Clinical trials: Venous Insufficiency of Leg
Vascular, DVT - Deep Vein Thrombosis
Outcomes of Iliac Vein Stenting With Dedicated Venous Stents in Treatment of Chronic Post-thrombotic Venous Ulcers
Outcomes of iliac vein stenting with dedicated venous stents in treatment of chronic post-thrombotic venous ulcers Deep vein thrombosis (DVT) affects 1 to 3 individuals per 1000 annually.
- Conditions
- Vascular, DVT - Deep Vein Thrombosis, Post Thrombotic Syndrome, Venous Ulcer of Leg
- Trial name
- NCT07762222
- Testing
- dedicated venous stenting, Dedicated venous stent / iliofemoral dedicated venous stenting
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Venous Stasis Ulcers, Venous Insufficiency
Taliderm Dressing for Venous Ulcers
The study will test a new wound healing dressing called Taliderm® on leg ulcers caused by chronic venous insufficiency (CVI). Some people with CVI have poor vein circulation that causes ulcers to develop on the lower legs.
- Trial name
- NCT00720239
- Testing
- Taliderm wound healing dressing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Varicose Ulcer, Venous Insufficiency of Leg
Utilization of Compreflex Wraps in Patients With Chronic Venous Insuffciency
This is a multicentre, quasi-experimental study to evaluate the Conformitè Europëenne-marked Compreflex standard calf and foot (with basic liner) under routine conditions.
- Trial name
- NCT05364112
- Testing
- Compreflex
- Where
- Malaysia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kuala Lumpur General Hospital
Venous Leg Ulcer, Venous Ulcer
Tissue Repair Gel in Venous Leg Ulcers (US)
The goal of this clinical trial is to learn if TR987 0.1% gel + Standard of Care works better than Standard of Care alone to treat Venous Leg Ulcers (VLUs).
- Conditions
- Venous Leg Ulcer, Venous Ulcer, Venous Stasis Ulcer, Venous Stasis
- Trial name
- TRIVIA (NCT06707090)
- Testing
- TR987 0.1% gel + Standard of Care, Standard of care
- Where
- 33 sites in United States
- Volunteers
- 312 people
- Sponsor
- TR Therapeutics
Varicose Veins, Venous Insufficiency
Lower Limb Venous Insufficiency and the Effect of Radiofrequency Treatment Versus Open Surgery
200 patients with insufficient great saphenous veins will be randomized to either radiofrequency ablation or high ligation/stripping (open surgery).
- Trial name
- NCT02397226
- Testing
- Radiofrequency ablation, High ligation/stripping, Radiofrequency ablation catheter
- Where
- 2 sites in Sweden
- Volunteers
- 198 people
- Sponsor
- University Hospital, Linkoeping
Venous Ulcer
Immediate Versus Early Endovenous Ablation In Venous Ulcer
The study is conducted to assess the effects of immediately started foam sclerotherapy in venous ulcer compared to early intervention.
- Trial name
- NCT03795064
- Testing
- Foam sclerotherapy, Endothermal ablation
- Where
- Finland
- Volunteers
- 23 people
- Sponsor
- Oulu University Hospital
Varicose Veins
LivRelief Varicose Veins Cream in the Treatment of Varicose Veins
Phase IV interventional design where all participants used the test product as per package instructions for 6-weeks. Baseline observations were compared to those collected after 6-weeks of treatment.
- Trial name
- NCT03653793
- Testing
- Natural Health Product: LivRelief Varicose Veins Cream
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Delivra, Inc.
Wound Healing, Diabetic Foot
EDX110 - Efficacy and Safety in the Management of Hard-to-heal Wounds
Post-market study to determine the efficacy of EDX110 dressing system in hard-to-heal wounds.
- Conditions
- Wound Healing, Diabetic Foot, Foot Ulcer, Diabetic, Venous Ulcer
- Trial name
- NCT06640985
- Testing
- EDX110 wound dressing system
- Where
- Chile
- Volunteers
- 43 people
- Sponsor
- ConvaTec Inc.
Varicose Veins of Lower Limb, Hemorrhoids
HEMOVAR Study on Hemorrhoids and Varicose Veins
The HEMOVAR Study is a prospective observational study designed to evaluate the association between hemorrhoidal disease and lower extremity varicose veins.
- Trial name
- HEMOVAR (NCT07317492)
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Aydin Adnan Menderes University
Venous Insufficiency of Leg
Impact of Endovenous Water Vapor Treatment on Quality of Life in Superficial Venous Insufficiency of the Lower Limbs
The prevalence of superficial chronic venous insufficiency (CVI) of the lower limbs is estimated at 18 million French people. The number of patients operated for varicose veins is around 300,000 per year.
- Trial name
- INVOLVE (NCT04534244)
- Testing
- VBox Hybrid
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Postthrombotic Syndrome
DVT Burden and the Risk of Post-thrombotic Syndrome
Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT), with major consequences for patient quality of life and cost of management.
