Clinical trials: Ventilator Weaning
Ventilator Dependency
The Impact of Inspiratory Muscle Strength Training
The study is a pre-post test with quasi experimental design. Forty-two intubated-adults who had been mechanically ventilated for more than 21 days were selected on the basis of inclusion criteria in respiratory care ward.
- Trial name
- IMT (NCT03997214)
- Testing
- inspiratory muscle strength training
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Fooyin University
Prolonged Mechanical Ventilation, Ventilator Weaning
Standardized Tracheostomy Weaning Protocol for Prolonged Mechanical Ventilation
This study evaluated the feasibility and clinical outcomes of a standardized weaning protocol for tracheostomized patients requiring prolonged mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Tracheostomy
- Trial name
- NCT06642714
- Testing
- Standardized Stepwise Weaning Protocol
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Capital Medical University
Mechanical Ventilator Weaning, Critically Ill
Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: Will weaning with neurally adjusted ventilatory assist (NAVA) mode…
- Conditions
- Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
- Trial name
- NCT06157593
- Testing
- NAVA
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Respiration, Artificial
Use of a New Isokinetic Device for Inspiratory Muscle Training
Introduction: It is well established that physical fitness improves muscle performance either in sedentary people or in athletes.
- Trial name
- NCT02932189
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- Universidade Federal Fluminense
Mechanical Ventilation
Optimization of Serum Phosphorus Level and Weaning From Mechanical Ventilation
The goal of this clinical trial is to test the impact of serum phosphorus level optimization on weaning from mechanical ventilation in adult ICU patients in Alexandria University Hospitals.
- Trial name
- NCT05682846
- Testing
- Sodium glycerophosphate pentahydrate solution
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Alexandria University
Ventilated Patient in Intensive Care
Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning
Patients in the ICU who are being taken off of a breathing machine (ventilator weaning) commonly experience anxiety, agitation, sleep disruption, and physiologic stress.
- Trial name
- NCT07710469
- Testing
- Weighted blanket, Standard hospital linens
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Neoplasms, Musculoskeletal Diseases
Therapy Study of Automated Protocolized vs. Physician-Directed Non-Protocolized Weaning
The purpose of this study was to determine whether computer-driven protocolized weaning is superior to physician-directed non-protocolized weaning in over-24-hours-ventilated surgical intensive care unit (ICU) patients.
- Conditions
- Neoplasms, Musculoskeletal Diseases, Digestive System Diseases, Respiratory Tract Diseases
- Trial name
- NCT00606788
- Testing
- SmartCare/PS (Automated Weaning), Conventional weaning
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Luebeck
Ventilator Weaning
Interaction Diaphragm and Cardiac Function During Ventilator Weaning
Weaning failure is associated with prolonged duration of mechanical ventilation that itself can worsen patient's prognosis. Therefore, identification of the causes and mechanisms leading to weaning failure is important in daily…
- Trial name
- I-DISCO (NCT03486249)
- Testing
- Repetition of medical examinations performed as part of the care
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation, Sedation
Sedation and Ventilator Weaning Protocol in PICU
This research is a single-blinded, randomized controlled trial involving mechanically ventilated children in Pediatric Intensive Care Unit, Cipto Mangunkusumo Hospital, Indonesia.
- Trial name
- NCT04788589
- Testing
- Sedation and ventilator weaning protocol
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Universitas Indonesia
Acute Respiratory Failure, Mechanical Ventilation Complication
Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation
The goal of this physiological cross-over clinical trial is to evaluate the effect of different clinically used weaning trials on regional mechanical ventilation in a population of patients undergoing weaning from mechanical…
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury, Weaning Failure
- Trial name
- WEAN-EIT (NCT05726513)
- Testing
- Weaning trial - Low support, high Positive end-expiratory pressure, Weaning trial - Low support, zero positive end-expiratory pressure, Weaning trial - Zero support, zero positive end-expiratory pressure
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Respiratory Insufficiency, Weaning, Ventilator
Parasternal Intercostal Ultrasound vs RSBI for Weaning Prediction
Mechanical ventilation is essential in the management of critically ill patients, but deciding the proper time to wean and extubate remains a significant challenge.
- Conditions
- Respiratory Insufficiency, Weaning, Ventilator, Respiration, Artificial, Intensive Care Units
- Trial name
- NCT07144878
- Testing
- Parasternal Intercostal Ultrasound and RSBI Assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Mechanical Ventilator Weaning, Predictive Value of Tests
ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure
Observational study in two medical-surgical intensive care units of the Clermont-Ferrand University Hospital to develop a composite score for prediction of 72h-extubation failure in patients at risk of extubation failure.
- Conditions
- Mechanical Ventilator Weaning, Predictive Value of Tests, Ventilator Weaning, Airway Extubation
- Trial name
- I-SWEAR (NCT05114551)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ventilator Weaning
Spontaneous Breathing Trial With T-piece or Inspiratory Pressure Augmentation
Weaning is an important process to gradually separate mechanically ventilated patients from ventilators. A good weaning strategy aims to early identify mechanically ventilated patients who are ready for extubation but not to…
- Trial name
- SBT-TIP (NCT04222205)
- Testing
- Spontaneous breathing trial (SBT) crossover sequence 1, Spontaneous breathing trial (SBT) crossover sequence 2
- Where
- 3 sites in Taiwan
- Volunteers
- 2,143 people
- Sponsor
- National Taiwan University Hospital
Delirium, Agitation
A Comparison of Dexmedetomidine and Haloperidol in Patients With Intensive Care Unit (ICU)-Associated Agitation and Delirium
The purpose of the study is to determine whether dexmedetomidine is a more effective medication than haloperidol in the treatment of agitation and delirium in patients receiving mechanical ventilation in an intensive care unit.
- Conditions
- Delirium, Agitation, Ventilator Weaning, Respiration, Artificial
- Trial name
- Dex (NCT00505804)
- Testing
- dexmedetomidine, haloperidol
- Volunteers
- 20 people
- Sponsor
- Austin Health
COPD
COPD Exacerbations
Detecting exacerbations to prevent a severe and / or to early treat an exacerbation is crucial in patients with COPD in order to prevent hospitalization.
- Trial name
- NCT02798575
- Testing
- Astral 150 ventilator
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- RWTH Aachen University
Ventilator-induced Diaphragm Dysfunction, VIDD
Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in Mechanically Ventilated Patients.
Up to 76% of ICU patients on mechanical ventilation develop significant respiratory muscle atrophy within the first 24 hours, contributing to prolonged ventilation, increased morbidity, and higher healthcare costs.
- Conditions
- Ventilator-induced Diaphragm Dysfunction, VIDD, Weaning Failure
- Trial name
- NCT07363902
- Testing
- Heecap
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Tesai Care SL
Ventilator Weaning, Respiratory Failure
Assessments of Diaphragm-pleural Mechanics During the Weaning From Prolonged Mechanical Ventilation
Weaning failure from mechanical ventilator is commonly seen in respiratory failure and increases duration of ventilator use, ICU stay, ventilator associated pneumonia and even mortality.
- Trial name
- NCT03842280
- Testing
- Diaphragm ultrasound assessment & Esophageal pressure measurement
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Failure, Ventilator Weaning Assessment
Electrical Impedance Tomography-derived Flow Index During Spontaneous Breathing Trial Stratifies the Risk of Reintubation Within 48 h After Extubation
Accurate prediction of readiness to liberate patients from mechanical ventilation remains challenging. Conventional indices such as the rapid shallow breathing index (RSBI) and maximal inspiratory pressure (MIP) often miss early…
- Trial name
- EIT-FI Weaning (NCT06876792)
- Testing
- electrical impedance tomography
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital
Ventilator Weaning, Ultrasonography
Role of Lung Ultrasound in Predicting Weaning Outcomes
We aimed to verify the potencial role of bedside lung ultrasound findings of critically ill patients candidates to liberation from mechanical ventilation in predicting weaning outcomes.
- Trial name
- NCT02022839
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Hospital Moinhos de Vento
Spinal Cord Injury, Tetraplegia
Abdominal Functional Electrical Stimulation (AFES) to Assist Ventilator Weaning in Tetraplegia
Compromised respiratory function as a result of tetraplegia leads to many tetraplegics requiring mechanical ventilation during the acute phase of injury.
- Trial name
- NCT02200393
- Testing
- Abdominal FES
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Glasgow