Clinical trials: Ventilator-Associated Pneumonia
Urinary Tract Infection, Complicated, Acute Pyelonephritis
Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae
A multi-center, retrospective study of cases of serious bacterial infections including complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP), Hospital Acquired Bacterial Pneumonia (HABP), Ventilator Acquired…
- Conditions
- Urinary Tract Infection, Complicated, Acute Pyelonephritis, Hospital Acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia
- Trial name
- NCT02420366
- Where
- 22 sites in United States, Greece and 2 more
- Volunteers
- 257 people
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Ventilator Acquired Pneumonia, Mechanical Ventilation Complication
ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units.
- Trial name
- ClusterVAP (NCT07245888)
- Where
- 4 sites in France, Portugal and 1 more
- Volunteers
- 400 people
- Sponsor
- Region Skane
Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC)
A Study to Assess the Safety and Risk of Hypersensitivity Reactions of Sulbactam-durlobactam in Adults With Acinetobacter Baumannii-calcoaceticus (ABC) Complex Infection
The goal of this observational study is to evaluate the safety of sulbactam-durlobactam, as well as the risk of hypersensitivity reactions (including anaphylaxis) in participants with Acinetobacter baumannii-calcoaceticus complex…
- Trial name
- NCT06746883
- Testing
- Non-interventional
- Where
- 12 sites in United States
- Volunteers
- 100 people
- Sponsor
- Innoviva Specialty Therapeutics
Ventilator Associated Pneumonia
Pharmacodynamics Study of Imipenem in Patients With Ventilator Associated Pneumonia
Imipenem is a carbapenem antibacterial agent with a broad spectrum of activity against Gram-negative and Gram-positive bacteria.
- Trial name
- NCT01379157
- Testing
- Imipenem
- Where
- Thailand
- Volunteers
- 8 people
- Sponsor
- Prince of Songkla University
Methicillin-Resistant Staphylococcus Aureus (MRSA), Hospital-Acquired Pneumonia
Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin
The objective of this study is to review the local management of patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia treated with vancomycin or linezolid with the goal to define if any difference…
- Trial name
- NCT01561469
- Testing
- Linezolid, Vancomycin
- Volunteers
- 188 people
- Sponsor
- Pfizer
Chronic Kidney Disease, Glomerular Filtration Rate
The Relationship Between Renal Functions and Multi Drug Resistant Organisms
Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in patients receiving invasive mechanical ventilation (MV).
- Conditions
- Chronic Kidney Disease, Glomerular Filtration Rate, Drug Resistance
- Trial name
- NCT04833231
- Where
- Turkey (Türkiye)
- Volunteers
- 133 people
- Sponsor
- Konya Numune Hospital
Ventilator Associated Pneumonia
Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma
Examine the use of 0.12% Chlorhexidine Gluconate as an adjunct to current oral care protocol for trauma patients on ventilator support to decrease the incidence of Ventilator Associated Pneumonia and oral bacterial load.
- Trial name
- NCT01382446
- Testing
- Chlorhexidine gluconate, Toothpaste
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Infection Resistant to Multiple Drugs
Prospective Observational Pilot-study for the Evaluation of the Nephro- an Neurotoxicity in the Anti-infectious Therapy With Inhalative Colistin Therapy for Patients With Ventilator-associated Pneumonia (VAP)
Multi-Drug resistant pathogens (MDR) are reported worldwide with increasing incidence, especially in intensive care settings. One of the drugs which are effective against MDRs, is colistin (polymyxin E).
- Trial name
- LOKALE (NCT01894347)
- Testing
- TDM, Monitoring of Neuro-and Nephropathology
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- Charite University, Berlin, Germany
Hospitalized Children With Suspected or Confirmed Nosocomial Pneumonia
Single-dose PK Study of Ceftazidime-Avibactam In Hospitalized Children Receiving Systemic Antibiotics for Nosocomial Pneumonia
This is a multicenter, multinational, open label single dose pharmacokinetic (PK) study enrolling at least 32 subjects. The study aims to characterize the pharmacokinetics (PK) of a single intravenous dose of CAZ AVI in pediatric…
- Trial name
- NCT04040621
- Testing
- Ceftazidime-avibactam
- Where
- 4 sites in China, Taiwan
- Volunteers
- 4 people
- Sponsor
- Pfizer
Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC)
A Study to Assess Sulbactam-durlobactam in Pediatric Patients With Acinetobacter Baumannii-calcoaceticus Complex Infection
The goal of this clinical trial is to investigate the use of Sulbactam-Durlobactam (SUL-DUR) in pediatric patients and is being conducted to collect pharmacokinetic (PK) and safety data to enable the identification of appropriate…
- Trial name
- NCT06801223
- Testing
- Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Sulbactam 20mg/kg-Durlobactam 20mg/kg (Every 8 hours), Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 8 hours)
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Innoviva Specialty Therapeutics
Ventilator Associated Pneumonia
Application of VAP Bundle Among ICU Nurses
Background: Ventilator associated pneumonia (VAP) is a recognized healthcare-associated infection in lungs parenchyma that occurs in patients in which they are connected to mechanical ventilator.
