Clinical trials: Ventilator Acquired Pneumonia
Healthcare-Associated Pneumonia
Hospital-acquired Pneumonia Prevention: Intervention, Evaluation & Research
The purpose of this study is to determine the effectiveness of a universal, standardized oral care protocol on prevention of non-ventilated hospital-acquired pneumonia (NV-HAP) in the acute care setting.
- Trial name
- HAPPIER-1 (NCT04915898)
- Testing
- Oral Hygiene - teeth brushing
- Where
- United States
- Volunteers
- 8,709 people
- Sponsor
- Orlando Health, Inc.
Ventilator Associated Pneumonia
Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients
Many hospitals employ a common canister inhaler protocol in patients that do not require mechanical ventilator support. Common canister refers to a single inhaler paired with standardized cleaning methods for use on more than one…
- Trial name
- NCT01935388
- Testing
- Common canister
- Where
- United States
- Volunteers
- 354 people
- Sponsor
- Barnes-Jewish Hospital
Chlorhexidine, Ventilator Associated Pneumonia
Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0%
This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher…
- Trial name
- NCT03442023
- Testing
- Chlorhexidine gluconate at 2%, Chlorhexidine gluconate at 0.12%
- Where
- Mexico
- Volunteers
- 74 people
- Sponsor
- Universidad de Guanajuato
VAP - Ventilator Associated Pneumonia
Bacteriophage Cocktail Therapy for Multidrug-Resistant Gram-Negative Ventilator-Associated Pneumonia
The purpose of this study is to systematically evaluate the efficacy and safety of bacteriophage cocktail therapy in patients with ventilator-associated pneumonia caused by Gram-negative bacterial infections.
- Trial name
- NCT07202234
- Testing
- Phage cocktail administered via nebulization, Nebulized normal saline inhalation therapy
- Volunteers
- 248 people
- Sponsor
- Chinese PLA General Hospital
Ventilator Associated Pneumonia
Pravastatin and Ventilatory Associated Pneumonia
Statins present anti-inflammatory and immunomodulatory effects. They may modify the regulation of cytokines, (released from the cellular damage) and may reduce the production of C-reactive protein levels.
- Trial name
- EPRAVAP (NCT00702130)
- Testing
- Pravastatin
- Where
- 2 sites in Greece
- Volunteers
- 152 people
- Sponsor
- University of Thessaly
Ventilator Associated Pneumonia, Covid19
Incidence of VAP in Patients With Severe COVID-19
Combined retrospective and prospective cohort study to evaluate the incidence of microbiologically confirmed VAP in mechanically ventilated patients with COVID-19.
- Trial name
- CoV-AP (NCT04766983)
- Testing
- bronchoalveolar lavage
- Where
- Italy
- Volunteers
- 323 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilator Associated Pneumonia, Infections
Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial
Probiotics are commercially available live bacteria thought to have health benefits when ingested. A literature review of probiotic studies in the intensive care unit (ICU) found that in patients who receive probiotics, there is…
- Conditions
- Ventilator Associated Pneumonia, Infections, C-Difficile, Antibiotic-associated Diarrhea
- Trial name
- PROSPECT (NCT02462590)
- Testing
- L. rhamnosus GG - Probiotic
- Where
- 44 sites in United States, Canada and 1 more
- Volunteers
- 2,650 people
- Sponsor
- McMaster University
Ventilator Associated Pneumonia
Study of Different Etiologic Diagnostic Methods in Ventilator Associated Pneumonia (VAP)
The study is designed to evaluate sensitivity, specificity and accuracy of non-bronchoscopic bronchoalveolar lavage and endotracheal aspirate in comparison with bronchoscopic bronchoalveolar lavage (gold standard), as methods for…
- Trial name
- NCT02363023
- Testing
- Collect tracheal and pulmonary secretions
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Uberlandia
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Nosocomial Pneumonia, Healthcare-Associated Pneumonia
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
Oropharyngeal bacteria play an important role in the pathogenesis of nosocomial pneumonia in critically ill patients. Oral cleansing with chlorhexidine has been shown to decrease incidence of pneumonia in patients undergoing open…
- Conditions
- Nosocomial Pneumonia, Healthcare-Associated Pneumonia, Aspiration Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- NCT00610324
- Testing
- Chlorhexidine gluconate, Potassium permanganate
- Where
- India
- Volunteers
- 512 people
- Sponsor
- King Edward Memorial Hospital
Trauma Injury, Brain Injuries
The Effect of Supraglottic and Oropharyngeal Decontamination on the Incidence of Ventilator-associated Pneumonia
Oropharynx is the main source of pathogen microorganisms for the ventilator - associated pneumoniae. As known bacteriophages can eliminate different pathogen microorganisms or reduce a degree of a pathogen's colonization.
- Conditions
- Trauma Injury, Brain Injuries, Abdominal Sepsis, Pancreatitis
- Trial name
- SGDC-VAP (NCT04325685)
- Testing
- Control, Antiseptic Solution, Bacteriophage
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Northern State Medical University
Ventilator-associated Pneumonia
Nebulized and Intravenous Colistin in Ventilator Associated-pneumonia
Few antimicrobials are available to treat ventilated associated pneumonia (VAP) caused by Gram negative multi-resistant (MDR) bacteria. Colimycin often remains the only active antibiotic.
- Trial name
- COLIVAP (NCT02906722)
- Testing
- Intravenous colimycin, Nebulized colimycin
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pneumonia
STATIN-VAP STATIN-VAP - STATINs and Ventilator-Associated Pneumonia
The objective is to assess the efficacy and safety of oral simvastatin in patients with a suspicion of ventilator-associated pneumonia (VAP).
- Trial name
- NCT01057758
- Testing
- SIMVASTATIN
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Ventilator Acquired Pneumonia, Hospital Acquired Pneumonia
Steriwave ICU Pilot Study
This is a single-center, non-blinded, prospective, pilot study enrolling patients admitted to the critical care unit at Royal Columbian Hospital.
- Conditions
- Ventilator Acquired Pneumonia, Hospital Acquired Pneumonia, Hospital Acquired Infections, Nasal Decolonization of Staphylococcus Aureus
- Trial name
- NCT06867458
- Testing
- Antimicrobial photodynamic therapy (aPDT) nasal decolonization device
- Where
- Canada
- Volunteers
- 227 people
- Sponsor
- Fraser Health
Pneumonia
Oral Care Protocol for Preventing Ventilator- Associated Pneumonia
The Nosocomial Pneumonia remains to be a major complication for patients who were incubated with ventilation. Most cases are attributed to increased bacteria flora in oropharyngeal secretion and aspiration of those organisms.
- Trial name
- VAP (NCT00604916)
- Testing
- standardized oral care protocol - electronic toothbrush, mimic protocol
- Volunteers
- 53 people
- Sponsor
- Mackay Memorial Hospital
Ventilator Associated Pneumonia, Oral Hygiene
Effects of Oral Care in the Neuroscience ICU
The purpose of this study is to compare how effective different ways of mouth cleaning are for patients in a neuroscience intensive care unit with a breathing tube in their mouth.
- Trial name
- NCT00518752
- Testing
- Standard Oral Care, Comprehensive Oral Care
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Pneumonia
Ceftobiprole in Hospital Acquired Pneumonia
The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril (the water-soluble prodrug [form] of ceftobiprole) referred to as ceftobiprole versus a comparator in the treatment of patients with…
- Trial name
- NCT00229008
- Testing
- linezolid plus ceftazidime
- Volunteers
- 106 people
- Sponsor
- Basilea Pharmaceutica
Respiratory Insufficiency, Ventilator-associated Pneumonia
Biofilm Formation on Different Endotracheal Tube Materials
Three endotracheal tubes (ETTs) with different surfaces properties will be studied regarding formation and structure of the biofilm formed on those ETTs.
- Trial name
- NCT02284438
- Testing
- Endotracheal tube
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Region Skane
Ventilator Associated Pneumonia, Lung Ultrasound
Transthoracic Ultrasound in the Diagnosis and Follow-up of Ventilator Associated Pneumonia
To evaluate the sensitivity, specificity and diagnostic accuracy of bedside transthoracic ultrasound examination in the diagnosis and follow up of ventilator associated pneumonia.
- Trial name
- NCT04057625
- Testing
- transthoracic ultrasound
- Volunteers
- 1 people
- Sponsor
- Assiut University
Ventilator Associated Pneumonia ( VAP)
Clinical Outcomes of Inhaled Amikacin in Ventilator Associated Pneumonia
Article: Clinical Outcomes of Inhaled Amikacin in Ventilator-Associated Pneumonia: A group randomized controlled,add-on trial English:Patients in intensive care units often need ventilators to breathe.
- Trial name
- RCT (NCT07369336)
- Testing
- Amikacin (Inhalation), Standard-of-Care Intravenous Antibiotics
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Postgraduate Medical Institute, Lahore