Clinical trials: Ventilators, Mechanical
Respiratory Failure, Cardiovascular Surgery
Early Percutaneous Tracheostomy for Cardiac Surgery (ETOC)
This is a phase III clinical trial comparing early tracheostomy (day 4) versus prolonged endotracheal intubation in ICU patients needing prolonged ventilatory support after cardiovascular surgery.
- Trial name
- ETOC (NCT00347321)
- Testing
- Dilatational Percutaneous tracheostomy
- Where
- France
- Volunteers
- 212 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Airway Extubation, Ventilator Weaning
Mechanical Ventilation Reconnection for One Hour After Spontaneous Breathing Trial
The aim of this study is to evaluate the feasibility to perform a future larger clinical trial to analyze whether the mechanical ventilation reconnection for 1 hour after a successful spontaneous breathing trial reduces the risk…
- Trial name
- NCT05999526
- Testing
- Reconnection to mechanical ventilation for 1 hour, Direct extubation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar Unimed de Joinville
Prolonged Mechanical Ventilation, Ventilator Weaning
Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation
This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged…
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Ventilator Dependent, Exoskeleton Device
- Trial name
- NCT07445035
- Testing
- lower-limb exoskeleton, Standard medical treatment
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Fu Jen Catholic University
Airway Extubation
Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure
Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated.
- Trial name
- NCT04356625
- Testing
- MEPic
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Ventilator-Induced Lung Injury, Mechanical Ventilation Complication
Protective Mechanical Ventilation and Risk of Postoperative Complications in Abdominal Surgery
Randomized controlled trial, comparing two groups of 40 patients each scheduled for open major abdominal surgery. The intervention group was ventilated with a protective strategy consisting on a low Tidal volume (Vt) (6ml/kg of…
- Conditions
- Ventilator-Induced Lung Injury, Mechanical Ventilation Complication, Postoperative Complications
- Trial name
- NCT03165760
- Testing
- protective ventilation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mongi Slim Hospital
Ventilator Lung
Life-dependent Home Mechanical Ventilation
In Denmark, life-dependent home-mechanical ventilation (HMV) is given under the surveillance of a specifically trained respiratory patient caregiver (tPCG).
- Trial name
- NCT06151886
- Where
- Denmark
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infant, Newborn, Infant, Small for Gestational Age
Hydrocortisone for BPD
The Hydrocortisone and Extubation study will test the safety and efficacy of a 10 day course of hydrocortisone for infants who are less than 30 weeks estimated gestational age and who are intubated at 14-28 days of life.
- Conditions
- Infant, Newborn, Infant, Small for Gestational Age, Infant, Very Low Birth Weight, Infant, Premature
- Trial name
- NCT01353313
- Testing
- Hydrocortisone
- Where
- 20 sites in United States
- Volunteers
- 800 people
- Sponsor
- NICHD Neonatal Research Network
Mechanical Ventilation Complication, Brain Injuries
Mechanical Ventilation on Hippocampus
Ventilator-associated brain injury (VABI) frequently occurs in ICU patients. Although animal studies indicate the hippocampus as a key target of VABI, its relevance in human patients remains uncertain.
- Trial name
- NCT06480162
- Testing
- Mechanical ventilation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Sanbo Brain Hospital
Oxygenation, Manual Ventilation
AMBU Bag Manual Ventilation vs. Transport Ventilator Mechanical Ventilation for Transport
This is a clinical trial to compare the oxygenation and ventilation performance between manual ventilation and mechanical ventilation when transporting cardiac patients to the ICU.
- Conditions
- Oxygenation, Manual Ventilation, Mechanical Ventilation, Point of Care Ultrasound
- Trial name
- NCT06006208
- Testing
- Hamilton C1 ventilator during transport to the ICU
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Thomas Jefferson University
Community Health Workers, Filtration
Effectiveness of Respirators Fit Factor in Healthcare Providers With and Without Beard
The study aim will be to determine the fit factor of surgical masks and filtering respirators in healthcare providers with and without beard.
- Conditions
- Community Health Workers, Filtration, Masks
- Trial name
- NCT04391010
- Testing
- Surgical masks, Filtering respirators
- Where
- Spain
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Respiration, Artificial, Ventilators, Mechanical
Pivotal Evaluation of Abdominal Neuromuscular Electrical Stimulation (VentFree) for Weaning From Mechanical Ventilation
The objective of this study is to evaluate the efficacy of the VentFree Respiratory Muscle Stimulator (VentFree) in critically ill adult patients who require invasive mechanical ventilation, when compared to sham.
- Trial name
- PREVENT (NCT05759013)
- Testing
- Breath synchronized abdominal FES
- Where
- 27 sites in United States, Australia and 2 more
- Volunteers
- 250 people
- Sponsor
- Liberate Medical
Laparoscopic Bariatric Surgeries, Hypoxemia
Intra-Operative Modified Ventilator Mechanical Power in Laparoscopic Bariatric Surgeries
To compare the effects of two levels of mechanical power on the incidence of post-operative hypoxemia in morbid obese patients undergoing laparoscopic bariatric surgeries.
- Conditions
- Laparoscopic Bariatric Surgeries, Hypoxemia, Obese Patients
- Trial name
- NCT07065370
- Testing
- Group I ( volume-controlled ventilation with tidal volume 6-8ml/kg (predicted body weight) with respiratory rate 12-14 cycle/minute., Group II: (volume-controlled ventilation with tidal volume 6-8ml/kg )
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Respiratory Distress, Newborn, Ventilator Induced Lung Injury
Ventilatory Parameters and Inflammatory Responses of Neonates Ventilated by Different Modes of Ventilation
The main purpose of this study is to investigate effects of SIMV+VG (synchronized intermittent mandatory ventilation+volume guarantee) or PSV+VG (pressure support ventilation+volume guarantee) ventilation on vital signs, patient…
- Trial name
- NCT01514331
- Testing
- SIMV+VG mode of ventilation (synchronized intermittent mandatory ventilation+volume guarantee), PSV+VG (pressure support ventilation+volume guarantee)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)
National Surveillance and Prevention of Neonatal VAP
The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD), Antibiotic-Resistant Organisms (AROs), Health-Care Associated Infection (HAI)
- Trial name
- NCT07109791
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Respiratory Distress Syndrome, Adult
The Role of Morphological Phenotype in ARDS
Although most of the information focuses on understanding how the ventilator produces lung damage, the pulmonary factors that predispose to ventilator-induced lung injury (VILI) have been less studied.
- Trial name
- MPARDS (NCT04157946)
- Testing
- CT
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Hospital El Cruce
Ventilators, Mechanical, Intensive Care Units
Postoperative INTELLiVENT-ASV Ventilation
The aim of this study is to investigate whether postoperative ventilation with INTELLiVENT-ASV(adaptive support ventilation) in high risk patients, after cardiothoracic surgery, is as effective, more user-friendly and as safe as…
- Conditions
- Ventilators, Mechanical, Intensive Care Units, Postoperative Care
- Trial name
- POSITiVE (NCT03180203)
- Testing
- INTELLiVENT-ASV, Conventional modes
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Mechanical Ventilation Complication
National Approach to Standardize and Improve Mechanical Ventilation
This is a pre-post implementation cohort study. This is a data driven quality improvement project which aims to improve the care of mechanically ventilated patients through the implementation of a bundle of evidence based…
- Trial name
- NASAM (NCT03790150)
- Testing
- Evidence-based practices
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 27,966 people
- Sponsor
- King Abdullah International Medical Research Center
Ventilator Associated Pneumonia, Brain Injuries
M-I/E for Preventing VAP in Post-neurosurgical Patients
Ventilator-associated pneumonia (VAP) is a common infection in critically ill patients, especially those with acute brain injuries, leading to increased mortality and longer ICU stays.
- Conditions
- Ventilator Associated Pneumonia, Brain Injuries, Mechanical Insufflation-exsufflation
- Trial name
- NCT06511986
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Beijing Sanbo Brain Hospital