Clinical trials: Ventricular
Heart Defects, Congenital
Long-term Survival After Single-ventricle Palliation
A nationwide observational study. Children operated with single-ventricle palliation between January 1994 and December 2017 operated in Sweden will be included retrospectively.
- Trial name
- NCT03356574
- Testing
- Single-ventricle palliation surgery
- Where
- 2 sites in Sweden
- Volunteers
- 800 people
- Sponsor
- Karolinska University Hospital
Aortic Valve Stenosis
Oxford - Fibrates in Aortic Stenosis
Aortic stenosis (AS) is characterised by left ventricular (LV) hypertrophy and altered myocardial substrate metabolism. Peroxisome proliferator-activated receptor (PPARα), a regulator of lipid metabolism is deactivated in…
- Trial name
- OxFAST (NCT05256758)
- Testing
- Fenofibrate Capsules, Placental Lactogen
- Where
- United Kingdom
- Volunteers
- 67 people
- Sponsor
- University of Oxford
Pulmonary Regurgitation, Pulmonary Insufficiency
Pulmonic Valve REplacement Multi-discIpline EMEA Registry
The purpose of this registry is to retrospectively and prospectively obtain clinical data in consecutively treated patients, in order to demonstrate that the commercially available Edwards SAPIEN Valve with the RF3 delivery…
- Conditions
- Pulmonary Regurgitation, Pulmonary Insufficiency, Pulmonary Stenosis
- Trial name
- PREMIER (NCT01356108)
- Testing
- Transcatheter Pulmonic Valve Replacement (TPVR) (Edwards SAPIEN™ THV)
- Where
- 16 sites in Belgium, Germany and 7 more
- Volunteers
- 127 people
- Sponsor
- Edwards Lifesciences
Atrial Fibrillation, Ischemic Ventricular Tachycardia
Study of a New Catheter Using Force Sensing Capabilities for the Treatment of Atrial Fibrillation and Ventricular Tachycardia
The purpose of this study is to study the treatment of Atrial Fibrillation and ischemic Ventricular Tachycardia using a RF ablation catheter with contact force sensing capabilities.
- Trial name
- EZCF-125 (NCT01032317)
- Testing
- Radiofrequency Catheter Ablation
- Where
- Czechia
- Volunteers
- 22 people
- Sponsor
- Biosense Webster, Inc.
Low-gradient Aortic Stenosis, Aortic Stenosis
AI Assessment of Low-Gradient Aortic Stenosis Severity Based on Echocardiography
The purpose of this study is to evaluate the effectiveness of an artificial intelligence (AI) model developed by the investigators for identifying severe low-gradient aortic valve stenosis.
- Trial name
- ASAI-POL (NCT07144189)
- Testing
- AI diagnostic test for severe low-gradient aortic stenosis
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Death, Sudden, Cardiac, Ventricular Fibrillation
Failure of Chronically Implanted Defibrillator Leads -Incidence and Management
Comparison of two different approaches to address the problem of malfunctioning ICD-leads. These leads consist of two parts. One that is used for detection of arrhythmias(and pacing if required) (Pace/Sense) and a second part…
- Trial name
- NCT00614718
- Where
- 3 sites in Germany, Switzerland
- Volunteers
- 1,317 people
- Sponsor
- University Hospital, Basel, Switzerland
Heart Failure, Ventricular Dysfunction
Austrian Wearable Cardioverter Defibrillator Registry
Background: The wearable cardioverter defibrillator (WCD) is an established treatment option for patients at high risk for ventricular tachycardia / ventricular fibrillation (VT/VF), either in whom this risk may only be…
- Conditions
- Heart Failure, Ventricular Dysfunction, Sudden Death, Sudden Cardiac Arrest
- Trial name
- NCT02816047
- Testing
- Registry
- Where
- Austria
- Volunteers
- 450 people
- Sponsor
- Medical University of Graz
Aortic Stenosis
Biological Factors Associated With Subclinical Valvular Thrombosis
A prospective, multicentric cohort study including 166 patients with symptomatic aortic stenosis treated with transcatheter aortic valve implantation (TAVI).
- Trial name
- START (NCT03847948)
- Testing
- CT SCAN
- Where
- 2 sites in Spain
- Volunteers
- 166 people
- Sponsor
- Hospital San Carlos, Madrid
Aortic Stenosis
Conscious Sedation vs General Anesthesia in TAVR Patients
This is a randomized controlled trial investigating the effect of general anesthesia versus conscious sedation on operative times in patients undergoing transcatheter aortic valve replacement.
- Trial name
- NCT03084978
- Testing
- General Anesthesia, Conscious Sedation
- Sponsor
- Montefiore Medical Center
Ventricular Tachycardia
Stereotaxis Idiopathic Ventricular Tachycardia (VT) Study
This study will assess the outcomes of using magnetic navigation to treat ventricular tachycardia (VT) or premature ventricular contractions (PVCs) that occur for unknown reasons and are not related to structural heart disease.
- Trial name
- NCT01401608
- Testing
- RF Ablation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stereotaxis
Aortic Stenosis Disease
Impact of Enhanced Information on Subjective Information Level and PROMs in Patients with Aortic Stenosis
The aim of this trial is to evaluate if an enhanced information by using a mobile App can increase subjective information level in patients with severe aortic stenosis and may therefore improve patient-reported outcomes.
- Trial name
- TAVI-SDM-APP (NCT06706635)
- Testing
- Application of App
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation
A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter
The purpose of this study is to assess the safety and feasibility of the investigational catheter for mapping the atrial and ventricular regions of the heart.
- Conditions
- Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Ventricular Tachycardia
- Trial name
- FEATHER (NCT07116525)
- Testing
- Paddle-Shaped, High-Density, Multi-Electrode Mapping Catheter
- Where
- 5 sites in Belgium, France and 1 more
- Volunteers
- 90 people
- Sponsor
- Biosense Webster, Inc.
Metabolic Syndrome, Insulin-resistance
Metabolic and Cardiovascular Effects of Armolipid Plus in Subjects With Metabolic Syndrome
Aim of the study is to evaluate the effects of Armolipid Plus on insulin sensitivity in patients with MetS and increased LV mass.
- Conditions
- Metabolic Syndrome, Insulin-resistance, Left Ventricular Hypertrophy
- Trial name
- ARMP-11 (NCT02295176)
- Testing
- Armolipid Plus
- Where
- 3 sites in Italy
- Volunteers
- 159 people
- Sponsor
- Rottapharm
Paroxysmal Supraventricular Tachycardia
Radiofrequency Ablation of Paroxysmal Supraventricular Tachycardia Using a Novel Catheter Equipped With Mini Electrodes
Paroxysmal supraventricular tachycardia is treated with radiofrequency ablation recently. This procedure is performed by ablating slow pathway or accessory pathway using radiofrequency ablation catheter.
- Trial name
- NCT04215640
- Testing
- Microfidelity (MIFI) catheter, Conventional ablation catheter
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Yong Seog Oh
Pulmonary Arterial Hypertension
Goal Oriented Strategy to Preserve Ejection Fraction Trial
In this prospective long term feasibility study we examine whether a goal oriented therapeutic strategy that is able to preserve right ventricular function will result in improved clinical outcome in patients with pulmonary…
- Trial name
- GOSPEL (NCT03236818)
- Testing
- ERA and PDE-5I (Sildenafil, Tadalafil, Bosentan, Macitentan)
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Amsterdam UMC, location VUmc
Sepsis
Prognostic Value of Right Ventricular-pulmonary Arterial Coupling Assessed by Echocardiography in Septic Patients
Sepsis and septic shock are common clinical conditions, representing a significant healthcare challenge due to their high mortality rates and increasing incidence.
- Trial name
- NCT06887140
- Testing
- Echocardiography
- Where
- Vietnam
- Volunteers
- 215 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Ventricular Tachycardia (VT)
Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of Ventricular Tachycardia (Sphere-9 VT EFS)
Sphere-9 VT EFS is a prospective, multi-center, non-randomized, unblinded feasibility study. Adult subjects with recurrent, sustained, scar-related monomorphic ventricular tachycardia will be enrolled and treated with the…
- Trial name
- NCT06703489
- Testing
- Sphere-9 Catheter with the Affera Mapping and Ablation System
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Coronary Disease
Real Time 3-Dimensional Stress Echocardiography
An echocardiogram is an ultrasound technique used to gather information about the heart. Standard echocardiograms create images of the heart in two dimensions, thereby named 2D (two-dimensional) echocardiography.
- Trial name
- NCT00001886
- Testing
- Real time 3-dimensional stress echocardiography
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Valve Stenosis
Transcaval Access for Transcatheter Aortic Valve Replacement in People With No Good Options for Aortic Access
Background: Some people who need a transcatheter aortic valve replacement (TAVR) have leg arteries that are too small and are too sick for standard techniques. But they may benefit from a new technique called transcaval TAVR.
- Trial name
- NCT02280824
- Testing
- CA-TAVR, Amplatzer Duct Occluder
- Where
- 15 sites in United States
- Volunteers
- 172 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Kidney Disease
Acute Effects of Cinacalcet on Arterial Stiffness and Ventricular Function in Hemodialysis Patients
The primary objective is to determine whether reduction of serum calcium concentration by cinacalcet leads to reduction of mean blood pressure adjusted c-fPWV.
- Trial name
- ECIRA (NCT01250405)
- Testing
- Cinacalcet
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Laval University
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