Clinical trials: Ventilatory Depression
Respiratory Depression
Effects of Sequential Exposure to Nitrogen Dioxide and Ozone in Healthy Adult Human Volunteers.
The U.S. Environmental Protection Agency has traditionally examined the effects of single pollutant exposure on human health outcomes; however, to provide a better assessment of pollutant exposure-associated effect on human…
- Trial name
- ENDZONE (NCT02133586)
- Testing
- Ozone, Nitrogen dioxide
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Lung Cancer, Radiation-Induced Disorder
Functional Lung Avoidance SPECT-guided Radiation Therapy of Lung Cancer
Study aims to determine if functional lung avoidance based on perfusion single photon emission (SPECT)/CT scan, improves toxicity outcomes for patients with advanced lung cancer undergoing chemo-radiotherapy.
- Conditions
- Lung Cancer, Radiation-Induced Disorder, Radiation Pneumonitis, Pulmonary Disease
- Trial name
- ASPECT (NCT04676828)
- Testing
- Single-photon-emission CT scan
- Where
- 2 sites in Australia, Denmark
- Volunteers
- 90 people
- Sponsor
- University of Aarhus
Sedentary Lifestyle, Metabolic Disorders
Concurrent Training and Metabolic Profile, Lung Function, Quality of Life and Stress
Physical inactivity and sedentary time are highly prevalent worldwide and are associated with many adverse health outcomes. Workers adults spend two-thirds of their workday sitting, so they are particularly at risk.
- Conditions
- Sedentary Lifestyle, Metabolic Disorders, Concurrent Exercise, Lung Function Decreased
- Trial name
- NCT04868240
- Testing
- Concurrent training program
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Candle Burning, Cooking
Acute Health Effects Due to Ultrafine Particles From Candles and Cooking
People spend up to 90% of their life indoor, and the way we live and behave in our homes has substantial effects on our health and well-being.
- Conditions
- Candle Burning, Cooking, Lung Function Decreased, DNA Damage
- Trial name
- Ultrafine (NCT04315740)
- Testing
- Particles from candles, Particles from cooking, Clean Air
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypercapnia, Ventilatory Depression
Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation
Opioids can decrease breathing and co-administration of benzodiazepines with opioids can further decrease breathing. It is unknown whether certain other drugs also decrease breathing when co-administered with opioids.
- Trial name
- NCT04310579
- Testing
- Oxycodone and Midazolam, Oxycodone, Paroxetine, and Quetiapine
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Opioid Induced Respiratory Depression, Depressive Disorder
Influence of Oxycodone on Individuals Taking an SSRI
This study will determine whether selective serotonin reuptake inhibitors (SSRI) exacerbate opioid induced respiratory depression in patients initiating treatment for underlying conditions such as depression or an anxiety…
- Conditions
- Opioid Induced Respiratory Depression, Depressive Disorder, Anxiety Disorders
- Trial name
- OXIS (NCT05730062)
- Testing
- Oxycodone Hydrochloride
- Volunteers
- 55 people
- Sponsor
- Leiden University Medical Center
Weaning Failure, Central Respiratory Depression
Exploration of Mechanisms for Weaning Failure
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline…
- Conditions
- Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder
- Trial name
- NCT06424314
- Testing
- Monitoring of respiratory mechanics parameters
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Pain, Anesthesia
Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy
Purpose: 1. To determine the efficacy of low-dose esketamine in painless gastrointestinal endoscopy. 2. To determine the safety of low-dose esketamine in painless gastrointestinal endoscopy. 3.
- Trial name
- NCT04691076
- Testing
- Propofol, Esketamine, Fentanyl
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tianjin Union Medical Center
Obesity, Morbid, Postoperative Pain
Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting
The purpose of this research study is to evaluate the drug gabapentin (Neurontin®) for its ability to reduce postoperative pain, the need for morphine-like pain medication, and the severity and frequency of postoperative nausea…
- Conditions
- Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
- Trial name
- NCT00886236
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
Lung Function Decreased
Effect of Respiratory Muscle Training on Lung Function on Quarry Workers in Minia Government Egypt
forty quarry workers participated in the study with age range (40-60 years), body mass index (BMI) from 25 to 34.9 kg/m2 (over weight and class 1 obesity). The patients divided into two groups randomly.
- Trial name
- NCT06070584
- Testing
- aerobic exercises with electrical treadmill for 30 min and inspiratory muscle training for 10 minutes.,
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Deraya University
Post Surgical Respiratory Failure, Respiratory Complication
Clinical Evaluation of an Alarm Activated Detection System to Enable Early Intervention of Emerging Respiratory Decline With the Linshom Medical Continuous Predictive Respiratory Sensor (CPRS)
Investigators will enroll 493 patients who will undergo non-cardiac surgery, receive supplemental oxygen via face mask or nasal cannula, and will be on continuous pulse oximetry monitor in the Post Anesthesia Care Unit (PACU).
- Conditions
- Post Surgical Respiratory Failure, Respiratory Complication, Opioid Induced Respiratory Depression, Respiratory Arrest
- Trial name
- NCT07793981
- Testing
- Linshom Continuous Predictive Respiratory Monitoring
- Where
- 2 sites in United States
- Volunteers
- 394 people
- Sponsor
- Linshom Medical, Inc.
Pain, Postoperative, Pain Uterus
Effects of Tapentadol Versus Oxycodone After Hysterectomy.
Opioids remain the first-line drugs for the treatment of moderate to severe postoperative pain, but the use is limited by well-known side-effects, most of which are dose-dependent.
- Conditions
- Pain, Postoperative, Pain Uterus, Pain, Acute, Opioid Use
- Trial name
- NCT03314792
- Testing
- Tapentadol, Oxycodone
- Where
- Norway
- Volunteers
- 86 people
- Sponsor
- Oslo University Hospital
Respiratory Depression
ENA-001 for Post Operative Respiratory Depression (PORD)
This study is a Phase II, randomized, placebo-controlled, double-blind trial in 200 subjects having general anesthesia for major elective surgery with postoperative pain management to evaluate the efficacy, safety and…
- Trial name
- NCT06137638
- Testing
- ENA-001
- Volunteers
- 200 people
- Sponsor
- Enalare Therapeutics Inc.
Atelectases, Postoperative Pulmonary
The Effectiveness of the Jamboxx Respiratory Therapy Device: Study 3
The Effectiveness of the Jamboxx Respiratory Therapy Device in Treatment of Patients with Decreased Respiratory Function is a proposal for investigation of the application of gaming to improving respiratory health.
- Trial name
- NCT03547349
- Testing
- Digital Incentive Spirometer, Jamboxx Respiratory Therapy Device
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- My Music Machines Inc.
Pain
Use of Intrathecal Hydromorphone in Elective Cesarean Deliveries
The purpose of this study is to determine if intrathecal hydromorphone will relieve pain as well as intrathecal morphine after cesarean delivery, with fewer side effects.
- Trial name
- NCT01866254
- Testing
- Hydromorphone, Morphine
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Grace Shih, MD
Chronic Pancreatitis, Respiratory Insufficiency
Is There an Association Between Chronic Pancreatitis and Pulmonary Function
To evaluate pulmonary function in chronic pancreatitis compared with healthy volunteers and patients with cirrhosis.
- Conditions
- Chronic Pancreatitis, Respiratory Insufficiency, Cirrhosis, Liver, Lung Function Decreased
- Trial name
- RespPanc (NCT03850977)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique for evaluating the bile duct, pancreatic duct, and ampulla.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07051980
- Testing
- Supraglottic Oxygen Delivery via an Endotracheal Tube
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University