Clinical trials: Ventilator-Associated Pneumonia (VAP)
Ventilator Associated Pneumonia
Effectiveness of a VAP Prevention Bundle in the PICU
This observational monocentric prospective study aims to evaluate the efficacy of new measures for ventilator associated pneumonia (VAP) management in the pediatric population in the pediatric intensive care unit (PICU) of…
- Trial name
- NCT03763695
- Testing
- Measures for the VAP prevention in the PICU, Evaluation of VAP incidence before the protocol introduction
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial
Critically ill people who need a breathing machine often develop hospital-acquired lung infections. These infections are commonly treated with the antibiotics piperacillin/tazobactam or meropenem.
- Conditions
- Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP), Nosocomial Respiratory Infection, Critical Illness
- Trial name
- ROAD-RCT (NCT07820501)
- Testing
- Resistance-Optimised Precision Dosing, Standard Care Dosing
- Volunteers
- 610 people
- Sponsor
- The University of Queensland
Ventilator Associated Pneumonia, Brain Injuries
M-I/E for Preventing VAP in Post-neurosurgical Patients
Ventilator-associated pneumonia (VAP) is a common infection in critically ill patients, especially those with acute brain injuries, leading to increased mortality and longer ICU stays.
- Conditions
- Ventilator Associated Pneumonia, Brain Injuries, Mechanical Insufflation-exsufflation
- Trial name
- NCT06511986
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Sanbo Brain Hospital
Ventilator-associated Pneumonia
A Pharmacokinetic-pharmacodynamic Dose Comparison Study of 8 mg/kg of Inhaled or Parenteral Gentamicin in 12 Mechanically Ventilated Critically Ill Patients Treated for Ventilator-associated Pneumonia
Ventilator associated pneumonia (VAP) remains in the intensive care unit the infection associated with the highest morbidity and mortality. Respiratory infection with resistant organism are increasing in prevalence.
- Trial name
- GENTAERO (NCT02515448)
- Testing
- gentamicin
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Poitiers University Hospital
Pneumonia Ventilator Associated
VAP Incidence and Adequation to SRLF 2017 Diagnostic Among an Intensive Care Medicine Service for the Period 2022 à 2024
The goal of this observational study is to to analyze respiratory samples performed in mechanically ventilated ICU patients and to assess whether the SRLF criteria for defining VAP were respected among patients admited to the…
- Trial name
- PAVM-RéaCHSF (NCT07181824)
- Testing
- Diagnostic tedst
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Sud Francilien
Complicated Intra-Abdominal Infections, cIAIs, Hospital-acquired Pneumonia (HAP)
Real-World Effectiveness of Aztreonam-Avibactam Against MBL-Producing CRE
Why This Study is Needed Some bacterial infections have become resistant to common antibiotics, making them very difficult to treat. This is a growing and serious health problem.
- Conditions
- Complicated Intra-Abdominal Infections, cIAIs, Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
- Trial name
- AWARE (NCT07268560)
- Testing
- Aztreonam-Avibactam
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
Antimicrobial Resistance (AMR)
NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria
This is an explorative, mono-center study including prospectively collected patient samples from the University Hospital of Basel.
- Trial name
- AntiResist (NCT05017766)
- Testing
- analysis of antimicrobial resistance
- Where
- Switzerland
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
VAP - Ventilator Associated Pneumonia
The Effectiveness of the Modified Bundle in the Prevention of VAP.
Ventilator-associated pneumonia (VAP) is an important cause of prolonged intensive care unit and hospital length of stay, healthcare costs and mortality in mechanically ventilated patients.
- Trial name
- VAP (NCT04038814)
- Testing
- Routine prevention of VAP, Modified prevention of VAP
- Where
- Poland
- Volunteers
- 386 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
Pneumonia, Ventilator-associated
Early Detection of Ventilator-associated Pneumonia (VAP)
The study goal consists in the sequential collection of exhaled breath condensates (EBC) from patients receiving invasive ventilation.
- Trial name
- cheqVAP (NCT02753608)
- Testing
- Collection of exhaled breath condensate
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Jena University Hospital
Pneumonia, Ventilator-Associated, Pneumonia, Bacterial
Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Patients With Hospital-acquired Pneumonia
VAPERO is a randomized, unblinded, controlled study to measure the impact of a strategy based on the Unyvero® multiplex PCR test on the adjustment of antimicrobial therapy in patients suspected with ventilator-associated or…
- Trial name
- VAPERO (NCT03711331)
- Testing
- FilmArray® Pneumonia panel plus, Standard care
- Where
- France
- Volunteers
- 161 people
- Sponsor
- University Hospital, Lille
Ventilators, Mechanical
Bacterial Lysates on Respiratory Tract Microecology and Evaluation of the Efficacy of Prevention and Treatment of VAP
The purpose of this study is to assess the effect of bacterial lysates on respiratory tract microecology in patients with mechanical ventilation and the efficacy of prevention and treatment of ventilator associated pneumonia.
- Trial name
- NCT05270018
- Testing
- Bacterial Lysates, normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sheng Wang MD PhD
Ventilator Associated Pneumonia, Covid19
Presepsin Biomarker for Ventilator-associated Pneumonia Diagnosis in COVID-19 Patients
This study is observational and double blind. It evaluates the validity of presepsin (a serum biomarker of bacterial infections) as early biomarker of Ventilator Associated Pneumonia.
- Trial name
- NCT04840940
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- San Luigi Gonzaga Hospital
Ventilator Associated Pneumonia, Infection
Probiotic Prophylaxis for Microbiome Modulation and VAP or Infections Prevention in Multitrauma Patients
Ventilator-associated pneumonia (VAP), is a type of pneumonia that develops more than 48 hours after endotracheal intubation, is common in intensive care units (ICUs).
- Conditions
- Ventilator Associated Pneumonia, Infection, Trauma
- Trial name
- NCT03074552
- Testing
- LactoLevure
- Where
- Greece
- Volunteers
- 112 people
- Sponsor
- Aristotle University Of Thessaloniki
Ventilator-Associated Pneumonia
Diagnostic and Prognostic Value of Reticulated Platelet Fraction in Ventilator-Associated Pneumonia (REPLAY-VAP)
Ventilator-associated pneumonia (VAP) is a serious infection that occurs in patients who have been on mechanical ventilation for more than 48 hours in the intensive care unit (ICU).
- Trial name
- REPLAY-VAP (NCT07013032)
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Konya City Hospital
Ventilator-Associated Pneumonia (VAP)
Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial
Previous studies have identified Acinetobacter baumannii (AB), Pseudomonas aeruginosa (PA), and Klebsiella pneumoniae (KP) as the predominant pathogens responsible for ventilator-associated pneumonia (VAP).
- Trial name
- CIVAP (NCT06834971)
- Testing
- Colistimethate sodium (CMS)
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Qilu Hospital of Shandong University
Ventilator Associated Pneumonia
Inhibition Effects of Probiotics on Pathogens Associated With VAP
This study evaluates that P. aeruginosa, A. baumannii, K. pneumonia and Staph aureus which are obtained from patients' tracheal aspiration culture who treated with mechanical ventilation will be compared with Lactobacillus (LAB)…
- Trial name
- NCT02928042
- Testing
- Lactobacillus bacteria
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Ventilator Associated Pneumonia
Bronchoscopy vs. Clinical Pulmonary Infection Score Guided Approach in Suspected Ventilator-Associated Pneumonia (VAP)
The reported incidence of ventilator associated pneumonia (VAP) is 10 to 15 per 1,000 ventilator days. VAP leads to an excess cost exceeding $40,000 per patient and is associated with a crude mortality rate as high as 76%.
- Trial name
- NCT00588588
- Testing
- Bronchoscopy, Clinical pulmonary infection score (CPIS)
- Sponsor
- Mayo Clinic
VAP - Ventilator Associated Pneumonia
Performance Study of Targeted Sequencing Technology for VAP
Main purpose: To evaluate the feasibility of tNGS for pathogen detection and drug resistance analysis in VAP patients. Research site and research population: This study is planned to be conducted in hospitals, targeting VAP…
- Trial name
- NCT06035796
- Testing
- tNGS
- Volunteers
- 150 people
- Sponsor
- The First Hospital of Jilin University
Ventilator Associated Pneumonia
Perpetual Observational Study - Ventilator Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation.
- Trial name
- POS-VAP (NCT05719259)
- Where
- 35 sites in Albania, Belgium and 11 more
- Volunteers
- 20,000 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
VAP - Ventilator Associated Pneumonia
Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial
This is a prospective pilot/feasibility trial of a bundled diagnostic stewardship intervention at the level of the microbiologic testing pathway in ventilator-associated pneumonia (VAP).
- Trial name
- NCT05176353
- Testing
- VAP diagnostic stewardship bundle
- Where
- United States
- Volunteers
- 4,892 people
- Sponsor
- University of Michigan