Clinical trials: Ventilator Lung
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Ventilator-Induced Lung Injury, Acute Respiratory Distress Syndrome
Comparing Mechanical Power in Different Inspiratory Times
We aimed to compare mechanical power and energy values using geometric methods at varying inspiratory rise times.
- Trial name
- NCT06413472
- Testing
- Mechanical ventilator adjustment for PCV, Mechanical ventilator adjustment for VCV
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Work of Breathing, Lung Transplantation
Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA
Protective ventilatory strategy should be applied to reduce ventilator-induced lung injury (VILI) after Lung Transplantation (LTx) or in case of acute respiratory failure requiring invasive mechanical ventilation.
- Conditions
- Work of Breathing, Lung Transplantation, Neurally Adjusted Ventilatory Assist, Ventilator-Induced Lung Injury
- Trial name
- NAVAMECH (NCT05689476)
- Testing
- NAVA GROUP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Prematurity, Respiratory Disease
Caffeine as an Adjuvant Therapy for Late Preterm Infants With Respiratory Distress
Use of caffeine citrate in late-preterm infants with respiratory distress is questionable. Oliphant and colleagues found in a recently published study that caffeine therapy use in late-preterm infants at a loading dose of 20 and…
- Conditions
- Prematurity, Respiratory Disease, Ventilator Lung; Newborn
- Trial name
- CAT/LPT (NCT06026163)
- Testing
- Caffeine citrate
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 134 people
- Sponsor
- Ministry of Health, Saudi Arabia
Burn Injury, Inhalational Injury
Biphasic Positive Airway Pressure Ventilation Versus Flow-Controlled Ventilation in Burn Patients
The goal of this clinical trial is to learn if the new ventilation mode flow-controlled ventilation (FCV) is a more protective mode of ventilation for adult patients after severe burn injury.
- Conditions
- Burn Injury, Inhalational Injury, Pulmonary Complications, Ventilator-induced Lung Injury (VILI)
- Trial name
- BIFLOWBURN (NCT07041957)
- Testing
- Individualized flow-controlled ventilation strategy, Pressure-controlled ventilation strategy via the application of Biphasic Positive Airway Pressure ventilation
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Bergmannsheil Bochum
Lung Transplant; Complications, Ventilator-Induced Lung Injury
Inspiratory Work of Breathing Before and After Extubation
Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator).
- Conditions
- Lung Transplant; Complications, Ventilator-Induced Lung Injury, Ventilator Associated Pneumonia
- Trial name
- INTEGRATION (NCT07017608)
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- University Health Network, Toronto
Ventilator Lung, Echocardiography
Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants
The primary aim of this work is to evaluate the role of high frequency oscillatory ventilation (HFOV) in recruitment of lung in preterm newborns 32 to 37 weeks gestational age with moderate to severe respiratory distress.
- Conditions
- Ventilator Lung, Echocardiography, Chest Ultrasound, High Frequency Ventilation
- Trial name
- NCT05726578
- Testing
- Lung recruitment
- Where
- 2 sites in Egypt
- Volunteers
- 72 people
- Sponsor
- Alexandria University
Ventilator Lung, Ventilator-Induced Lung Injury
Phrenic Identification in the ICU
This will be a prospective observational study where the investigator will scan patients' necks with an ultrasound and look for anatomical landmarks that may help identify the phrenic nerve.
- Conditions
- Ventilator Lung, Ventilator-Induced Lung Injury, Diaphragm Disease, Phrenic Nerve
- Trial name
- NCT05875883
- Testing
- Neck ultrasound
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome (ARDS), Ventilator-induced Lung Injury
Electrical Impedance Tomography-Based Prognostic Model for ARDS
This multicenter, prospective, observational study aims to develop and validate an EIT-based prognostic model for ARDS. By focusing on the pathophysiological characteristics of ARDS and the causes of ventilator-induced lung…
- Trial name
- NCT06967207
- Testing
- Not applicable- observational study
- Where
- 4 sites in China
- Volunteers
- 625 people
- Sponsor
- XiaoJing Zou,MD
Fluid Overload Pulmonary Edema, Fluid Overload
Lung Ultrasound-guided Fluid Therapy in Pediatric Intensive Care Unit Patients
A randomized clinical trial to evaluate the effect of using pulmonary ultrasound to guide fluid therapy on distinct variables.
- Conditions
- Fluid Overload Pulmonary Edema, Fluid Overload, Pneumonia, Ventilator-Associated, Fluid Overload Without Edema
- Trial name
- NCT04215692
- Testing
- Pulmonary ultrasound
- Where
- Mexico
- Volunteers
- 68 people
- Sponsor
- Instituto Mexicano del Seguro Social
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
EIT-Guided Ventilator Settings in AHRF
This exploratory study aims to investigate the effect of Electrical Impedance Tomography (EIT)-guided ventilator settings on mechanical power in patients with acute hypoxemic respiratory failure (AHRF), including both ARDS and…
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Mechanical Power, Ventilator Induced Lung Injury
- Trial name
- NCT06936618
- Testing
- Electrical Impedance Tomography (EIT), Enlight 2100
- Where
- Thailand
- Volunteers
- 17 people
- Sponsor
- Mahidol University
Adult Respiratory Distress Syndrome
Prevention of Lung Injury Induced by Mechanical Ventilation in Acute Respiratory Distress Syndrome ARDS Patients
Given the huge volume of mechanically ventilated patients at risk of ARDS, optimizing hematosis by limiting pulmonary and systemic aggression associated with artificial ventilation techniques is a key objective if we are to…
- Trial name
- PULMODEL (NCT06835881)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Long Term Follow up of Children Enrolled in the REDvent Study
This is a prospective observational follow-up study of children enrolled in a single center randomized controlled trial (REDvent).
- Conditions
- Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury, Neurocognitive Dysfunction, Quality of Life
- Trial name
- NCT03709199
- Testing
- Ventilation Inhomogeneity, Diaphragm Ultrasound, Respiratory Inductance Plethysmography
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Children's Hospital Los Angeles
Ventilation, Mechanical, ARDS (Acute Respiratory Distress Syndrome)
Pleural Strain by Speckle-Tracking Ultrasound: Feasibility and Driving Pressure Associations
What is this study about? This research aims to test a new ultrasound technology called "speckle tracking" to measure how much the lining of your lungs (pleura) stretches during breathing, especially if you're on a breathing…
- Trial name
- NCT06911450
- Where
- China
- Volunteers
- 75 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Mechanical Ventilation Complication, Caffeine
The Caffeine Therapy in the Fetal to Neonatal Transition
Introduction: The caffeine is used in the treatment for apnea of prematurity and it has several positive effects in the neurodevelopment of preterm babies.
- Conditions
- Mechanical Ventilation Complication, Caffeine, Ventilator Lung; Newborn
- Trial name
- NCT05454332
- Testing
- Early Caffeine administration, Control Group
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Ventilator-Induced Lung Injury
Intraop Ventilation Management and Postop Pulmonary Complications in High Risk Patients for OSA
Lung protective ventilation (LPV) has been proposed to reduce the incidence of postoperative pulmonary complications (PPCs), and protect against ventilator induced lung injury (VILI).
- Trial name
- NCT03135691
- Where
- United States
- Sponsor
- Ohio State University
Ventilator-Induced Lung Injury, Ventilatory Failure
"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs"
Little is known about how lung mechanics are affected during the very early phase after starting mechanical ventilation. Since the conventional method of measuring esophageal pressure is complicated, hard to interpret and…
- Conditions
- Ventilator-Induced Lung Injury, Ventilatory Failure, Ventilator Lung, Ventilation Therapy; Complications
- Trial name
- LUNAR (NCT04484727)
- Testing
- PEEP-step method
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Göteborg University
Critical Care, Acute Hypoxic Respiratory Failure
A Pilot Trial of Pressure Muscle Index-Targeted PSV Trial
Pressure support ventilation (PSV) is one of the most frequently used ventilator modes in the intensive care unit (ICU). The successful implementation of PSV depends on matching the patient's inspiratory effort with the…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator Lung
- Trial name
- NCT06769360
- Testing
- PMI-targeted PSV setting, VT/RR-targeted PSV setting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Extremely Low Birthweight Infant, Continuous Tracheal Gas Insufflation
Ventilation of the Extremely Premature Infants Optimized by Dead Space Washout
The Continuous Tracheal Gas Insufflation (CTGI) is a ventilation option of conventional mechanical ventilation that is used to reduce or even eliminate the dead space caused by respiratory prostheses.
- Conditions
- Extremely Low Birthweight Infant, Continuous Tracheal Gas Insufflation, Medical Device, Lung Protection
- Trial name
- Volem (NCT06334523)
- Testing
- Ventilation with Dead Space Washout via Continuous Tracheal Gas Insufflation (CTGI)
- Where
- 4 sites in France
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Preterm, Ventilator Lung; Newborn
Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound
This study aims to evaluate the effect of non-invasive ventilation (nIPPV) , (nCPAP), and nasal high flow cannula (NHFC) as a primary mode of ventilation in preterm neonates <37 gestational week with moderate to severe RD using…
- Trial name
- NCT06550219
- Testing
- Nasal humidified heated high flow cannula (NHHHC), Nasal intermittent positive pressure ventilation (NIPPV), Nasal continuous positive airway pressure NCPAP
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Alexandria University