Clinical trials: Ventilatory Failure
Ventilatory Failure
Postextubation Management in Patients at Risk for Extubation Failure
At the time of weaning from mechanical ventilation, patients with heart and/or lung conditions will be given oxygen support with alternating bilevel positive airway pressure (BiPAP; oxygen via face mask) and heated high flow…
- Trial name
- NCT04258020
- Testing
- BiPAP, HFNC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- OhioHealth
Acute Respiratory Distress Syndrome, Shock
Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure
The objective of our study is to evaluate the efficacy of helmet ventilation as compared with Face mask in patients with respiratory failure.
- Conditions
- Acute Respiratory Distress Syndrome, Shock, Ventilatory Failure, Cardiogenic Pulmonary Edema
- Trial name
- NCT01680783
- Testing
- Non invasive ventilation using a helmet hyperbaric device, Noninvasive ventilation via facemask
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Chicago
CSF Circulation
Influence of Yogic Breathwork on CSF Circulation
The purpose of this research study is to determine the influence of yoga breathing practices on cerebrospinal fluid (CSF) circulation, and to find out primarily if a regular practice of 8-week yoga breathing would enhance CSF…
- Trial name
- CSF (NCT03858309)
- Testing
- Breathing Group 1, Breathing Group 2
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Surgery, Hypoventilation
A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement Techniques
The estimation of the partial pressure of carbon dioxide (PCO2) in the arterial blood is used to judge the adequacy of ventilation during spontaneous and controlled ventilation.
- Trial name
- NCT00954733
- Testing
- Arterial blood draw
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Oxygen Deficiency, Desaturation of Blood
THRIVE Use in Pediatric Populations- Multi Site
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT04322994
- Testing
- Transnasal Humidified Rapid-Insufflation Ventilatory Echange
- Where
- 5 sites in United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Adults, Stress
Breathing Interventions for Relaxation: Dosing Through Extended Exhale
Breathing exercises are categorized as a mind-body practice. One in ten adults in the U.S. use breathing exercises for health purposes.
- Trial name
- NCT02870868
- Testing
- Slow breathing
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Uncontrolled Partial Epilepsy, Ictal Hypoventilation
Efficacy of Fluoxetine in Reducing Ictal Hypoventilation in Patients With Partial Epilepsy
The purpose of this study is to determine the effects of fluoxetine on breathing mechanisms during seizures. Patients with partial epilepsy commonly have changes in their breathing mechanisms during seizures.
- Trial name
- NCT00986310
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, Davis
Respiratory Insufficiency, Obesity Hypoventilation Syndrome
Juno Perth Clinical Trial
This study is to evaluate the efficacy of a new therapy (Automatic Expiratory Positive Airway Pressure with intelligent Volume Assured Pressure Support (AutoEPAP iVAPS)) designed to treat respiratory insufficiency, respiratory…
- Conditions
- Respiratory Insufficiency, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Disease
- Trial name
- NCT02317042
- Testing
- Juno
- Where
- 2 sites in Australia
- Volunteers
- 25 people
- Sponsor
- ResMed
Respiratory Failure
NAVA Versus BiPAP Non-Invasive Respiratory Support in Infants Following Congenital Heart Surgery
Pediatric patients often require prolonged mechanical ventilation after cardiac surgery which comes with many undesirable effects.
- Trial name
- NAVA (NCT03180385)
- Testing
- Neurally-Adusted Ventilatory Assist (NAVA), Biphasic Positive Airway Pressure Support (BiPAP)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Spinal Cord Injuries, Slow Breathing
Slow Yogic-Derived Breathing and Respiration and Cardiovascular Variability in Spinal Cord Injury Patients
This research will aid in understanding of slow-breathing and its effect on heart rate and blood pressure in people with a spinal cord injury (SCI).
- Trial name
- SCOGA (NCT05480618)
- Testing
- Slow Breathing
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Spaulding Rehabilitation Hospital
Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease
Clinical Stabilization of Hypercapnia: NIPPV v HVNI
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation [NIPPV].
- Conditions
- Hypercapnic Respiratory Failure, Chronic Obstructive Pulmonary Disease, Dyspnea, Hypercapnic Acidosis
- Trial name
- HYPERACT (NCT04709562)
- Testing
- High Velocity Nasal Insufflation (HVNI), Noninvasive Positive Pressure Ventilation (NIPPV)
- Where
- 7 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Vapotherm, Inc.
Nocturnal Hypoventilation, Neuromuscular Disease
Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed Patients
The aim of the study is to compare the efficacy and tolerance of autotitrating non-invasive ventilation (NIV) versus standard NIV in patients with newly diagnosed nocturnal hypoventilation who have never experienced nocturnal…
- Conditions
- Nocturnal Hypoventilation, Neuromuscular Disease, Chest Wall Disorder
- Trial name
- NCT00901485
- Testing
- AutoVPAP, VPAPIIIST-A
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- ResMed
Oxygen Deficiency, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Procedures
THRIVE (Transnasal Humidified Rapid-Insufflation Ventilatory Exchange) refers to the use of high-flow nasal cannula to augment the ability to oxygenate and ventilate a patient under general anesthesia.
- Conditions
- Oxygen Deficiency, Desaturation of Blood, Hypoventilation, Anesthesia; Adverse Effect
- Trial name
- NCT03430206
- Testing
- High-flow nasal cannula
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Stanford University
Hypoventilation, Hypoxia
Using Capnography to Reduce Hypoxia During Pediatric Sedation
The investigators hypothesize that the addition of capnography during moderate sedation will improve recognition of hypoventilation and apnea.
- Trial name
- NCT01463527
- Testing
- Nellcor NPB-70 Capnograph
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Yale University
Obesity Hypoventilation Syndrome
AVAPS-AE Efficacy Study
The purpose of this study is to evaluate the feasibility of using of the Average Volume Assured Pressure Support (AVAPS-AE) mode versus Continuous Positive Airway Pressure (CPAP) and bilevel pressure support ventilation (PSV)…
- Trial name
- NCT01368614
- Testing
- AVAPS-AE Mode of Therapy, Respironics OnmiLab BiPAP S mode, Respironics OmniLab Advanced CPAP mode
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Philips Respironics
Respiratory Insufficiency, Sleep Disordered Breathing
Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm
The aim of the study is to test the hypothesis that an automated algorithm for desired mask pressure improves breathing pattern and sleep quality in patients with hypercapnic ventilatory failure.
- Trial name
- NCT01403584
- Testing
- AutoVPAP with addition of AutoEPAP, AutoVPAP with EPAP manually selected
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- ResMed
Respiratory Depression, Respiratory Failure
Assessment of a Oral Endotracheal Tube Fastener on Patients Intubated With Oral Endotracheal Tubes
Assessment of AnchorFast Guard Oral Endotracheal Tube Fastener on Patients Intubated with Oral Endotracheal Tubes with Subglottic Suction
- Conditions
- Respiratory Depression, Respiratory Failure, Ventilatory Depression
- Trial name
- NCT02760927
- Testing
- Endotracheal Tube Fastener
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Hollister Incorporated
Hypoventilation
Ketamine Infusion and Hypoventilation
Procedures performed under sedation have the same severity in regards to morbidity and mortality as procedures performed under general anesthesia1.
- Trial name
- NCT01535976
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwestern University
Respiration Disorder, Respiratory Failure
Impact of the Inspiratory Cortical Control on the Outcome of the Ventilatory Weaning Test in Patients Intubated in Resuscitation
In case of respiratory distress, patients are intubated to be connected to an artificial respirator to ensure gas exchanges. Before any ventilatory weaning, a breathing test in spontaneous ventilation under artificial nose is…
- Conditions
- Respiration Disorder, Respiratory Failure, Weaning Failure, Respiratory Compensation
- Trial name
- NCT03372252
- Testing
- Electroencephalography
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Poitiers University Hospital
Hypercapnia, Respiratory Insufficiency
Extracorporeal Lung Assist to Avoid Intubation in Patients Failing Noninvasive Ventilation for Hypercapnic ARF
The study´s intention is to evaluate the feasibility, safety and effectiveness of a pump driven extracorporeal device for removal of carbon dioxide from the blood in oder to avoid intubation and invasive mechanical ventilation in…
- Trial name
- ECLAIR (NCT01784367)
- Testing
- vv-ECCO2R (Novalung GmbH, Germany)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf