Clinical trials: Ventilated Patients
Weaning Failure, Fluid Overload
Fluid unLoading On Weaning (FLOW)
The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning…
- Conditions
- Weaning Failure, Fluid Overload, Cardiac Failure Acute
- Trial name
- FLOW (NCT04496583)
- Testing
- Fluid depletion strategy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Respiratory Failure
A Pilot Study Investigating the Detection of Episodes of Severe Patient-Ventilator Asynchrony
The goal of this study is to determine what percent of severe patient-ventilator asynchrony is detected in mechanically ventilated patients in the adult ICU and to determine delays in detecting those asynchronies by the staff…
- Trial name
- NCT04550871
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Autonomous Healthcare, Inc.
Assessment of Intravascular Volume Status in Mechanically Ventilated Critically Ill Patients
Evaluation of Jugular Venous Distensibility Index in Intravascular Fluid Management and Comparison of the Effectiveness of Noninvasive and Minimally Invasive Methods
Assessment of intravascular volume status is an important component of hemodynamic management in critically ill patients. Several noninvasive and minimally invasive parameters, including the pleth variability index (PVI), pulse…
- Trial name
- NCT07807709
- Testing
- Pleth variability index, Pulse pressure variation, Stroke volume variation
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Indirect Calorimetry, Mechanical Ventilation
Effect of PEEP on Indirect Calorimetry in Critically Ill Patients
Indirect calorimetry is used in intensive care to measure how much oxygen a patient consumes and how much carbon dioxide is produced.
- Conditions
- Indirect Calorimetry, Mechanical Ventilation, Positive End-Expiratory Pressure
- Trial name
- IC-PEEP (NCT07796698)
- Testing
- Protocolized PEEP Adjustment
- Volunteers
- 20 people
- Sponsor
- Vastra Gotaland Region
Tracheostomy Complication, Covid19
A Cohort Study of Mechanically Ventilated COVID-19 Patients Undergoing Tracheostomy
COVIDTrach aims to assess the outcomes of tracheostomy in mechanically ventilated patients with COVID-19. The use of personal protective equipment and incidence of COVID-19 amongst operators is also recorded.
- Conditions
- Tracheostomy Complication, Covid19, Ventilator Lung
- Trial name
- COVIDTrach (NCT04572438)
- Testing
- Tracheostomy
- Where
- United Kingdom
- Volunteers
- 2,234 people
- Sponsor
- University College, London
Electrical Impedance Tomography
Evaluation of Postoperative Ventilation Distribution With Electrical Impedance Tomography
Postoperative patients require respiratory management . It is known that the intrapulmonary ventilation distribution becomes uneven due to dorsal atelectasis and ventral hyperinflation during mechanical ventilation management…
- Trial name
- NCT05389735
- Where
- Japan
- Volunteers
- 130 people
- Sponsor
- Osaka University
Ventilation Therapy; Complications
Diaphragmatic Mobility In Ventilated Assisted Patients
The study was a randomized controlled trial. A total of 24 patients who met the inclusion criteria were included in this study and randomly divided by sealed envelope method into Experimental and Control groups with 12 patients…
- Trial name
- NCT04733261
- Testing
- Diaphragmatic mobility, Chest Physiotherapy
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Atelectasis
Efficacy and Ventilatory Responses to VHI in Atelectasis Patients
The purpose of this study include (1) To investigate the efficacy of ventilator hyperinflation technique to re-expand lung atelectasis on patients with critical trauma who intubated and mechanical ventilation in the intensive…
- Trial name
- NCT02768350
- Testing
- Ventilator hyperinflation technique, Conventional treatment
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Khon Kaen University
Prone Position, Pressure Ulcer
Evaluation of the Impact of the PRONEtect Education Hub vs. Classic Lecture, on the Competencies of Nursing Students
The goal of this randomised controlled trial is to compare the impact of online educational material versus a classic lecture on the confidence levels, knowledge and knowledge application of final-year nursing students.
- Trial name
- NCT05575869
- Testing
- (online) PRONEtect educational material, Classic (normal) one hour lesson/lecture
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Ghent
Intensive Care Unit Acquired Weakness, Critical Care
TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients
Background: Patients in the intensive care unit (ICU) are the sickest in hospital, and need advanced life-support. Survivors of critical illness are very vulnerable to weakness and disability.
- Conditions
- Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
- Trial name
- TryCYCLE (NCT01885442)
- Testing
- In-bed leg cycle ergometry
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- McMaster University
Critical Illness
Cortisol Levels as a Measure of Accumulated Physiological Stress in ICU Patients Undergoing Mechanical Ventilation
Critical illness is a situation of severe and prolonged stress for patients with mechanical ventilation (MV). Between 40-80% of these patients present the Post-ICU syndrome, a set of physical, cognitive, psychological alterations…
- Trial name
- Corti-COG (NCT03736135)
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Corporacion Parc Tauli
COVID-19, Pneumonia
COVID-19 Mortality Prediction Model
The objective of this study is to develop and evaluate an algorithm which accurately predicts mortality in COVID-19, pneumonia and mechanically ventilated ICU patients.
- Conditions
- COVID-19, Pneumonia, Mechanical Ventilation
- Trial name
- NCT04358510
- Testing
- COViage
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Dascena
Quality of Life
Health-related Quality of Life and Nursing-sensitive Outcomes in Mechanically Ventilated Patients
This study will allow us to determine the perceived Health-Related Quality of Life (HRQL) a year after ICU discharge, and compare it with HRQL measured earlier on in the process, as well as analyse the negative experiences they…
- Trial name
- NCT02636660
- Volunteers
- 184 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Respiratory Distress Syndrome, Respiratory Insufficiency
Recruitment Manoeuvres in Critically Ill Patients
Diseases of the lungs can be life-threatening. When these organs fail to adequately work, treatments to support their function are offered, often in Intensive Care Units (ICU).
- Conditions
- Respiratory Distress Syndrome, Respiratory Insufficiency, Respiratory Failure, Shock Lung
- Trial name
- RMCIP (NCT05508724)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Acute Respiratory Failure, Critical Illness
Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients
Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.
- Trial name
- NCT06189924
- Testing
- Proteomic analysis of exhaled breath condensate
- Where
- 2 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Delirium, Critical Illness
Pilot Study of Haloperidol to Treat Critical Illness Delirium
The goal of this study is to determine whether haloperidol reduces the time on the breathing machine in critically ill patients with delirium.
- Trial name
- NCT00429676
- Testing
- Haloperidol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Mechanically Ventilated and Intubated Subjects
A Safety and Efficacy Study of Dexmedetomidine in ICU Patients Requiring Continuous Sedation
The purpose of this study is to evaluate the safety and efficacy of dexmedetomidine in ICU subjects who are initially intubated, mechanically ventilated and require sedation for beyond 24 hours.
- Trial name
- NCT00216190
- Testing
- Dexmedetomidine HCL Injection, Midazolam Injection
- Where
- 96 sites in United States, Argentina and 3 more
- Volunteers
- 420 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Mechanical Ventilation, Intensive Care (ICU)
Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients
RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia.
- Trial name
- PERMISS pilot (NCT07077174)
- Testing
- Permissive lung-protective ventilation, Conventional lung-protective ventilation
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Respiratory Failure, Respiratory Disease
Clinical Evaluation of EZVent in Hospitalized Mechanically Ventilated Patients
Investigation Device: EZVent Ventilator System is designed for respiratory support in hospitalized mechanical ventilated patients. The Ventilator is designed to be used for adults patients.
- Trial name
- NCT05399017
- Testing
- EZVent
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Triclinium Clinical Development Middle East and North Africa
Ischemic Stroke, Intracerebral Hemorrhage
Early Tracheostomy in Ventilated Stroke Patients
Patients with severe ischemic and hemorrhagic strokes, who require mechanical ventilation, have a particularly bad prognosis. If they require long-term ventilation, their orotracheal tube needs to be, like in any other intensive…
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- SETPOINT (NCT01261091)
- Testing
- Early Tracheostomy, Late Tracheostomy
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University