Clinical trials: Ventilator Acquired Pneumonia
Multi-drug Resistant Gram-negative Bacilli Colonization
Multidrug Resistant Gram-negative Bacilli Colonization and Infection in Burn
This is a prospective observational study to determine the role of colonization and identify the timing of development of drug resistance in multidrug resistant Gram-negative bacilli (MDR-GNB) causing infection among critically…
- Trial name
- NCT02653157
- Testing
- MDR-GNB
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Ventilator Associated Pneumonia
Usage of Meropenem/Gentamicin Versus Ceftazidime/Avibactam in ARDS
This was a prospective double blind study conducted on 200 polytrauma patients admitted to King Abdul-Aziz Specialized Hospital, Taif, KSA between July 2018 and December 2019 in surgical ICU.
- Trial name
- NCT04402359
- Testing
- meropenem, ceftazidime 2 grams and avibactam 500, ventilator
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Ventilator-associated Pneumonia, Sepsis
Diagnostic Value of Pulmonary Ultrasound in the Diagnosis of Ventilator-associated Pneumoniae
This study evaluates the respective values and combined CPIS (Clinical Pulmonary Infection Score), bronchoalveolar lavage (BAL), tracheal aspiration and pulmonary ultrasonography (LUS - Lung Ultrasound) for early diagnosis of…
- Trial name
- PAVM (NCT02536547)
- Testing
- VAP
- Volunteers
- 100 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Ventilator-Associated Pneumonia
Atropine for Preventing Ventilator-Associated Pneumonia
A double-blind, placebo controlled trial of atropine eye drops used by sublingual way for preventing Ventilator-Associated Pneumonia.
- Trial name
- NCT02704923
- Testing
- Atropine
- Volunteers
- 40 people
- Sponsor
- Universidade de Passo Fundo
Ventilator-Associated Pneumonia
Diagnostic Value of Lung Ultrasound for Ventilator-Associated Pneumonia
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection acquired by mechanically-ventilated patients in the intensive care unit (ICU).
- Trial name
- VPLUS (NCT02244723)
- Testing
- Lung ultrasound examination
- Where
- 2 sites in France, Italy
- Volunteers
- 98 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Intubation Complication, Stroke, Ischemic
Prevention of Infection of the Respiratory Tract Through Application of Non-Invasive Methods of Secretion Suctioning
Adults who are unconscious or severely ill and need a breathing tube connected to a ventilator are at high risk of developing a lung infection (pneumonia) within the first few days in the intensive care unit.
- Conditions
- Intubation Complication, Stroke, Ischemic, Stroke Hemorrhagic, Head Trauma
- Trial name
- PIRAMIDES (NCT06113939)
- Testing
- airway clearance, subglottic secretion aspiration, Ceftriaxone 2 grams daily
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital San Carlos, Madrid
Tracheobronchitis, Pneumonia
Tracheobronchitis Prevention Trial
We aim to study whether the use of inhaled antibiotics may have an impact on the incidence of tracheobronchitis and pneumonia associated with the use of mechanical ventilation.
- Trial name
- TRAMA (NCT01025921)
- Testing
- colistin (Tadim), inhaled normal saline
- Where
- Greece
- Volunteers
- 84 people
- Sponsor
- University of Thessaly
Infection, Bacteremia
Pharmacodynamic Parameters of Two Different Doses of Cefepime
Pharmacokinetics is the study of the disposition of drugs in the body, while pharmacodynamics considers the interaction of the drug at the site of infection over time.
- Conditions
- Infection, Bacteremia, Pneumonia
- Trial name
- NCT00177736
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Pittsburgh
VAP - Ventilator Associated Pneumonia
The Effectiveness of the Modified Bundle in the Prevention of VAP.
Ventilator-associated pneumonia (VAP) is an important cause of prolonged intensive care unit and hospital length of stay, healthcare costs and mortality in mechanically ventilated patients.
- Trial name
- VAP (NCT04038814)
- Testing
- Routine prevention of VAP, Modified prevention of VAP
- Where
- Poland
- Volunteers
- 386 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
VAP - Ventilator Associated Pneumonia
Efficiency and Safety of the Prolonged Use of Heat and Moisture Exchangers in ICU
FILTRex is a single-centre, controlled, randomised, prospective, non-inferiority clinical trial to compare the efficiency and safety of prolonged (72-hours) versus standard (24-hours) duration of use for Heat and Moisture…
- Trial name
- FILTRex (NCT06410664)
- Testing
- 72-hour HME exchange interval group, 24-hour HME exchange interval group
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic
Pneumonia - Bacterial
Impact of BioFire FilmArray Pneumonia Panel vs Routine Diagnostics on Antimicrobial Outcomes (DOOR-MAT)
Multidrug-resistant bacterial infections are a growing global health concern. Hospital-acquired pneumonia is one of the most common infections occurring during hospitalization and can be associated with high mortality, reaching…
- Trial name
- NCT07585604
- Testing
- Multiplex PCR-based pneumonia panel (BIOFIRE® FILMARRAY® Pneumonia Panel)
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Ventilator Acquired Pneumonia
Study to Determine Quicker Methods of Diagnosing Pneumonia Caused by a Breathing Machine in Critically Ill Patients
Critically ill patients on a breathing machine are at risk of developing a type of pneumonia called Ventilator Acquired Pneumonia (VAP).
- Trial name
- NCT00938002
- Testing
- Acceler8 Pheno
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Denver Health and Hospital Authority
The Incidence of Ventilator-associated Pneumonia and Rate of Compliance With Survey Criteria
Investigation of Compliance With Ventilator-Associated Pneumonia Prevention Methods and Incidence of Ventilator-Associated Pneumonia in Intensive Care Units
Ventilator-associated Pneumonia (VAP) is a high-mortality hospital infection that occurs in patients undergoing invasive Mechanical Ventilation (MV) and is frequently encountered in intensive care units.
- Trial name
- NCT04174274
- Testing
- ventilator-associated pneumonia-developed group followed by mechanical ventilation, not ventilator-associated pneumonia-developed group followed by mechanical ventilation
- Volunteers
- 100 people
- Sponsor
- Diskapi Teaching and Research Hospital
Lower Respiratory Tract Infection, Ventilator Associated Pneumonia
RASCALS: Rapid Assay for Sick Children With Acute Lung Infection Study
Lower Respiratory Tract infections are a common cause of admission to the intensive care unit. Children routinely receive antibiotics until the tests confirm whether the infection is bacterial or viral.
- Conditions
- Lower Respiratory Tract Infection, Ventilator Associated Pneumonia, COVID19
- Trial name
- RASCALS (NCT04233268)
- Testing
- Rapid Pathogen Detection
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Critical Illness, Mechanical Ventilation Complication
Impact of Tracheal Cuff Shape on Microaspiration in Intensive Care Units
The investigators hypothesized that PVC tapered-cuff tracheal tubes would reduce microaspiration of gastric content as determined by pepsin level in tracheal aspirate.
- Conditions
- Critical Illness, Mechanical Ventilation Complication, Ventilator Associated Pneumonia
- Trial name
- BestCuff (NCT01948635)
- Testing
- tapered PVC-cuffed tracheal tubes, Standard PVC-cuffed tracheal tube
- Where
- 9 sites in France
- Volunteers
- 326 people
- Sponsor
- University Hospital, Lille
Ventilator-associated Pneumonia and Oral Health
The Effect of Two Different Oral Care Solutions on Ventilator-Associated Pneumonia and Oral Health of Mechanically Ventilated Patients in the Intensive Care Unit
The aim of this observational study is to evaluate the effects of two different oral care solutions on ventilator-associated pneumonia and oral health in mechanically ventilated participants in the intensive care unit.
- Trial name
- NCT06966817
- Testing
- control group(chlorhexidine), Experimental Group(cetylpyridinium chloride)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Pneumonia
Ventilator Associated Pneumonia and Late Complications of Percutaneous Tracheostomy
The purpose of this study is to investigate the incidence of ventilator associated pneumonia and late complications by comparing two different cannulas and two different percutaneous tracheostomy techniques.
- Trial name
- NCT00184925
- Testing
- Tracheostomy, cannula with subglottic drainage
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Ventilator Associated Pneumonia
The Effectiveness of Oral Care With Chlorhexidine in Medical Intensive Care Unit
Oral care with chlorhexidine was used to be considered an effective way to prevent ventilator-associated pneumonia (VAP). However, recent evidence revealed that oral care with chlorhexidine may associate with higher mortality and…
- Trial name
- NCT05913856
- Testing
- Normal saline, Chlorhexidine
- Where
- Taiwan
- Volunteers
- 141 people
- Sponsor
- National Taiwan University Hospital
Ventilator-associated Bacterial Pneumonia (VABP), Hospital-acquired Bacterial Pneumonia (HABP)
ASK0912 Versus Polymyxin B for Injection in Adults With Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia
This is a randomized, active-controlled, multicenter phase II clinical trial. The study aims to evaluate the efficacy, safety and tolerability of two different dosing regimens of ASK0912 for Injection compared with Polymyxin B…
- Trial name
- NCT07759934
- Testing
- ASK0912 for Injection, Polymyxin B Sulfate for Injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiangsu Aosaikang Pharmaceutical Co., Ltd.
Ventilator Associated Pneumonia
Effectiveness of a VAP Prevention Bundle in the PICU
This observational monocentric prospective study aims to evaluate the efficacy of new measures for ventilator associated pneumonia (VAP) management in the pediatric population in the pediatric intensive care unit (PICU) of…
- Trial name
- NCT03763695
- Testing
- Measures for the VAP prevention in the PICU, Evaluation of VAP incidence before the protocol introduction
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS