Clinical trials: Ventilator-acquired Pneumonia
Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
Macrophage Programing in Acute Lung Injury: MiniBAL
The goal of this observational clinical trial is to learn about the role white blood cells (macrophages) play in lung inflammation in people with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT05767671
- Testing
- Non-Bronchoscopic Mini Bronchoalveolar Lavage
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- William Janssen, MD
Ventilator-Associated Pneumonia, Nosocomial Pneumonia
Effectiveness of Dental Brushing for Preventing Ventilator-Associated Pneumonia
Poor oral hygiene is associated with respiratory pathogen colonization and secondary lung infection.The possible association between oral care and incidence of VAP, and the role of dental plaque, mouth and tracheal colonization…
- Conditions
- Ventilator-Associated Pneumonia, Nosocomial Pneumonia, Pneumonia
- Trial name
- RASPALL (NCT00842478)
- Testing
- Toothbrushing
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Ventilator-associated Pneumonia, Cardiac Arrests With Shockable Rhythm
Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications
Mild therapeutic hypothermia is currently recommended in management of cardiac arrests with shockable rhythm. In mechanically ventilated patients who were resuscitated after out-of-hospital cardiac arrests, mild therapeutic…
- Conditions
- Ventilator-associated Pneumonia, Cardiac Arrests With Shockable Rhythm, Mild Therapeutic Hypothermia, Preventive Antibiotics
- Trial name
- ANTHARTIC (NCT02186951)
- Testing
- Amoxicillin - clavulanic acid
- Where
- 16 sites in France
- Volunteers
- 197 people
- Sponsor
- University Hospital, Limoges
Pneumonia, Mechanical Ventilation Complication
Oral Care of Intubated Intensive Care Patient
The aim of the research was to examine the effect of oral care bundle application on oral health, salivary pH (power of hydrogen), dry mouth and ventilator associated pneumonia in intubated patients compared to standard oral care.
- Conditions
- Pneumonia, Mechanical Ventilation Complication, Salivation, Dry Mouth
- Trial name
- NCT06258603
- Testing
- oral care bundle, clinical oral care
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nigde Omer Halisdemir University
Pneumonia
Prevention of Pneumonia Comparing Ceftriaxone With Subglottic Aspiration
The primary purpose of the trial is to compare the efficacy and safety of two measures which claim to prevent early-onset ventilator-associated pneumonia.
- Trial name
- NCT00374959
- Testing
- ceftriaxone, Endotracheal tube for aspiration of subglottic secretions.
- Where
- 3 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Universitario Principe de Asturias
Ventilator Associated Pneumonia
Ventilator Associated Pneumonia Multiplex PCR for Anti-Infective Regimens
Ventilator-associated pneumonia (VAP) remains one of the main nosocomial infections acquired in the intensive care unit (ICU). VAP is pneumonia occurring 48 hours after intubation.
- Trial name
- VAMPAIR (NCT06554327)
- Testing
- Multiplex PCR
- Where
- France
- Volunteers
- 265 people
- Sponsor
- CHU de Reims
Nosocomial Infection, Nosocomial Pneumonia
Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection
Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.
- Conditions
- Nosocomial Infection, Nosocomial Pneumonia, Tracheobronchitis, Mechanical Ventilation Complication
- Trial name
- ABSENTA (NCT06310941)
- Testing
- Mechanical insufflation-exsufflation, Standard of Care, Hypertonic saline with hyaluronic acid
- Where
- 8 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Hospital San Carlos, Madrid
Ventilator Associated Pneumonia
Impact of Imipenem With Amikacin Pharmacokinetic and Pharmacodynamic
The study is a prospective open trial conducted in 4 centers, and designed to determine if pharmacokinetic (PK) and pharmacodynamic (PD) parameters of imipenem, associated with amikacin as empirical therapy, impact…
- Trial name
- IMPACT (NCT00950222)
- Testing
- Imipenem/Amikacin
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ICU's Patients Under Mechanical Ventilation
Effect of Drainage of Subglottic Secretions on Pneumonia Acquired Under Mechanical Ventilation
The purpose of this study is to determine whether drainage of subglottic secretions is effective to reduce the incidence of pneumonia acquired under mechanical ventilation in ICU's patients.
- Trial name
- NCT00219661
- Testing
- drainage of subglottic secretions (HiLo Evac tube)
- Where
- 4 sites in France
- Volunteers
- 440 people
- Sponsor
- Poissy-Saint Germain Hospital
Ventilator Associated Pneumonia
Study of Povidone Iodine to Reduce Pulmonary Infection in Head Trauma and Cerebral Hemorrhage in Intensive Care Unit
Head trauma and severe cerebral hemorrhage are major risk factors for development of ventilator-associated pneumonia. In a previous open labelled, single center study the investigators showed that repeated oropharyngeal…
- Trial name
- SPIRIT-ICU (NCT00950027)
- Testing
- povidone iodine
- Where
- 7 sites in France
- Volunteers
- 179 people
- Sponsor
- Rennes University Hospital
Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP)
Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in Carbapenem-Resistant Enterobacteriaceae Infections
The study will evaluate the efficacy and safety of Meropenem and Pralurbactam versus Best Available Therapy in the treatment of Carbapenem-Resistant Enterobacteriaceae Infections.
