Clinical trials: Vein Injury
Ischemic Central Retinal Vein Occlusion
Rubeosis Anti-VEGF (RAVE) Trial for Ischemic Central Retinal Vein Occlusion
The RAVE (Rubeosis Anit-VEgf) trial, utilizes monthly intravitreal Ranibizumab (Lucentis) injections for 9 months to see if total VEGF blockade will prevent neovascular glaucoma and eliminate the need for panretinal…
- Trial name
- NCT00406471
- Testing
- Ranibizumab (Lucentis)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Greater Houston Retina Research
Diabetic Foot Ulcer, Venous Leg Ulcer
Efficacy and Tolerance of URGO AWC_008 and URGO AWC_022 Dressings (EXPANSION)
Evaluation of the efficacy (wound epithelialization and time to closure) and tolerance (emergence and nature of adverse event) of the new URGO AWC_008 and URGO AWC_022 dressings in local management of acute and chronic wounds at…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Pressure Ulcer, Wound Infection
- Trial name
- NCT05772507
- Testing
- URGO AWC_008 dressing or URGO AWC_022 dressing
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Laboratoires URGO
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Traumatic Brain Injury, Mechanical Ventilation Complication
Effects of Positive End-expiratory Pressure on Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The impact of PEEP on ICP was dependent on the difference between elevated CVP levels and baseline ICP levels. ICP would increase once elevated CVP through PEEP adjustment exceeds the baseline ICP.
- Trial name
- PEEP，ICP，CVP (NCT03296293)
- Testing
- PEEP at 5cmH2O, PEEP at 10cmH2O, PEEP at 15cmH2O
- Volunteers
- 38 people
- Sponsor
- Hongpeng Li
Atrial Fibrillation, Femoral Vein Injury
Haemostasis After Venous Access in Atrial Fibrillation Catheter Ablation: The HARNESS Trial
Atrial fibrillation (AF) is the most common heart rhythm disorder affecting adults in the United Kingdom. In patients with AF who continue to experience symptoms despite medications, catheter ablation is an established…
- Conditions
- Atrial Fibrillation, Femoral Vein Injury, Bleeding
- Trial name
- HARNESS (NCT06470555)
- Testing
- A figure-of-eight suture secured with a three-way tap, Shortened bed rest duration of 2-hours, Manual compression
- Where
- United Kingdom
- Volunteers
- 336 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Venous Thromboembolism, Deep Vein Thrombosis
SToP: Venous Thromboembolism Screening in the Trauma Population
This is a prospective, randomized vanguard trial of trauma patients admitted to the trauma surgery service at Intermountain Medical Center who are deemed to be at high risk for venous thromboembolism.
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Trauma, Multiple
- Trial name
- SToP (NCT02978950)
- Testing
- Duplex ultrasound surveillance, No ultrasound surveillance
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Intermountain Health Care, Inc.
Wound Infection
Vacuumtherapy After Venous Hybrid Procedures
All patients with deep venous obstruction below the sapheno-femoral junction elective for hybrid procedure with creation of an arterio venous-fistula (AVF) in the MUMC or patients with primary percutaneous procedure (and thus…
- Trial name
- NCT02905955
- Testing
- Prevena, KCI, Acelity, NPWT
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Venous Leg Ulcers, Mixed Ulcer
Chemical Debridement and Leg Ulcers
A pilot study to investigate the relative effectiveness and safety of chemical wound debridement and curettage in the treatment of venous and mixed aetiology leg ulcers.
- Trial name
- NCT06652360
- Testing
- Chemical Debridement, Curettage debridement
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- DEBx Medical B.V.
Punch Biopsy Wounds, Healing Times
Healing of Punch Graft Wounds. Comparative Study Between MariGen and Oasis: a Non-inferiority Study
The objective is to determine, if healing of punch biopsy wounds treated with the fish skin derived MariGen Wound dressing is non-inferior to healing with wounds treated with pig intestines derived Oasis Sheet wound dressing.
- Trial name
- NCT01917591
- Testing
- Punch biopsies treated with MariGen Wound ECM dressing, Punch biopsies treated with Oasis ECM dressing
- Where
- Iceland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Kerecis Ltd.
