson NeuroSciences
Subarachnoid Haemorrhage (SAH)
Evaluation of Transcutaneous Trigeminal Nerve Stimulation for Prevention of Cerebral Vasospasm After Subarachnoid Haemorrhage
Subarachnoid haemorrhage (SAH) secondary to ruptured aneurysm represents 5 to 15% of all cases of stroke. The mortality rate of SAH is 40% and the risk of serious neurological sequelae among survivors is 10 to 20%.The causes of…
- Trial name
- TRIVASOSTIM (NCT02482883)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Poitiers University Hospital
Traumatic Brain Injury, Brain Inflammation
"The Effect of Stellate Ganglion Block in Severe Brain Injury"
Blood flow through the brain is reduced after brain damage. Secondary brain ischemia caused by hypoxia and hypotension, further increase the susceptibility of the ischemically compromised brain to secondary impairment during this…
- Conditions
- Traumatic Brain Injury, Brain Inflammation, Cerebral Vasospasm
- Trial name
- NCT04208477
- Testing
- one site blockade of the stellate ganglion
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Traumatic Brain Injury
Physiologic Mechanisms in Pediatric Traumatic Brain Injury (TBI)
The aims of this study explore the relationships between cerebral vasospasm, apolipoprotein-E (apo-E) genotype, physiologic symptoms, and neurocognitive outcomes that may either intensify or ameliorate secondary injury, for…
- Trial name
- NCT01763892
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Aneurysmal Subarachnoid Hemorrhage
Cervical Spinal Cord Stimulation for the Prevention of Cerebral Vasospasm
The study investigates safety, feasibility and effectiveness of cervical spinal cord stimulation (SCS) in prevention of cerebral arterial vasospasm following aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- NCT00766844
- Testing
- spinal cord stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Konstantin V. Slavin
Aneurysmal Subarachnoid Hemorrhage
Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping
The aim of this study is to demonstrate that clazosentan, administered as a continuous intravenous infusion at 5 mg/h until Day 14 post aneurysmal subarachnoid hemorrhage (aSAH), reduces the incidence of cerebral vasospasm…
- Trial name
- CONSCIOUS-2 (NCT00558311)
- Testing
- Clazosentan
- Where
- 117 sites in United States, Australia and 27 more
- Volunteers
- 1,157 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Brain Aneurysm, Aneurysm, Ruptured
Superior Cervical Ganglion Block, Transcranial Doppler
The aim of this study is to assess blood flow velocity in middle cerebral artery measured by transcranial doppler to determine the efficacy of SCG block in decreasing incidence or severity of vasospasm after MCA aneurysm surgery.
- Trial name
- NCT04439760
- Testing
- Superior Cervical Ganglion Block
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Fatma Ibrahim El Sayed Salman
Aneurysmal Subarachnoid Hemorrhage
Clinical Research Study With Clazosentan to Evaluate Its Effects on Preventing Complications Due to the Narrowing of the Blood Vessels (Vasospasm) in the Brain, Caused by Bleeding Onto the Surface of the Brain
This study will evaluate if clazosentan (on top of normal routine medical care) can reduce the risk of developing complications related to cerebral vasospasm and permanent brain damage as compared to normal routine medical care…
- Trial name
- REACT (NCT03585270)
- Testing
- Clazosentan
- Where
- 80 sites in United States, Austria and 13 more
- Volunteers
- 409 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)
In all the Western populations, the annual incidence of subarachnoid hemorrhage (SAH) increase with age. In patients older than 70 years, the occurrence of SAH exposes them to high risk of morbidity and a poor quality of life.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus, Cerebral Vasospasm
- Trial name
- FASHE (NCT00692744)
- Where
- 2 sites in France
- Volunteers
- 353 people
- Sponsor
- University Hospital, Rouen
Aneurysmal Subarachnoid Hemorrhage
EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH
The intention of the study is to investigate whether drainage of cerebral spinal fluid via a lumbar route ("Tuohy-drain") will improve outcome after intracranial aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- EARLYDRAIN (NCT01258257)
- Testing
- Insertion of a lumbar drain
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Aneurysmal Subarachnoid Hemorrhage
Application of Magnesium-rich Artificial Cerebrospinal Fluid in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is a common type of acute hemorrhagic stroke. One of its complications, cerebral vasospasm (CVS), is the main cause of death and disability, with an incidence of up to 30%-90%.
- Trial name
- NCT04358445
- Testing
- Magnesium-Rich Artificial Cerebrospinal Fluid
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Aneurysmal Subarachnoid Hemorrhage, Neurobehavioral Manifestations
Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin
A Blind-adjudication Multi-center Phase II Randomized Clinical Trial of Continuous Low-dose Intravenous Heparin Therapy in Coiled Low-grade Aneurysmal Subarachnoid Hemorrhage Patients with Significant Hemorrhage Burden.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Neurobehavioral Manifestations, Vasospasm, Intracranial, Intracranial Aneurysm
- Trial name
- ASTROH (NCT02501434)
- Testing
- Continuous Low-Dose IV Unfractionated Heparin Infusion
- Where
- 9 sites in United States
- Volunteers
- 88 people
- Sponsor
- Robert F. James
Subarachnoid Hemorrhage, Cerebral Vasospasm
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study
Cerebral vasospasm following subarachnoid hemorrhage (SAH) is the most common cause of morbidity and mortality. Recent studies indicate that Rho-kinase play an important role in the occurrence of such cerebral vasospasm.
- Trial name
- EVAS (NCT00839449)
- Testing
- Eicosapentaenoic acid ethyl ester
- Where
- 5 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Yamaguchi University Hospital
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage
The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT07614906
- Where
- 2 sites in United States, Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Brain Injury
Vasospasm in Pediatric Traumatic Brain Injury
The purpose of this study is to assess for vasospasm using Transcranial Doppler (TCD) and brain injury biomarkers, and evaluate neurocognitive outcome data in pediatric traumatic brain injury (TBI) patients who have experienced a…
- Trial name
- PTBI (NCT01461902)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
Aneurysm, Vasospasm
Balloon Prophylaxis of Aneurysmal Vasospasm
The purpose of this study is to determine if early transluminal ballooning of the major cerebral arteries prevents severe vasospasm and improves neurological outcome in patients with Fisher Grade III aneurysmal subarachnoid…
- Trial name
- NCT00282893
- Testing
- transluminal ballooning, currently existing therapies for the treatment of vasospasm
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 170 people
- Sponsor
- University of California, Davis
SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm
Incidence, Characteristics and Evolution of Cerebral Vasospasm With Clinical Impact in Moderate to Severe Traumatic Brain Injury Complicated by Subarachnoid Hemorrhage at Martinique University Hospital
Context : Moderate to severe head trauma with altered state of consciousness is an extremely common pathology (between 60 and 120 cases per 100 000 people per year depending on the country and age group), and is responsible for…
- Conditions
- SAH (Subarachnoid Hemorrhage), Cerebral Vasospasm, Moderate Traumatic Brain Injury, Severe Traumatic Brain Injury
- Trial name
- VASO-TC (NCT06560372)
- Testing
- Additional realization of a brain perfusion scan sequence which would allow the radiological diagnosis of CV
- Where
- France
- Volunteers
- 154 people
- Sponsor
- University Hospital Center of Martinique
Subarachnoid Hemorrhage, Cerebral Vasospasm
Effect of Intraventricular tPA Following Aneurysmal Subarachnoid Hemorrhage
This study will evaluate the hypothesis that the administration of intraventricular tPA reduces the rates of cerebral vasospasm and ventriculoperitoneal shunt-dependent hydrocephalus in patients with aneurysmal subarachnoid…
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Cerebral Aneurysm, Hydrocephalus
- Trial name
- NCT01878136
- Testing
- Tissue Plasminogen Activator
- Where
- United States
- Sponsor
- Rush University Medical Center
Cerebral Vasospasm
Non-Significant Risk Study Comparing the Nautilus NeuroWaveTM to Transcranial Doppler as an Aid to Diagnosing Vasospasm
The purpose of the study is to determine the sensitivity, specificity and predictive values of the Jan Medical NeuroWave System in detecting moderate and severe vasospasm in comparison to Trans Cranial Doppler(TCD).
- Trial name
- NCT01595802
- Testing
- Nautilus NeuroWave, Transcranial Doppler (TCD)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Jan Medical, Inc.
Cerebral Vasospasm, Subarachnoid Hemorrhage
Identification of Novel Molecular Markers for Vasospasm
The purpose of the study is to identify novel genetic and protein markers for the process of cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
- Trial name
- NCT02389634
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix