Clinical trials: Vasospasm, Intracranial
Aneurysmal Subarachnoid Hemorrhage
Application of Magnesium-rich Artificial Cerebrospinal Fluid in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is a common type of acute hemorrhagic stroke. One of its complications, cerebral vasospasm (CVS), is the main cause of death and disability, with an incidence of up to 30%-90%.
- Trial name
- NCT04358445
- Testing
- Magnesium-Rich Artificial Cerebrospinal Fluid
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Subarachnoid Hemorrhage
Safety and Pharmacokinetic Evaluation of Nitrite for Prevention of Cerebral Vasospasm
The purpose of the study is to examine the safety of a 14 day infusion of sodium nitrite, and to study the pharmacokinetics of nitrite, during a 14 day infusion in patients with ruptured cerebral aneurysms.
- Trial name
- NCT00873015
- Testing
- Sodium nitrite, Saline
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Hope Pharmaceuticals
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral
Early Warning of Delayed Cerebral Ischemia
The goal of this observational study is to learn about the possibility to predict clinical course of subarachnoid hemorrhage (SAH) patients by performing the retrospective analysis of clinical data available in early…
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral, Ischemia, Outcome, Fatal
- Trial name
- EWoDCI (NCT06006975)
- Testing
- Computed Tomography (CT) and Computed Tomography Angiography (CTA), Multimodal physiological monitoring
- Where
- Lithuania
- Volunteers
- 250 people
- Sponsor
- Vilnius University
Subarachnoid Hemorrhage, Cerebral Vasospasm
Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage
The purpose of this study is to determine the role of Proteomics and Metallomics in Cerebral Vasospasm following Subarachnoid Hemorrhage
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hydrocephalus
- Trial name
- NCT01799018
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- State University of New York - Upstate Medical University
Aneurysmal Subarachnoid Haemorrhage, SAH
Goal Directed Therapy After Aneurysmal Subarachnoid Haemorrhage
The objective of this study is to determine whether a goal-directed therapy can reduce the incidence of delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage.
- Trial name
- PiSAH (NCT01832389)
- Testing
- PiCCO
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- Technical University of Munich
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to test whether treatment with a drug called Simvastatin prevents and improves outcome in patients who have Subarachnoid bleeding.
- Trial name
- NCT00487461
- Testing
- Simvastatin 40 mg, Simvastatin 80 mg
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Illinois at Chicago
Subarachnoid Hemorrhage, Cerebral Vasospasm
Sildenafil for DCI
Each year, approximately 30,000 people in the United States suffer an intra-cranial hemorrhage due to aneurysmal rupture. Of those surviving the initial event, up to 40% will go on to have further neurological injury secondary to…
- Trial name
- NCT03028298
- Testing
- Low dose sildenafil citrate, High dose sildenafil citrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Mississippi Medical Center
Aneurysmal Subarachnoid Hemorrhage, Vasospasm
Transcriptomic Signature of Vasospasm Consecutive to Sub-arachnoid Aneurismal Hemorrhage
Rational: The main danger with intracranial aneurism is its rupture conjugated with subarachnoid hemorrhage (SAH) occurrence. SAH is a severe pathology leading not only to neurological but also extra cerebral disorders.
- Trial name
- NCT01779713
- Testing
- Case-control transcriptomic study
- Where
- France
- Volunteers
- 89 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Subarachnoid Hemorrhage
Evaluation of Cerebral Spinal Fluid and Blood in Patients With Subarachnoid Hemorrhage
In this project we are collecting cerebrospinal fluid and blood from patients at Vanderbilt Medical Center who have a subarachnoid hemorrhage which has followed the rupture of a brain aneurysm.
- Trial name
- NCT00593268
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University Medical Center
Aneurysmal Subarachnoid Hemorrhage
Erythropoietin Therapy for Subarachnoid Hemorrhage
ABSTRACT: Delayed ischemic deficits (DID) and strokes caused by low cerebral blood flow (CBF) are major sources of poor outcome following aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT00140010
- Testing
- erythropoietin beta
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Cambridge
Aneurysmal Subarachnoid Hemorrhage
Hypercapnia to Prevent Secondary Ischemia in SAH
Delayed cerebral vasospasm and secondary ischemic infarction are feared complications after aneurysmal subarachnoid hemorrhage (aSAH). To date, there is no effective therapy to prevent these ischemic complications.
- Trial name
- SAHCO2 (NCT01799525)
- Testing
- Hypercapnia by reduction of respiratory volume
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Wuerzburg University Hospital
Vasospasm, Intracranial, Subarachnoid Hemorrhage
Lumenate Observational Vasospasm Interventional Trial (LOVIT)
The LOVIT study is a European prospective, multi-center, open-label, single-arm feasibility trial designed to determine the safety and angiographic effectiveness through 30 days post treatment with Lumenate Intraluminal Device in…
- Trial name
- LOVIT (NCT03511040)
- Testing
- Lumenate Intraluminal Device
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 20 people
- Sponsor
- Neurvana Medical
Coronary Disease, Intracranial Embolism
A Registry Study of Shuxuening Injection Used in Hospitals in China
The purpose of this study is get to know what and how Shuxuening injection in hospital results in adverse events or adverse drug reactions from a cohort event monitoring.
- Conditions
- Coronary Disease, Intracranial Embolism, Stroke, Angina Pectoris
- Trial name
- RSCMI-VII (NCT01752946)
- Volunteers
- 30,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Subarachnoid Hemorrhage, Cerebral Vasospasm
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study
Cerebral vasospasm following subarachnoid hemorrhage (SAH) is the most common cause of morbidity and mortality. Recent studies indicate that Rho-kinase play an important role in the occurrence of such cerebral vasospasm.
- Trial name
- EVAS (NCT00839449)
- Testing
- Eicosapentaenoic acid ethyl ester
- Where
- 5 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Yamaguchi University Hospital
Subarachnoid Hemorrhage, Aneurysmal
SAHaRA: A Randomized Controlled Trial
The SAHaRA trial will clarify the role of treating anemia with Red Blood Cell (RBC) transfusion in a unique and vulnerable patient population, and determine whether that impacts on functional outcomes and mortality.
- Trial name
- NCT03309579
- Testing
- Liberal RBC Transfusion Strategy, Restrictive RBC Transfusion Strategy
- Where
- 23 sites in United States, Australia and 1 more
- Volunteers
- 742 people
- Sponsor
- Ottawa Hospital Research Institute
Aneurysmal Subarachnoid Hemorrhage
EARLYdrain - Outcome After Early Lumbar CSF-drainage in Aneurysmal SAH
The intention of the study is to investigate whether drainage of cerebral spinal fluid via a lumbar route ("Tuohy-drain") will improve outcome after intracranial aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- EARLYDRAIN (NCT01258257)
- Testing
- Insertion of a lumbar drain
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Cerebral
The Effect of Transcutaneous Vagal Nerve Stimulation (tVNS) on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage
The significance of developing a safe and effective therapy for aneurysmal subarachnoid hemorrhage (aSAH) patients suffering cerebral vasospasm (CVS) cannot be overstated.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Cerebral, Transcutaneous Vagal Nerve Stimulation (tVNS), Endovascular Treatment
- Trial name
- NCT07131696
- Testing
- Transcutaneous Vagal Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Marshall Holland
Subarachnoid Hemorrhage, Vasospasm
Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
The purpose of this study is to determine if giving blood transfusions to anemic patients with subarachnoid hemorrhage will reduce their chances of having a stroke from vasospasm.
- Trial name
- NCT00968227
- Testing
- Red blood cell transfusion
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Washington University School of Medicine
Cerebral Vasospasm After Subarachnoid Hemorrhage
Safety Study of Dantrolene to Treat Cerebral Vasospasm After Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a devastating acute brain injury due to bleeding onto the brain surface from a ruptured aneurysm.
- Trial name
- NCT00964548
- Testing
- Dantrolene
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Aneurysmal Subarachnoid Hemorrhage, Delayed Neurological Deficit
Effects of Donepezil on Regional Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage
Introduction Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding around the under surface of the brain caused by rupture of an aneurysm arising from a blood vessel.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Delayed Neurological Deficit, Delayed Cerebral Ischemia, Vasospasm
- Trial name
- DASH (NCT02222727)
- Testing
- Donepezil
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- St George's, University of London