Clinical trials: Ventricular
Heart Failure
Right Ventricular Function and Exercise Capacity in Patients With Continuous-flow Left Ventricular Assist Devices
Exercise capacity in continous-flow left ventricular assist device (CF-LVAD) patients remains severely reduced post-implant. While the effect of right ventricular (RV) failure early after pump implantation, and its effect on…
- Trial name
- NCT02658136
- Testing
- Cardiac Computed tomography
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Finn Gustafsson
Cardiovascular Diseases
Clinical Study of CMR to Evaluate the Effect of Ivabradine on the Improvement of Left Ventricular Remodeling in STEMI Patients After Primary PCI
This study aim to investigate the effect of ivabradine on reducing infarct size and improving left ventricular remodeling after in patients undergoing primary PCI for ST-elevation myocardial infarction through myocardial enhanced…
- Trial name
- NCT05348057
- Testing
- Ivabradine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Qian geng
Ventricular Tachycardia
REnal Sympathetic dEnervaTion as an a Adjunct to Catheter-based VT Ablation
Despite significant advances in the management of ventricular arrhythmias through the use of ICD therapy, AADs, and catheter-based ablation strategies, considerable challenges remain.
- Trial name
- RESET-VT (NCT01858194)
- Testing
- Renal sympathetic denervation, VT ablation alone
- Where
- 2 sites in United States, Czechia
- Volunteers
- 21 people
- Sponsor
- Vivek Reddy
Primary Hypertension
Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease
The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension.
- Trial name
- NCT00865501
- Testing
- spironolactone
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Heart Diseases, Ventricular Arrhythmia
Prognostic Significance of T Wave Alternans
To evaluate whether T Wave Alternans can predict ventricular arrhythmias and sudden cardiac death (SCD) in a prospective epidemiologic natural history study.
- Conditions
- Heart Diseases, Ventricular Arrhythmia, Ventricular Fibrillation, Death, Sudden, Cardiac
- Trial name
- NCT00006501
- Testing
- ECG
- Where
- United States
- Volunteers
- 549 people
- Sponsor
- Columbia University
Wound Contamination
Prospective Randomised Study for Use of CHG Dressing at Entry Site of EVD's to Reduce EVD-associated Infections
The objective of this study is to assess the efficacy of 3M™ Tegaderm™ CHG I.V. Securement Dressing at the entry-site of a EVD in reducing quantity of microorganisms (CFU/cm2) after a time period of 5 days as a surrogate marker…
- Trial name
- EVDAI (NCT02078830)
- Testing
- 3M™ Tegaderm™ CHG I.V. Securement Dressing
- Where
- Switzerland
- Volunteers
- 57 people
- Sponsor
- University Hospital, Basel, Switzerland
Pulmonary Hypertension, Ventricular Function
Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension
The aim of the present study is to identify changes in the cardiovascular system in patients with pulmonary hypertension (PH) by magnetic resonance imaging (MRI).
- Conditions
- Pulmonary Hypertension, Ventricular Function, MR Phase Contrast Velocity Imaging, Late Enhancement Patterns
- Trial name
- NCT00575692
- Where
- Austria
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Coronary Artery Stenoses, Aortic Stenosis
A Prospective Study of Fractional Flow Reserve Assessment of Intermediate Coronary Stenoses in Severe Aortic Stenosis
Coronary artery blockages can reduce blood flow to the heart muscle. Fractional flow reserve (iFR or FFR) assessment is an invasive tool used to determine how much blood flow is reduced.
- Trial name
- NCT03442400
- Testing
- Volcano iFR/FFR Verrata Plus coronary pressure/flow wire
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The Cleveland Clinic
Chronic Renal Failure
EPO-BUL-01 - Study of the Optimization of Anemia Management of EPREX (Epoetin Alfa) in Predialysis Patients With Chronic Renal Failure
The purpose of the study is to evaluate the effectiveness, safety and clinical outcome of Epoetin alfa with dosing regime in accordance with Summary of Product Characteristics in the treatment of anemia in predialysis.
- Trial name
- NCT00338000
- Testing
- Epoetin alfa
- Volunteers
- 292 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Cardiovascular Diseases, Heart Diseases
Medications and the Risk of Sudden Cardiac Death
To investigate a potential relationship between four different classes of non-cardiovascular drugs and the risk of sudden cardiac death.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Death, Sudden, Cardiac, Ventricular Fibrillation
- Trial name
- NCT00241800
- Volunteers
- 1,200 people
- Sponsor
- Vanderbilt University Medical Center
Hypertrophic Obstructive Cardiomyopathy
The Effect of TASH in Patients With HOCM
To examine patients with hypertrophic obstructive cardiomyopathy (HOCM) before and after septal alcohol ablation, to investigate the effect of the treatment in regards to changes in myocardial function, perfusion, invasive…
- Trial name
- Post-TASH (NCT04066777)
- Testing
- alcohol septal ablation
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steen Hvitfeldt Poulsen
Heart Failure, Congestive
Reversal of Ventricular Remodeling With Toprol-XL
The purpose of this study is to determine whether treatment with Toprol-XL for 12 months in asymptomatic heart failure subjects will improve their heart structure and thus prevent the progression to symptomatic disease.
- Trial name
- NCT00038077
- Testing
- Seloken ZOK/Toprol-XL
- Where
- 44 sites in United States
- Volunteers
- 300 people
- Sponsor
- AstraZeneca
Coronary Arteriosclerosis, Heart Failure, Congestive
Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study)
Viability assessment remains a clinical challenge in patient with coronary artery disease and left ventricular dysfunction. Several imaging modalities are available for evaluating myocardial viability, based either on perfusion…
- Conditions
- Coronary Arteriosclerosis, Heart Failure, Congestive, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT00213746
- Where
- 8 sites in Belgium, France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Rouen
COPD, Pulmonary Vascular Disorder
Pulmonary Vasculature and Right Heart Dysfunction in Chronic Obstructive Pulmonay Disease
The pulmonary vasculopathy and right heart dysfunction in COPD are drawing increasing attention these days. Recent researches show that pulmonary vasculopathy and right heart dysfunction relate to greater severity in COPD.
- Conditions
- COPD, Pulmonary Vascular Disorder, Right Ventricular Dysfunction
- Trial name
- NCT03184727
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Ventricular Septal Defect
Immune Heterogeneity Before and After Cardiopulmonary Bypass in Children
The goal of this observational study is to learn about functional heterogeneity of immune cells before and after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD).
- Trial name
- NCT06214182
- Where
- China
- Volunteers
- 3 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Hypertension
Clinical Efficacy of Telmisartan in Reducing Cardiac Remodeling Among Obese Patients With Hypertension
Hypertension is closely related to metabolic abnormalities such as obesity, dyslipidemia and diabetes. When hypertension is complicated with metabolic abnormalities, target organ damage is more serious, the risk of cardiovascular…
- Trial name
- NCT03956823
- Testing
- telmisartan, amlodipine
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Stem Cell Transplantation
The Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis Pilot Study (The POSEIDON-Pilot Study)
The technique of transplanting progenitor cells into a region of damaged myocardium, termed cellular cardiomyoplasty, is a potentially new therapeutic modality designed to replace or repair necrotic, scarred, or dysfunctional…
- Trial name
- NCT01087996
- Testing
- Auto-hMSCs, Allo-hMSCs
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Miami
Torsades de Pointe Caused by Drug (Disorder), Torsades de Pointes
Pharmacist Use of ECG to Inform Drug Therapy Decisions for Patients Receiving QT Prolonging Medications
Torsade de pointes (TdP) is a cardiac arrhythmia associated with QT interval prolongation which may lead to cardiac arrest. Prescription medications which cause QT interval prolongation are commonly used in daily practice.
- Conditions
- Torsades de Pointe Caused by Drug (Disorder), Torsades de Pointes, Qt Interval, Variation in
- Trial name
- NCT04000542
- Testing
- Pharmacist Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northeast Iowa Medical Education Foundation
Muscular, Ventricular
Emergency/Compassionate Use - Muscular VSD Occluder
Expanded access to the AMPLATZER Muscular VSD Occluder
- Conditions
- Muscular, Ventricular, Septal, Defects
- Trial name
- NCT00590382
- Testing
- AMPLATZER Muscular VSD Occluder
- Sponsor
- Abbott Medical Devices
Myocarditis, Ventricular Arrythmia
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management
Myocarditis is a complex inflammatory disease, usually occurring secondary to viral infections, autoimmune processes or toxic agents.
- Conditions
- Myocarditis, Ventricular Arrythmia, Inflammatory Cardiomyopathy, Genetic Predisposition
- Trial name
- MYOCAR (NCT04521790)
- Testing
- support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Scientific Institute San Raffaele
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