- Trial name
- DVT-Burden (NCT06385353)
- Testing
- Quantification of deep vein thrombosis burden and assessment of post-thrombotic syndrome
- Where
- 27 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Lymphedema
CVR Registry Evaluating Flexitouch Plus and Conservative Care vs Conservative Care Only for Treatment of Lymphedema
Subjects with lower extremity lymphedema will be prescribed, per standard of care, to either Flexitouch Plus with conservative care or conservative care only and be followed for 12 months.
- Trial name
- NCT04116099
- Testing
- Conservative care, Flexitouch Plus
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- Tactile Medical
Vascular Diseases, Peripheral, Venous Insufficiency of Leg
Safety and Efficacy Study of Endovenous Microwave Ablation for Treatment of Varicose Veins
The purpose of this study was to evaluate the efficacy and safety of microwave ablation catheter in the treatment of varicose veins in lower extremities,meanwhile, to compare the quality of subjects'lives before and after…
- Conditions
- Vascular Diseases, Peripheral, Venous Insufficiency of Leg, Varicose Veins of Lower Limb
- Trial name
- EMINENCE (NCT04645771)
- Testing
- Questionnaires
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Chronic Venous Disease, Vein Disease
Randomized, Placebo-crontrolled Clinical Trial Evaluating the Efficacy and Safety of Heparan Sulfate 120 mg Prolonged-Release Tablets Compared With Placebo in Patients With Chronic Venous Disease
This multicenter, randomized, double-blind study is a phase III evaluates the safety and effectiveness of CLR prolonged-release tablets in patients with chronic venous insufficiency, has been shown to be effective in reducing the…
- Conditions
- Chronic Venous Disease, Vein Disease, Venous Insufficiency of Leg
- Trial name
- CLR-18 (NCT07684833)
- Testing
- CLR Tablets - Heparan Sulphate
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Barbara Maglione
Venous Leg Ulcer
DEep VEin Lesion OPtimisation (DEVELOP) Trial
This is a prospective, single centre, randomised controlled, feasibility study recruiting patients with lower limb venous ulceration and Great Saphenous incompetence.
- Trial name
- Develop (NCT03640689)
- Testing
- Endovenous ablation + iliac US +/- iliac stenting, Endovenous ablation of Great Saphenous Vein
- Where
- 2 sites in Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Ireland, Galway, Ireland
Venous Insufficiency
Feasibility, Efficacy, and Safety of Venous Ulcer Treatment Using a Hand Plasma Generator (PlasmaDerm) Chronisch venöser Ulzerationen (PlasmaDerm)
The purpose of this study is to prove the safety and efficacy of plasma as an add-on treatment in combination with conventional treatment in cases of chronical venous Ulcus cruris.
- Trial name
- NCT01415622
- Testing
- PlasmaDerm, standard care of Ulcera crurum
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Cinogy GmbH
Venous Stasis Ulcers
Study of Thymosin Beta 4 in Patients With Venous Stasis Ulcers
The purpose of this study is to evaluate the safety, tolerability and effectiveness of Thymosin Beta 4 administered topically in patients with Venous Stasis ulcers
- Trial name
- SSVS (NCT00832091)
- Testing
- Thymosin Beta 4
- Where
- 8 sites in Italy, Poland
- Volunteers
- 72 people
- Sponsor
- RegeneRx Biopharmaceuticals, Inc.
Venous Insufficiency of Leg
SOCKNLEG Compression Stocking Kit: Physical Properties
This study evaluates physical properties of a innovative leg compression stocking compared to a standard compression stocking of the same compression strength in patients with chronic venous insufficiency clinical stadium C3 and…
- Trial name
- SOCKNLEGLCA (NCT03743597)
- Testing
- SOCKNLEG, Sigvaris COTTON
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- University of Zurich
Ulcer, Venous Ulcer
ECM and Blood Components for Wound Healing
The Extracellular Matrix (ECM) and Blood Components for Wound Healing feasibility study is a clinical trial approved by Health Canada to study the safety of extracellular matrix (ECM) and autologous blood products in wound…
- Conditions
- Ulcer, Venous Ulcer, Foot Ulcer, Diabetic
- Trial name
- NCT01909908
- Testing
- ECM, Blood Products, ECM in Blood Products
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Cook Group Incorporated
Venous Insufficiency
Efficacy of Antistax® in Improving Microcirculation of the Skin in the Leg in Patients Suffering From Chronic Venous Insufficiency
Study to determine the efficacy and safety of Antistax® film coated tablets in improving microcirculation of the skin in the leg of patients with chronic venous insufficiency (CVI)
- Trial name
- NCT02191163
- Testing
- Antistax®
- Volunteers
- 71 people
- Sponsor
- Boehringer Ingelheim