- Trial name
- NCT05517759
- Testing
- Educational program
- Where
- Bahrain
- Volunteers
- 58 people
- Sponsor
- University of Bahrain
Ventilator-associated Pneumonia
Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates
The goal of this pilot study is to test the hypothesis that mechanically ventilated infants receiving Biotene OralBalance® gel for oral care would have a reduced intubation time compared to infants receiving oral care placebo.
- Trial name
- NCT01314742
- Testing
- Biotene OralBalance® gel, Sterile Water moisten cotton tipped applicator
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Ventilator Associated Pneumonia
Diagnostic Stewardship for Ventilator Associated Pneumonia
The goal of this pragmatic cluster-randomized crossover trial is to test if less unnecessary antibiotics are prescribed when the lab reports respiratory culture test results in a specific way for patients who have respiratory…
- Trial name
- NCT05989269
- Testing
- Modified lab reporting
- Where
- 3 sites in United States
- Volunteers
- 161 people
- Sponsor
- University of Maryland, Baltimore
Multi-drug Resistant Gram-negative Bacilli Colonization
Multidrug Resistant Gram-negative Bacilli Colonization and Infection in Burn
This is a prospective observational study to determine the role of colonization and identify the timing of development of drug resistance in multidrug resistant Gram-negative bacilli (MDR-GNB) causing infection among critically…
- Trial name
- NCT02653157
- Testing
- MDR-GNB
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Endotracheal Intubation During Surgery, Hospital Acquired Infections
BIP ETT Clinical Tolerability, Safety and Performance Study
The objective of the study is to determine Bactiguard coated BIP Endotracheal tube´s tolerability, safety and performance and compare it to a standard un-coated Endotracheal tube.
- Trial name
- BIPETT (NCT01682486)
- Testing
- BIP ETT (Bactiguard), Standard ETT
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Bactiguard AB
Ventilator Associated Pneumonia
Probiotics to Actively Counter Ventilator Associated Pneumonia (PROACT)
PROACT study aims to resolve uncertainties to influence actual practice guidelines or public health policing regarding VAP prevention in ICU by using probiotics administration.
- Trial name
- PROACT (NCT06092554)
- Testing
- LactoLevure
- Where
- 10 sites in Belgium, Italy
- Volunteers
- 213 people
- Sponsor
- University of Bari
Pneumonia, Ventilator-Associated
Microbiologic Response With Linezolid And Vancomycin In Ventilator-Associated Pneumonia Due To Methicillin Resistant Staphylococcus Aureus
Ventilator-associated pneumonia (VAP) is a commonplace complication of intensive care patients ventilated for longer than 48 hours.
- Trial name
- NCT00572559
- Testing
- Vancomycin, Linezolid
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 149 people
- Sponsor
- Pfizer
Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP)
A Trial of HRS-8427 in the Treatment of Adults With Bacterial Pneumonia
The purpose of this study is to evaluate the efficacy and safety of HRS -8427 in patients with HABP/VABP.
- Trial name
- NCT06841731
- Testing
- HRS-8427, Meropenem
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Ventilator Associated Pneumonia ( VAP), Intensive Care (ICU)
Integrated vs Manual Endotracheal Tube Cuff Pressure Monitoring and Ventilator-Associated Pneumonia
Ventilator-associated pneumonia (VAP) is a frequent complication in mechanically ventilated patients in intensive care unit (ICU).
- Trial name
- ICPM-VAP (NCT07423208)
- Testing
- Continous measurement of cuff pressure in endotracheal tube, Intermittent manual cuff pressure monitoring with manometer.
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Microbial Colonization, Ventilator Associated Pneumonia
Frequent Standardized Oral Care to Improve Health Outcomes in Premature Infants in the Neonatal Intensive Care Unit
Premature very low birth weight (VLBW) infants are susceptible to complications related to infrequent and non-standardized oral care.
- Trial name
- NCT05167318
- Testing
- frequent standardized oral care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Florida