Clinical trials: Ventilation, Mechanical
PaO2/FiO2 Ratio
The Effect of FiO2 on PaO2/FiO2 Ratio
The PaO2/FiO2 ratio is frequently used to determine the severity of lung injury in mechanically ventilated patients. However, several mathematical models have shown that PaO2/FiO2 ratio depends on FiO2.
- Trial name
- NCT03156218
- Testing
- Modulation of FiO2
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Mechanical Ventilation Complication
National Approach to Standardize and Improve Mechanical Ventilation
This is a pre-post implementation cohort study. This is a data driven quality improvement project which aims to improve the care of mechanically ventilated patients through the implementation of a bundle of evidence based…
- Trial name
- NASAM (NCT03790150)
- Testing
- Evidence-based practices
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 27,966 people
- Sponsor
- King Abdullah International Medical Research Center
Rapid Shallow Breathing
Prediction of Weaning Outcomes by Using Rate of Change of Rapid Shallow Breathing Index
This trial examines weaning outcomes using the rapid shallow breathing index rate.
- Trial name
- NCT00366197
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Atlantic Health System
Mechanical Ventilation Complication, Fiberoptic Bronchoscopy
Ventilator Settings for Bronchoscopy During Mechanical Ventilation: a Randomized Controlled Study
Fiberoptic bronchoscopy (FOB) can cause a significant increase in respiratory resistances and airway pressure during mechanical ventilation (MV), which can jeopardize the delivery of the ventilatory assistance.
- Conditions
- Mechanical Ventilation Complication, Fiberoptic Bronchoscopy, Critical Illness, Acute Respiratory Failure
- Trial name
- VentSetFib (NCT06562725)
- Testing
- specific ventilator settings
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Centre Hospitalier Arras
Congenital Heart Disease, Mechanical Ventilation Complication
Mechanical Ventilation During Cardiopulmonary Bypass
The study is about a protocol of protective mechanical ventilation during cardiopulmonary bypass used during cardiosurgery for the correction of congenital heart diseases, to evaluate what's the best for the lungs
- Conditions
- Congenital Heart Disease, Mechanical Ventilation Complication, Cardiopulmonary Bypass
- Trial name
- VENICE (NCT03629574)
- Testing
- Ventilation during cardiopulmonary bypass
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Padova
Retinopathy
Anesthesia for Retinopathy of Prematurity
Premature infants experience more respiratory problems after surgical procedures. The investigators aimed to compare general anesthesia with sedation on the need for post-operative mechanical ventilation in infants undergoing…
- Trial name
- NCT01955135
- Testing
- Ketamine, Sevoflurane, propofol
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Congestive Heart Failure, Infections
Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?
There is evidence to suggest that patients make different end-of-life decisions if they understand the risks, benefits and alternatives of CPR and mechanical ventilation.
- Conditions
- Congestive Heart Failure, Infections, Sepsis, Acute Renal Failure
- Trial name
- NCT01878968
- Testing
- Script and CPR/Mechanical ventilation video.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jewish Hospital, Cincinnati, Ohio
Critical Illness
Diagnosis of Microaspiration in Intubated Critically Ill Patients: Pepsin vs 99m Technetium
Microaspiration of contaminated oropharyngeal secretions and gastric contents frequently occurs in intubated critically ill patients, and plays a major role in the pathogenesis of ventilator-associated pneumonia.
- Trial name
- NCT02169193
- Testing
- 99mTc-Rhenium Sulfide Nanocolloid
- Where
- France
- Sponsor
- University Hospital, Lille
Mechanical Ventilation
Hyperoxemia and Ventilator-associated Pneumonia
The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence.
- Trial name
- SOH-VAP (NCT03434821)
- Where
- France
- Volunteers
- 534 people
- Sponsor
- University Hospital, Lille
Respiratory Failure, Mechanical Ventilation Complication
Effect of Sedation Strategy on Duration Mechanical Ventilation in Patient After Cardiac Surgery
There is a direct relationship between the sedative agent and the duration of ventilation.
- Conditions
- Respiratory Failure, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- NCT05451121
- Testing
- Propofol, Dexmedetomidine, Propofol and dexmedetomidine
- Where
- Ukraine
- Volunteers
- 356 people
- Sponsor
- Anesthesia Research Group UA
Respiratory Diseases, Chronic and Acute Respiratory Failure
Validation of a Simulated Clinical Evaluation of Ventilators
The purpose of this study is to evaluate the ability of a device reproducing patients' respiratory characteristics to select in-VITRO the most appropriate ventilator for a given pathology.
