Clinical trials: Ventilated Patients
Mechanical Ventilation Complication
The Effect of 6 ml/kg vs 10 ml/kg Tidal Volume on Diaphragm Dysfunction in Critically Mechanically Ventilated Patient
This is a randomized clinical trial to measure the effect of tidal volume (group 6 ml/kg vs 10 ml/kg) on diaphragm dysfunction on mechanically ventilated critical patient.
- Trial name
- NCT05370248
- Testing
- Tidal volume 6 ml/kg, Tidal volume 10 ml/kg
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Acute Respiratory Distress Syndrome
Study to Find the Highest Safe Dose of Soluble Guanylate Cyclase (sGC) Activator, BAY 1211163 Administered as Multiple Doses by Inhalation to Patients Who Cannot Breathe by Their Own and Suffer From a Type of Lung Failure That Causes Fluid to Build up in the Lungs Making Breathing Difficult (ARDS)
With this study researchers want to find the highest safe dose of the soluble Guanylate Cyclase (sGC) Activator, BAY 1211163 and how safe and well the study drug works.
- Trial name
- NCT04609943
- Testing
- BAY1211163
- Where
- 4 sites in Germany
- Volunteers
- 16 people
- Sponsor
- Bayer
Patient Ventilator Interactions
Analysis and Evaluation of Asynchronies Between NIV Patients and Their Prisma VENT or LUISA Ventilator
This study aims to analyze the types, rates, and patterns of disturbances between the breathing of patients receiving non-invasive ventilation and their ventilator (patient-ventilator asynchronies, PVA) during routine therapy…
- Trial name
- NCT07768748
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Löwenstein Medical Technology GmbH & Co. KG
Nutrition
Pilot: Feasibility of Intermittent Enteral Feeding in Ventilated MICU Patients
Specific Aims: Aim 1: Evaluate the feasibility of intermittent feeding in intensive care unit patients who are mechanically ventilated.
- Trial name
- NCT04164108
- Testing
- Intermittent Enteral Nutrition Protocol
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Yale University
COVID-19
Use of Multiple Doses of Convalescent Plasma in Mechanically Intubated Patients With COVID-19
This study will assess the feasibility and safety of administering multiple doses of convalescent plasma to Covid-19 positive patients admitted to the Intensive Care Unit (ICU) receiving mechanical ventilation.
- Trial name
- NCT05595538
- Testing
- Multiple doses of anti-SARS-CoV-2 Convalescent Plasma
- Where
- Panama
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Regional Dr. Rafael Estévez
Respiratory Insufficiency
"TRAcheostomy With Single Use Bronchoscopes vs. Conventional Bronchoscopes"
Optical guidance for percutaneous tracheostomy in intensive care is usually performed by conventional multi use bronchoscopy. Recently a single use bronchoscope has been introduced that allows for endotracheal visualization.
- Trial name
- TraSUB (NCT03952247)
- Testing
- Single Use Bronchoscopy for PDT, Conventional Multi Use Bronchoscopy for PDT
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Critical Illness, Ventilator Lung
Early and Intensive Occupational Therapy in Mechanical Ventilated Patients
This study evaluates the efficacy of an early and intensive occupational therapy (OT) protocol in critical adult patients requiring mechanical ventilation. Evaluating the functional independence at hospital discharge.
- Conditions
- Critical Illness, Ventilator Lung, Impairment, Cognitive, Impairment, Coordination
- Trial name
- NCT04819529
- Testing
- Early and Intensive Occupational Therapy
- Where
- Chile
- Volunteers
- 226 people
- Sponsor
- University of Chile
Sedation and Analgesia, Pain Intensity Assessment
Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units
Introduction: Pain is a subjective symptom, a physiological response that is difficult to assess, which affects the body physically and/or emotionally.
- Conditions
- Sedation and Analgesia, Pain Intensity Assessment, Mechanical Ventilation Complication
- Trial name
- PainICU (NCT07182851)
- Where
- 4 sites in Brazil
- Volunteers
- 370 people
- Sponsor
- Centro Universitário Augusto Motta
Pleural Effusion, Drainage
Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT
Evacuation of pleural effusion (PE) represents a disputable therapy in mechanically ventilated patients. Patients on mechanical ventilation indicated by the physician to pleural fluid evacuation will be monitored throughout the…
- Conditions
- Pleural Effusion, Drainage, Electric Impedance Tomography
- Trial name
- NCT03231072
- Testing
- Electrical Impedance Tomography record
- Where
- Czechia
- Volunteers
- 19 people
- Sponsor
- Czech Technical University in Prague
Delirium in the Intensive Care Unit
Methadone vs. Transdermal Fentanyl for Opioid Withdrawal Syndrome
Many patients in the general intensive care unit experience pain, as a result of an injury or underlying disease, surgery or an invasive procedure.
- Trial name
- NCT05697783
- Testing
- Administration of methadone instead of fentanyl patch
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
Muscle Weakness, Critical Illness
Electromagnetic Stimulation of the Phrenic Nerve in Critically Ill Mechanically Ventilated Patients (STIMIT-II)
Ventilator-induced diaphragmatic dysfunction is a common issue in critically ill patients. Muscle stimulation has shown to have beneficial effects in muscle groups on the extremities.
- Conditions
- Muscle Weakness, Critical Illness, Mechanical Ventilation Complication
- Trial name
- STIMIT-II (NCT05238753)
- Testing
- Non-invasive electromagnetic stimulation
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charite University, Berlin, Germany
Mechanically Ventilated Patients
Opioid vs. Benzodiazepine-based Sedation for Mechanically Ventilated Patients in the Internal Medicine Ward
Opioid-based sedation as a first line in mechanically ventilated patients has been considered the "gold standard" in intensive care unit patients around the world for several decades.
- Trial name
- NCT04983615
- Testing
- fentanyl-based sedation, midazolam-based sedation
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Intra-Abdominal Hypertension
The Influence of Furosemide on Fluid Balance and Intra-abdominal Pressure in Critically Ill Patients
Intra-abdominal hypertension (IAH) is a frequent cause of organ dysfunction in critically ill patients. Secondary IAH is mainly caused by excessive fluid resuscitation.The World Society for the Abdominal Compartment Syndrome…
- Trial name
- NCT01072071
- Testing
- furosemide
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Ziekenhuis Netwerk Antwerpen (ZNA)
Critical Illness
The Effect of High Protein and Early Resistance Exercise Versus Usual Care in Critically Ill Patients
This is a 2-arm, parallel-group, randomized controlled trial that investigates the effect of combined high protein and early resistance exercise versus usual care on muscle mass, quality and strength, clinical outcomes…
- Trial name
- EFFORT-X (NCT04261543)
- Testing
- High protein and early exercise, Usual Care
- Where
- Malaysia
- Volunteers
- 51 people
- Sponsor
- University of Malaya
Ventilated Patient in Intensive Care, Management of the Expiratory End-expiratory Pressure (PEEP) and Body Position
Effect of PEEP and Trendelenburg on Ultrasound Size of Internal Jugular and Subclavian Veins
There is no recommendation for the management of the positive end-expiratory pressure (PEEP) during setting of a central venous catheter (CVC) in a ventilated patient.
- Trial name
- PEEPUS (NCT02569424)
- Testing
- Patient's position
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Clermont-Ferrand
Assess the Prediction of Successful SBT and Extubation of Trachea by Bedside Lung Ultrasound in Mechanically Ventilated Patients
Prediction of Weaning Outcome From Mechanical Ventilation Using Ultrasound
Examine the predictive value of lung ultrasound in assessing the success of SBTs and tracheal extubation among patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- NCT06685224
- Testing
- Ultrasound Assessment of the aeration of lung tissue and Parasternal Intercostal Muscle Thickness
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Ventilator-Associated Events, Acute Kidney Injury
Effectiveness of an Evidence-Based Respiratory and Renal Care Training With Case-Based Discussion on Nurses' Clinical Reasoning, Knowledge & Practice, Nurse-Physician Collaboration and Mechanically Ventilated Patient Outcomes in a Tertiary-Level ICU in Bangladesh
This study will evaluate the effectiveness of an evidence-based respiratory and renal care training program combined with case-based discussion on nurses' clinical reasoning, knowledge \& practice, nurse-physician collaboration…
- Conditions
- Ventilator-Associated Events, Acute Kidney Injury, Clinical Reasoning
- Trial name
- NCT07796724
- Testing
- evidence-based respiratory and renal care training with case-based discussion
- Where
- Bangladesh
- Volunteers
- 140 people
- Sponsor
- Hiroshima University
Congenital Central Hypoventilation Syndrome, Patients With Nocturnal Ventilatory Assistance
Evaluation of the Awakening Capability by a Vibrating Bracelet (BRASSARD)
As part of developing a relay alarm project, the aim of the study is to test a sleeper's capability to wake up via a vibrating alarm around the wrist (vibrating bracelet).
- Conditions
- Congenital Central Hypoventilation Syndrome, Patients With Nocturnal Ventilatory Assistance, Healthy Volunteers
- Trial name
- BRASSARD (NCT03053011)
- Testing
- Vibrating bracelet
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Adult ICU Patients, Pain, Acute
Incidence of Inadequate Pain Treatment in Ventilated Critically Ill Surgical Patients
In SICU, Siriraj hospital there were no protocols place for the management of pain. All decisions were made according the attending physicians.
- Trial name
- NCT03641911
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Mahidol University
Thyroid Diseases, Respiratory Failure
Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome
Although it is now recognized that a variety of respiratory abnormalities, such as diaphragmatic dysfunction, can be present in primary hypothyroidism and reverse with adequate hormone treatment, the role of thyroid hormone…
- Trial name
- NCT03157466
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS