Clinical trials: Ventilator-acquired Pneumonia
Nosocomial Infection, Nosocomial Pneumonia
Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection
Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.
- Conditions
- Nosocomial Infection, Nosocomial Pneumonia, Tracheobronchitis, Mechanical Ventilation Complication
- Trial name
- ABSENTA (NCT06310941)
- Testing
- Mechanical insufflation-exsufflation, Standard of Care, Hypertonic saline with hyaluronic acid
- Where
- 8 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital San Carlos, Madrid
Bacteremia Associated With Intravascular Line, Ventilator Associated Pneumonia
Simplified Selective Digestive Tract Decontamination for the Prevention of Intensive Care Unit Acquired Infections
A simplified graded gut decontamination protocol combined with rigorous bi-weekly screening and appropriate bacterial prophylaxis, will lead to a 25% reduction in the acquisition of blood stream infections and to a 25% reduction…
- Conditions
- Bacteremia Associated With Intravascular Line, Ventilator Associated Pneumonia, Bacteremia
- Trial name
- SDDICU (NCT01798537)
- Testing
- Neomycin Colistin Nystatin Vancomycin
- Where
- Israel
- Volunteers
- 2,400 people
- Sponsor
- Rambam Health Care Campus
Ventilator Associated Pneumonia
Study of Different Etiologic Diagnostic Methods in Ventilator Associated Pneumonia (VAP)
The study is designed to evaluate sensitivity, specificity and accuracy of non-bronchoscopic bronchoalveolar lavage and endotracheal aspirate in comparison with bronchoscopic bronchoalveolar lavage (gold standard), as methods for…
- Trial name
- NCT02363023
- Testing
- Collect tracheal and pulmonary secretions
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Uberlandia
Ventilator Associated Pneumonia
Oro-nasal Decontamination to Prevent Ventilator-associated Pneumonia
It has been shown that oral hygiene reduces the incidence of ventilator-associated pneumonia (VAP). The nasopharynx is considered to be an important source of contaminated micro aspiration to the lung however, the effect of…
- Trial name
- NCT05895773
- Testing
- Povidone-Iodine, Saline spray
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Menoufia University
Ventilator Associated Pneumonia
Role of Oral Chlorhexidine Gel in Prevention of Ventilator Associated Pneumonia
The purpose of this study is to determine if oral mucosal application of chlorhexidine gel will prevent the development of ventilator associated pneumonia in children.
- Trial name
- NCT00597688
- Testing
- Chlorhexidine gel
- Where
- India
- Volunteers
- 86 people
- Sponsor
- All India Institute of Medical Sciences
Ventilator Associated Pneumonia, Multi-antibiotic Resistance
Ventilator Associated Pneumonia by Multi-Drug Resistant Organism
Ventilator-associated pneumonia (VAP) is an infection of the pulmonary parenchyma in patients exposed to invasive mechanical ventilation for at least 48 h and is part of ICU-acquired pneumonia.
- Trial name
- VAP-MDR (NCT05549427)
- Testing
- Ventilation
- Where
- Oman
- Volunteers
- 319 people
- Sponsor
- Sultan Qaboos University
Ventilation Acquired Pneumonia
Effect of Acetylcysteine Inhalation on Incidence and Time to Develop Ventilator Associated Pneumonia in Critically Ill Mechanically Ventilated Patients
Background Mechanical ventilation is an essential medical intervention in the context of critical illness. However, the intervention is associated with a risk of significant, potentially preventable complications.
- Trial name
- NCT07409727
- Testing
- Acetyl cysteine, Normal (0.9%) saline
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Ventilator Associated Pneumonia
Oral Care as a Preventive Measure of VAP; Miswak Versus Chlorhexidine and Toothbrush.
Dental plaque score calculation and swabs of Oropharynx and teeth were collected on admission. For group I, Miswak stick was used 4 hourly for oral care. For group II, 0.12% Chlorhexidine/ toothbrush were used 4 hourly
- Trial name
- NCT02288390
- Testing
- Oral care in mechanically ventilated patients
- Volunteers
- 40 people
- Sponsor
- University of Alexandria
Ventilator Associated Pneumonia
A Multi-Center Observational Surveillance Study of VAP Causing Bacteria
Detect the clinical causitive pathogen of Ventilator Associated Pneumonia (VAP) patients by the bronchoalveolar lavage (BAL) method.
- Trial name
- NCT00484588
- Volunteers
- 500 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Ventilator Acquired Pneumonia
Procalcitonin Versus Serum Zinc for Diagnosis of Ventilator-Associated Pneumonia in ICU Patients
Ventilator-associated pneumonia (VAP) is a common and serious infection among mechanically ventilated ICU patients. Early diagnosis remains challenging because clinical and radiological findings may lack specificity.
- Trial name
- PROZINC-VAP (NCT07696897)
- Testing
- Serum Procalcitonin Measurement, Serum Zinc Measurement
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Sohag University
Ventilator-associated Pneumonia
CDC Prevention Epicenters Wake Up and Breathe Collaborative
Ventilator-associated pneumonia (VAP) is a common complication of mechanical ventilation associated with significant morbidity, including prolongation of mechanical ventilation and increased ICU and hospital length-of-stay.
- Trial name
- NCT01583413
- Testing
- Daily SAT & SBT
- Where
- 5 sites in United States
- Volunteers
- 3,342 people
- Sponsor
- Harvard Pilgrim Health Care
Pneumonia, Ventilator-Associated
Microbiologic Response With Linezolid And Vancomycin In Ventilator-Associated Pneumonia Due To Methicillin Resistant Staphylococcus Aureus
Ventilator-associated pneumonia (VAP) is a commonplace complication of intensive care patients ventilated for longer than 48 hours.
- Trial name
- NCT00572559
- Testing
- Vancomycin, Linezolid
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 149 people
- Sponsor
- Pfizer
Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia
A Clinical Trial to Assess the Safety and PK of OMN6 in HABP or VABP Caused by Acinetobacter Baumannii Complex
This is a phase 2a, multinational, multicenter, double-blind, randomized, placebo-controlled, dose-ranging safety, tolerability and PK study in patients with HABP (Hospital Acquired Bacterial Pneumonia) or VABP (Ventilator…
- Trial name
- NCT06087536
- Testing
- OMN6
- Where
- 15 sites in Greece, Israel
- Volunteers
- 54 people
- Sponsor
- Omnix Medical Ltd
HAP - Hospital Acquired Pneumonia, VAP - Ventilator Associated Pneumonia
HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array
Multicenter, randomized, controlled, open-label trial to assess if semiquantitative multiplex PCR assay, as compared to conventional microbiology, can reduce the percentage of patients without microbiological diagnosis in the…
- Trial name
- LIGHTNING (NCT05952648)
- Testing
- Lower tract respiratory samples, Multiplex PCR assay (Film-array Pneumonia Panel Plus), Lower respiratory tract standard culture
- Where
- 4 sites in Italy
- Volunteers
- 126 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pneumonia, Ventilator-Associated
Bilateral Bronchoalveolar Lavage in Ventilator-associated Pneumonia
The purpose of this study is to assess microbiologic concordance rates between right- and left-lung bronchoalveolar lavage cultures from patients with suspected ventilator-associated pneumonia, identify predictors of concordance…
- Trial name
- NCT02542553
- Testing
- Bilateral BAL
- Volunteers
- 79 people
- Sponsor
- Catholic University of the Sacred Heart
Ventilator-Associated Pneumonia
Mobile-Based Microlearning for Improving ICU Nurses' Adherence to Ventilator-Associated Pneumonia Prevention Protocols
Ventilator-associated pneumonia (VAP) is one of the most common healthcare-associated infections among mechanically ventilated patients and is associated with increased morbidity, mortality, length of intensive care unit stay…
- Trial name
- VAP-ML (NCT07866027)
- Testing
- Mobile-Based Microlearning Program, Routine Education
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pneumonia, Bacterial, Nosocomial Infection
A Study of the Safety and Effectiveness of Doripenem in Filipino Patients With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Complicated Urinary Tract Infections
The purpose of this study is to assess the safety and effectiveness of doripenem treatment among Filipino patients with nosocomial pneumonia, complicated intra-abdominal infections, and complicated urinary tract infection.
- Conditions
- Pneumonia, Bacterial, Nosocomial Infection, Intraabdominal Infections, Urinary Tract Infection
- Trial name
- NCT01763008
- Testing
- No intervention
- Where
- 4 sites in Philippines
- Volunteers
- 170 people
- Sponsor
- Janssen Pharmaceutica
The Incidence of Ventilator-associated Pneumonia and Rate of Compliance With Survey Criteria
Investigation of Compliance With Ventilator-Associated Pneumonia Prevention Methods and Incidence of Ventilator-Associated Pneumonia in Intensive Care Units
Ventilator-associated Pneumonia (VAP) is a high-mortality hospital infection that occurs in patients undergoing invasive Mechanical Ventilation (MV) and is frequently encountered in intensive care units.
- Trial name
- NCT04174274
- Testing
- ventilator-associated pneumonia-developed group followed by mechanical ventilation, not ventilator-associated pneumonia-developed group followed by mechanical ventilation
- Volunteers
- 100 people
- Sponsor
- Diskapi Teaching and Research Hospital
Ventilator Associated Pneumonia, Corona Virus Infection
Epidemiology and Outcome of Ventilator-associated Pneumonia Among Critically Ill COVID-19 Patients
The aim of this study is to determine the risk factors for development of ventilator-associated pneumonia (VAP) and to identify the prognostic factors of VAP among Coronavirus Disease 2019 (CoViD-19) patients.
- Trial name
- NCT04372576
- Testing
- Assessment of ventilator-associated pneumonia criteria
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
Ventilator-Associated Pneumonia (VAP)
Efficacy and Safety of Prophylactic Antibiotics in Preventing Ventilator-associated Pneumonia: A Randomized, Double Blind, Placebo-controlled Trial
Evaluate efficacy and safety of prophylactic antibiotics in preventing early ventilator-associated pneumonia
- Trial name
- NCT07203638
- Testing
- Beta Lactam Antibiotics, Salin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Esraa Salah Mohamed Abdallah Eladl