- Trial name
- SIMULVENTI (NCT01113255)
- Testing
- bench-evaluation, of three ventilators
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Segmental Lung Atelectasis
Segmental Lung Recruitment: a Randomized Controlled Trial
This study compares two ways of reopening collapsed parts of the lung in patients on a ventilator. In one group, doctors use a small camera (bronchoscope) to guide air pressure directly to the blocked part of the lung.
- Trial name
- NCT07442708
- Testing
- Segmental lung recruitment, Conventional lung recruitment
- Volunteers
- 20 people
- Sponsor
- Clinical Hospital Center Rijeka
ICU Patients, Intubation
Pulmonary and Ventilatory Effects of Trigger Modulation in Intubated ICU
Pressure support ventilation allows intubated ICU patients to breathe spontaneously. Among specific settings, the adjustment of the trigger value (or threshold for triggering the ventilator) has not been explored to date.
- Conditions
- ICU Patients, Intubation, Spontaneously Breathing, Pulmonary Function
- Trial name
- Trigger (NCT04041817)
- Testing
- Trigger setting of pressure support ventilation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Distress Syndrome, Mechanical Ventilation
A Role for RAGE/TXNIP/Inflammasome Axis in Alveolar Macrophage Activation During ARDS (RIAMA): a Proof-of-concept Clinical Study
RAGE (the receptor for advanced glycation end-products) is a marker of alveolar type I cell injury and a pivotal mediator of acute inflammation and innate immunity.
- Trial name
- NCT02545621
- Testing
- RAGE TXNIP Inflammasome axis
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pneumonia, Bacterial
Aerosolized Amikacin and Fosfomycin in Mechanically Ventilated Patients With Gram-negative Pneumonia
To demonstrate the safety and efficacy of adjunctive therapy with the Amikacin fosfomycin inhalation system (AFIS) versus aerosolized placebo to treat Gram-negative pneumonia in mechanically ventilated patients receiving IV…
- Trial name
- IASIS (NCT01969799)
- Testing
- Amikacin fosfomycin inhalation solution
- Where
- 41 sites in United States, France and 5 more
- Volunteers
- 143 people
- Sponsor
- Cardeas Pharma
Long-term Sedation for Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Remimazolam vs Propofol for Long-Term Sedation in Mechanically Ventilated ICU Patients
This multicenter, randomized, controlled, non-inferiority trial is designed to determine whether remimazolam is non-inferior to propofol for prolonged sedation in adult ICU patients requiring mechanical ventilation for ≥48 hours.
- Trial name
- RePro-ICU (NCT07880548)
- Testing
- Remimazolam group, Propofol group
- Where
- 21 sites in China
- Volunteers
- 274 people
- Sponsor
- Sun Yat-sen University
Respiratory Insufficiency Requiring Mechanical Ventilation
Effects of Neuromuscular Electrical Stimulation on Critically Ill Patients With Mechanical Ventilation
Up to 25% of patients who require mechanical ventilation (MV) more than seven days in the intensive care unit (ICU) develop muscle weakness, which comprises deep muscle weakness , including the respiratory muscles.Early active…
- Trial name
- NCT05217511
- Testing
- Neuromuscular Electrical Stimulation
- Where
- China
- Volunteers
- 47 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Prone Positioning and Thoracoabdominal Binding on Lung and Muscle Protection in ARDS Patients During Spontaneous Breathing
Ventilator-induced diaphragmatic dysfunction and intensive care unit (ICU)-acquired weakness are two consequences of prolonged mechanical ventilation and critical illness in patients with acute respiratory distress syndrome…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, ICU Acquired Weakness
- Trial name
- NCT05826847
- Testing
- Prone Positioning, Thoracoabdominal Binding, Control
- Where
- Chile
- Volunteers
- 14 people
- Sponsor
- University of Chile
Patients With Postoperative Mechanical Ventilation After Liver Transplantation
Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation
Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively.
- Trial name
- NCT02402634
- Testing
- Mechanical ventilatory lung care
- Where
- South Korea
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Yonsei University
ARDS, Human, Obesity, Morbid
Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
The goal of this clinical trial is to test a personalized intervention aiming to optimize the mechanical ventilator settings in morbidly obese patients suffering from moderate to severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- TGV-MOA (NCT06119516)
- Testing
- Esophageal pressure-guided strategy,
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris