Clinical trials: Ventilation and Oxygenation
Coronavirus Disease 2019, ARDS
Prone Positioning in COVID-19 Patients
Prone positioning improves oxygenation in patients with ARDS (1-3). Patients with severe ARDS due to COVID-19 are candidates for prone position. It should be started within 36-48 h and maintained 1, 3).
- Conditions
- Coronavirus Disease 2019, ARDS, Mechanical Ventilation Pressure High
- Trial name
- NCT05150847
- Testing
- Oxygenation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Tepecik Training and Research Hospital
Robot-Assisted Radical Prostatectomy
Effect of Control Ventilation, PEEP, and PEEP With ARM in Robot-assisted Radical Prostatectomy
The goal of this clinical trial is to determine whether different ventilatory strategies improve oxygenation and hemodynamic stability in patients undergoing robot-assisted radical prostatectomy under general anesthesia.
- Trial name
- NCT07462689
- Testing
- PEEP group, PEEP + ARM group
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ilsan Cha hospital
One-Lung Ventilation, Thoracic Surgery, Video-Assisted
Effect of Sevoflurane and Remimazolam on Arterial Oxygenation During One-lung Ventilation
The goal of this clinical trial is to compare the effect of sevoflurane and remimazolam on arterial oxygenation during one lung ventilation in patients undergoing video-assisted thoracoscopic surgery.
- Conditions
- One-Lung Ventilation, Thoracic Surgery, Video-Assisted, Remimazolam
- Trial name
- NCT05907525
- Testing
- Remimazolam, 1% propofol
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Pusan National University Yangsan Hospital
COVID -19, Respiratory Failure
Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.
To determine whether the use of oxygen hoods as compared to conventional high-flow oxygen delivery systems, and the effects on oxygenation, mechanical ventilation and mortality rates in hypoxic patients with COVID-19.
- Conditions
- COVID -19, Respiratory Failure, Hypoxia
- Trial name
- NCT04407260
- Testing
- Oxygen Hood
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Northwell Health
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in patients with pulmonary…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude Effects, High Altitude
- Trial name
- NCT07804576
- Testing
- Re-ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Coronary Artery Disease
Breathing-Induced Myocardial Oxygenation Reserve
This is a clinical trial to test the clinical feasibility and safety of a novel CMR protocol, combined with a specific breathing maneuver to identify myocardial regions exposed to severe coronary artery stenosis.
- Trial name
- B-MORE-Pilot (NCT03050346)
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Thoracic Surgery, One-lung Ventilation
Individualized PEEP in Thoracic Surgery
Intraoperative protective ventilation with low tidal volumes (TV), positive end-expiratory pressure (PEEP) and possibly lung recruitment maneuvers (RMs) reduces postoperative pulmonary complications.
- Conditions
- Thoracic Surgery, One-lung Ventilation, Respiratory Mechanics, Artificial Respiration
- Trial name
- NCT04740151
- Testing
- Best PEEP, Standard PEEP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Trieste
ARDS, Human, Lung, Wet
Treatment of ARDS With Instilled T3
It is hypothesized that instillation of Liothyronine Sodium (T3) into the airspace will be safe, well tolerated, and will increase alveolar fluid clearance and decrease inflammation in patients with ARDS, reflected in improved…
- Conditions
- ARDS, Human, Lung, Wet, Thyroid, Pulmonary Edema
- Trial name
- ARDS+T3 (NCT04115514)
- Testing
- Liothyronine Sodium (T3+0.9% sodium chloride) modified formulation specifically for airway instillation., Non-intervention
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Minnesota
Morbid Obesity
Oxygenation and Pulmonary Function in Morbidly Obese Patients Undergoing Bariatric Surgery
This is a randomized controlled study in which morbidly obese patients undergoing bariatric surgery will be recruited in the preoperative clinic.
- Trial name
- NCT01002599
- Testing
- Boussignac TM CPAP, Venturi Face Mask
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University Health Network, Toronto
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)
This study will test the hypothesis that noninvasive ventilation (NIV) as prescribed in current medical practice for use in amyotrophic Lateral Sclerosis (ALS) patients fails to deliver adequate breathing support over a night of…
- Trial name
- NCT00537641
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Columbia University
Chronic Bronchitis
Effects of Pursed Lip Breathing Technique Versus Stacked Breathing Technique Among Chronic Bronchitis Patients
Chronic bronchitis is a non-allergic, inflammatory disease that is developed because of inflamed bronchial walls, and, is characterized by persistent cough with sputum for 3 months for 2 consecutive years at least.
- Trial name
- NCT06242210
- Testing
- pursed lip, Stacked Breathing
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Respiratory Distress Syndrome, Adult
Can Novel Oxygenation Indices Guide the Diagnosis of Acute Respiratory Distress Syndrome
This study aims to determine the cut-off values of the new oxygenation indices and further investigate their capabilities in diagnosing ARDS and predicting its severity in ICU.
- Trial name
- NCT06430619
- Where
- Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Critical Illness, Respiratory Failure
CONFOCAL-2 Interventional Pilot Study
This study is designed to assess the feasibility of identifying and administering individualized blood pressure targets early critical illness.
- Conditions
- Critical Illness, Respiratory Failure, Shock, Delirium
- Trial name
- NCT07296029
- Testing
- Autoregulation-based precision blood pressure management
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Queen's University
Anaesthesia, General, Anesthesia, Intravenous
Oxygenation by 100% Oxygen Via High Flow Nasal Cannula in Surgical Patients
Oxygenation with high-flow nasal cannula with 100% oxygen has only been evaluated in a limited number of studies. Although data are convincing it is of importance to evaluate this new concept in our department before implementing…
- Conditions
- Anaesthesia, General, Anesthesia, Intravenous, Ventilation
- Trial name
- NCT02706431
- Testing
- Hyperventilation
- Volunteers
- 31 people
- Sponsor
- Karolinska University Hospital
Anesthesia, General, Apnea
High Flow Nasal Cannula for Safe Apnea
This is a prospective randomized controlled trial comparing high flow nasal cannula and buccal oxygenation as method of oxygenation during apnea in children.
- Trial name
- NCT04849520
- Testing
- High flow nasal cannula, Buccal oxygenation
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital
Extremely Low Birth Weight Infants
Post-Extubation Assessment of Clinical Stability in ELBW Infants
This is an observational, proof-of-concept, feasibility study that aims to evaluate the feasibility of a monitoring system that integrates clinical data, high-resolution waveforms from the bedside monitor, regional oxygenation…
- Trial name
- PEACE (NCT06037083)
- Testing
- Oxygen saturation probe, Near infrared spectroscopy sensors, Electrical impedance tomography
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Apneic; Oxygenation
Apneic Oxygenation With a Nasal Cannula in the Obese and Morbidly Obese Surgical Patient
This prospective, randomized, double-blind study is intended to enroll a total of 100 patients with a BMI ≥ 40 kg/m2 and another 100 patients with a BMI ≥ 30 kg/m2 (but less than 40 kg/m2) undergoing surgery with general…
- Trial name
- NCT03671837
- Testing
- Oxygen, Air
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Stroke
Ventilation Strategies, Anesthetic Techniques and Cerebral Oxygenation in the Beach Chair Position
The seated or "beach chair" position during surgery and general anesthesia decreases brain oxygen levels and can result in stroke. As such, poor neurological outcome following beach chair positioning is a growing concern.
- Trial name
- NCT01535274
- Testing
- Inspired oxygen fraction / end tidal carbon dioxide
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Michigan
One-Lung Ventilation, Thoracic Surgery
The Effect of Anesthesia on Cerebral Oxygenation
One-lung ventilation (OLV) may cause negative changes in the oxygenation of cerebral tissue which results in postoperative cognitive dysfunction.
- Conditions
- One-Lung Ventilation, Thoracic Surgery, Postoperative Cognitive Complications
- Trial name
- NCT04760262
- Testing
- Sevoflurane, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Total Pulmonary Resistance sPAP/CO Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in patients with pulmonary arterial hypertension PAH, who live permanently…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude, Echocardiography
- Trial name
- NCT07804524
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini