Clinical trials: Ventricular
Ventricular Fibrillation
VERRARI - "Are Ventricular Arrhythmic Episodes Reduced by Rate Response in ICDs?"
"The purpose of this study is to evaluate the influence of the rate response function of implantable cardioverter defibrillators (ICDs) on the frequency of ventricular arrhythmias in patients with an ICD."
- Trial name
- NCT00180427
- Testing
- ICD
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Guidant Corporation
Ventricular Tachycardia, ICD
Improving Patient Reported Outcome Measures in Catheter Ablation
This study will assess whether more frequent measurement of patient reported outcome measures (PROMs) - specifically health related quality of life (HRQL) - can improve the evaluation of the clinical effectiveness and…
- Conditions
- Ventricular Tachycardia, ICD, Quality of Life
- Trial name
- NCT04499326
- Testing
- Validated quality of life questionnaire (EQ-5D & C-CAP)
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Barts & The London NHS Trust
Heart Failure, Photoplethysmography
Seerlinq: Non-invasive LVFP Monitoring in HF
Left ventricular filling pressure (LVFP) monitoring has been associated with improved quality of life, survival and reduced hospitalization rates.
- Conditions
- Heart Failure, Photoplethysmography, Right Heart Catheterization
- Trial name
- PPG-HF (NCT06649435)
- Testing
- PPG measurement
- Where
- Slovakia
- Volunteers
- 131 people
- Sponsor
- Seerlinq s. r. o.
Heart Valve Diseases
Clinical Investigation of the Freedom SOLO Stentless Heart Valve
This is a trial to demonstrate the safety and effectiveness of the Freedom SOLO heart valve when used to replace a diseased or dysfunctional aortic valve or aortic valve prosthesis.
- Trial name
- NCT00876525
- Testing
- Surgical Replacement of the diseased native aortic heart valve with the Freedom SOLO Valve prosthesis
- Where
- 19 sites in Austria, Belgium and 6 more
- Volunteers
- 702 people
- Sponsor
- Corcym S.r.l
Monomorphic Ventricular Tachycardia, Myocardial Infarction
Using Ripple Mapping to Guide Substrate Ablation of Scar Related Ventricular Tachycardia.
The heart beat is controlled by electrical signals. Following a heart attack, part of the heart muscle dies and is later replaced by scar tissue.
- Conditions
- Monomorphic Ventricular Tachycardia, Myocardial Infarction, Dilated Cardiomyopathy
- Trial name
- Ripple-VT (NCT02216760)
- Testing
- Ripple Mapping guided VT ablation, Conventional VT ablation
- Where
- United Kingdom
- Sponsor
- Imperial College London
Aortic Valve Stenosis
Direct Left Ventricular Rapid Pacing Via the Valve Delivery Guide-wire in TAVI
The purpose of this study is to determine whether a left ventricular rapid pacing using the valve delivery guide-wire in transcatheter aortic valve implantation (TAVI) reduces the overall procedure duration in comparison with the…
- Trial name
- EASY TAVI (NCT02781896)
- Testing
- pacing catheter, valve delivery guidewire
- Where
- 9 sites in France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Mutualiste de Grenoble
Myocardial Bridge of Coronary Artery
Correlates of Left Ventricular Global Longitudinal Strain and Surgical Intervention on Myocardial Bridges
To examine the changes in left ventricular (LV) global longitudinal strain (GLS), using two-dimensional speckle tracking analysis, after left anterior descending (LAD) unroofing, in myocardial bridges (MBs) refractory to optimal…
- Trial name
- NCT04082546
- Testing
- Surgical unroofing of muscle-briged coronary artery
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Coronary Artery Disease, Aortic Valve Stenosis
Comparative Analysis of the Microcirculation During Cardiac Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the proposed study is to evaluate microcirculatory alterations in patients undergoing open heart surgery with minimal invasive versus conventional extracorporeal circulation.
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Mitral Disease
- Trial name
- NCT05479188
- Testing
- Sublingual microscopy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Aortic Valve Stenosis, Myocardial Fibrosis
Echocardiography Findings in Patients With Myocardial Fibrosis and Severe Aortic Stenosis
Patients with aortic stenosis waiting for aortic valve repair were investigated with echocardiography preoperatively, and a myocardial biospy was taken during the operation.
- Trial name
- SAS-fibrosis (NCT07331116)
- Testing
- Transthoracic echocardiography, Cardiac magnetic resonance imaging
- Where
- Norway
- Volunteers
- 22 people
- Sponsor
- Norwegian University of Science and Technology
Pediatric Disorder, Pediatric Obesity
Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
Pediatric primary hypertension is increasingly common, occurring in 5-10% of normal-weight children and up to 25% of children with obesity. It is a risk factor for adult cardiovascular and renal disease.
- Conditions
- Pediatric Disorder, Pediatric Obesity, Primary Hypertension
- Trial name
- PHRAS (NCT03310684)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mitral Valve Prolapse, Left Ventricular Fibrosis
PRIMARY Ancillary Substudy
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological…
- Conditions
- Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
- Trial name
- NCT07103733
- Testing
- Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy
- Where
- 25 sites in United States, Germany and 1 more
- Volunteers
- 250 people
- Sponsor
- Annetine Gelijns
Right Ventricular Dysfunction, Cardiac Arrest
Emergency Department Assessment of Right Ventricular Function and Size in the Post Cardiac Arrest Patient
The right side of the heart of often overlooked in patients who are acutely unwell, as the main area of focus when performing echocardiography tends to be the left ventricle.
- Trial name
- NCT03309852
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Manitoba
Left Ventricular Function Systolic Dysfunction
Pacemaker Upgrade to Cardiac Resynchronisation Therapy in Patients With Left Ventricular Dysfunction Dependant Upon Right Ventricular Pacing
Patients with pacemakers often have undiagnosed heart muscle weakness. When a pacemaker battery has run down, it is easily replaced by a short procedure.
- Trial name
- PRE-Empt (NCT01652248)
- Testing
- Cardiac resynchronisation therapy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Leeds
Parkinson's Disease
Precise Transplantation of hAESCs Into the Ventricle for Parkinson's Disease.
The purpose of this study is to evaluate the safety of multiple treatments of hAESCs treatments, while exploring the effectiveness of hAESCs treatments for PD.
- Trial name
- NCT05435755
- Testing
- hAESCs treatment
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Shanghai East Hospital
Congestive Heart Failure, Insulin Resistance
Metformin in Insulin Resistant Left Ventricular (LV) Dysfunction (TAYSIDE Trial)
Will metformin improve exercise capacity in chronic heart failure patients who has insulin resistance (pre-diabetic- means before they become diabetic)?
- Trial name
- TAYSIDE (NCT00473876)
- Testing
- Metformin
- Where
- United Kingdom
- Volunteers
- 62 people
- Sponsor
- University of Dundee
Kidney Failure, Hemodialysis
SGLT2 Inhibition in Hemodialysis
Dapagliflozin will be compared with placebo to evaluate its effects on cardiac structure and safety in patients with kidney failure receiving maintenance hemodialysis.
- Conditions
- Kidney Failure, Hemodialysis, Diabetes Mellitus, Type 2, Chronic Kidney Disease
- Trial name
- DAPA-HD (NCT05179668)
- Testing
- Dapagliflozin 10 MG
- Where
- 9 sites in Austria
- Volunteers
- 220 people
- Sponsor
- Medical University of Vienna
Takotsubo Cardiomyopathy, Beta-blockers
Beta-Blockers in Takotsubo Syndrome Study
The Beta-blockers in Takotsubo syndrome (TTS) (β-Tako) trial, is an academic, pragmatic, prospective, multicenter randomized clinical trial, aiming to assess the efficacy of beta-blockers (BB) in TTS patients.
- Conditions
- Takotsubo Cardiomyopathy, Beta-blockers, Echocardiography, Left Ventricular Function
- Trial name
- β-Tako (NCT06509074)
- Testing
- Beta blocker
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Cardiology
ST Elevation Myocardial Infarction, Arrhythmia Ventricular
Different Reperfusion Timing and Ventricular Arrhythmias in STEMI Patients
The aim of this study was to investigate the association between different reperfusion timing and ventricular arrhythmias (VAs) to provide evidence for clinical decision-making for patients with ST-segment elevation myocardial…
- Trial name
- NCT04660474
- Where
- China
- Volunteers
- 517 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Ventricular Tachycardia
Cardiac RadiothErapy for VEntricular Tachycardia
Objective: To explore in our center the feasibility and safety of a SBRT treatment method for VT. Study population: Patients with ventricular tachycardia that are refractory to dose-escalated antiarrhythmic drugs and where…
- Trial name
- CREVET (NCT05973578)
- Testing
- Stereotactic radiotherapy
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Aortic Valve Stenosis
A Registry to Evaluate the Direct Flow Medical Transcatheter Aortic Valve System
The purpose of this postmarket Registry is to assess the standard of care and clinical outcomes of the Direct Flow Medical Transcatheter Aortic Valve System used in clinical routine according to the approved commercial…
- Trial name
- DISCOVER (NCT01845285)
- Testing
- Aortic Valve Replacement
- Where
- 2 sites in Germany, Italy
- Volunteers
- 1,000 people
- Sponsor
- Direct Flow Medical, Inc.
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