Vein Injury
Vascular Graft Storage Solution Preserves Endothelial Function
Since Saline is still the most widely used storage and flushing solution in cardiovascular procedures despite knowing evidence of its influence on the human endothelial cell function the main aim of this study was to assess the…
- Trial name
- VGE (NCT04614077)
- Testing
- ex vivo organ bath testing, preservation of vein sections without contact to patient
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Klinikum Floridsdorf
Venous Leg Ulcer, Wound Healing
FORCEREPAIR - A Wound Exudate Investigation
The observational longitudinal study will collect wound exudate from twenty patients with venous leg ulcers. Wound exudate samples are collected using twenty-four-hour collection with polyurethane foam, bandages and the NovaSwab…
- Conditions
- Venous Leg Ulcer, Wound Healing, Non-healing Wound, Cytokines
- Trial name
- NCT06109844
- Testing
- Standard of Care
- Where
- 2 sites in Denmark
- Volunteers
- 13 people
- Sponsor
- Bispebjerg Hospital
Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care
SEPREVEN: a Stepped-wedge Randomised Controlled Trial
Adverse events are frequent in Neonatal Intensive Care Units' (NICU) patients and account for a high morbidity and mortality. Possible severe adverse events are central line associated bloodstream infections (CLABSI), ventilator…
- Conditions
- Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care, Catheter-related Bloodstream Infection (CRBSI) Nos, Quality of Healthcare
- Trial name
- SEPREVEN (NCT02598609)
- Testing
- Education program for NICU caregivers
- Where
- 12 sites in France
- Volunteers
- 8,000 people
- Sponsor
- Dr Caeymaex Laurence
Thorax Injuries, Embolism Vein
Retrospectively Analyze the Risk Factors of VTE in 5774 Patients With Thoracic Trauma From 33 Hospitals in China, and Established a Risk Prediction Model
Retrospectively analyze the risk factors of VTE in 5774 patients with thoracic trauma from 33 hospitals in China, and established a risk prediction model
- Conditions
- Thorax Injuries, Embolism Vein, Embolism, Pulmonary, Rib Fractures
- Trial name
- MCTTVTE (NCT05770232)
- Where
- China
- Volunteers
- 5,774 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Shock, Septic, Renal Failure, Acute
Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care)
Sepsis and septic shock are still important causes of mortality in intensive care medicine. Renal replacement therapy by standard volume haemofiltration is currently used, but a higher-volume haemofiltration may improve the…
- Trial name
- IVOIRE (NCT00241228)
- Testing
- Venovenous haemofiltration (renal replacement therapy)
- Where
- 16 sites in Belgium, France and 1 more
- Volunteers
- 139 people
- Sponsor
- University Hospital, Bordeaux
Intraoperative, Venous Congestion
Venous Congestion and Cardiac Surgery-Associated Acute Kidney Injury
Venous pressure is often overlooked as an important hemodynamic parameter. Elevated venous pressure and blood stasis in organ tissues can lead to interstitial edema.
- Conditions
- Intraoperative, Venous Congestion, Cardiac Surgery-associated Acute Kidney Injury
- Trial name
- NCT07232277
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters and kidney function assessments, collection of biological (laboratory) parameters
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Zhuan Zhang
Chronic Ulcers
Efficacy and Safety of ZKARE® Gel and Its Accessory ZKAPI® in the Treatment of Chronic Ulcers.
This prospective, randomized, single-blind, controlled clinical investigation evaluates the efficacy and safety of ZKARE®, a topical polymeric gel dressing, and its accessory applicator ZKAPI®, for the treatment of chronic…
- Trial name
- NCT07406152
- Testing
- ZKARE®, Standard Wound Care
- Where
- Spain
- Volunteers
- 134 people
- Sponsor
- i+Med S.Coop.
Lower Extremity Wound Infected, Venous Stasis Ulcers
V.A.C. VeraFlo™ Instillation Therapy vs V.A.C. Ulta™ Therapy on Biofilm in Chronically Infected Wounds
This study would like to determine if using negative pressure wound therapy with an instillation of .125% Dakins is more effective than using negative pressure wound therapy alone on biofilm removal, disruption and elimination in…
- Trial name
- NCT02009501
- Testing
- VAC VeraFlo with Dakins Instillation, VAC Ulta Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Venous Thromboembolism, Pulmonary Embolus
Multicenter Registry for Comparative Effectiveness Analysis of Venous Thromboembolism in Trauma Patients
Venous thromboembolism (VTE) remains a leading cause of death in trauma patients. Based on the EAST Management Guidelines for the prevention of VTE in trauma patients, a number of research questions could be addressed by a…
- Conditions
- Venous Thromboembolism, Pulmonary Embolus, Deep Vein Thrombosis
- Trial name
- CLOTT (NCT01890044)
- Where
- United States
- Sponsor
- Scripps Health
Venous Leg Ulcer
Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras
Evaluation of the non-inferiority of TulleGras M.S.® versus Urgotul® in pain associated with removal of wound dressing during care of venous leg ulcer
- Trial name
- NCT02104180
- Testing
- Urgotul, TulleGras M.S.
- Where
- 27 sites in France
- Volunteers
- 62 people
- Sponsor
- Mylan Inc.
Hypertensive Ischemic Leg Ulcer, Calciphylaxis
Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU)
Martorell hypertensive ischemic leg ulcer is a severe type of skin necrosis (skin infarction) which occurs in long-term hypertensive subjects.
- Trial name
- NCT01578382
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich