Clinical trials: Ventilator Acquired Pneumonia
Ventilator Associated Pneumonia
Diagnostic Modalities for VAP Detection
asses diagnostic performance of different methods for detection of ventilator associated pneumonia.
- Trial name
- NCT04911244
- Testing
- bronchoalveolar lavage
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pneumonia, Viral, Ventilator Associated Pneumonia
Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BAL
Almost 90 out of 100 people carry herpes simplex viruses (HSV). Once a person has been infected with the herpes viruses, he or she can't get rid of them for the rest of her/his life.
- Conditions
- Pneumonia, Viral, Ventilator Associated Pneumonia, Community-acquired Pneumonia, Herpes Simplex
- Trial name
- HerpMV (NCT06134492)
- Testing
- Acyclovir
- Where
- 28 sites in Germany
- Volunteers
- 616 people
- Sponsor
- Jena University Hospital
Ventilator Associated Bacterial Pneumonia (VABP), Critical Illness
Effect of Ventilator Hyperinflation Combined With Body Positioning on ABG in VAP
This study aims to evaluate the effect of ventilator hyperinflation combined with body positioning on arterial blood gases in patients with ventilator-associated pneumonia.
- Trial name
- NCT07854730
- Testing
- Ventilator hyperinflation, Manual hyperinflation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Zaytoonah University of Jordan
Gram-negative Bacterial Infections, Bloodstream Infections (BSI)
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participants
The primary objectives of this study are: To assess the safety and tolerability of cefiderocol after single-dose administration in hospitalized paediatric participants 3 months to < 18 years of age with suspected or confirmed…
- Conditions
- Gram-negative Bacterial Infections, Bloodstream Infections (BSI), Complicated Intra-abdominal Infection (cIAI), Hospital Acquired Pneumonia (HAP)
- Trial name
- NCT04335539
- Testing
- Cefiderocol, Standard of Care
- Where
- 23 sites in Belgium, Estonia and 7 more
- Volunteers
- 53 people
- Sponsor
- Shionogi
Pneumonia, Ventilator-Associated
Effect of Additional Nebulized Amikacin in Ventilator-Associated Pneumonia Caused by Gram Negative Bacteria
The purpose of this study is to determine the cure rate from ventilator-associated pneumonia (VAP) caused by Gram negative bacteria when administering add on nebulized amikacin to intravenous antibiotics compared to intravenous…
- Trial name
- NCT02574130
- Testing
- Amikacin
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Thammasat University
HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia
HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array
Multicenter, randomized, controlled, open-label trial to assess if semiquantitative multiplex PCR assay, as compared to conventional microbiology, can reduce the percentage of patients without microbiological diagnosis in the…
- Trial name
- LIGHTNING (NCT05952648)
- Testing
- Lower tract respiratory samples, Multiplex PCR assay (Film-array Pneumonia Panel Plus), Lower respiratory tract standard culture
- Where
- 4 sites in Italy
- Volunteers
- 126 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pneumonia, Ventilator-Associated
Can we Better Understand the Development of VAP and Eventually Predict and Prevent it?
Pathogens of ventilator-associated pneumonia (VAP) come from colonizers of the trachea. The hypothesis of the investigators is that during the first days of intubation, independently of the use of antibiotics, there is a change…
- Trial name
- NCT01875692
- Where
- Switzerland
- Volunteers
- 286 people
- Sponsor
- University Hospital, Geneva
VAP - Ventilator Associated Pneumonia
Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using mNGS
VAP（Ventilator-associated pneumonia）is the most common complication of mechanical ventilation in severely ill patients. VAP is defined as pneumonia occurring 48 hours after patients receive mechanical ventilation, including…
- Trial name
- NCT04955821
- Testing
- mNGS diagnose of VAP
- Volunteers
- 400 people
- Sponsor
- Children's Hospital of Fudan University
Ventilator Acquired Pneumonia, Mechanical Ventilation Complication
ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units.
- Trial name
- ClusterVAP (NCT07245888)
- Where
- 4 sites in France, Portugal and 1 more
- Volunteers
- 400 people
- Sponsor
- Region Skane
Ventilator Associated Pneumonia, Bronchopulmonary Dysplasia
Frequent Standardized Oral Care Using Human Milk in the Neonatal Intensive Care Unit
Premature infants are susceptible to complications related to infrequent and non-standardized oral care. Although the benefits of frequent standardized oral care are known to reduce oral dysbiosis (increased level of potentially…
- Conditions
- Ventilator Associated Pneumonia, Bronchopulmonary Dysplasia, Respiratory Disease
- Trial name
- NCT06000761
- Testing
- Standardized oral Care
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Florida
Cross Infection, Pneumonia, Bacterial
Intravenous Colistin Versus Intravenous Colistin Plus Nebulized Colistin in VAP Due MDR Acinetobacter Baumannii
Compare the clinical efficiency evaluated by the treatment of the intravenous colistin plus inhaled colistin opposite to the treatment with colistin intravenous plus inhaled saline solution in patients with VAP due to baumannii…
- Trial name
- NCT00645723
- Testing
- Colistin, Colistin and saline solution
- Where
- Spain
- Volunteers
- 67 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Ventilator-associated Pneumonia
Short Infusion Versus Prolonged Infusion of Ceftolozane-tazobactam Among Patients with Ventilator Associated-pneumonia
The main objective of this study is to compare the median exposures at pharmacokinetic equilibrium of the two modalities of administration: 4-hours infusion of ceftolozane-tazobactam at a dosage of 2 gram three times a day vs…
- Trial name
- CEFTOREA (NCT03581370)
- Testing
- 1 hour infusion, 4 hours infusion
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Toulouse
Ventilator-acquired Pneumonia
Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia
Researchers are looking at two different types of breathing tubes to see if one is better than the other at preventing pneumonia.
- Trial name
- PreVent2 (NCT03705286)
- Testing
- EVAC-PU-ETT, PVC-ETT
- Where
- United States
- Volunteers
- 1,074 people
- Sponsor
- Yale University
Wounds and Injuries, Respiratory Failure
Prehospital Ventilator-Associated Pneumonia Prevention Trial
Traumatic injury in rural America is a significant cause of morbidity and mortality, and the challenges of a rural trauma system can put patients at unique risk.
- Conditions
- Wounds and Injuries, Respiratory Failure, Pneumonia, Ventilator-Associated
- Trial name
- P-VAPP (NCT01902446)
- Testing
- Chlorhexidine gluconate
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Nicholas M Mohr
Pneumonia, Ventilator-Associated
Comparison Between Two Methods of Oral Care on the Incidence of VAP
Patients on ventilator are in high risk to develop ventilator associated pneumonia (VAP). This acquired infection significantly increases morbidity and mortality of these patients.
- Trial name
- NCT00521677
- Testing
- Sage oral care, Traditional oral care
- Where
- Israel
- Volunteers
- 108 people
- Sponsor
- HaEmek Medical Center, Israel
Ventilator Associated Pneumonia, Etiological Organisms
A Clinico-Bacteriological Study and Effect of Stress Ulcer Prophylaxis on Occurrence of Ventilator Associated Pneumonia
Objective of this study was to determine incidence, risk factors, etiological micro-organisms and their antimicrobial susceptibility pattern and outcome of VAP; and to study effect of ranitidine vs.
- Conditions
- Ventilator Associated Pneumonia, Etiological Organisms, Antimicrobial Drug Susceptibility Pattern, Stress Ulcer Prophylaxis
- Trial name
- NCT00702871
- Testing
- Ranitidine, Sucralfate
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Maulana Azad Medical College
Pneumonia, Ventilator-Associated
INCIPAVE Study: Incidence of Ventilator Acquired Pneumonia in Children
Rationale : ventilator associated pneumonia (VAP) has been extensively studied in adults, however, few data exist regarding VAP in the paediatric intensive care population.
- Trial name
- INCIPAVE (NCT03105414)
- Testing
- Mechanical ventilation
- Where
- France
- Volunteers
- 2,100 people
- Sponsor
- Sylvie Chevret
Ventilator-Associated Pneumonia, Mechanical Ventilation
Prevention of Ventilator-Associated Pneumonia by Automatic Control of the Tracheal Tube Cuff Pressure
Background: The aspiration of contaminated secretions pooled above the endotracheal tube cuff secondary to inadvertent falls of cuff pressure is the main pathogenic mechanism of ventilator-associated pneumonia (VAP).
- Trial name
- NCT00364299
- Testing
- Automatic control of tracheal tube cuff pressure
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Hospital Clinic of Barcelona
Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection
Impact of Nurses' Behavior Change and Evidence-Based Practice Implementation on Quality Indicators in Intensive Care Units in Low- and Middle-Income Countries
Study title: Impact of nurses' behavior change and implementing evidence-based practice to improve quality indicators in intensive care units in low-and middle-income countries Background and Rationale: Quality care is crucial…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection, Pressure Ulcers (Hospital-acquired Pressure Injuries), Prolonged Intensive Care Unit Length of Stay
- Trial name
- NCT07397364
- Testing
- Evidence based practices bundles of care
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Pseudomonas Aeruginosa, Ventilation Acquired Pneumonia
Impact of the Contamination Mode on the Clinical Evolution During Pseudomonas Aeruginosa Ventilator Acquired Pneumonia (PYO GEN)
Pseudomonas aeruginosa is the main pathogen of nosocomial respiratory infections. Its increasing resistance to antibiotics requires the development of new strategies for prevention and control, demanding a better understanding of…
- Trial name
- PYO GEN (NCT01745796)
- Where
- France
- Volunteers
- 77 people
- Sponsor
- University Hospital, Grenoble