Clinical trials: Venous Insufficiency of Leg
Venous Leg Ulcer, Venous Ulcer
Evaluation of the Efficacy of Multilayer Compression & UrgoStart Plus
Historically, venous leg ulcers have been very difficult to manage, with associated poor healing rates, and the likelihood of recurrence.
- Conditions
- Venous Leg Ulcer, Venous Ulcer, Venous Insufficiency of Leg, Leg Ulcer
- Trial name
- NCT06007703
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Venous Leg Ulcer
Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU)
A 12 month, multicenter, open-label registry to observe chronic venous insufficiency resulting in VLU treated with Varithena.
- Trial name
- VIEW-VLU (NCT03257254)
- Testing
- Varithena
- Where
- 14 sites in United States, Canada
- Volunteers
- 76 people
- Sponsor
- Boston Scientific Corporation
Venous Reflux, Venous Insufficiency
Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections
Randomized Controlled Trial to determine if the outcomes of sclerotherapy of the ulcer bed alone differ from a combination of ablation and sclerotherapy injections.
- Conditions
- Venous Reflux, Venous Insufficiency, Venous Ulcer, Venous Disease
- Trial name
- NCT05633277
- Testing
- Polidocanol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- ProMedica Health System
Heart Failure，Congestive, Leg Edema
The ROle of Compression StocKings in Heart Failure Patients
Congestive heart failure (CHF) occurs when the heart is weak and not able to effectively pump blood to the body. One of the common manifestations of CHF is fluid overload and swelling of the legs.
- Conditions
- Heart Failure，Congestive, Leg Edema, Venous Insufficiency, Venous Ulcers
- Trial name
- ROCK-HF (NCT06350695)
- Testing
- low grade compression stockings (10-15 mmHg), high grade compression stockings (20-30 mmHg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Venous Insufficiency, Leg Ulcer
The Evaluation of OrCel for the Treatment of Venous Ulcers
This study was designed to confirm the clinical benefits and safety of OrCel in the treatment of venous ulcers. OrCel and standard care are compared to standard care alone.
- Trial name
- NCT00270972
- Testing
- Bilayered Cellular Matrix (OrCel)
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Ortec International
Vascular Diseases, Peripheral, Venous Insufficiency of Leg
The Study of Reducing Adverse Effects After Radiofrequency Ablation Combined With Sclerotherapy
The purpose of this study is to evaluate whether adding sulodexide to the patients with varicose veins who received radiofrequency ablation combined with sclerotherapy can reduce or improve the impact of adverse events。
- Conditions
- Vascular Diseases, Peripheral, Venous Insufficiency of Leg, Varicose Veins of Lower Limb
- Trial name
- NCT05654233
- Testing
- Sulodexide
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Behcet Disease, Behcet Disease and Vascular Involvement
Immunosuppressive Therapy Alone Versus Plus Oral Anticoagulation in the Treatment of VT Associated With Behcet's Disease
This study is a Phase III, multicenter, prospective, randomized, double-blind, placebo-controlled clinical trial investigating the treatment of lower extremity venous thrombosis associated with Behçet's Disease.
- Conditions
- Behcet Disease, Behcet Disease and Vascular Involvement, Deep Venous Thromboses, Post Thrombotic Syndrome
- Trial name
- BETTER (NCT06925698)
- Testing
- Rivaroxaban plus immunosupression
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Marmara University
Venous Thrombosis
The GORE Viabahn Endoprosthesis for the Treatment of Venous Occlusions and Stenoses
To study the safety and efficacy of drug coated stents for the treatment of venous occlusions and stenoses in the lower extremity.
- Trial name
- NCT01406795
- Testing
- Gore Viabahn Heparin Coated Stent
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Chronic Venous Insufficiency, Varicose Veins of Lower Limb
Daily Duration of Compression Treatment in Patients With Symptomatic Chronic Venous Disease
Aim of study is to investigate the optimal duration and daily regimen of compression treatment in patients with chronic venous disease
- Trial name
- NCT06175546
- Testing
- Compression socks
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Pirogov Russian National Research Medical University
Varicose Veins of Lower Limb
RCT Comparing EVLA Versus Polidocanol Foam in the Treatment of SSV Insufficiency
FOVELASS is a multicentre-RCT (11 centres) comparing ultrasound-guided-foam sclerotherapy (UGFS) and Endovenous Laser Ablation (EVLA) for treating SSV insufficiency, conducted by the French Society of Phlebology.
- Trial name
- FOVELASS (NCT05468450)
- Testing
- Ultrasound-guided-foam sclerotherapy (UGFS) using Polidocanol sclerosant, Endovenous Laser Ablation (EVLA)
- Volunteers
- 161 people
- Sponsor
- Societe Francaise de Phlebologie
Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI
Efficacy and Safety of Endovenous Ablation for Relief of Knee Pain in Elderly Patients With Lower Extremity Varicose Veins: A Prospective Observational Study
Lower extremity varicose veins (LEVV) are common among elderly patients and can cause leg heaviness, pain, and swelling. In some older adults, venous congestion may contribute to knee or peri-knee pain, which is often…
- Conditions
- Varicose Veins of Lower Limb, Chronic Venous Insufficiency, CVI, Knee Pain, Knee Osteoarthritis
- Trial name
- EVA-Knee-Elder (NCT07239284)
- Testing
- Endovenous Ablation for Varicose Veins
- Volunteers
- 50 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Venous Leg Ulcer, Venous Ulcer
Tissue Repair Gel in Venous Leg Ulcers in AU/US
The goal of this clinical trial is to learn if TR987 0.1% gel + Standard of Care works better than Standard of Care alone to treat Venous Leg Ulcers (VLUs).
- Conditions
- Venous Leg Ulcer, Venous Ulcer, Venous Stasis Ulcer, Venous Stasis
- Trial name
- TRIVIA (NCT06707103)
- Testing
- TR987 0.1% gel + Standard of Care, Standard of care
- Where
- 12 sites in United States, Australia
- Volunteers
- 312 people
- Sponsor
- TR Therapeutics
Lower Extremity Chronic Venous Insufficiency, Onychodystrophy
Prevalence of Onychodystrophy in Patients With Chronic Venous Disease of the Lower Limbs
The objective of this study is to determine the degree of correlation between the clinical severity of chronic venous disease and the prevalence of onychodystrophy.
- Trial name
- NCT02731222
- Testing
- observational cross-sect. analytical inferential unicentric
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Venous Insufficiency, Venous Leg Ulcer
PICO Venous Leg Ulcers (VLU) Reimbursement Study
This study intends to demonstrate the superiority of PICO treatment when applied up to 12 weeks, versus Standard of Care (SOC) in the treatment of hard to heal Venous Leg Ulcers (VLU) by community-based practitioners.
- Trial name
- NCT06510777
- Testing
- PICO Treatment, Standard of Care (SOC) Treatment
- Where
- 44 sites in France
- Volunteers
- 142 people
- Sponsor
- Smith & Nephew, Inc.
Varicose Veins, Varicose Veins of Lower Limb
The Evaluation of the Pathophysiology of Varicose Veins in Pregnancy
Varicose veins (VV) are the early sign of Chronic venous insufficiency (CVI) which are characterised by abnormal tortuosity and dilatation of superficial veins of lower limb extremities.
- Conditions
- Varicose Veins, Varicose Veins of Lower Limb, Chronic Venous Insufficiency, Varicose; Vessel
- Trial name
- NCT05058989
- Testing
- Advanced ultrasound measurements (Duplex ultrasound (DUS) and Vector flow imaging (VFI), Clinical interventions and procedures
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Varicose Veins of Lower Limb, Venous Insufficiency of Leg
Clinical Outcomes, Safety, and Cost-Effectiveness Analysis of Two Catheters (Xianrui Da and Medtronic) in Radiofrequency Ablation for Varicose Veins
This study aims to systematically compare the clinical efficacy (venous closure rate and symptom relief rate), safety (perioperative and postoperative complications), and cost-effectiveness (direct medical costs) of domestic…
- Conditions
- Varicose Veins of Lower Limb, Venous Insufficiency of Leg, Vascular Disease，Peripheral
- Trial name
- NCT07046286
- Testing
- Compare the two brands of radiofrequency ablation catheters for the treatment of lower limb varicose veins.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Varicose Veins, Venous Reflux
Comparison of Zero- and Two-centimeter Distance From Sapheno-femoral Junction in Laser Ablation of Varicose Vein
EVLA is used in in treating refluxing veins, commonly the GSV. The tip of catheter is usually placed 2-2.5 cm distal to the sapheno-femoral junction.
- Conditions
- Varicose Veins, Venous Reflux, Venous Insufficiency, Venous Leg Ulcer
- Trial name
- NCT05707169
- Testing
- Saphenous Ablation, Endogenous Laser Ablation (EVLA), mixture of 20 mL 2% lidocaine, 1: 200,000 adrenaline and 20 mL 0.5% levobupivacaine in 1 L of 0.9% saline
- Where
- Egypt
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Venous Insufficiency
Non-Invasive Management of Chronic Venous Insufficiency
The purpose of this study is: -item one to use two new non-invasive technologies to evaluate scarring and swelling associated with chronic venous insufficiency.
- Trial name
- NCT00950378
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
Compression; Vein, Venous Insufficiency
Digital Supported Compression Bandaging in Patients With Chronic Edema in the Lower Limbs
Patients with chronic edema of the lower limb referred to compression bandaging in a hospital setting will be invited to participate in the validation study of a novel sensor (CIMON), which have been developed for assessing the…
- Conditions
- Compression; Vein, Venous Insufficiency, Lymphedema of Leg, Digital Technology
- Trial name
- CIMON (NCT06438133)
- Testing
- CIMON, Sens Motion
- Where
- 5 sites in Denmark
- Volunteers
- 52 people
- Sponsor
- Carsten Bogh Juhl