Clinical trials: Vasospasm
Subarachnoid Hemorrhage, Cerebral Vasospasm
Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage
The purpose of this study is to determine the role of Proteomics and Metallomics in Cerebral Vasospasm following Subarachnoid Hemorrhage
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hydrocephalus
- Trial name
- NCT01799018
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- State University of New York - Upstate Medical University
Coronary Vasospasm, Cardiac Death
Coronary Spasm Presenting Aborted Sudden Cardiac Death, the Multicenter Registry
The purpose of this study is to evaluate the natural course of coronary spasm patients presenting aborted sudden cardiac death and analyze risk factors.
- Trial name
- NCT02298543
- Testing
- coronary spasm
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seung-Jung Park
Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus
Quality of Life in Elderly After Aneurysmal Subarachnoid Hemorrhage (SAH)
In all the Western populations, the annual incidence of subarachnoid hemorrhage (SAH) increase with age. In patients older than 70 years, the occurrence of SAH exposes them to high risk of morbidity and a poor quality of life.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Hydrocephalus, Cerebral Vasospasm
- Trial name
- FASHE (NCT00692744)
- Where
- 2 sites in France
- Volunteers
- 353 people
- Sponsor
- University Hospital, Rouen
Subarachnoid Hemorrhage, Aneurysmal
Angiotensin Metabolite Profile After Subarachnoid Hemorrhage
The outcome of subarchnoid hemorrhage depends on the severity of the bleeding and the development of secondary neurologic deficits caused by cerebral vasospasm.
- Trial name
- NCT05222542
- Testing
- Sampling of plasma and cerebrospinal fluid at specified time points
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Dr. Roman Ullrich
Subarachnoid Haemorrhagic Stroke
Investigation of the Role of Inflammatory Markers in the Early Detection of Cerebral Vasospasm, Delayed Cerebral Ischemia, and Meningitis Associated With External Cerebrospinal Fluid Drainage After Non-Traumatic Subarachnoid Hemorrhage - A Prospective Case-Control Study
Background Non-traumatic subarachnoid haemorrhage (SAH) is frequently complicated by delayed cerebral ischaemia (DCI) and by ventriculitis/meningitis when external CSF drains are used; bedside TCCD has limited accuracy for…
- Trial name
- NCT07129603
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Tamas Vegh, MD
Subarachnoid Hemorrhage
Ventriculostomy in Subarachnoid Hemorrhage (SAH): Intracranial Pressure (ICP) Open or Not?
The purpose of this study is to explore two currently accepted methods of intracranial pressure (ICP) management through cerebral spinal fluid (CRF) drainage for patients diagnosed with subarachnoid hemorrhage (SAH).
- Trial name
- VISION 2 (NCT01169454)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Stroke, Brain Ischemia
Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
Dexmedetomidine is a unique sedative medication able to provide sedation without causing respiratory depression and maintaining neurological functions.
- Conditions
- Stroke, Brain Ischemia, Vasospasm, Intracranial, Hemorrhage, Intracranial
- Trial name
- NCT01845441
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University Hospitals Cleveland Medical Center
Sub-arachnoid Haemorrhage
Levosimendan as Treatment of Aneurysmal SubArachnoid Haemorrhage
Sub-arachnoid haemorrhage (SAH) are often due to ruptured intracerebral aneurysms and are associated with an importante morbi-mortality.
- Trial name
- LEVOSAH (NCT05664191)
- Testing
- Levosimendan
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vasospasm
Comparing the Nautilus NeuroWaveTM to TCD or DSA for the Detection of Vasospasm
To determine the efficacy of using the Jan Medical NNW system as a diagnostic aid in detection of moderate and severe vasospasm for detection of vasospasm in patients with subarachnoid hemorrhage.
- Trial name
- NCT02071875
- Testing
- Nautilus NeuroWaveTM recording
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- Jan Medical, Inc.