- Conditions
- Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP), Complicated Intra-abdominal Infection (cIAI), Complicated Urinary Tract Infection (cUTI)
- Trial name
- NCT07089186
- Testing
- Meropenem and Pralurbactam, Best Available Therapy (e.g., colistin, meropenem, tegecycline, amikacinceftezidime-avibatam)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Serial Endocan Measurements
Endocan in Ventilator-associated Pneumonia
In this study; in patients undergoing mechanical ventilation, making the day series Endocan measurements during the first 5 day to look at whether there is a relationship between the levels of VAP with Endocan.
- Trial name
- NCT02916277
- Testing
- endocan
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Erzincan University
Critically Ill, Oral Health Care
Professional Oral Care and Staff Education in Critically Ill Patients
This study evaluated oral health in critically ill patients admitted to two intensive care units in Budapest, Hungary, and examined whether professional oral care and education of intensive care staff could improve oral hygiene.
- Conditions
- Critically Ill, Oral Health Care, Critical Illness, Oral Care Performance
- Trial name
- NCT07831564
- Testing
- Professional Oral Care, Standard Oral Care, ICU Staff Oral Care Education
- Where
- 2 sites in Hungary
- Volunteers
- 161 people
- Sponsor
- Semmelweis University
Hospital-acquired Pneumonia, Healthcare Associated Infection
Modular Prevention Bundle for Non-ventilator-associated Hospital-acquired Pneumonia (nvHAP)
Background: Hospital acquired pneumonia (HAP) is divided in two distinct groups, ventilator-associated pneumonia (VAP) and non-ventilator-associated HAP (nvHAP).
- Conditions
- Hospital-acquired Pneumonia, Healthcare Associated Infection, Infection Prevention
- Trial name
- NCT03361085
- Testing
- nvHAP Prevention Bundle
- Where
- Switzerland
- Volunteers
- 45,000 people
- Sponsor
- University of Zurich
Pneumonia Ventilator Associated
Early-onset Ventilator-associated Pneumonia in Adults: Comparison of 8 Versus 15 Days of Antibiotic Treatment
The duration of treatment of community acquired pulmonary infection varies between 5 and 14 days according to the authors (22), or even 3 days with new drugs having long half-life (2).
- Trial name
- NCT01559753
- Testing
- Augmentin, Ceftriaxone, Cefotaxime, netilmycin, tobramycin, compare 8 to15 days of antibiotic treatment
- Volunteers
- 225 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pneumonia, Ventilator-associated, Gram-Negative Pneumonia
Nebulized Colistin for Gram Negative VAP Prevention.
Colistin is used as an elective treatment of infections of multi drug resistant gram negative bacteria. Until now colistin is used in the therapeutic regimen of these infections intravenous or nebulized.
- Trial name
- VAPICO (NCT04208945)
- Testing
- Colistin
- Where
- 3 sites in Greece
- Volunteers
- 152 people
- Sponsor
- University of Thessaly
Pneumonia
Ceftobiprole in Hospital Acquired Pneumonia
The purpose of this study is to compare the clinical cure rate of ceftobiprole medocaril (the water-soluble prodrug [form] of ceftobiprole) referred to as ceftobiprole versus a comparator in the treatment of patients with…
- Trial name
- NCT00210964
- Testing
- linezolid plus ceftazidime
- Volunteers
- 781 people
- Sponsor
- Basilea Pharmaceutica
Ventilator Acquired Pneumonia
Procalcitonin Versus Serum Zinc for Diagnosis of Ventilator-Associated Pneumonia in ICU Patients
Ventilator-associated pneumonia (VAP) is a common and serious infection among mechanically ventilated ICU patients. Early diagnosis remains challenging because clinical and radiological findings may lack specificity.
- Trial name
- PROZINC-VAP (NCT07696897)
- Testing
- Serum Procalcitonin Measurement, Serum Zinc Measurement
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Sohag University
Hospital-acquired Pneumonia
0.12% Chlorhexidine Oral Care for the Prevention of Non-ventilator Hospital-acquired Pneumonia
Chlorhexidine is a effective strategy in reducing ventilator associated pneumonia. However, it is unclear if prophylactic 0.12% chlorhexidine oral rinse can reduce the risk of non-ventilator hospital-acquired pneumonia among…
- Trial name
- NCT04403971
- Testing
- 0.12% Chlorhexidine Oral Liquid Product, Listerine Oral Liquid Product, Normal Saline Product
- Where
- Taiwan
- Volunteers
- 103 people
- Sponsor
- National Cheng-Kung University Hospital
Pneumonia, Ventilator-Associated
The Efficacy of Adjuvant Oral Care in Prevention of Ventilator Associated Pneumonia.
A Randomized Controlled Trial (RCT) at Services Hospital, Lahore, aims to reduce Ventilator-Associated Pneumonia (VAP) incidence and mortality rates while shortening ICU stays in mechanically ventilated patients by adding…
- Trial name
- NCT06039995
- Testing
- Comprehensive Oral Care, Traditional Oral Care, Mechanical Tooth Brushing using 0.2% Chlorhexidine
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore