Clinical trials: Vein Occlusion
Non-Ischemic Central Retinal Vein Occlusion
Effect of Ozurdex® 0.7 mg on Improvement of Efficacy of Bevacizumab for Central Retinal Vein Occlusion
This is a study designed to determine if the addition of Ozurdex® to bevacizumab (Avastin®) eye injections reduces the need for repeat bevacizumab eye injections in patients with nonischemic central retina vein occlusion.
- Trial name
- NCT01295112
- Testing
- Active bevacizumab and Active dexamethasone
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Texas Retina Associates
Coronary Artery Disease
Radial Artery Versus Saphenous Vein Patency (RSVP) Trial - 10 Year Follow-up
During coronary bypass surgery, veins are taken from the leg and applied to the heart and aorta to 'bypass' narrowings in the coronary arteries.
- Trial name
- NCT01622387
- Testing
- Coronary artery bypass (CABG) surgery using a radial arterial conduit, Coronary artery bypass surgery using a long saphenous vein conduit
- Where
- United Kingdom
- Sponsor
- Imperial College London
Neovascular Glaucoma
Clinical Characteristics of Neovascular Glaucoma
The goal of this observational study is to explore the clinical characteristics of patients with neovascular glaucoma (NVG), and to analyze the relationship between NVG and various underlying diseases, ocular conditions…
- Trial name
- NCT07177807
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Chronic Venous Insufficiency, Chronic Venous Thrombosis
Best Endovenous Treatment, Including STenting, Versus Non-endovenous Treatment in Chronic Proximal Deep Venous Disease
Chronic obstruction of the iliac veins or inferior vena cava can occur as a result of deep vein thrombosis (DVT), or due to extrinsic compression in non-thrombotic iliac vein lesions (NIVLs).
- Conditions
- Chronic Venous Insufficiency, Chronic Venous Thrombosis, Iliac Vein Stenosis, Iliac Vein Obstruction
- Trial name
- BEST (NCT05622500)
- Testing
- Deep venous stenting, Best medical therapy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Complications
Standard Length Catheters vs Long Catheters in Peripheral Vein Cannulation.
The Long and Short is a prospective, randomized, controlled, open label trial to test the complications of different device for peripheral vein cannulation, standard length (about 5 cm in length) and long catheter (about 12 cm in…
- Trial name
- Long&short (NCT01917253)
- Testing
- Standard Device for peripheral vein cannulation, Long Catheters for peripheral vein cannulation
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- ASL TO2 Torino
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Coronary Artery Bypass Graft Surgery, Presence of Heparin/Platelet Factor 4 Antibody
Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion
Heparin/Platelet Factor 4 (PF4) antibody testing will be performed in subjects who have just undergone coronary artery bypass grafting (CABG) surgery.
- Trial name
- NCT01246011
- Testing
- Argatroban and warfarin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Hepatocellular Carcinoma
Pringle's Maneuver Versus Selective Hepatic Vascular Exclusion in Hepatectomy
To confirm that SHVE is a safe and effective procedure and it can prevent bleeding of the hepatic vein. To evaluate the recurrence and metastasis in HCC patients undergoing hepatectomy by SHVE.To evaluate that SHVE can improve…
- Trial name
- SHVE (NCT00820339)
- Testing
- Selective Hepatic Vascular Exclusion, Pringle's Maneuver
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Coronary Artery Disease
Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients
Antiplatelet treatment is important for coronary artery disease(CAD) patients .Some patients are resistant to antiplatelet treatment based on platelet function tests(PFT).Currently the results of PFT are mainly based on the…
- Trial name
- DPABIAP (NCT03078257)
- Testing
- tirofiban in PV, tirofiban in IC, antiplatelet thrombolysin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis
DOAC in Unusual Site Venous Thrombosis
Unusual site venous thromboembolism (VTE) refers to thrombosis occurring in venous districts outside the veins of the lower extremities and the pulmonary arteries, and includes splanchnic vein thrombosis (SVT), cerebral vein…
- Conditions
- Splanchnic Vein Thrombosis, Cerebral Vein Thrombosis, Ovarian Vein Thrombosis, Renal Vein Thrombosis
- Trial name
- DUST (NCT03778502)
- Testing
- Direct Oral Anticoagulants
- Where
- 24 sites in United States, Canada and 8 more
- Volunteers
- 358 people
- Sponsor
- University of Malta
Healthy
Effects of Miconazole on Blood Flow
This study will investigate the effect of the drug miconazole on blood vessel dilation. Miconazole stops production of EDHF, a substance that causes arteries to dilate. EDHF is produced by the cells that line blood vessels.
- Trial name
- NCT00004575
- Testing
- Miconazole, L-NMMA, Bradykinin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Bypass Grafting
Randomized Endo-Vein Graft Prospective
Coronary artery bypass grafting (CABG) is the most common major surgical procedure in the United States with over 300,000 cases performed each year.
- Trial name
- REGROUP (NCT01850082)
- Testing
- Vein Harvesting Procedures
- Where
- 16 sites in United States
- Volunteers
- 1,150 people
- Sponsor
- VA Office of Research and Development
Hepatic Veno-occlusive Disease
Compassionate Use of Defibrotide for Patients With Veno-occlusive Disease of the Liver
Veno-occlusive disease (VOD) of the liver is a significant complication for some patients undergoing hematopoietic stem cell transplantation.
- Trial name
- NCT00143546
- Testing
- Defibrotide
- Where
- United States
- Sponsor
- St. Jude Children's Research Hospital
Retinal Vein Occlusion
Parnaparin vs Aspirin in the Treatment of Retinal Vein Occlusion
Retinal vein occlusion (RVO) is the second commonest retinal disease after diabetic retinopathy, and is a common cause of unilateral visual loss.
- Trial name
- PARVO (NCT00732927)
- Testing
- parnaparin, aspirin
- Where
- Italy
- Volunteers
- 67 people
- Sponsor
- Università degli Studi dell'Insubria
Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration
Changes in Intraocular Pressure After Intravitreal Injection
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections introduce additional fluid volume into the eye, which can cause an acute, transient elevation in intraocular pressure (IOP).
- Conditions
- Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration, Retinal Vein Occlusion, Ocular Hypertension
- Trial name
- NCT07826286
- Volunteers
- 50 people
- Sponsor
- Assiut University
Sickle Cell Disease, Sickle Cell Crisis
Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease
Pediatric patients who present with acute vaso-occlusive pain crisis may have equivalent pain reduction scores at lower dosing of intravenous Ketorolac compared to standard dosing of 0.5 mg/kg/dose IV (<16yo max 15mg, >16yo max…
- Conditions
- Sickle Cell Disease, Sickle Cell Crisis, Veno-occlusive Disease
- Trial name
- NCT06579703
- Testing
- Ketorolac
- Volunteers
- 102 people
- Sponsor
- Children's Blood and Cancer Center at Dell Children's Medical Center
Macular Edema, Branch Retinal Vein Occlusion
A Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Branch Retinal Vein Occlusion
This is a Phase III, multicenter, randomized, double-masked, active comparator-controlled, parallel-group study evaluating the efficacy, safety, and pharmacokinetics of faricimab administered by intravitreal (IVT) injection at…
- Trial name
- BALATON (NCT04740905)
- Testing
- Faricimab, Aflibercept
- Where
- 150 sites in United States, Argentina and 20 more
- Volunteers
- 553 people
- Sponsor
- Hoffmann-La Roche
Atrial Fibrillation, Atrial Flutter
Suture Closure AFtEr VEIN Access for Cardiac Procedures (SAFE-VEIN) Trial
Primary objective: To compare the safety and efficacy of closure strategies post venous access procedures. Hypothesis: We anticipate that the use of a venous closure device will decrease the time to hemostasis (TTH), time to…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Heart Block, Pulmonary Embolism and Thrombosis
- Trial name
- SAFE-VEIN (NCT04632641)
- Testing
- Perclose ProGlide Suture-Mediated Closure System (SMC) - LARGE-BORE PROCEDURES, Figure 8 Suture - LARGE-BORE PROCEDURES
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Wake Forest University Health Sciences
Occlusive Portal Vein Thrombosis (OPVT), Cavernous Transformation of Portal Vein
Mesenteric Vein Access for OPVT-Related Recurrent Variceal Bleeding: An Ambispective Cohort
Occlusive portal vein thrombosis (OPVT) is defined as complete thrombosis of the main portal vein trunk, resulting in total interruption of portal venous inflow and representing the most severe form of portal vein thrombosis.
- Conditions
- Occlusive Portal Vein Thrombosis (OPVT), Cavernous Transformation of Portal Vein, Gastroesophageal Varices Bleeding
- Trial name
- NCT07666256
- Testing
- Percutaneous mesenteric vein-assisted interventional treatment
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Air Force Military Medical University, China
Coronary Artery Disease, Atherosclerosis
Radial Artery Patency and Clinical Outcomes Trial
Coronary Artery Bypass Graft (CABG)Surgery is commonly used to treat patients with coronary artery disease (atherosclerosis) for the relief of angina (chest pain) and improve heart muscle function.
- Trial name
- RAPCO (NCT00475488)
- Testing
- Coronary artery bypass grafting
- Where
- Australia
- Volunteers
- 605 people
- Sponsor
- Austin Health