Glaucoma, Open-Angle
Ginkgo Biloba and Ocular Blood Flow in Primary Open-angle Glaucoma
Glaucoma is one of the leading causes of blindness. Ginkgo biloba may be part of an effective treatment strategy for glaucoma because it has been shown to improve blood flow, it has antioxidant properties, it can relax smooth…
- Trial name
- NCT02376114
- Testing
- Ginkgo biloba
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Cerebral Ischemia, Subarachnoid Hemorrhage
Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage
The objective of this multi-centre, randomized controlled trial is to investigate the outcome after induced hypertension versus no induced hypertension in patients with delayed cerebral ischemia (DCI) after aneurysmal…
- Trial name
- HIMALAIA (NCT01613235)
- Testing
- Induced hypertension
- Where
- 2 sites in Netherlands
- Volunteers
- 26 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Vasospasm, Intracranial, Subarachnoid Hemorrhage
Lumenate Observational Vasospasm Interventional Trial (LOVIT)
The LOVIT study is a European prospective, multi-center, open-label, single-arm feasibility trial designed to determine the safety and angiographic effectiveness through 30 days post treatment with Lumenate Intraluminal Device in…
- Trial name
- LOVIT (NCT03511040)
- Testing
- Lumenate Intraluminal Device
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 20 people
- Sponsor
- Neurvana Medical
Sub Arachnoid Hemorrhage, Vasospasm
An Innovative Non-invasive Acoustic Approach to Detect and Monitor Cerebral Vasospasm
The lack of a precise diagnostic technique for cerebral vasospasm associated with traumatic brain injury (TBI) limits the ability to detect and treat this phenomenon.
- Trial name
- NCT02093182
- Where
- Israel
- Sponsor
- HeadSense Medical
Subarachnoid Hemorrhage
Evaluation of Cerebral Spinal Fluid and Blood in Patients With Subarachnoid Hemorrhage
In this project we are collecting cerebrospinal fluid and blood from patients at Vanderbilt Medical Center who have a subarachnoid hemorrhage which has followed the rupture of a brain aneurysm.
- Trial name
- NCT00593268
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University Medical Center
Aneurysmal Subarachnoid Hemorrhage
Cervical Spinal Cord Stimulation for the Prevention of Cerebral Vasospasm
The study investigates safety, feasibility and effectiveness of cervical spinal cord stimulation (SCS) in prevention of cerebral arterial vasospasm following aneurysmal subarachnoid hemorrhage (aSAH).
- Trial name
- NCT00766844
- Testing
- spinal cord stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Konstantin V. Slavin
Cardiovascular Diseases, Metabolic Disease
Vascular Lab Resource (VLR) Biorepository
This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases.
- Conditions
- Cardiovascular Diseases, Metabolic Disease, Peripheral Artery Disease, Carotid Disease
- Trial name
- NCT05628948
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- The Cleveland Clinic
Brain Aneurysm, Aneurysm, Ruptured
Superior Cervical Ganglion Block, Transcranial Doppler
The aim of this study is to assess blood flow velocity in middle cerebral artery measured by transcranial doppler to determine the efficacy of SCG block in decreasing incidence or severity of vasospasm after MCA aneurysm surgery.
- Trial name
- NCT04439760
- Testing
- Superior Cervical Ganglion Block
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Fatma Ibrahim El Sayed Salman
Aneurysmal Subarachnoid Hemorrhage
Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to evaluate the safety and potential therapeutic benefit of use of clazosentan in reversing cerebral vasospasm (a narrowing of blood vessels in the brain due to the presence of blood in the space…
- Trial name
- REVERSE (NCT02560532)
- Testing
- Clazosentan
- Where
- 11 sites in Finland, France and 1 more
- Volunteers
- 25 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Subarachnoid Hemorrhage, Brain Ischemia
Dapsone Use in Patients With Aneurysmal Subarachnoid Hemorrhage.
Dapsone is a drug that has been used clinically for several decades due to its anti-infective effect, making it widely available. Its neuroprotective effects have been found through its glutamate receptors antagonistic effect.
- Conditions
- Subarachnoid Hemorrhage, Brain Ischemia, Subarachnoid Hemorrhage, Aneurysmal, Aneurysmal Subarachnoid Hemorrhage
- Trial name
- NCT05131295
- Testing
- Dapsone, Aluminum Hydroxide Gel
- Where
- Mexico
- Volunteers
- 49 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm
Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm
The objective of this study is to determine whether acetaminophen (APAP), N-acetylcysteine (NAC), and APAP in combination with NAC will inhibit lipid peroxidation in aneurysmal subarachnoid hemorrhage (aSAH), utilizing F2-IsoPs…
- Trial name
- NCT00585559
- Testing
- APAP 1 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly, APAP 1.5 gm q6 hours, plus NAC IV infusion at 0.5 gm hourly
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Vanderbilt University Medical Center